Protection of Corneal Limbus from Riboflavin Prevents Epithelial Stem Cell Loss after Collagen Cross-Linking by Hyo Kyung Lee, Jin Suk Ryu, Hyun Jeong Jeong, Mee Kum Kim, Joo Youn Oh

“…The numbers of BrdU-labelled and p63+ limbal epithelial cells were markedly reduced in the group without a ring, but significantly increased when a ring was used. …”
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Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb) by Hiroaki Tanaka, Yasuhiro Tanaka, Yoichi Aoki, Masayuki Endo, Tomoaki Ikeda, Shintaro Maki, Masafumi Nii, Kayo Tanaka, Satoshi Tamaru, Toru Ogura, Yuki Nishimura, Tomomi Kotani, Akihiko Sekizawa, Masahiko Nakata, Koji Nakamura, Kenji Nagao, Ichiro Yasuhi, Hiroshi Kawamura, Sho Takakura, Mayumi Kotera, Takafumi Ushida, Norihiko Kikuchi, Tadatsugu Kinjo, Mayumi Takano, Sachie Suga, Michi Kasai, Osamu Yasui, Yuka Maegawa, Shigeru Aoki, Yoshio Yoshida

“…Introduction TheTADAlafil treatment for Fetuses with early-onset growth Restriction: multicentrer, randomizsed, phase II trial (TADAFER II) study showed the possibility of prolonging the pregnancy period in cases of early-onset fetal growth restriction; however, it was an open-label study. To establish further evidence for the efficacy of tadalafil in this setting, we planned a multicentre, randomised, placebo-controlled, double-blind trial.Methods and analysis This trial will be conducted in 180 fetuses with fetal growth restriction enrolled from medical centres in Japan; their mothers will be randomised into three groups: arm A, receiving two times per day placebo; arm B, receiving one time per day 20 mg tadalafil and one time per day placebo and arm C, receiving 20 mg two times per day tadalafil. …”
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Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 Years by Nunzia Giordano, Valérie Tikhonoff, Paolo Palatini, Anna Bascelli, Giovanni Boschetti, Fabia De Lazzari, Carla Grasselli, Bortolo Martini, Sandro Caffi, Antonio Piccoli, Alberto Mazza, Patrizia Bisiacchi, Edoardo Casiglia

“…The BP vectors of lower MMSE, MI-10, and CLOX were directed towards higher values of systolic and diastolic BP, that of low CRI towards higher systolic and lower diastolic. The label of hypertension and higher values of systolic or pulse BP are associated to worse memory and executive functions. …”
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MAC30 Knockdown Inhibits Proliferation and Enhance Apoptosis of Gastric Cancer by Suppressing Wnt/β-Cateninsignaling Pathway by Xiaohong Wu, Yong Zhang, Junping Guo, Xun Yan, Li Shen, Jianping Zhou, Jun Zhao, Min Zhuang, Zhihong Cao

“…Lentiviral vector pGCSIL-shMAC30-GFP of the RNA interference (RNAi) of the MAC30 gene was transfected into gastric cancer BGC-823 cell line and the expression of lentivirus label protein GFP was observed via fluorescence microscope, while cell proliferation and apoptosis were determined with flow cytometry and MTT assay, respectively. …”
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Role of the hospital pharmacists during COVID-19 pandemic in the RN Macedonia by Zorica Naumovska, Biljana Lazarova, Maja Kovaceva, Aleksandra Kapedanovska Nestorovska, Maja Simonoska Crcarevska, Evgenija Mihajloska, Aleksandar Dimkovski

“…Opinions varied on the use of off-label drugs, and pharmacists played a key role in pharmacovigilance practices, with 36.4% reporting adverse events. …”
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Personal glucose meter-based portable method for creatine kinase assay by Jinhwan Lee, Yejin Oh, Hyoyong Kim, Sangmo Lee, Hyun Gyu Park

“…We herein developed a simple and label-free method to detect the creatine kinase (CK) activity by employing a personal glucose meter (PGM) as a detection device. …”
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Endothelial Differentiation of Human Adipose-Derived Stem Cells on Polyglycolic Acid/Polylactic Acid Mesh by Meng Deng, Yunpeng Gu, Zhenjun Liu, Yue Qi, Gui E. Ma, Ning Kang

“…Cell adhesion, viability, and distribution of hADSCs on PGA/PLA mesh were observed by CM-Dil labeling, live/dead staining, and SEM examination while endothelial differentiation was evaluated by flow cytometry, Ac-LDL/UEA-1 uptake assay, immunofluorescence stainings, and gene expression analysis of endothelial related markers. …”
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Detection of N-Glycolyl GM3 Ganglioside in Neuroectodermal Tumors by Immunohistochemistry: An Attractive Vaccine Target for Aggressive Pediatric Cancer by Alejandra M. Scursoni, Laura Galluzzo, Sandra Camarero, Jessica Lopez, Fabiana Lubieniecki, Claudia Sampor, Valeria I. Segatori, Mariano R. Gabri, Daniel F. Alonso, Guillermo Chantada, María Teresa G. de Dávila

“…The monoclonal antibody 14F7, a mouse IgG1 that specifically recognizes NeuGc-GM3, and a peroxidase-labeled polymer conjugated to secondary antibodies were used. …”
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Sensitivity Analysis of Biosensor-Based SiGe Source Dual Gate Tunnel FET Having Negative Capacitance by Dipshika Das, Rudra Sankar Dhar, Pradip Kumar Ghosh, Yash Sharma, Amit Banerjee

“…The biosensor works on the principle of dielectric modulation for label-free detection, where the cavity lies under the source and gate metal just around the tunneling junction of the dual gate TFET. …”
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A Novel Liquid Chromatography–Tandem Mass Spectrometry Method to Quantify Tryptophan and Its Major Metabolites in Serum to Support Biomarker Studies in Patients with Cancer Undergo... by Anna Siemiątkowska, Barbara Kuźnar-Kamińska, Katarzyna Kosicka-Noworzyń, Kamila Nowaczewska, Hanna Winiarska, Dominika Popiołek, Filip Kamiński, Franciszek K. Główka

“…We also recorded a mutual cross-talk between kynurenine and isotope-labeled TRP. Different origins of the observed cross-signal contribution were proposed. …”
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Expert Consensus on Molecular Tumor Boards in Taiwan: Joint Position Paper by the Taiwan Oncology Society and the Taiwan Society of Pathology by Ming-Huang Chen, Wan-Shan Li, Bin-Chi Liao, Chiao-En Wu, Chien-Feng Li, Chia-Hsun Hsieh, Feng-Che Kuan, Huey-En Tzeng, Jen-Fan Hang, Nai-Jung Chiang, Tse-Ching Chen, Tom Wei-Wu Chen, John Wen-Cheng Chang, Yao-Yu Hsieh, Yen-Lin Chen, Yi-Chen Yeh, Yi-Hsin Liang, Yu-Li Su, Chiung-Ru Lai, James Chih-Hsin Yang

“…Results: The joint statement proposes key recommendations: (1) MTB discussions encompass diverse molecular analyses including next-generation sequencing (NGS), RNA sequencing, whole-exon sequencing, and whole-genomic sequencing addressing relevant genomic changes, tumor mutation burden, microsatellite instability, and specific biomarkers for certain cancers. (2) MTB meetings should involve multidisciplinary participants who receive regular updates on NGS-related clinical trials. (3) Prioritize discussing cases with unique clinical needs, gene alterations lacking treatments, untreatable neoplasms, or oncogenes unresponsive to targeted therapies. (4) Base MTB discussions on comprehensive patient data, including genetics, pathology, timing of specimen collection, and NGS outcomes. (5) MTBs offer treatment recommendations: standard therapies, off-label use, clinical trials, genetic counseling, and multidisciplinary reviews. (6) MTB effectiveness can be gauged by member composition, case reviews, treatment suggestions, and patient outcomes. …”
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Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway by Yuqin Ye, Yongxiang Yang, Chen Chen, Ze Li, Yanfeng Jia, Xinhong Su, Chaoxian Wang, Xiaosheng He

“…BrdU/NeuN immunofluorescence was performed to label newborn neurons in the hippocampus after EA treatment. …”
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Frequency of Diplopia in Zygomatic Complex Fractures—A Cross-Sectional Descriptive Study by Maria Shabbir, Ruqaya Shah, Muhtada Ahmad, Rakhi Issrani, Zafar Khan, Salah Nazal Alotha, Basant Mousa Alsiyat, Mohammed Saad Alqarni, Ahmed Saleh Albalawi, Namdeo Prabhu, Mohammad Khursheed Alam, Zahid Qayyum

“…If, during the examination, the patient complained of double vision, this was labeled as diplopia positive (Yes) and negative (No) if the patient did not have any such complain. …”
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Astronomaly Protege: Discovery through Human-machine Collaboration by Michelle Lochner, Lawrence Rudnick

“…PROTEGE is designed to provide well-selected recommendations for visual inspection, based on a small amount of optimized human labeling. The resulting sample contains rare or unusual sources that are simultaneously as diverse as the human trainer chooses and of scientific interest to them. …”
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Comparative Study of Bulgarian Linden Honey (<i>Tilia</i> sp.) by Anastasiya Yankova-Nikolova, Desislava Vlahova-Vangelova, Desislav Balev, Nikolay Kolev, Stefan Dragoev, Biljana Lowndes-Nikolova

“…Another key finding was that 39% of linden honey labeled or declared as monofloral linden honey on the Bulgarian market does not meet the established criteria for monofloral honey.…”
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Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation by Imelda Ontoria-Oviedo, Itziar Palacios, Joaquín Panadero, Belén Sánchez, Francisco García-García, Adolfo López-Cerdán, Akaitz Dorronsoro, Delia Castellano, Luis Rodríguez-Borlado, Antonio Bernad, Pilar Sepúlveda

“…The CPC and BM-MSC receptome were analyzed by proteomic analysis of biotin-labeled surface proteins. Rats transplanted with CPCs showed a greater improvement in cardiac function after MI than those transplanted with BM-MSCs, and this was associated with a smaller infarct size. …”
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The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout by Caiyu Zheng, Caiyu Zheng, Qingwen Tong, Qingwen Tong, Zhijun Zhang, Chunmei Lin, Zhiyi Wang, Dongshu Kang, Yanmei Lin, Jianqing Tian

“…ObjectiveThe study focuses on comparing the efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout.MethodsA prospective, randomized, open-labeled trial of men with gout and renal uric acid underexcretion was conducted. …”
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The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon by Lu Zou, Dan Cao, Qing Sun, Wenjun Yu, Bingzong Li, Guoqiang Xu, Liang Zhou

“…In this study, we explored the interactome for CRBN using proximity labeling technique TurboID and quantitative proteomics, and then investigated the antileukemia effect of Len. …”
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Rapid Detection of Astaxanthin in Antarctic Krill Meal by Computer Vision Combined with Convolutional Neural Network by Quantong ZHANG, Yao ZHENG, Liu YANG, Shuaishuai ZHANG, Quanyou GUO

“…A total of 70 Antarctic krill meal samples were analyzed using high-performance liquid chromatography to determine their astaxanthin contents as label, and corresponding images of the samples were acquired using a computer vision system to form the dataset and the dataset was augmented. …”
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Study protocol of the PRINCESS trial—PReoperative INtermittent fasting versus CarbohydratE loading to reduce inSulin resiStance versus standard of care in orthopaedic patients: a r... by Markus W Hollmann, Abraham H Hulst, Benedikt Preckel, Jeroen Hermanides, Ayla Y Stobbe, Eline S de Klerk, Robert van Wilpe, Arthur J Kievit, Kee Fong Choi, Mireille F M van Stijn

“…We hypothesise that TRF, as well as CHL, improve postoperative IR.Methods and analysis This open-label, single-centre, randomised controlled trial will compare the effect of short-term preoperative TRF, CHL and standard preoperative fasting on perioperative IR. …”
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