Clinical Characteristics of Virologically Confirmed Respiratory Syncytial Virus in English Primary Care: Protocol for an Observational Study of Acute Respiratory Infection by Uy Hoang, Utkarsh Agrawal, José Manuel Ordóñez-Mena, Zachary Marcum, Jennifer Radin, Andre Araujo, Catherine A Panozzo, Orsolya Balogh, Mihir Desai, Ahreej Eltayeb, Tianyi Lu, Catia Nicodemo, Xinchun Gu, Rosalind Goudie, Xuejuan Fan, Elizabeth Button, Jessica Smylie, Mark Joy, Gavin Jamie, William Elson, Rachel Byford, Joan Madia, Sneha Anand, Filipa Ferreira, Stavros Petrou, David Martin, Simon de Lusignan

“…According to data from the UK Health Security Agency, the peak RSV swab positivity was in International Standards Organization week 48, 2023. Data collection remains ongoing, and results from the subset of practices participating in this study are not yet available. …”
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Reliability, validity, and minimal clinically important differences for the Thai-version of the Aberdeen Varicose Vein Questionnaire (AVVQ-Thai) in patients with chronic venous dis... by Suchat Wongsuwanich, Chaowanun Pornwaragorn, Chumpon Wilasrusmee, Termpong Reanpang, Pinit Noorit, Boonying Siribumrungwong, Kittipan Rerkaserm, Andrew Malcolm Garratt, Thoetphum Benyakorn, Saritphat Orrapin, Kanoklada Srikuea

“…Minimal clinically important differences (MCID) of the AVVQ-Thai also be estimated. Methods International standards for PROM translation were followed including the forward-backwards translation of the AVVQ. …”
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STANDARDIZATION OF CLINICAL PHARMACIST FUNCTIONAL RESPONSIBILITIES IN HOSPITAL SETTING IN UKRAINE AND ABROAD by Andriy Zimenkovsky, Х.І. Макух, Myroslava Sekh, Marta Zayats

“…The object of research: survey protocols of national clinical pharmacists (n=22); international standards of professional activity for clinical pharmacists (n=7); experience of implementing clinical pharmacy services abroad (n=7). …”
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Development and validation of an LC-MS/MS method for the simultaneous estimation of tadalafil and macitentan in rat plasma: Greenness assessment and design of experiment approach by Sravanthi Gandu, Kumaraswamy Gandla, Lalitha Repudi

“…The retention times were 4.13 min for tadalafil, 5.32 min for macitentan, and 7.89 min for the internal standard, ritonavir. The method adhered to regulatory validation guidelines, linearity was observed over a concentration range of 20 to 400 ng/mL for tadalafil and 5 to 100 ng/ml for macitentan, yielding correlation coefficients of 0.9997 and 0.9998, respectively, with limits of quantitation (LOQs) of 19.10 ng/mL for tadalafil and 4.21 ng/mL for macitentan. …”
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مداخلة علمیة حول النشر العلمى فى مصادر الوصول الحر Open Access بین التأیید والرفض by Gamal Al Dahshan

“…Scientific publishing is the scientific and important way, but it is one of themost important criteria used to estimate the level of scientific productionIt has also become one of the most important international standards forthe classification of universities, Therefore, universities and research centers areinterested in publishing the results of their scientific research in the publishedpublishing vessels, which adopt the strict scientific standardsSuch as specialized scientific journals or conference books, in order toshare knowledge and results so that research can continue and its results andobjectives will be integrated.The Free Access and Free publishing movement has emerged in the pasttwo decades as a result of its benefits in improving the flow of information. …”
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Microplastic analysis in soils: A comparative assessment by Stoyana Peneva, Quynh Nhu Phan Le, Davi R. Munhoz, Olivia Wrigley, Flora Wille, Heidi Doose, Crispin Halsall, Paula Harkes, Michael Sander, Melanie Braun, Wulf Amelung

“…Yet, our data indicate that adding stained large MiP as an internal standard could enhance extraction control, while Soxhlet-extraction with subsequent 1H NMR analysis is most powerful for controlling future thresholds of small MiP from biodegradable materials.…”
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Detection Methods for Asparagine and Glutamine Contents in Fruits and Vegetables and Recommendations for Dietary Intake of Fruits and Vegetables in Patients with Urea Cycle Disorde... by YE Xinyu, LI Ziying, TANG Shujun, SUN Liping, ZHAO Yunxia, XIAO Weimin, GU Yaping, KUANG Huiying, CHEN Xin, YANG Guowu, HUANG Yali

“…The mass spectrometer was equipped with an electrospray ionization source and operated in the positive ion mode with multiple reaction monitoring (MRM), and quantification was achieved using stable isotope-labeled internal standards. The calibration curves for Asn and Gln showed a good linearity in the range of 10–1 000 ng/mL (R2 > 0.999), with limit of detection (LOD) and limit of quantification (LOQ) of 1.5 and 5.0 mg/100 g, respectively. …”
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Hotspots in peril: Misalignment of conservation efforts and ecological values in a shallow coastal sea by Kasper J. Meijer, Oscar Franken, Sterre Witte, Sander J. Holthuijsen, Tjisse van der Heide, Laura L. Govers, Han Olff

“…We first spatially overlay and translate the different protection measures to international standards. We then determine hotspots of ecological quality based on nationally and internationally used indicators of biodiversity and seafloor status and map their overlap with protected areas. …”
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Validity of the Systemic Lupus Erythematosus Disease Activity 2000-Glucocorticoid Index, its association with the Physician Global Assessment, and potential association with diseas... by Basma M. Medhat, Lobna A. Maged, Doaa A. Teleb, Sally S. Mohamed, Angie Y. Afifi, Dina M. T. Koptan, Walaa Abdelrahman, Dalia Dorgham, Eman Hany Elsebaie, Naglaa Afifi, Sahar A. Ahmed, Mervat E. Behairy, Hala Ramadan

“…The PGA (scale: 0–3) was categorized according to the PGA international standardization consensus in SLE study (PISCOS). …”
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Identification of ketamine and norketamine in dried bloodstains on crime-scene surfaces by Risha Jasmine Nathan, Babajide Okeleye, Rabiu Abdullahi, Waliyu Oyebode

“…Analytes were solvent-extracted using a dichloromethane: hexane (1:3 v/v) mixture, followed by gas chromatography-mass spectrometry (GC–MS) analysis with ketamine-d4 as the internal standard. Results At least 4.3 ng/mL and 8.7 ng/mL ketamine and norketamine, respectively, were detected in dried stains prepared from 5 to 50 µL whole blood corresponding to a concentration range of 10–100 ng/mL. …”
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Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suri... by Antoon W Grünberg, William Hawkins, Wilco Zijlmans, Jeffrey Wickliffe, Ashna Hindori-Mohangoo, Sigrid MacDonald-Ottevanger, Paul Ouboter, Gwendolyn Landburg, John Codrington, Jimmy Roosblad, Gaitree Baldewsingh, Radha Ramjatan, Anisma Gokoel, Firoz Abdoel Wahid, Lissa Fortes Soares, Cecilia Alcala, Esther Boedhoe, Arti Shankar, Emily Harville, S S Drury, Hannah Covert, Maureen Lichtveld

“…Follow-up will take place until children are 48 months old.Findings to date Biospecimens and questionnaire data on physiological and psychosocial health in pregnant women have been analysed. 39.1% had hair mercury (Hg) levels exceeding values considered safe by international standards. Median hair Hg concentrations in women from Paramaribo (N=522) were 0.64 µg/g hair (IQRs 0.36–1.09; range 0.00–7.12), from Nickerie (N=176) 0.73 µg/g (IQR 0.45–1.05; range 0.00–5.79) and the interior (N=178) 3.48 µg/g (IQR 1.92–7.39; range 0.38–18.20). 96.1% of women ate fish, respective consumption of the three most consumed carnivorous species, Hoplias aimara, Serrasalmus rhombeus and Cichla ocellaris, known to have high Hg levels, was 44.4%, 19.3% and 26.3%, respectively, and was greater among the interior subcohort. 89% frequently consumed the vegetable tannia, samples of which showed presence of worldwide banned pesticides. 24.9% of pregnant women had Edinburgh Depression Scale scores indicative of probable depression.Future plans Fish consumption advisories are in development, especially relevant to interior women for whom fish consumption is likely to be the primary source of Hg exposure. …”
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Analysis of PM10 trends in open-pit mining: Assessing emission controls and WHO guideline compliance by Roberto Rojano, Heli A. Arregocés, Gloria Restrepo

“…These results underscore the importance of considering control measures in the planning of mining activities and highlight the need to incorporate these observations to comply with national and international standards.…”
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Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma by Jiahui Lin, Jiahui Lin, Aiting Jiang, Juntao Zheng, Jingjing Wu, Hao Li, Hao Li, Shirong Cai, Yulong He, Xiao Chen, Guoping Zhong, Ke-Jing Tang, Ke-Jing Tang, Xinhua Zhang, Yanzhe Xia

“…The ion pairs of ripretinib, DP-5439 and internal standard D8-ripretinib were m/z 510.1→m/z 417, m/z 496.11→m/z 402.9 and m/z 518.15→m/z 420, respectively. …”
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TAX COMPLIANCE RISK AS AN ELEMENT OF THE TAX RISK MANAGEMENT CONCEPT IN AN ENTERPRISE by Olha Mashchenko, Anastasiia Khodus

“…The purpose of the study is to confirm the need to apply a tax compliance risk management system in the activities of business entities in the context of integration of domestic legislation and the modern economy in accordance with international standards. Determine the principles, segments and criteria of compliance risk introduced by the legislation. …”
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New Technological Knowledge Integration in Industries with Long-Wave Innovation: Case Study of Iran Mining and Mineral Industry by akbar Mohammadi, Nima Garosi Mokhtarzade, Ahmad Jafar nejad

“…Conclusion This study reveals that activities such as aligning new technology with operational functions, adopting new technology at the right time to match the firm's knowledge base, maintaining equipment, evaluating product compatibility with international standards, and implementing integrated technology information systems are crucial for firms to achieve greater success in knowledge integration. …”
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Determination of Modelling Error Statistics for Cold-Formed Steel Columns by R. P. Rokade, K. Balaji Rao, B. Palani

“…In this article, an attempt has been made to estimate the Modelling Error (ME) associated with compression capacity models available in international standards for different failure modes of compression members fabricated from Cold-Formed Steel (CFS) lipped channel sections. …”
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UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research by Zhan R, Liu Y, Wu J, Shen Y, Xu X, Lin G, Chen X

“…Ruanjuan Zhan,1,* Yanan Liu,1,2,* Jun Wu,1,2 Yuxin Shen,1,2 Xinhao Xu,1,2 Guanyang Lin,1,2 Xiaocheng Chen1 1The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China; 2School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanyang Lin; Xiaocheng Chen, Email 13867702133@163.com; cxcwzcn@139.comBackground: Givinostat, a potent histone deacetylase (HDAC) inhibitor, is promising for the treatment of relapsed leukemia and myeloma.Purpose: This study aimed to develop and verify a quick assay for the measurement of givinostat concentration using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) with eliglustat as the internal standard (IS), establishing a basic pharmacokinetic profile for its pre-clinical application and metabolic stability in vitro.Methods: Sample preparation was performed via protein precipitation using acetonitrile. …”
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Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis by Soojin Jang, Ho-Shin Gwak, Kyue-Yim Lee, Jun Hwa Lee, Kyung-Hee Kim, Jong Heon Kim, Jong Bae Park, Sang Hoon Shin, Heon Yoo, Yun-Sik Dho, Kyu-Chang Wang, Byong Chul Yoo

“…Methods We quantitatively measured amino acids, biogenic amines, hexoses, acylcarnitines (AC), cholesteryl esters (CE), glycerides, phosphatidylcholines (PC), lysophosphatidylcholines (LPC), sphingomyelins (SM), and ceramides (Cer) in 117 CSF samples from various groups of healthy controls (HC, n = 10), patients with LM (LM, n = 47), parenchymal brain tumor (PBT, n = 45), and inflammatory disease (ID, n = 13) with internal standards using the Absolute IDQ- p400® targeted mass spectrometry kit. …”
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Prevalence of overweight and obesity among preschool children in Hainan: a cross-sectional study in China's largest free-trade zone by Wei-Jia Wu, Wei-Jia Wu, Ping-Hao Chen, Ping-Hao Chen, Zhen-Ning Huang, Zhen-Ning Huang, Xue-Lu Lei, Xue-Lu Lei, Chen Wang, Chen Wang, Chun-hui Zhang, Chun-hui Zhang, Ping Wang, Ping Wang, Chui-can Huang, Qing Luo, Qing Luo, Li-Chun Fan, Li-Chun Fan

“…Considering that the growth and development indicators for children under 7 years old in Hainan Island are generally lower than international standards, the use of Chinese standards may be more suitable for detecting overweight and obesity among preschool children in this area. …”
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Exploring policy processes against microbial threats in Iran: a qualitative policy analysis by Amirhossein Takian, Ali Akbari Sari, Masud Yunesian, Azam Raoofi

“…The discrepancies in M&E varied, with some programmes having regular evaluations and others lacking compliance with international standards. Barriers to effective M&E included inadequate data access, limited information-sharing and inefficiencies in the M&E system.Conclusions Iran needs to prioritise infectious diseases, invest in preventive measures, improve governance and coordination, strengthen health system capacity, enhance M&E and so on, to combat microbial threats effectively. …”
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