4D Radar Imaging and Camera Fusion for Road Crossing Detection and Classification Using Deep Learning by Liyaana Shahirah Wan Abd Aziz, Farah Nadia Mohd Isa, Faridah Abd Rahman, Arvind Hari Narayanan, Ahmad Reza Alghooneh, George Shaker

“…Two road-crossing scenes were simulated to collect data, generating a point cloud dataset labeled with target classes for neural network training and testing. …”
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A qualitative study of stigma among disabled elders with stroke and their primary caregivers (脑卒中失能老人及其主要照顾者病耻感的质性研究) by KE Ke (柯珂), HE Juanfeng (贺娟凤), WANG Wei (汪维)

“…Results By analyzing and sorting out the data, 3 themes and 9 sub-themes related to the experience of stigma were put forward: cognitive attribution (label recognition, abnormal behavior, attitudes of others, lack of social support), negative emotional response (guilt and remorse, anomaly discrimination, belief in suicide) and non-adaptive coping style (social withdrawal, conceal illness). …”
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Impact of iron chelation with deferasirox on telomere length and oxidative stress in hemodialysis patients: A randomized study by Blanca Olivia Murillo Ortiz, Joel Ramírez Emiliano, Marcos Javier Romero Vázquez, Lauro Fabián Amador Medina, Sandra Martínez Garza, Edna Montserrat Ramos Rodríguez

“…Methods: This is an open-label study, with a control group of patients undergoing hemodialysis, who will receive treatment with deferasirox 15 mg/kg/day for 6 months for iron chelation. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…[xx] Low-income Medicaid patients are 2.6 times more likely to be labelled non-compliant as privately insured patients.…”
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Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease by Zhen Zhu, Guangxin Luan, Song Wu, Yiyi Song, Shuang Shen, Kaiyue Wu, Shengnan Qian, Weiping Jia, Jun Yin, Tao Ren, Jianping Ye, Li Wei

“…Detection of autophagic flux in cells by transfecting Ad-mCherry-GFP-LC3B dual fluorescence labeled adenovirus. Various fluorescent probes and energy detector are used to detect mitochondrial apoptosis, ROS, and respiration of mitochondrion. …”
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Safety of a co-designed cognitive behavioural therapy intervention for people with type 1 diabetes and eating disorders (STEADY): a feasibility randomised controlled trialResearch... by Marietta Stadler, Natalie Zaremba, Amy Harrison, Jennie Brown, Divina Pillay, Jacqueline Allan, Rachael Tan, Salma Ayis, Emmanouela Konstantara, Janet Treasure, David Hopkins, Khalida Ismail

“…Methods: Feasibility parallel-group, randomised (blocks of four) controlled open-label trial (RCT) of STEADY against usual care (Control) at King's College London, UK. …”
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Evaluation of long‐acting cabotegravir safety and pharmacokinetics in pregnant women in eastern and southern Africa: a secondary analysis of HPTN 084 by Sinead Delany‐Moretlwe, Brett Hanscom, Xu Guo, Clemensia Nkabiito, Patricia Mandima, Patricia Ntege Nahirya, Juliet Mpendo, Muchaneta Bhondai‐Mhuri, Nyaradzo Mgodi, Rebecca Berhanu, Jennifer Farrior, Estelle Piwowar‐Manning, Susan L. Ford, Craig W. Hendrix, Alex R. Rinehart, James F. Rooney, Adeola Adeyeye, Raphael J. Landovitz, Myron S. Cohen, Mina C. Hosseinipour, Mark A. Marzinke, the HPTN 084 Study Team

“…Pregnancy testing was performed at each visit; participants with a positive test had study product withheld and were offered open‐label TDF/FTC. Pregnancies were confirmed on two tests at least 4 weeks apart. …”
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Dynamics of Somatic and Comorbid Mental Disorders (Distress, Anxiety, Somatisation and Depression) in Patients with Irritable Bowel Syndrome during Therapy with Alimemazine: Result... by V. T. Ivashkin, O. Z. Okhlobystina, M. V. Mayevskaya, O. S. Shifrin, Z. A. Mamieva, Yu. E. Azimova

“…This study is aimed at investigating the efficacy and safety of alimemazine (Teraligen®) therapy in patients with irritable bowel syndrome (IBS) associated with comorbid mental disorders (distress, anxiety, somatisation and depression).Materials and methods. During an open-label, non-comparative and non-interventional study, 60 patients diagnosed with the K58 (K 58.0, K58.9) irritable bowel syndrome were observed (12 men and 48 women, average age 39.6 ± 11.1 years) and treated with Teraligen® (alimemazine) with a gradual dose increase from 2.5 to 15 mg per day against the background of the standard symptomatic treatment used for such states. …”
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Topological Analysis of Brain Glucose Metabolic Connectivity Networks of Patients with Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment by LIANG Shengxiang, YANG Junchao, ZHANG Yusi, YIN Xiaolong, HUANG Li, LI Zuanfang

“…Using the cerebellum as reference area, standardized uptake value ratio (SUVR) of the anatomical automatic labeling (AAL) module brain regions of each subject was extracted to construct the glucose metabolism connectivity brain network. …”
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Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study by Chenyu Mao, Anwen Xiong, Jiong Qian, Wenxiang Wang, Ying Liu, Tao Zhang, Zhihai Wu, Haiqing Ni, Jia Lu, Sixiang Long, Li Zhao, Yuling Chen, Caicun Zhou, Nong Xu

“…Herein, we evaluate the safety and efficacy of IBI110 (anti-LAG-3 antibody) with sintilimab (an anti-PD-1 antibody) in Chinese patients with advanced solid tumors. Methods In this open-label phase I study, phase Ia dose escalation of IBI110 monotherapy and phase Ib combination dose escalation of IBI110 plus sintilimab were conducted in patients with advanced solid tumors. …”
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The efficacy of LASIK and secondary piggyback IOL implantation for the enhancement after cataract surgery by E.P. Gurmizov, K.B. Pershin, N.F. Pashinova, A.Yu. Tsygankov

“…</i> </p> <p> <i><b>Patients and Methods:</b> prospective open-label study included 74 patients (98 eyes) who underwent cataract surgery (53 eyes) or refractive lens exchange (45 eyes) with the implantation of various IOL models. …”
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Mechanism of Electroacupuncture at Baihui and Shenting Alleviating Cerebral Ischemia-reperfusion Injury via Regulating BNIP3L-Mediated Mitophagy by ZHONG Xiaoyong, LI Cheng, WANG Fang, CHEN Bin, LIANG Hui, RUAN Su

“…After 7 days of intervention, the left cerebral cortex tissue of each group was obtained, hematoxylin-eosin (HE) staining was used to observe the pathological changes of the brain tissue, the expression level of LC3-Ⅱ/LC3-Ⅰ protein was detected by Western blot, and the tissue immunofluorescence technology was applied to detect the expression and colocalization of mitophagy-related protein BNIP3L and SQSTM1 labeled. The TUNEL method detected the apoptosis rate of rat nerve cells in each group.Results1) The neurological scores of the rats in the operation group were significantly increased 2 hours after the MCAO, and the rats in the sham-operation group did not show symptoms of neurological deficit. …”
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The graded heat-health risk forecast and early warning with full-season coverage across China: a predicting model development and evaluation studyResearch in context by Qing Wang, Chen Chen, Huaiyue Xu, Yuanyuan Liu, Yu Zhong, Jing Liu, Menghan Wang, Mengxue Zhang, Yiting Liu, Jing Li, Tiantian Li

“…With its full-season coverage and graded warning levels for heat-related health risks, the HHSEW model and system can provide timely early warnings to the public, leading to significant health benefits. This methodology, labeled “full-season coverage and population health-oriented graded early-warning”, should be implemented globally to mitigate the escalating health risks associated with high temperature. …”
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FAP-targeted radioligand therapy with 68Ga/177Lu-DOTA-2P(FAPI)2 enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy by Liang Zhao, Long Sun, Kaili Fu, Qin Lin, Xiaoyuan Chen, Qicong Luo, Hua Wu, Jianhao Chen, Yangfan Zhou, Yizhen Pang, Guoqiang Su, Haojun Chen

“…However, further exploration is required to understand the therapeutic efficacy and underlying mechanisms of combining 68Ga/177Lu-DOTA-2P(FAPI)2 radioligand therapy with PD-1/PD-L1 immunotherapy.Methods Regarding the change in PD-L1 expression and DNA double-strand breaks induced by radiopharmaceuticals, CT26-FAP tumor cells were incubated with 68Ga and 177Lu labeled DOTA-2P(FAPI)2, respectively. Monotherapy with 68Ga-DOTA-2P(FAPI)2, 177Lu-DOTA-2P(FAPI)2, and PD-L1 immunotherapy as well as combination therapy (68Ga/177Lu-DOTA-2P(FAPI)2 and PD-L1 immunotherapy) were tested and evaluated to evaluate in vivo antitumor efficacy. …”
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Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial by David Coyle, Paula Ormandy, Nancy Fernandes da Silva, Simon Davies

“…Objectives This study aimed to develop an effective public and patient involvement participation model, ensuring that the patient voice was heard by the Trial Management Group, with a Patient Advisory Group undertaking coproduction of all participant-facing documents and communications, including dissemination of the trial results, with the main purpose of maximising participant engagement in the study. Design An open-label randomised controlled trial in which 439 participants from 34 centres were allocated for regular assessments of their bodily fluid content with or without the use of bioimpedance measurements. …”
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Effect of the Iridoid-rich Fraction from <italic>Valeriana jatamansi</italic> Jones on Oxidative Stress in Rats with Spinal Cord Injury by Jiaojuan HUANG, Wenchun WANG, Deqi XIONG, Hao LU, Wu XIANG, Xiaohua ZHAO, Ruihan ZHOU, Anren ZHANG

“…The rats were sacrificed on third days after administration, and the contents of oxidative stress indexes superoxide dismutase(SOD)and malondialdehyde(MDA)in serum were detected by enzyme linked immunosorbent assay(ELISA); the related biochemical kit was used to test glutathione peroxidase(GSH-PX)and catalase(CAT)viability of the spinal cord tissue; the expression levels of apoptosis-related proteins of Caspase-3, B cell lymphoma(Bcl-2)associated X protein(Bax), and Bcl-2 were detected by Western blot; and the Hematoxylin/eosin(HE)staining was used to observe the pathological changes of the spinal cord tissue at the perilesional area; and Terminal-deoxynucleoitidyl transferase mediated nick end labeling(TUNEL)was used to observe the apoptosis of nerve cells of the spinal cord tissue at the perilesional area.Results:The results of ELISA showed that compared with the sham-operated group, the SOD content in the serum of the model group decreased, and the MDA content increased; compared with the model group, the SOD content in the serum of the treatment group with iridoid-rich fraction from <italic>Valeriana jatamansi</italic> Jones increased significantly(<italic>P</italic>&lt; 0.05), and the MDA content decreased significantly(<italic>P</italic>&lt; 0.01). …”
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Cow Hoof Slippage Detecting Method Based on Enhanced DeepLabCut Model by NIAN Yue, ZHAO Kaixuan, JI Jiangtao

“…The RMSE between the predicted body key points and manually labeled points was only 2.99 pixels, with localization results for the right hind hoof, right front hoof, left hind hoof, left front hoof, and head improved by 12.1%, 44.9%, 0.04%, 48.2%, and 39.7%, respectively. …”
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Jiedu Xiaozheng Decoction Augments 5-fluorouracil Induced Anti-hepatic Carcinoma Effect <italic>in Vitro</italic> and <italic>in Vivo</italic> by Zhiyun CAO, Liangpu ZHENG, Wei LIN, Xuzheng CHEN, Xiaoqin ZHU, Jiumao LIN, Wei LIN, Jian DU

“…The apoptosis rate of tumor was evaluated by terminal dexynucleotidyl transferase(TdT)-mediated dUTP nick end labeling(TUNEL).Results：EE-JXD, 5-FU and EE-JXD+5-FU inhibited proliferation of HepG2 cells in a concentration-dependent manner. …”
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The Role of Iranians in Istanbul in Publishing and Distributing Modernist and Constitutionalist Texts by Mohammad Hossein Sadeghi, Hassan Hazrati

“…While the Ottoman government justified the ban on these texts for religious and political reasons, no document explicitly labeled these texts as containing constitutionalist ideas. …”
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Stage actor tracking method based on infrared ink marking(基于红外油墨标记的舞台演员跟踪算法) by 李平(LI Ping), 陈书界(CHEN Shujie), 王登辉(WANG Denghui), 刘钟淋(LIU Zhonglin), 王勋(WANG Xun), 周迪(ZHOU Di), 丁勇(DING Yong)

“…More specifically, the infrared ink marks are painted on actors' performance costumes in the form of binary ring codes. Then class labels of the ring codes are designated to associated actors as their identities for stable tracking. …”
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