Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists by Atefeh Saadabadi, Linda Wilkman, Marja Rantanen, Ari-Pekka Koivisto, Outi M. H. Salo-Ahen

“…To identify potential TRPV4 inhibitors for drug development, we screened a library of ion channel-modulating compounds using both structure- and ligand-based virtual screening approaches. …”
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Accumulation and distribution of cadmium at organic-mineral micro-interfaces across soil aggregates by Qi Li, Linfeng Li, Bohao Yin, Xiaoyang Lin, Anwen Xiao, Weijie Xue, Hengjie Liu, Yichun Li

“…Pot experiments were conducted to assess the impacts of mineral, organic, and microbial amendments on the Cd distribution in soil aggregates using synchrotron radiation-based Fourier transform infrared (SR-FTIR) spectroscopy and nano-scale secondary ion mass spectrometry (NanoSIMS). Our results revealed that different soil amendments exerted varying effects on Cd accumulation in soil aggregates. …”
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Phytochemicals and Biological Properties of Azorean <i>Camellia sinensis</i> Black Tea Samples from Different Zones of Tea Plantation by Lisete Sousa Paiva, Ana Paula Dias, Madalena Hintze Motta, José António Bettencourt Baptista

“…The free radical scavenging activity (FRSA), ferric reducing antioxidant power (FRAP), ferrous ion chelating (FIC) activities, total phenolic content (TPC), total flavonoid content (TFC), and tannins were determined by colorimetric methods, and catechin and theaflavin contents were analyzed by high-pressure liquid chromatography. …”
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Dystonia caused by ANO3 variants is due to attenuated Ca2+ influx by ORAI1 by Jiraporn Ousingsawat, Khaoula Talbi, Hilario Gómez-Martín, Anne Koy, Alberto Fernández-Jaén, Hasan Tekgül, Esra Serdaroğlu, Juan Darío Ortigoza-Escobar, Rainer Schreiber, Karl Kunzelmann

“…Abstract Background Dystonia is a common neurological hyperkinetic movement disorder that can be caused by mutations in anoctamin 3 (ANO3, TMEM16C), a phospholipid scramblase and ion channel. We previously reported patients that were heterozygous for the ANO3 variants S651N, V561L, A599D and S651N, which cause dystonia by unknown mechanisms. …”
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Apolipoprotein C-I Levels Are Associated with the Urinary Protein/Urinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study by Jun Odaka, Takahiro Kanai, Takane Ito, Takashi Saito, Jun Aoyagi, Hiroyuki Betsui, Takanori Yamagata

“…We used surface-enhanced laser desorption/ionization time of flight MS for sample analysis. Four ion peaks with a mass-to-charge ratio (m/z) of 6,444, 6,626, 8,695, and 8,915 were significantly elevated during ISSNS Phase A1 compared to Phase A2, Phase A3, and Group C. …”
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Radiofrequency thermocoagulation of Gasserian ganglion in trigeminal neuralgia by Natalia Maria Rulewska, Filip Grabowski, Dagmara Neska, Jakub Siemko, Dominika Prystacka-Szar, Justyna Stadler-Szajda, Adrianna Czyżnikiewicz, Wenancjusz Stołowski, Magdalena Bujak, Magdalena Waśniowska, Jakub Chodkowski

“…Conclusion: The exact mechanisms behind trigeminal neuralgia are still unclear, but several theories suggest that factors such as inflammation, ion channel dysfunction, neuroinflammatory conditions, or bioresonance issues may be involved. …”
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Integration of Metabolomics and Transcriptomics to Reveal the Antitumor Mechanism of <i>Dendrobium officinale</i> Polysaccharide-Based Nanocarriers in Enhancing Photodynamic Immuno... by Shengchang Tao, Huan Wang, Qiufeng Ji, Yushan Yang, Gang Wei, Ruiming Li, Benjie Zhou

“…The metabolic analysis showed 69 and 60 differentially expressed metabolites (DEMs) in positive- and negative-ion modes, respectively, in the treated samples compared to the Control samples. …”
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A sedimentological oxymoron: highly evolved glauconite of earliest diagenetic origin by Tribovillard, Nicolas, Bout-Roumazeilles, Viviane, Guillot, François, Baudin, François, Deconinck, Jean-François, Abraham, Romain, Ventalon, Sandra

“…Glauconite formation allegedly requires protracted episodes of ion capture from the water column, which is no longer possible when glauconite gets trapped within authigenic carbonates. …”
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Effect of bicarbonate buffer on artificial membrane permeation of drugs by Shiori Ishida, Sam Lee, Balint Sinko, Karl Box, Kiyohiko Sugano

“…Experimental approach: The μFlux apparatus (pION Inc.) was used for permeability measurements. …”
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Structural, Optical and Electrochromic Properties of Sol–Gel V2O5 Thin Films by M. Benmouss, A. Outzourhit, R. Jourdani, A. Bennouna, E. L. Ameziane

“…The films show reversible multichromism (yellow–green–blue) upon Li+ ion insertion/extraction. The absorbance of films colored at three different potentials is measured in the UV–VIS–PIR wavelength range, and this study shows that the changes in the optical absorption are consistent with the film color changes. …”
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Influencing factors and quantitative prediction of gas content of deep marine shale in Luzhou block by Xinyang He, Kun Zhang, Shu Jiang, Zhenxue Jiang, Xueying Wang, Wei Jiang, Jing Li, Yijia Wu, Zhi Gao, Tian Tang, Cheng Yang, Xuejiao Yuan, Fengli Han, Zeyun Wang, Laiting Ye

“…In this study, the deep marine shale of Longmaxi Formation in Luzhou area was taken as an example, vitrinite reflectance analysis, kerogen microscopy experiment, TOC content analysis, mineral composition analysis, gas content measurement, isothermal adsorption experiment, physical property analysis and argon ion polishing scanning electron microscopy experiment were carried out to find out factors affecting the gas content of deep marine shale, and a gas content prediction model has been worked out. …”
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Three-Dimensional Morphology and Connectivity of Organic Pores in Shale from the Wufeng and Longmaxi Formations at the Southeast Sichuan Basin in China by Tao Jiang, Zhijun Jin, Zongquan Hu, Wei Du, Zhongbao Liu, Jianhua Zhao

“…Organic pore types and their structural characteristics were studied using a total organic carbon (TOC), thin section, focused ion beam scanning electron microscope (FIB-SEM), and nano-CT. …”
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Adsorption Performance of La(III) and Y(III) on Orange Peel: Impact of Experimental Variables, Isotherms, and Kinetics by Li Liu, Yunzhang Rao, Changshun Tian, Tao Huang, Jiacheng Lu, Meidao Zhang, Min Han

“…The optimal adsorption conditions were obtained at pH of 6, temperature of 40°C, appropriate dosage of 2 g/L and 3 g/L, contact time of 30 min, and initial ion concentration of 32 mg/L. Under the same condition, adsorption performance of La(III) is better than that of Y(III). …”
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Manipulating polarization attenuation in NbS2–NiS2 nanoflowers through homogeneous heterophase interface engineering toward microwave absorption with shifted frequency bands by Yiru Fu, Yuping Wang, Junye Cheng, Yao Li, Jing Wang, Yongheng Jin, Deqing Zhang, Guangping Zheng, Maosheng Cao

“…The strong electron transfer at the interface promotes electron transport throughout the material, which results in less scattering, promotes conduct ion loss and dielectric polarization relaxation, improves dielectric loss, and results in a good impedance matching of the material. …”
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Unravelling Lithium Interactions in Non-Flammable Gel Polymer Electrolytes: A Density Functional Theory and Molecular Dynamics Study by Nasser AL-Hamdani, Paula V. Saravia, Javier Luque Di Salvo, Sergio A. Paz, Giorgio De Luca

“…These findings offer insights into the Li⁺ transport mechanism at the molecular scale in the GPE by suggesting that lithium-ion transport does not occur by hopping between polymer functional groups but by diffusion into the solvent/counter anion system. …”
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Influence of Frying Methods on Quality Characteristics and Volatile Flavor Compounds of Giant Salamander (Andrias davidianus) Meatballs by Wengang Jin, Jinjin Pei, Xiaohua Chen, Jingzhang Geng, Dejing Chen, Ruichang Gao

“…There was little distinction in sensory score, cohesiveness, and chewiness between the two frying methods (p>0.05). Gas chromatography ion migration chromatography (GC-IMS) was used for flavor compound analysis, and 50 flavor compounds were analyzed, containing 22 aldehydes, 11 ketones, 6 olefins, 4 acids, 3 esters, 3 alcohols, and 1 phenol. …”
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Compound-Specific Chlorine Isotope Analysis of Organochlorine Pesticides by Gas Chromatography-Negative Chemical Ionization Mass Spectrometry by Jing Zhang, Shenghua Liu, Jianye Gui, Xiaoya Li, Guochen Qi

“…An ionization energy of 90 eV and emission current of 90 μA were selected, and the precisions for eight organochlorine pesticides were in the range of 0.37‰–2.15‰ in single ion monitoring (SIM) mode when the injected amount was 0.50 mg L−1 (viz. 0.5 ng on column). …”
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Infiltration-driven performance enhancement of poly-crystalline cathodes in all-solid-state batteries by Junghwan Sung, Junyoung Heo, Dong-Hee Kim, Hawon Gu, Yung-Soo Jo, Heetaek Park, Jun-Ho Park, Jeong-Hee Choi, Yoon-Cheol Ha, Doohun Kim, Jun-Woo Park

“…Abstract All-solid-state batteries (ASSBs) with adequately selected cathode materials exhibit a higher energy density and better safety than conventional lithium-ion batteries (LIBs). Ni-rich layered cathodes are benchmark materials for traditional LIBs owing to their high energy density. …”
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Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism by Susan Lin, Aravind R Gade, Hong-Gang Wang, James E Niemeyer, Allison Galante, Isabella DiStefano, Patrick Towers, Jorge Nunez, Maiko Matsui, Theodore H Schwartz, Anjali Rajadhyaksha, Geoffrey S Pitt

“…Developmental and epileptic encephalopathies (DEEs), a class of devastating neurological disorders characterized by recurrent seizures and exacerbated by disruptions to excitatory/inhibitory balance in the brain, are commonly caused by mutations in ion channels. Disruption of, or variants in, FGF13 were implicated as causal for a set of DEEs, but the underlying mechanisms were clouded because FGF13 is expressed in both excitatory and inhibitory neurons, FGF13 undergoes extensive alternative splicing producing multiple isoforms with distinct functions, and the overall roles of FGF13 in neurons are incompletely cataloged. …”
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A Reinforcement-Learning Based Approach for Designing High-Voltage SiC MOSFET Guard Rings by Tejender Singh Rawat, Chia-Lung Hung, Yi-Kai Hsiao, Wei-Chen Yu, Surya Elangovan, Wei-Ting Lin, Yi-Rong Lin, Kai-Lin Yang, Nien-Yi Jan, Yung-Hui Li, Hao-Chung Kuo

“…This work explores the implementation of machine learning on SiC guard ring parameters such as ion implanted dose and energy. In this work, the reinforcement learning method has been successfully implemented on the 1.7 kV SiC guard ring device TCAD simulated data for the prediction of parameters. …”
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