Tocilizumab Controls Paraneoplastic Inflammatory Syndrome but Does Not Suppress Tumor Growth of Angiomatoid Fibrous Histiocytoma by Hideaki Sabe, Akitomo Inoue, Shigenori Nagata, Yoshinori Imura, Toru Wakamatsu, Satoshi Takenaka, Hironari Tamiya

“…In some reports, high interleukin-6 (IL-6) production promotes tumor growth by autocrine stimulation and tocilizumab, an IL-6 receptor antagonist, can control AFH growth. …”
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Hsa_circ_0000190 Promotes NSCLC Cell Resistance to Cisplatin via the Modulation of the miR-1253/IL-6 Axis by Hua He, Tian Li

“…Analyses of NSCLC expression of hsa_circ_0000190, miR-1253, and interleukin 6 (IL-6) were conducted via a quantitative real-time polymerase chain reaction (qPCR) approach, while the ability of these tumor cells to resist DDP treatment was evaluated with a CCK-8 assay. …”
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A Study of Inflammatory/Necrosis Biomarkers in the Fracture of the Femur Treated with Proximal Femoral Nail Antirotation by Mariapaola Marino, Giuseppe Palmieri, Marco Peruzzi, Flavia Scuderi, Emanuela Bartoccioni

“…Serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and plasma creatin kinase (CK) were evaluated 1 hour preoperatively and 24 hours postoperatively. …”
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HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient by Carlo Guerrero, Tania Jain, Katalin Kelemen

“…HHV-8 promotes lymphoproliferation via the activation of the interleukin-6 receptor signaling pathway, as well as a host of other regulatory mechanisms. …”
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Purification and identification of anti-inflammatory peptides from sturgeon (Acipenser schrenckii) cartilage by Li Yuan, Qian Chu, Bei Yang, Wei Zhang, Quancai Sun, Ruichang Gao

“…Among these five peptides, LTGP, LLLE, LLEL and VGPAGPAGP reduced the production of nitric oxide (NO) and interleukin-6 (IL-6) while increasing interleukin-10 (IL-10) excretion. …”
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IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING by Xue Zeng, Xiaosong Li, Yundong Zhang, Chaoxia Cao, Qin Zhou

“…Endometrial carcinoma (EC) is a commonly diagnosed gynecological malignancy. Interleukin-6 (IL6) plays a critical role in modulating the progression of several types of tumors, including EC. …”
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Effect of Interleukin and Hepcidin in Anemia of Chronic Diseases by Maha F. Yacoub, Hala Fouad Ferwiz, Fadwa Said

“…Recent studies revealed that interleukin-6 (IL-6), a proinflammatory cytokine, and hepcidin, an antimicrobial hepatic peptide, play a key role in ACD pathogenesis. …”
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Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1 by Xiao-hui Li, Xia Gong, Li Zhang, Rong Jiang, Hong-zhong Li, Meng-jiao Wu, Jing-yuan Wan

“…In addition, PD inhibited CLP-induced serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production, lung cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) protein expressions and NF-κB activation. …”
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Elevated Circulating IL-1<mml:math> <mml:mi>&#x03B2;</mml:mi> </mml:math> and TNF-Alpha, and Unaltered IL-6 in First-Trimester Pregnancies Complicated by Threatened Abortion With...

“…Serum levels of Th1-type cytokines interleukin-1<mml:math> <mml:mi>&#x03B2;</mml:mi> </mml:math> (IL-1<mml:math> <mml:mi>&#x03B2;</mml:mi> </mml:math>), tumor necrosis factor alpha (TNF-alpha), and Th2-type cytokine interleukin 6 (IL-6) were measured, by ELISA, in 22 women with TACP and adverse outcome at admission (group A) and compared with the corresponding levels of 31 gestational age-matched women with TACP and successful outcome at admission (group B1) and discharge (group B2) and 22 gestational age-matched women with first-trimester uncomplicated pregnancy (group C) who served as controls. …”
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Spatiotemporal Pattern of Neuroinflammation After Impact-Acceleration Closed Head Injury in the Rat by Servan Rooker, Sebastian Jander, Jos Van Reempts, Guido Stoll, Philippe G. Jorens, Marcel Borgers, Jan Verlooy

“…We analyzed the spatiotemporal expression pattern of the proinflammatory key molecules: interleukin-1β, interleukin-6, tumor necrosis factor-α, and inducible nitric oxide synthase in a rat closed head injury (CHI) paradigm. 51 rats were used for RT-PCR analysis after CHI, and 18 for immunocytochemistry. …”
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Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective by Didar Murad, Rehan Zafar Paracha, Maryum Nisar

“…Simulation results highlight key components affected, including thrombin, tissue plasminogen activator, plasmin, fibrin degradation products, interleukin 6 (IL-6), the IL-6 and IL-6R complex, and the terminal complement complex (C5b-9). …”
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Role of cytokines in myocardial ischemia and reperfusion by H. S. Sharma, D. K. Das

“…For instance, hypoxic cardiomyocytes produce interleukin-6 (IL-6) which could contribute to the myocardial dysfunction observed in ischemia reperfusion injury. …”
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A Case of Severe Multisystem Inflammatory Syndrome in Children (MIS-C) Treated with Multiple Biologics by Beenish Zulfiqar, Hira Imran, Kathleen Collins

“…He was treated successfully with immunomodulating medicines including intravenous immune globulin (IVIG), steroids, interleukin-6 inhibitor, tumor necrosis factor-a inhibitor, interleukin-1 inhibitor, and Janus kinase inhibitor.…”
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MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia by Jingjing Fan, Xianjuan Kou, Yi Yang, Ning Chen

“…Several proinflammatory cytokines, especially interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), play crucial roles in modulation of inflammatory signaling pathway during the aging-related loss of skeletal muscle. …”
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Exploring the Link between Periodontal Disease and Systemic Conditions: Implications for Alzheimer’s, Parkinson’s, and Rheumatoid Arthritis by Kanimozhi, K. Aishwarya, Sweta Yadav, Ajith A. Chandy, Ramyashri Muralikrishna, Rohan Shinkre

“…Measurements were made of serum biomarkers for inflammation, such as interleukin-6 (IL-6) and C-reactive protein (CRP). Multivariate regression models were used to examine correlations between the severity of periodontal disease and the underlying systemic diseases. …”
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Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway by Sang-Hoon Lee, Sung-Hwan Eom, Na-Young Yoon, Moon-Moo Kim, Yong-Xin Li, Sang Keun Ha, Se-Kwon Kim

“…An enzyme-linked immunosorbent assay and cytometric bead array assay demonstrated that FF significantly reduced the production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor-α, and that of the monocyte chemoattractant protein-1. …”
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TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose Regulation by Xia Li, Ju Zhu, Na Liu, Jie Liu, Zhecheng Zhang

“…In this study, we investigated the serum tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels in peripheral neuropathy impaired patients with impaired glucose regulation (IGR). …”
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Remimazolam Combined with Andrographolide Improve Postoperative Cognitive Dysfunction in Rats after Cardiopulmonary Bypass through the AMPK/SIRT1 Signaling Pathway by Chong Chen, Lixia Lan, Kai Xu

“…Cognitive function was assessed using the Morris Water Maze test, and the concentrations of tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) in serum were measured by enzyme-linked immunosorbent assay (ELISA). …”
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Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseas... by Lindner Ewald, Langner-Wegscheider Beate, Sarny Stephanie, Renner Wilfried, El-Shabrawi Yosuf

“…Purpose. Interleukin 6 (IL-6) plays a crucial role in both adaptive and innate immunity. …”
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TNF-α Promotes IFN-γ-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells by Wenyi Gu, Jiezhong Chen, Lei Yang, Kong-Nan Zhao

“…Furthermore, only cotreatment with tumour necrosis factor-α and interferon-γ induced Myb-transformed hematological cells to express interleukin-6. These results suggest that tumour necrosis factor-α plays a key regulatory role in the development of dendritic cells from hematological progenitor cells induced by interferon-γ.…”
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