RNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons by Temirlan Shilikbay, Aatiqa Nawaz, Megan Doon, Stephanie Ceman

“…Results We generated a brain-specific knockout mouse (Mov10 Deletion) with greatly reduced MOV10 expression in cortex and hippocampus. …”
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RLS-associated MEIS transcription factors control distinct processes in human neural stem cells by Volker Kittke, Chen Zhao, Daniel D. Lam, Philip Harrer, Wojciech Krezel, Barbara Schormair, Konrad Oexle, Juliane Winkelmann

“…They can execute redundant functions when co-expressed in the same cell types, but their roles during early stages of neural differentiation have not been systematically compared. By separate knockout and overexpression of MEIS1 and MEIS2 in human neural stem cells, we find they control specific sets of target genes, associated with distinct biological processes. …”
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Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response by Guo Liu, Feng Liu

“…Furthermore, studies in various animal models show that Bach2 knockout animals spontaneously develop Th2 inflammation in the airway and gastrointestinal tract. …”
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Muscular TOR knockdown and endurance exercise ameliorate high salt and age-related skeletal muscle degradation by activating the MTOR-mediated pathway. by Shi-Jie Wang, Deng-Tai Wen, Ying-Hui Gao, Jing-Feng Wang, Xing-Feng Ma

“…TOR overexpression yielded similar results to the high salt diet(HSD) alone, with the opposite effect of TOR knockout found in regard to endurance exercise and HSD-induced age-related skeletal muscle degradation. …”
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Lactoferrin alleviates the adverse effects of early-life inflammation on depression in adults by regulating the activation of microglia by Wenli Wang, Qin An, Yunxia Zou, Yunping Dai, Qingyong Meng, Yali Zhang

“…Lactation LF-deficient mice were established by nursing wild-type mice using LF systemic knockout mother mice. Additionally, 14-day-old mice were injected with lipopolysaccharide (LPS) and subjected to chronic unpredictable mild stress when they reached 6 weeks of age. …”
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GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells by Fumiya Ito, Wakiko Iwata, Yoshihiro Adachi, Hiromi Sesaki, Miho Iijima

“…GRHL2 was upregulated in ER cells, and its knockdown and knockout significantly reduced erlotinib resistance. …”
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The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling by Naoyuki Kondo, Yuko Mimori-Kiyosue, Keizo Tokuhiro, Giuseppe Pezzotti, Tatsuo Kinashi

“…LFA1 clusters co-trafficked with LC3, facilitating LFA1 accumulation at the contact surface. LC3b knockout decreased lymphocyte adhesiveness. LFA1 activation did not induce autophagy, whereas it increased mTOR and AMPK activity. …”
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Physiological consequences of Aldolase C deficiency during lactation. by James A Votava, Jing Fan, Brian W Parks

“…Here, we investigate the role of Aldoc in lactation, by utilizing a whole-body Aldoc knockout mouse. Our results demonstrate that Aldoc has a significant impact on lactation, whereby pups nursing from Aldoc-/- dams have reduced body weight. …”
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Loss of Kat2b impairs intraflagellar transport and the Hedgehog signaling pathway in primary cilia by Jae Hee Jun, Hwayeon Cha, Je Yeong Ko, Ho-Shik Kim, Kyung Hyun Yoo, Jong Hoon Park

“…Kat2b regulates the rate of cilia assembly, particularly in the early stages, and loss of Kat2b reduces the recruitment of intraflagellar transport (IFT) components to the ciliary axoneme and impairs Hedgehog (Hh) signaling activation. In addition, Kat2b-knockout mice showed mild abnormalities and ciliary IFT defects in the kidneys. …”
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The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome by Blazej Misiak, Marta Krolik, Anna Kukowka, Anna Lewera, Przemyslaw Leszczynski, Joanna Stankiewicz-Olczyk, Ryszard Slezak

“…Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). …”
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Selectivity of Inhibition of N-Succinyl-l,l-Diaminopimelic Acid Desuccinylase in Bacteria: The product of dapE-gene Is Not the Target of l-Captopril Antimicrobial Activity by Narasimha Rao Uda, Marc Creus

“…Here, we tested the selectivity of l-captopril against DapE in bacteria. Since DapE knockout strains of gram-negative bacteria are viable upon chemical supplementation with mDAP, we reasoned that the antimicrobial activity of compounds targeting DapE should be abolished in mDAP-containing media. …”
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Generation of a genetically double-attenuated Plasmodium berghei parasite that fully arrests growth during late liver stage development. by Melanie Schmid, Raphael Beyeler, Reto Caldelari, Ruth Rehmann, Volker Heussler, Magali Roques

“…In vivo experiments demonstrated that PbHscB-deficient parasites exhibited a delay in prepatency of 2-4 days, emphasizing the significance of PbHscB for exo-erythrocytic development. Although knockout of PbHscB alone allowed breakthrough infections, it is a potent candidate for a dual gene deletion strategy. …”
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The Expanding Role for Retinoid Signaling in Heart Development by Loretta L. Hoover, Elizabeth G. Burton, Bonnie A. Brooks, Steven W. Kubalak

“…Germline and conditional knockout mice have revealed which molecular players in the vitamin A signaling cascade are potentially responsible for regulating specific developmental events, and many of these molecules have been temporally and spatially characterized. …”
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Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1−/− Mouse by Luciana Garbugino, Eleonora Centofante, Francesca R. D’Amato

“…The results show that double mothering normalized the abnormal response to maternal separation in Oprm1−/− pups and increased social motivation in juveniles and adult knockout mice. Additionally, we observed that Oprm1−/− mice act as less attractive social partners than wild types, which suggests that social motivation can be modulated by the stimulus employed. …”
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Nuclear Factor Erythroid 2-Related Factor 2 Intervenes the Release of Neutrophil Extracellular Traps during Lipopolysaccharide-Induced Acute Lung Injury in Mice by Junying Lu, Guilan Xiong, Hongxiang Li, Dong Zhang, Xiaohao Zhang

“…Results showed that the levels of Cit-H3 measured by western blot in Nrf2-knockout (KO) mice were higher compared with the WT mice after LPS stimulation. …”
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Spontaneous Type 2 Diabetic Rodent Models by Yang-wei Wang, Guang-dong Sun, Jing Sun, Shu-jun Liu, Ji Wang, Xiao-hong Xu, Li-ning Miao

“…On the basis of their strains, features, advantages, and disadvantages, various types of animal models of T2DM can be divided into spontaneously diabetic models, artificially induced diabetic models, and transgenic/knockout diabetic models. Among these models, the spontaneous rodent models are used more frequently because many of them can closely describe the characteristic features of T2DM, especially obesity and insulin resistance. …”
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Screening and Functional Verification of Selectable Marker Genes for Cordyceps militaris by Haiwei Lou, Yu Zhao, Renyong Zhao, Zhiwei Ye, Junfang Lin, Liqiong Guo

“…The selectable marker genes are necessary resistance genes for gene knockout, gene complementation, and gene overexpression in filamentous fungi. …”
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Trichostatin A suppresses hearing loss by reducing oxidative stress and inflammation in an Alport syndrome model. by Yoon Seok Nam, Eun-Ji Gi, Yoo-Seung Ko, Sungsu Lee, Hyong-Ho Cho

“…We investigated the effect of Trichostatin A (TSA), an HDACi, to assess its potential to inhibit hearing deterioration in AS. Col4a3 knockout (KO) mice were treated with TSA at 3 weeks of age, and hearing levels were measured using auditory brainstem response (ABR). …”
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FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells by Xiangchen Kong, Bingfeng Li, Yushen Deng, Xiaosong Ma

“…Consistently, ADCY8 expression was suppressed by the knockdown of FXR in INS-1 832/13 cells, as well as the islets from FXR knockout mice. On the contrary, ADCY8 expression was increased in FXR-overexpressed INS-1 832/13 cells or in the case of FXR activation. …”
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SLC35A2 gene product modulates paramyxovirus fusion events during infection. by Yanling Yang, Yuchen Wang, Danielle E Campbell, Heng-Wei Lee, Wandy Beatty, Leran Wang, Megan Baldridge, Carolina B López

“…As expected, SLC35A1 knockout (KO) cells showed drastic reduction in infections with SeV, NDV and MuV due to the lack of cell surface sialic acids receptors. …”
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