What drives consumers’ intention towards fairness-oriented products purchasing? An emotion-extended model of theory of planned behaviour by Antonella Samoggia, Giulia Rossi, Andrea Fantini, Evangelia Mouchtaropoulou, Notis Argiriou

“…Furthermore, the study applied an ANOVA analysis to identify sociodemographic differences, indicating varied perceptions and beliefs among different age groups, educational levels, and those valuing fairtrade labels. The value of current research aims at understanding how consumers perceive fairness throughout the agrifood chain. …”
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Flow Cytometry of the Side Population: Tips & Tricks by Irene Sales-Pardo, Ariadna Avendaño, Vanessa Martinez-Muñoz, Marta García-Escarp, Raquel Celis, Phil Whittle, Jordi Barquinero, Joan Carles Domingo, Pedro Marin, Jordi Petriz

“…Blood suspensions were prepared by erythrocyte lysis with ammonium chloride and hematopoietic cells were labeled with Ho342. Results: The Ho342 concentration and the staining procedure are critical for the optimal resolution of the SP cells. …”
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APOC1 knockdown induces apoptosis and decreases angiogenesis in diffuse large B-cell lymphoma cells through blocking the PI3K/AKT/mTOR pathway by Jing Gao, Xiaojuan Lu, Guanglei Wang, Tanling Huang, Zhongyu Tuo, Weiwei Meng

“…Advanced techniques, such as immunofluorescence, TUNEL assay, and immunohistochemical labeling were employed to analyze the effects of APOC1 knockdown on the PI3K/AKT/mTOR signaling pathway and tumor formation in nude mice. …”
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Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

“…Additionally, we review important considerations for the off-label use of these agents while contemporaneous clinical trials assessing front-line efficacy are ongoing. …”
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Decanoic acid-enriched ketogenic diet in refractory epilepsy by Hui Jin Shin, Seonae Ryu, NaRae Lee, Eunjoo Lee, Ara Ko, Hoon-Chul Kang, Joon Soo Lee, Se Hee Kim, Heung Dong Kim, Heung Dong Kim

“…ObjectiveTo assess the anti-seizure efficacy and safety of a C10-enriched medium-chain triglyceride (MCT) ketogenic diet (KD) compared with the classic KD in pediatric patients with refractory epilepsy.MethodsThis 16-week, open-label, randomized, controlled, crossover pilot study was conducted at Severance Children’s Hospital, Seoul, South Korea, between August 2022 and September 2023. …”
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It tastes sweeter when melted: Exploring the impact of food temperature on tongue temperature and perceived sweetness/vanilla by Hannah McNeill, Rebecca Ford, Ian Fisk, Margaret Thibodeau, Gloria Liu, Marion Doyennette, Qian Yang

“…Sweetness and vanilla intensity were recorded using a modified General Labelled Magnitude Scale. This study demonstrated that infrared imaging could effectively capture tongue surface temperature. …”
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The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial by Da Xu, Hongwei Wang, Quan Bao, Kemin Jin, Ming Liu, Wei Liu, Xiaoluan Yan, Lijun Wang, Yanqiao Zhang, Guangyu Wang, Yue Ma, Zhigang Ma, Chunhui Zhang, Jiebing Tang, Sha Wang, Jiaohui Pang, Ting Xu, Kun Wang, Baocai Xing

“…Abstract This open-label phase II trial (NCT04542837) aimed to evaluate the efficacy and safety of KN046 combined with lenvatinib in patients with advanced hepatocellular carcinoma (HCC), and explore the potential response biomarkers. …”
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Suppressing surface segregation by introducing lanthanides to enhance high-temperature oxygen evolution reaction activity and durability by Jingwei Li, Zichao Wu, Yuxiang Shen, Yuefeng Song, Houfu Lv, Xiaomin Zhang, Guoxiong Wang

“…Herein, lanthanides are introduced to substitute the Ba in BSCF, labeled as Ln _0.5 Sr _0.5 Co _0.8 Fe _0.2 O _3− _δ (LnSCF, Ln = La, Pr, Nd, Sm), to regulate its stability and performance. …”
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A New Antibody–Cytokine Construct Targeting Natural Killer Cells: An Immunotherapeutic Approach to Chronic Lymphocytic Leukemia by Michela Flego, Mauro Andreotti, Francesca Romana Mauro, Maria Beatrice Arasi, Silvia Zamboni, Zuleika Michelini, Sara Pepe, Clementina Maria Galluzzo, Roberta Amici, Diego Moricoli, Chiara Mazzei, Alessandro Ascione, Alessandra Mallano

“…We designed and developed a cis-acting immunocytokine composed of an anti-CD56 single-chain Fragment variable (scFv) and IL15, labeled scFvB1IL15. scFvB1IL15 was tested in vitro on peripheral blood mononuclear cells (PBMCs) obtained from both different healthy donors (HDs) and CLL patients in order to evaluate its ability to target NK cells and enhance their activation and NK-mediated directed cytotoxicity. scFvB1IL15 specifically induced strong degranulation and cytokine and chemokine production in NK cells in both HD- and CLL patient-derived PBMC samples. …”
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Prognostic significance of mast cell and microvascular densities in malignant peripheral nerve sheath tumor with and without neurofibromatosis type 1 by Roberto André Torres de Vasconcelos, Pedro Guimarães Coscarelli, Thyago Marsicano Vieira, Washington Silva Noguera, Davy Carlos Mendes Rapozo, Marcus André Acioly

“…MCD, MVD, and Ki‐67 labeling index (LI) were analyzed in all stained tissues by a computer‐based quantitative algorithm (Aperio ImageScope). …”
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In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney by Toshiki Tsuboi, Keita Hattori, Takuji Ishimoto, Kentaro Imai, Tomohito Doke, Junichiro Hagita, Jumpei Ariyoshi, Kazuhiro Furuhashi, Noritoshi Kato, Yasuhiko Ito, Yukiko Kamiya, Hiroyuki Asanuma, Shoichi Maruyama

“…The administration of Cy5-labeled-ASOs demonstrated an early increase in renal uptake, particularly in the renal proximal tubules, when modified with SNA. …”
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The N-acetyltransferase 10 inhibitor [11C]remodelin: synthesis and preliminary positron emission tomography study in mice by Rui Luo, Yiding Zhang, Katsushi Kumata, Lin Xie, Yusuke Kurihara, Masanao Ogawa, Tomomi Kokufuta, Nobuki Nengaki, Feng Wang, Ming-Rong R. Zhang

“…In this study, we synthesized C-11-labelled remodelin ([11C]remodelin) for the first time as a positron emission tomography (PET) probe and assessed its biodistribution in mice using PET. …”
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Identification and semi-quantification of protein allergens in complex mixtures using proteomic and AllerCatPro 2.0 bioinformatic analyses: a proof-of-concept investigation by Nora L. Krutz, Ian Kimber, Jason Winget, Minh N. Nguyen, Vachiranee Limviphuvadh, Sebastian Maurer-Stroh, Catherine Mahony, G. Frank Gerberick

“…Twelve commercial preparations of source materials (plant products, dust mite extract, and preparations of animal dander) known to contain allergenic proteins were analyzed by label-free proteomic analyses to identify and semi-quantify proteins. …”
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Multiphoton imaging-based quantifiable collagen signatures for predicting outcomes in patients with pancreatic ductal adenocarcinoma by Xiwen Chen, Jikui Miao, Xingxin Huang, Xiahui Han, Liqin Zheng, Jianxin Chen, Linying Chen, Lianhuang Li

“…Our statistical results demonstrate that as two new optical biomarkers, TACS- and M-TACS-score, are independent prognostic factors and have good discriminatory ability (high AUC) as well as risk stratification (high HR) comparing with traditional clinical model (combining seven clinical risk factors, age, sex, TNM stage, tumor location and differentiation, perineural and lymph-vascular invasion) in predicting overall survival (OS) of patients with PDAC, highlighting their potential prognostic and predictive value. A combination of label-free multiphoton imaging technique and computer-aided image processing method may offer a novel and promising approach for finding new biomarkers to improve prognosis prediction and thereby tailor treatment strategies more effectively.…”
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Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial by Nick Shortt, Alex Semprini, Mark Weatherall, Richard Beasley, Irene Braithwaite, Angela Liu, Melanie McConnell, Joseph Singer, Darmiga Thayabaran, Abbie Copinga, Abigail Cadwallader, Ahmad Zareh, Aidan Kortegast, Al-Sheibani Saif, Alaina van Zyl, Alex Graham, Alice Liu, Alice Manch, Alison van Wyke, Amanda Barkley, Amy Zhuang, Andrew Mcglashen, Androulla Kotrotsos, Angela Blackwood, Angeline Day-Mesuré, Annabel Turley, Anne Lim, Anne Marie-Nimmo, Anstey Harsant, Anthony Roberts, Ashley Cronin, Barbara Mcrae, Blair Finlayson, Bob Kim, Brandon, Brendon Mcintosh, Brian Johnston, Carina Soeteman, Carla Mcinness, Carrol Newman, Cassie Butler, Catherine Hosler, Cathy Hight, Chantel Kissick, Charlotte Schimanski, Chau Ly, Cheryl Mabbett, Chris Wrapson, Christy Biju, Chuck Varghese, Claire Livingston, Corry Bezems, Danielle Stewart, Daryl Sayer, David Postlewaight, Deb Lawrence, Debora Ngny, Deborah Ellison, Debra Clutterback, Delphine Destrez, Diana Montelli, Dipika Parmar, Dixie Howard, Donnie Loh, Eddie See, Elda Lubbe, Eric Li, Evan Tan, Fiona Mclachlan, Fiona Srush, Fran Chen, Garth Mitchinson, Gina Azer-Iskander, Glenn Summerville, Grace O’conner, Grant Bell, Hayley Garvin, Helen Jarvie, Henriette Meyer, Ingrid Nickson, Ingrid Reed, Irene Nicks, Jackie Jamieson, Jacqui Brus, Jacqui Craw, James Westbury, Jan Green, Janet Downing, Jayne Lewis, Jenna Ludlow, Jenni Puckley, Jennifer Gerbes, Jenny Sparks, Jenny Wu, Jess Barton, Jessica Ensor, Jilly Alexander, Jim Sherborne, Joanna Topliss, Jordan Jeffray, Jordon Hinton, Joseph Tsou, Joy Birch, Julia Mcdonald, Julie Earwaker, Julie Lamb, Julie Summers, Kadyn Lowe, Kaleigh Mackel, Karen Rich, Karen Chen, Karen Wainman, Karena Hall, Kate Adams, Kate Griffin, Kayleigh Mackel, Kelly Burgess, Kelly Harvey, Kelly Shearer, Kelsi Burns, Kerry Dean, Kerry Oxenham, Kritika Singh, Lara Blaikie, Leanne Hall, Leanne Herbert, Leanne Hosking, Leanne Steele, Leigh Vaughan, Lesley Robertson, Levi Bian, Linda Herman, Linda Joe, Linda Southby, Lisa Josephs, Lisa Mitchell, Lorina Lu, Lorraine Brunton, Lucy Armstrong, Lynda Bell, Malinda Ouk, Malli Kotali, Marcus Liddle, Margaret Helms, Marion Gray, Mark Arundel, Mark Webster, Martin Boyle, Maryanne Smyth, Mate Hegedus-Gaspar, Matthew Grey, Maureen Raju, Melanie Wong, Michelle Hwang, Michelle Nawisielski, Michelle Speirs, Natascha Roughton, Navjot Kaw, Neha Chand, Nehad Kamel, Neville Puckey, Nicholas Tee, Nimmi Gnanasekaran, Nolan Mcrae, Noor Al-Rawe, Oliver Rew, Olivia Haslam, Outi Kolju, Palak Mehta, Patrick Lim, Peter Neal, Rachael Gerretzen, Rachael Munns, Rachel Yang, Rachelle Smith, Raksha Goundar, Rav Singh, Ravniel Singh, Rebecca Coley, Rebecca Hesom, Rebekah Beard, Reece Olsen, Renee Belling, Robyn Morrison, Roseanna Mcdonald, Ruby Willing, Saif Al-Sherbeni, Sally Purdie, Sam Betty, Sam Appleford, Samantha Fordham, Samit Patel, Sara Preston, Sarah Wallace, Sascha Ion, Shahlaa Al Salih, Sharon Sullivan, Shazeel Rauf, Sheryl Montgomerie, Shilpa Narain, Shirin Namjou, Shuji Zhang, Simerjeet Singh, Sjaani Stanley, Sonia Schwaum, Steve Jo, Sultana Zannat, Tanya Baker, Tyler Pornchaisuksiri, Utsav Sharma, Vicki Douglas, Victoria Rameke, Vincent Ho, Vioky Usher, Violet Harley, Vishwatej Gangapuri, Warren Greene, Wendy Parkes, William Gia, Wilma Gordon, Yalun Weng, Yasmin Razoki, Yolanda Savage, Zheng Li

“…Objective To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis.Design Prospective parallel randomised controlled open-label superiority trial.Setting 76 community pharmacies across New Zealand between 10 September 2015 and 13 December 2017.Participants 952 adults randomised within the first 72 hours of a herpes simplex labialis episode.Interventions Random assignment 1:1 to either 5% aciclovir cream or medical grade kanuka honey (90%)/glycerine (10%) cream, both applied five times daily.Outcome measures The primary outcome was time from randomisation to return to normal skin (stage 7). …”
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Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides by Serkan Yazıcı, Emel Bülbül Başkan, Ferah Budak, Barbaros Oral, Şaduman Balaban Adim, Zübeyde Ceylan Kalin, Güven Özkaya, Kenan Aydoğan, Hayriye Saricaoğlu, Şükran Tunali

“…To determine prognostic value of cell surface antigens, cases were divided into two groups as stable and progressive disease. 17 flow cytometric analyses of 17 parapsoriasis (PP) and 11 analyses of 11 benign erythrodermic patients were included as control groups. Fluorescent labeled monoclonal antibodies were used to detect cell surface antigens: T cells (CD3+, CD4+, CD8+, TCRαβ+, TCRγδ+, CD7+, CD4+CD7+, CD4+CD7−, and CD71+), B cells (HLA-DR+, CD19+, and HLA-DR+CD19+), NKT cells (CD3+CD16+CD56+), and NK cells (CD3−CD16+CD56+). …”
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The Prevalence of Star-forming Clumps as a Function of Environmental Overdensity in Local Galaxies by Dominic Adams, Hugh Dickinson, Lucy Fortson, Kameswara Mantha, Vihang Mehta, Jürgen Popp, Claudia Scarlata, Chris Lintott, Brooke Simmons, Mike Walmsley

“…To obtain our clump sample, we use a Faster R-CNN object detection network trained on the catalog of clump labels provided by the Galaxy Zoo: Clump Scout project, then apply this network to detect clumps in approximately 240,000 Sloan Digital Sky Survey galaxies (originally selected for Galaxy Zoo 2). …”
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Serotype-specific serum immunoglobulin G at 18 months of age following one or two doses of a primary series of 10-valent or 13-valent pneumococcal conjugate vaccine and a booster d... by Alane Izu, Eleanora Aml Mutsaerts, Courtney Olwagen, Lisa Jose, Anthonet Koen, Amit J Nana, Clare L. Cutland, Shabir A. Madhi

“…This study evaluated the immune response at 18 months of age following a 1 + 1 compared to a 2 + 1 schedule of 10-valent (PCV10) and 13-valent (PCV13) vaccines.Research design and methods A single-center, open-label, randomized trial conducted in Soweto, South Africa, evaluated the immunogenicity of differing dosing schedule for PCV10 and PCV13. …”
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The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial by Marloes P. van der Aa, Vera Hoving, Ewoudt M. W. van de Garde, Antonius de Boer, Catherijne A. J. Knibbe, Marja M. J. van der Vorst

“…Obese adolescents treated off label with metformin in daily practice in an outpatient clinic with a follow-up of ≥18 months were identified. …”
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The Protective Effect of Docosahexaenoic Acid on Mitochondria in SH-SY5Y Model of Rotenone-Induced Toxicity by Britta Eggers, Jennifer Stepien, Anne-Katrin Reker, Svenja Esser, Kathy Pfeiffer, Magdalena Pawlas, Katalin Barkovits, Katrin Marcus

“…To study the potential protective effect of DHA, the cells were additionally pre-treated with DHA prior to rotenone administration. By combining SILAC labeling, mitochondria enrichment, and subsequent proteomic analyses, we aimed to determine the capacity of DHA to alleviate mitochondrial oxidative stress in vitro and further shed light on the molecular mechanisms contributing to the proposed neuroprotective effect. …”
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