Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis by Sumadhya Deepika Fernando, Chaturaka Rodrigo, Senaka Rajapakse

“…Diethylcarbamazine (DEC) remains the prime antifilarial agent with a well-established microfilaricidal and some macrofilaricidal effects. Ivermectin (IVM) is highly microfilaricidal but minimally macrofilaricidal. …”
Get full text

Therapeutic effectiveness of three commercial anthelmintics against strongylids in buffalo calves (Bubalus bubalis) by David Uzcátegui, Víctor Gutiérrez, María Rodríguez, Andrea González, Alfredo Sánchez

“…Furthermore, levamisole was most effective against strongylids. In the case of ivermectin, the FEC reduction percentage was less than 90% during the trial, resulting in a low-CI 95% of -7.2%, showing possible anthelmintic resistance. …”
Get full text

Insecticidal Activity of Some Traditionally Used Ethiopian Medicinal Plants against Sheep Ked Melophagus ovinus by Negero Gemeda, Walelegn Mokonnen, Hirut Lemma, Ashenif Tadele, Kelbessa Urga, Getachew Addis, Asfaw Debella, Mesaye Getachew, Frehiwot Teka, Kidist Yirsaw, Kissi Mudie, Solomon Gebre

“…Twelve medicinal plants and a commercially used drug Ivermectin were examined for insecticidal activity against Melophagus ovinus sheep ked at different time intervals using in vitro adult immersion test. …”
Get full text

Dermatitis due to Mixed Demodex and Sarcoptes Mites in Dogs by B. Sudhakara Reddy, K. Nalini Kumari, S. Sivajothi, R. Venkatasivakumar

“…Both dogs were treated with daily oral ivermectin at 100 to 400 μg/kg body weight as incremental doses, external application of amitraz and supportive treatments with topical antimicrobial shampoo. …”
Get full text

Rosacea-like skin reaction under treatment with dupilumab for atopic dermatitis by C. Grote, F. Zirkenbach, J. N. Wagner, M. Augustin

“…At first, dupilumab was continued alongside doxycycline, metronidazole gel and ivermectin cream.Results Following a worsening of her skin condition, dupilumab was discontinued. …”
Get full text

Anti-SARS-CoV-2 Biotherapeutics and Chemotherapeutics: An Insight into Product Specifications and Marketing Dynamics by Vijay Kotra, Dinakar Mallem, Anil Kumar Kanuri, Mahesh Reddy Burra, Shaik Nyamathullah, Looi Shu Ying, Khairul Anwar Husain, Ravi Varala, Madhadevi Sudhakar, Khang Wen Goh, Toong Hai Sam, Long Chiau Ming

“…There are several chemotherapeutics that have been studied for the treatment of COVID-19, including Paxlovid (Nirmatrelvir & Ritonavir) fixed dose combination, nirmatrelvir and ritonavir fixed dose combination, Remdesivir (Vekulary/Covifor) fixed dose combination, chloroquine and hydroxychloroquine, molnupiravir, favipiravir, Infliximab (Remsima®) fixed dose combination tocilizumab (Actimera), casirivimab+imdevimab (Ronapreve) fixed dose combination, ivermectin, methylprednisole. These drugs have been repurposed for use in COVID-19 due to their antiviral properties and ability to reduce inflammation. …”
Get full text

Strongyloides Hyperinfection in a Renal Transplant Patient: Always Be on the Lookout by Murtaza Mazhar, Ijlal Akbar Ali, Nelson Iván Agudelo Higuita

“…The patient was treated with a three-week course of ivermectin with complete resolution of signs, symptoms, peripheral eosinophilia, and the positive IgG serology. …”
Get full text

Knowledge, Attitude, and Practice of Community towards an Onchocerciasis Elimination Program from South West Ethiopia by Haile Worku, Misganaw Mola, Bizuwork Derebew Alemu, Sebwedin Surur Jemal, Aklilu Ayiza, Samuel Getachew, Nitin Mahendra Chauhan, Sunil Tulshiram Hajare, Suresh Chandra Singh, Mohammed Kuddus, Vijay J. Upadhye

“…The communities attitude towards community directed therapy (CDT) using Ivermectin is positive (68.5%). According to 56% of the community, offering incentives for community drug distributors (CDD) has the potential to make the elimination campaign more successful. …”
Get full text

Macrofilaricidal Activity, Acute and Biochemical Effects of Three Lichen Species Found on Mount Cameroon by Thierry Roland Kang, Jerome Nyhalah Dinga, Ayuk Elizabeth Orock, Elvis Monya, Moses Njutain Ngemenya

“…Onchocerciasis is a parasitic infection affecting a relatively small population globally but has very devastating pathological outcomes. Ivermectin and recently moxidectin are the only drugs approved for clinical management of the disease, both of which have several limitations. …”
Get full text

大熊猫伊维菌素中毒性休克 by 王成东 兰景超 沈富军 罗 娌 黄文俊 杨 智 刘 礼黄详明 吴孔菊 李明喜 杨奎兴 袁 博 谢 意

“…3只圈养大熊猫在按正常剂量口服伊维菌素(Ivermectin)进行常规体内外寄生虫病预防时突然发生中毒性休克反应,临床主要表现为:全身松软无力、可视粘膜苍白、四肢冰凉伴阵发性痉挛、呼吸微弱浅表、心率缓慢伴节律不齐、眼球深陷、瞳孔缩小至针尖样大小、四肢对疼痛刺激无应答。…”
Get full text

Participatory and Conventional Investigation of Tick Infestation in Camels and Cattle of Somali Pastoral Areas, Eastern Ethiopia by Mohamoud Mohamed Jama, Hassan Abdi Hussein, Shaban Mohamed Abdi, Teka Feyera

“…Livestock owners in Kebribayah and Afdem ranked topical acaricide application as the most effective tick control method, followed by ivermectin injections, with the traditional hand removal method being the least effective. …”
Get full text

A Homemade Snare: An Alternative Method for Mechanical Removal of Dirofilaria immitis in Dogs by Ana Margarida Alho, António Fiarresga, Miguel Landum, Clara Lima, Óscar Gamboa, José Meireles, José Sales Luís, Luís Madeira de Carvalho

“…To assure the death of both larvae and adults, postoperative treatment was successfully managed using ivermectin, doxycycline, and melarsomine, with no recurrence after surgery.…”
Get full text

Persistent intestinal myiasis caused by Oestrus ovis in a Nigerian university student: a case report by Winifred N. Adiri, Bruno Basil, Chinwe P. Onyia, Joy O. Ugwuanyi, Chinyere Azifuaku, Sam C. Iheukwumere, Olivia Obienu, Uchenna N. Ijoma, Sylvester C. Nwokediuko

“…Initial treatment with standard anti-helminthics failed, leading to prolonged treatment with ivermectin, nitazoxanide, and colonic washes, combined with levofloxacin for Helicobacter pylori eradication, resulting in the resolution of symptoms with no recurrence after 6 months. …”
Get full text

Addressing challenges in vector control: a review of current strategies and the imperative for novel tools in India’s combat against vector-borne diseases by Kuldeep Singh, Amit Sharma, Manju Rahi, Sanjeev Kumar Gupta, Gaurav Kumar, Rajendra Baharia, Sam Joy

“…The promising new vector control tools are insecticide-treated nets with synergist and/or pyrrole chlorfenapyr, alternatives/additions to synthetic pyrethroids like neonicotinoids, clothianidin for indoor residual spray, newer formulations such as Bacillus sphaericus for use in larvicides, attractive toxic sugar baits, especially to curtail outdoor transmission, endectocides like ivermectin for use in animals/humans, insecticidal paints, spatial repellents, insecticide-treated wearables and others. …”
Get full text

Druggability and molecular docking of essential secondary metabolites from Azadirachta indica leaf against angiotensin converting enzyme-2: Covid-19 in focus by Paul Chijioke Ozioko, Ukamaka Owohetete, Daniel Danladi Gaiya

“…Of the 12 secondary metabolites from A. indica and 5 FDA-approved drugs identified, azadirachtin A, azadirachtin D, azadirachtin H, azadirachtin F, azadirachtin I and nimbolin, and ivermectin showed relatively poor druggability. Of the 5 FDAapproved medications for the treatment of COVID-19 under investigation, only paritaprevir was able to dock (representing 20%); while 6 out of the 12 compounds from A. indica were able to dock perfectly (representing 50%). …”
Get full text

COVID-19 Infection Clinical Profile, Management, Outcome, and Antibody Response in Kidney Transplant Recipients: A Single Centre Experience by Sanjiv Jasuja, Gaurav Sagar, Anupam Bahl, Shalini Verma

“…The treatment options and used were steroids (100%), convalescent plasma (32.8%), ivermectin (58.2%), doxycycline (55.2%), remdesivir (34.3%), tocilizumab (10.4%), antibiotics (61.2%), anti-fungals (26.9%), low molecular weight heparin (45.3%), and oral anti-coagulants (26.9%). …”
Get full text

Molecular characterization and therapeutic insights into biofilm positive Staphylococcus aureus isolated from subclinical mastitis in dairy buffaloes by Muhammad Ijaz, Muhammad Umar Javed, Arslan Ahmed

“…Antimicrobial effects of non-antibiotics against study isolates accessed through the well diffusion method showed higher inhibition zones for meloxicam followed by flunixin, ketoprofen, and ivermectin. The combinations of amoxicillin/meloxicam, cotrimoxazole/flunixin, cotrimoxazole/ ketoprofen, and gentamicin/ flunixin on well diffusion method, and cotrimoxazole/ flunixin, amoxicillin/ketoprofen and gentamicin/flunixin on checkerboard assay revealed synergistic interactions. …”
Get full text

Risk Factors of Noncompliance to Preventive Mass Drug Administration for Eliminating Lymphatic Filariasis: A Case-Control Study in Jawi District, Northwest Ethiopia by Fetene Mihretu, Gebeyehu Tsega, Melesse Belayneh, Mesafint Molla Adane

“…Therefore, this study was conducted to identify the factors associated with noncompliance to prevent mass drug administration using ivermectin-with-albendazole for the elimination of lymphatic filariasis in Northwest Ethiopia. …”
Get full text

The Impact of Onchocerciasis Elimination Measures in Africa: A Systematic Review by Policarpo Ncogo, Christine Giesen, María Jesús Perteguer, Maria P. Rebollo, Rufino Nguema, Agustín Benito, Zaida Herrador

“…The main intervention retained in the different published studies was mass distribution of ivermectin (<i>n</i> = 51). According to our results, 11 African countries have managed to interrupt transmission of onchocerciasis in at least one area in the country; 11 countries have not achieved this goal, while 1 country has managed to eliminate the disease, but it has resurged. …”
Get full text

Development of Evidence-Based COVID-19 Management Guidelines for Local Context: The Methodological Challenges by Sarah Nadeem, Salima Saleem Aamdani, Bushra Ayub, Nashia Ali Rizvi, Fatima Safi Arslan, Russell Seth Martins, Maria Khan, Syed Faisal Mahmood

“…Regarding the use of antibiotics and ivermectin use in treating COVID-19 hospitalized patients, data from our review and WHO v 7.1 recommend against their use. …”
Get full text