Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera by Fabien Sourisseau, Craig A. Doupnik, Pierre Charnet, Mohamed Chahine

“…Kir (inwardly rectifying potassium) channels that play key roles in maintaining potassium homeostasis, neuronal excitability, and osmoregulation have been cloned and characterized in a variety of insects. …”
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Overexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model by Fang Li, Zhen Li, Shuying Li, Hong Zhou, Yunhui Guo, Yongchen Wang, Bo Lei, Yanying Miao, Zhongfeng Wang

“…Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells, which is involved in retinal ganglion cell apoptosis in glaucoma. …”
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Involvement of Inwardly Rectifying Potassium (Kir) Channels in the Toxicity of Flonicamid to <i>Drosophila melanogaster</i> by Xuan Liu, Yuying Gao, Tengfei Liu, Hailiang Guo, Jizu Qiao, Jianya Su

Subjects: “…inwardly rectifying potassium channels…”
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Toxicity of Flonicamid to <i>Diaphorina citri</i> (Hemiptera: Liviidae) and Its Identification and Expression of Kir Channel Genes by Jiangyue Zhu, Xinjing Wang, Yunfei Mo, Beibei Wu, Tuyong Yi, Zhongxia Yang

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Astrocytic proteins involved in regulation of the extracellular environment are increased in the Alzheimer's disease middle temporal gyrus by Henry Liu, Adelie Y.S. Tan, Nasim F. Mehrabi, Clinton P. Turner, Maurice A. Curtis, Richard L.M. Faull, Mike Dragunow, Malvindar K. Singh-Bains, Amy M. Smith

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Dynamic duo: Kir6 and SUR in KATP channel structure and function by Bruce L. Patton, Phillip Zhu, Assmaa ElSheikh, Camden M. Driggers, Show-Ling Shyng

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Atomic-level investigation of KCNJ2 mutations associated with ventricular arrhythmic syndrome phenotypes by Saba Munawar, Corey L. Anderson, Louise Reilly, Ryan Woltz, Yusra Sajid Kiani, Nipavan Chiamvimonvat, Lee L. Eckhardt

“…Abstract KCNJ2 encodes the inward rectifying potassium channel (Kir2.1) that underlies I K1 which maintains the cardiac resting membrane potential and regulates excitability. …”
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Physiological characterisation of human iPS-derived dopaminergic neurons. by Elizabeth M Hartfield, Michiko Yamasaki-Mann, Hugo J Ribeiro Fernandes, Jane Vowles, William S James, Sally A Cowley, Richard Wade-Martins

“…The neuronal cultures include cells positive for both tyrosine hydroxylase (TH) and G protein-activated inward rectifier potassium channel 2 (Kir3.2, henceforth referred to as GIRK2), representative of the A9 population of substantia nigra pars compacta (SNc) neurons vulnerable in PD. …”
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Reciprocal interaction between IK1 and If in biological pacemakers: A simulation study. by Yacong Li, Kuanquan Wang, Qince Li, Jules C Hancox, Henggui Zhang

“…Experimentally and computationally, it has been shown that bio-engineered pacemaker cells can be generated from non-rhythmic ventricular myocytes (VMs) by knocking out genes related to the inward rectifier potassium channel current (IK1) or by overexpressing hyperpolarization-activated cyclic nucleotide gated channel genes responsible for the "funny" current (If). …”
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Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. by Alberto Montalbano, Renato Corradetti, Boris Mlinar

“…Whole-cell voltage-clamp recording in brainstem slices were used to determine concentration-response relationships for the selected GIRK channel blockers on 5-HT1A autoreceptor-activated inwardly rectifying K+ conductance in rat dorsal raphe 5-HT neurons. 5-HT1A autoreceptor-activated GIRK conductance was completely blocked by the nonselective inwardly rectifying potassium channels blocker Ba2+ (EC50 = 9.4 μM, full block with 100 μM) and by SCH23390 (EC50 = 1.95 μM, full block with 30 μM). …”
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Unique pharmacological properties of etrasimod among S1P receptor modulators by Ibragim Gaidarov, H. Kiyomi Komori, Dariusz T. Stepniak, Karin Bruinsma, Huong Dang, Xiaohua Chen, Todd Anthony, Joel Gatlin, Lisa Karimi‐Naser, Anh‐Tuan Ton, Tim Indersmitten, Paul E. Miller, Andre Ghetti, Najah Abi‐Gerges, David Unett, Hussien Al‐Shamma, Christopher J. Rabbat, Catherine Crosby, John W. Adams

“…Relatively lower potency of etrasimod in inducing G protein signaling corresponded to significantly diminished activation of human cardiac G protein‐coupled inwardly rectifying potassium channels when compared to ozanimod. …”
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Loss of expression and function of Gβγ by GNB1 encephalopathy-associated L95P mutation of the Gβ1 subunit by Haritha P. Reddy, Tal Keren-Raifman, Galit Tabak, Nathan Dascal, Nathan Dascal, Daniel Yakubovich, Daniel Yakubovich

“…BackgroundG-proteins areindispensable regulators of cellular signaling, with G-protein-gated inwardly rectifying potassium channels (GIRK) as key effectors. GNB1 encephalopathy (GNB1E) is a congenital neurological syndrome resulting from mutations in the GNB1 gene, encoding the Gβ1 subunit of G-proteins trimer (Gαβγ). …”
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124I‐labelled BMSC‐Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP‐Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis by Yujie Pan, Xianteng Yang, Zhirui Zeng, Futao Liu, Jin Luo, Mao Shen, Wei Zhou, Jianyang Li, Guangfu Jiang, Li Sun, Haifeng Huang, Runsang Pan

“…Our previous research indicated that the inwardly rectifying potassium channel subfamily J member 2 (KCNJ2) inhibits the degradation of HIF‐1α in osteosarcoma. …”
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