New methods of treatment for severe and moderate postoperative pain syndrome in patients with cancer by D.V. Dmytriiev, M.M. Barsa

“…This was a multicenter, randomized, prospective, open-label study involving 60 inpatients who underwent mammoplasty as a result of breast cancer surgery. …”
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Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for COVID-19 treatment by Phanit Songvut, Jaratluck Akanimanee, Tawit Suriyo, Nanthanit Pholphana, Nuchanart Rangkadilok, Duangchit Panomvana, Porranee Puranajoti, Jutamaad Satayavivad

“…Aim Insufficient quality control and limited dissolution of Andrographis paniculata extract capsules restricts their bioavailability and hinder the clinical use for treating mild coronavirus disease 2019 (COVID-19) patients.Objective This study aims to investigate pharmacokinetics and safety of high-dosage A. paniculata ethanolic extract (equivalent to 180 or 360 mg/day of andrographolide), relevant dosages used for mild COVID-19 treatment.Methods An open-label, single-dose, and repeated-dose conducted in healthy volunteers. …”
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Comprehensive analysis of the succinylome in Vero cells infected with peste des petits ruminants virus Nigeria 75/1 vaccine strain by Xuelian Meng, Xueliang Zhu, Xiangwei Wang, Rui Zhang, Zhidong Zhang, Yuefeng Sun

“…Results In this study, a global profile of the succinylome in Vero cells infected with PPRV Nigeria 75/1 vaccine strain (PPRVvac) was performed by dimethylation labeling-based quantitative proteomics analysis. A total of 2633 succinylation sites derived from 823 proteins were quantified. …”
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Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes by Beatriz Tavira, Hugo Barcenilla, Jeannette Wahlberg, Peter Achenbach, Johnny Ludvigsson, Rosaura Casas

“…GAD-alum given into lymph nodes to type 1 diabetes patients participating in an open-label pilot trial resulted in preservation of C-peptide similar to promising results from other trials. …”
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Evaluation of health-related quality of life changes in an Australian rapid access chest pain clinic by J Andrew Black, James E. Sharman, Gang Chen, Andrew J. Palmer, Barbara de Graaff, Mark Nelson, Niamh Chapman, Julie A. Campbell

“…Study design Patients attending an Australian chest pain clinic were randomised into a prospective, open-label, blinded-endpoint study over a minimum 12-months follow-up. …”
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Dosing Patterns during Conversion to IPX066, Extended-Release Carbidopa-Levodopa (ER CD-LD), in Parkinson’s Disease with Motor Fluctuations by John C. Morgan, Rohit Dhall, Robert Rubens, Sarita Khanna, Suneel Gupta

“…CD-LD + entacapone (CLE; ASCEND-PD) in subjects with advanced PD included a 6-week, open-label conversion to ER CD-LD prior to treatment randomization. …”
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FERA-Net: A Novel Algorithm for Mars Water-Ice Cloud Segmentation Integrating Feature Enhancement, Residual, and Attention Mechanisms by Xu Ma, Jialong Lai, Zhicheng Zhong, Feifei Cui

“…This study proposes the Feature-Enhanced Residual Attention U-Net (FERA-Net) model, which is trained using cloud mask label data generated by the semiautomatic CM7 method. …”
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Quantitative proteomic studies of the intestinal mucosa provide new insights into the molecular mechanism of ulcerative colitis by Yandong Guo, Dahal Pabitra, Lei Pan, Lanbo Gong, Aimin Li, Side Liu, Jing Xiong

“…Methods Intestinal mucosal biopsy tissue specimens of inflamed (ulcerative colitis-inflamed, UC-I) and non-inflamed (ulcerative colitis-noninflamed, UC-N) tissue were obtained simultaneously during colonoscopy from newly diagnosed UC patients prior to any treatments. Label-free liquid chromatography tandem mass spectrometry (LC-MS/MS) quantitative proteomics was used to detect proteomic differences between UC-I, UC-N, and normal control subjects (n = 5). …”
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Allogenic faecal microbiota transplantation for antibiotic-associated diarrhoea in critically ill patients (FEBATRICE)-Study protocol for a multi-centre randomised controlled trial... by Ivana Cibulkova, Veronika Rehorova, Hana Soukupova, Petr Waldauf, Monika Cahova, Jan Manak, Martin Matejovic, Frantisek Duska

“…From growing number of case series it is clear that its off label use in the critically ill patients is increasing and that there is a burning need to objectively assess its efficacy and safety, which this trial aims.…”
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Human umbilical cord derived-mesenchymal stem cells alleviate lipid metabolism disturbances of hepatocytes via mitochondrial transport by Jing Xue, Xiangnan Hu, Suying Xia, Pengfei Ren, Aihong Wang

“…MitoTracker Red dye was used to label MSCs mitochondria, and flow cytometry showed that over 90 ​% of HepG2 cells had MitoTracker Red positive mitochondria, indicating a significant transfer of mitochondria from UC-MSCs to HepG2 cells. …”
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Impact of the Clinical Trials Act 2018 on clinical trial activity in Japan from 2018 to 2020: a retrospective database study using new and conventional Japanese registries by Hiroyuki Taruno, Mari S Oba, Osamu Takizawa, Kayoko Kikuchi, Kazuaki Matsui, Mayumi Shikano

“…The temporal trends in clinical trial activity after CTA enactment were examined.Results A total of 577 CTA-compliant specified clinical trials (ie, studies funded by pharmaceutical companies or studies evaluating the efficacy and safety of off-label drugs or devices in humans) were registered in the jRCT. …”
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Map Floodwater Radar Imagery using Machine Learning Algorithms by Thanh-Nghi Doan, Duc-Ngoc Le-Thi

“…In this study, radar imagery available on the Planetary Computer Data was utilized to train a U-Net model specifically designed to label flood-affected pixels in an image from a flood event. …”
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Exercise-Intervened Circulating Extracellular Vesicles Alleviate Oxidative Stress in Cerebral Microvascular Endothelial Cells Under Hypertensive Plus Hypoxic Conditions by Smara Sigdel, Shuzhen Chen, Gideon Udoh, Jinju Wang

“…Age- and sex-matched sedentary Alb1-Ren mice served as controls. cEVs were isolated from the blood of exercised and sedentary mice and are denoted as ET-cEV and nET-cEV, respectively. cEVs were labeled to determine their uptake efficiency and pathways. …”
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A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline by Amit Garg, Jun Xu, Mario Fioravanti, Taku Nakashima

“…Objective To evaluate the safety profile of nicergoline compared with placebo and other active agents from published randomised controlled trials.Design Systematic review and meta-analysis of nicergoline compared with placebo and other active agents across various indications.Data sources MEDLINE, Medline-in-process, Cochrane, EMBASE, EMBASE alerts, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR) and Cochrane Methodology Register (CMR) for all the randomised controlled trials, open-label or blinded, in adults treated with nicergoline. …”
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Online cognitive–behavioural therapy for traumatically bereaved people: study protocol for a randomised waitlist-controlled trial by Jos de Keijser, Lonneke Lenferink, Maarten Eisma, Geert Smid, Paul Boelen

“…Moreover, the effect of the quality of the therapeutic alliance on treatment effects and drop-out rates will be explored.Methods and analysis A two-arm (online CBT vs waiting list) open-label parallel randomised controlled trial will be conducted. …”
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Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI by Liam Timms, Tianyi Zhou, Ju Qiao, Codi Gharagouzloo, Vishala Mishra, Rita Maria Lahoud, John W. Chen, Mukesh Harisinghani, Srinivas Sridhar

“…Ferumoxytol (Ferahame, AMAG Pharmaceuticals, Waltham, MA) is increasingly used off-label as an MR contrast agent due to its relaxivity and safety profiles. …”
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A cluster randomized trial assessing the effect of a digital health algorithm on quality of care in Tanzania (DYNAMIC study). by Rainer Tan, Godfrey Kavishe, Alexandra V Kulinkina, Sabine Renggli, Lameck B Luwanda, Chacha Mangu, Geofrey Ashery, Margaret Jorram, Ibrahim Evans Mtebene, Peter Agrea, Humphrey Mhagama, Kristina Keitel, Marie-Annick Le Pogam, Nyanda Ntinginya, Honorati Masanja, Valérie D'Acremont

“…We conducted a cluster randomized, open-label trial in Tanzania evaluating the use of a digital clinical decision support algorithm (CDSA), enhanced by point-of-care tests, training and mentorship, compared with usual care, among sick children 2 to 59 months old presenting to primary care facilities for an acute illness in Tanzania (ClinicalTrials.gov NCT05144763). …”
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鼻咽癌中浸润的淋巴类细胞与瘤细胞凋亡的关系 by 宗永生, 李　智, 刘克拉, 买世娟, 梁英杰

“…应用 TUNEL ( TdT-mediated dUTP Nick End Labeling)方法定量检测凋亡癌细胞计数(每 5 000 个 鼻咽癌细胞中的凋亡细胞数)。以免疫组化法分别检测T 细胞,单核/巨噬细胞,B 细胞和树突状细胞。…”
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THE LEGAL REGIME OF NAMES EXCLUDED FROM PROTECTION BY INDICATIVE SIGNS by Adrian CURELEA

“…In a mercantile society based on the circulation of goods, an important factor in choosing a quality product originating in a certain regions is the sign or name that appears on the label and that gives the product „added value”, the consumer being thus aware of his choice and at the same time protected against deceptive practices. …”
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Risk of Multidrug Resistant Bacteria Acquisition in Patients with Declared β-Lactam Allergy during Hospitalization in Intensive Care Unit: A Retrospective Cohort Study (2007-2018) by Alessio Strazzulla, Maria Concetta Postorino, Nabil Belfeki, Laura Iordache, Astrid de Pontfarcy, Aurelia Pitsch, Pierre Leroy, Sebastien Jochmans, Mehran Monchi, Sylvain Diamantis

“…Overall, 3332 patients were included, 132/3332 (3.9%) were labelled β-lactam allergic, while 3200/3332 (96.1%) did not presented β-lactam allergy. …”
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