tPA‐GFP is a reliable probe for detecting compound exocytosis in human pancreatic β‐cells by Aishwarya A. Makam, Shruti Sharma, Prajwal Nagle, Nandhini M. Sundaram, Vidya Mangala Prasad, Nikhil R. Gandasi

“…Here, we used two cargo proteins (NPY and tPA) labeled with different fluorescent proteins (mCherry GFP and eGFP) and employed total internal reflection fluorescence microscopy (TIRF‐M) to capture distinct single‐granule and multi‐granular fusion events. …”
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Inhibition of miR-182-5p Targets FGF9 to Alleviate Osteoarthritis by Yang Sun, Sanmao Su, Mengjun Li, Ang Deng

“…TdT-mediated dUTP nick-end labeling (TUNEL) assays were used to calculate the apoptosis rate of cartilage. …”
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The effect of an additional pre-extubational loading dose of caffeine citrate on mechanically ventilated preterm infants (NEOKOFF trial): Study protocol for a multicenter randomize... by Kinga Kovács, Rita Nagy, Lilla Andréka, Brigitta Teutsch, Miklós Szabó, Péter Varga, Péter Hegyi, Péter Hársfalvi, Nándor Ács, Ágnes Harmath, Csaba Nádor, Ákos Gasparics

“…<h4>Methods</h4>The study is an open-label, multicenter randomized clinical trial testing the effectiveness and safety of pre-extubational loading dose of caffeine citrate. …”
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R&D Expenditure and Innovation in the EU and Selected Member States by Radka MacGregor Pelikánová

“…Their selection is made by the motivation to be representative and to face the (alleged) cliché about EU member states labeled as “good” (DE, FR), “lazy” PIGS (PT, IT, GR, SP), leaving (GB), particular Scandinavian (DK, FI, SW) and central (AT, CZ, PL). …”
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SkelETT&#x2014;Skeleton-to-Emotion Transfer Transformer by Pedro Victor Vieira Paiva, Josue Junior Guimaraes Ramos, Marina Gavrilova, Marco Antonio Garcia de Carvalho

“…Following this foundational knowledge acquisition, the model undergoes fine-tuning on a smaller, labeled dataset tailored for emotion classification tasks. …”
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An In Vitro Model of Diabetic Retinal Vascular Endothelial Dysfunction and Neuroretinal Degeneration by Qiyun Wang, Xinyuan Zhang, Kaiyue Wang, Ling Zhu, Bingjie Qiu, Xiaosi Chen, Xiao Lin, Yao Nie

“…The VEGF expression was assessed by ELISA. RGCs were labeled by neurons and RGC markers TUJ1 and BRN3A for quantitative and morphological analysis. …”
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Non-inferiority study to compare the efficacy of relugolix with dienogest for endometriosis-associated pain and usefulness of administering relugolix prior to dienogest (READY stud... by Fuminori Taniguchi, Motoko Fukui, Yutaka Osuga, Tasuku Harada, Jo Kitawaki

“…Methods A multicenter, open-label, active-controlled, non-inferiority randomized study will be conducted at 11 sites in Japan. …”
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Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study by Shibo Guo MD, Zhehao Lyu PhD, Chunyu Duan MD, Hui Wang PhD, Peng Xu MD, Wei Han BD, Peng Fu PhD

“…Objective The study was to evaluate the diagnostic value of aluminium-[ 18 F]fuoride(Al 18 F)-labelled fibroblast activation protein inhibitor (FAPI) PET/computed tomography (CT) in AS and to investigate its ability to assess disease activity during the development of AS. …”
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Assessing CNN and Semantic Segmentation Models for Coarse Resolution Satellite Image Classification in Subcontinental Scale Land Cover Mapping by Tesfaye Adugna, Wenbo Xu, Jinlong Fan, Haitao Jia, Xin Luo

“…We utilized time-series, coarse resolution (1 km) composite imageries acquired by FengYun-3C visible and infrared radiometer. Labeled datasets were collected as shapefiles and split into three independent datasets: training, validation, and test datasets, and preprocessed to meet each model&#x0027;s input format requirements. …”
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Safety and Efficacy of Hydroxypropyl Guar-Hyaluronic Acid Dual-Polymer Lubricating Eye Drops in Indian Subjects with Dry Eye: A Phase IV Study by Deborah Awisi-Gyau, Neha Kapur, Rajesh Parekh, Umesh Yeddula, Shreesha Kumar Kodavoor

“…Methods This prospective, open-label, single-arm, phase IV study was conducted in India. …”
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Safety and tolerability of intramuscular sotrovimab administered at different injection sites: results from the Phase 1 COSMIC study by Jennifer Moore, Alicia Aylott, Wen-Hung Chen, Jerzy Daniluk, Ian A. Hawes, Sergio Parra, Prosenjit Sarkar, Yasmin Sanchez-Pearson, Megan Turner, Amanda Peppercorn, Andrew Skingsley

“…However, there is a paucity of data on IM tolerability by injection site to guide mAb development. This Phase 1, open-label trial randomized healthy adults to receive 62.5 mg/mL sotrovimab IM into each dorsogluteal muscle (2 × 4 mL injections), or 100 mg/mL sotrovimab IM into the dorsogluteal muscle (1 × 5 mL), the anterolateral thigh muscle (1 × 5 mL) or each deltoid muscle (2 × 2.5 mL). …”
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Long-term efficacy and safety of alemtuzumab in participants with highly active MS: TOPAZ clinical trial and interim analysis of TREAT-MS real-world study by Tjalf Ziemssen, Ann D. Bass, Bart Van Wijmeersch, Sara Eichau, Stephan Richter, Frank Hoffmann, Nicole M. Armstrong, Magdalena Chirieac, Janete Cunha-Santos, Barry A. Singer

“…Sustained efficacy up to 9 years was observed in the phase IIIb/IV open-label TOPAZ clinical trial and assessed in the real-world retrospective and prospective study, TREAT-MS. …”
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Microsatellite loci variability in apple cultivars developed at VIR by A. V. Shlyavas, A. A. Trifonova, I. S. Chepinoga, A. S. Sidnin, K. V. Boris

“…A set of 10 SSR markers (CH02c02b, CH03d01, CH01f03b, CH02d08, CH02c02a, CH05e03, CH02c09, CHVf1, CH01h01, COL) was used for genotyping 35 apple cultivars developed at VIR and four parental forms. Fluorescently labeled PCR products were separated by capillary electrophoresis on ABI Prism 3130xl.Results. …”
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Biologic Cost per Effectively Treated Rheumatoid Arthritis Patient in a Large Managed Care Population: A Retrospective Cohort Study by Tao Gu, Neel Shah, Gaurav Deshpande, Derek H. Tang, Debra F. Eisenberg, David J. Harrison

“…The algorithm defined effectiveness during the 12-month post-index period as achieving all six of the following: high adherence (medication possession ratio ≥80% or infusions consistent with the product label); no increase in biologic dose or decrease in dosing interval; no new biologic; no new nonbiologic disease-modifying antirheumatic drug; no new or increased oral glucocorticoid use; and ≤1 glucocorticoid injection. …”
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Proteomic profiling of Labeo rohita intestine infected with Edwardsiella tarda: Unveiling the mucosal defense mechanisms, cell adhesion, and cytoskeletal pathways by Nevil Pinto, Mehar Un Nissa, Gowhar Iqbal, Yashwanth BS, Darshan P, Sanjeeva S, Mukunda Goswami

“…Histopathology was performed to overview changes in rohu intestine. Label-free quantitative proteomic analysis of the rohu intestine was performed to elucidate the proteome changes and its implications for immune response. …”
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Clinically SUspected ScaPhoid fracturE: treatment with supportive bandage or CasT? ‘Study protocol of a multicenter randomized controlled trial’ (SUSPECT study) by Max Reijman, Jan A N Verhaar, Abigael Cohen, Gerald A Kraan, Nina M C Mathijssen, Marc A Koopmanschap, Sander Mol, Joost W Colaris

“…We hypothesise that the functional outcome after 3 months is not inferior in patients treated with supportive bandage compared to patients treated with below-elbow cast, but with lower costs in the supportive bandage group.Methods and analysis The SUSPECT study is an open-labelled multicentre randomised controlled trial with non-inferiority design. …”
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Transformer-Based Person Detection in Paired RGB-T Aerial Images With VTSaR Dataset by Xiangqing Zhang, Yan Feng, Nan Wang, Guohua Lu, Shaohui Mei

“…However, existing person detection models designed for aerial images heavily rely on numerous labeled instances and exhibit limited tolerance towards complex lighting conditions commonly encountered in search and rescue (SaR) scenarios. …”
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Pengukuran Kemiripan Makna Menggunakan Cosine Similarity dan Basis Data Sinonim Kata by Ardi Sanjaya, Ahmad Bagus Setiawan, Umi Mahdiyah, Intan Nur Farida, Aprisa Risky Prasetyo

“…Furthermore, each group of words is broken down to be broken down into single words, stored in the word table labeled word ID and synonym ID. Synonym ID is based on the unique ID in the synonym table. …”
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Effect of an Electronic Pill Bottle on Hydroxychloroquine Adherence in Pediatric Lupus: Results of a Novel Direct‐to‐Family Pilot Trial by Rachel L. Randell, Laura E. Schanberg, Claire Beard, Thomas Phillips, Christoph P. Hornik, Michael Cohen‐Wolkowiez, Stephen J. Balevic, with the CARRA Registry investigators

“…Methods This was a self‐controlled, open label, direct‐to‐family pilot trial. Children with pSLE treated with HCQ were recruited from the Childhood Arthritis and Rheumatology Research Alliance Registry. …”
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Efficient Method for Robust Backdoor Detection and Removal in Feature Space Using Clean Data by Donik Vrsnak, Marko Subasic, Sven Loncaric

“…These attacks pose a significant security threat in critical applications, such as street sign or pedestrian recognition for autonomous vehicles, biometric authentication, image retrieval, semantic labeling, etc. To combat these threats, many defense mechanisms have been proposed. …”
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