Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 by Huizhen Fan, Chunyan Jiang, Baoyuan Zhong, Jianwen Sheng, Ting Chen, Qingqing Chen, Jingtao Li, Hongchuan Zhao

“…Five targets, including interleukin 6 (IL-6), the 26S proteasome, tumor necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and p53, and corresponding high-mobility group box 1 (HMGB1) signaling and T helper cell differentiation were thought to be associated with matrine’s mechanism. …”
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Plasma C1q/TNF-Related Protein-3 (CTRP-3) and High-Mobility Group Box-1 (HMGB-1) Concentrations in Subjects with Prediabetes and Type 2 Diabetes by Huili Wei, Hua Qu, Hang Wang, Huacong Deng

“…A multiple linear regression analysis showed both plasma CTRP-3 and HMGB-1 concentrations were independently associated with homeostasis model assessment for insulin resistance (HOMA-IR) and interleukin-6 (IL-6) (P<0.05 for all). Further multiple logistical regression analyses revealed that both plasma CTRP-3 and HMGB-1 levels were significantly associated with pre-DM and nT2DM after adjusting for several confounders (P<0.001 for all). …”
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Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor by Mohamed A. Morsy, Snehal S. Patel, Azza A. K. El-Sheikh, Jignasa K. Savjani, Anroop B. Nair, Jigar N. Shah, Katharigatta N. Venugopala

“…All tested compounds interacted with GR, but only boswellic acid and withaferin A showed docking results comparable to fluticasone, as well as similar in vivo anti-inflammatory effects, by significantly decreasing serum levels of interleukin-6 and tumor necrosis factor-α in cotton pellet-induced granuloma in rats. …”
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Circulating CTRP1 Levels Are Increased and Associated with the STOD in Essential Hypertension in Chinese Patients by Zhengjia Su, Shuya Tian, Wei Liang

“…Enzyme-linked immunosorbent assay (ELISA) was used to detect the CTRP1, adiponectin (APN), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). …”
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The Effect of Long-Term Exercise on the Production of Osteoclastogenic and Antiosteoclastogenic Cytokines by Peripheral Blood Mononuclear Cells and on Serum Markers of Bone Metabol... by J. Kelly Smith, Rhesa Dykes, David S. Chi

“…In a before and after trial involving 43 healthy adults, we measured the effect of six months of supervised exercise training on the spontaneous and phytohemagglutinin-induced production of osteoclastogenic cytokines (interleukin-1α, tumor necrosis factor-α), antiosteoclastogenic cytokines (transforming growth factor-β1 and interleukins 4 and 10), pleiotropic cytokines with variable effects on osteoclastogenesis (interferon-γ, interleukin-6), and T cell growth and differentiation factors (interleukins 2 and 12) by peripheral blood mononuclear cells. …”
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Markers of Inflammation Associated with Plaque Progression and Instability in Patients with Carotid Atherosclerosis by Enrico Ammirati, Francesco Moroni, Giuseppe Danilo Norata, Marco Magnoni, Paolo G. Camici

“…It is well accepted that circulating biomarkers, including C-reactive protein and interleukin-6, reliably predict major cardiovascular events, including myocardial infarction or death. …”
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Immune and Inflammatory Responses of the Intestinal Mucosa following Extended Liver Radiofrequency Ablation by Petros Ypsilantis, Maria Lambropoulou, Antonios Evagellou, Nikolaos Papadopoulos, Constantinos Simopoulos

“…Forty-eight hours later, ileal tissue specimens were excised for immunohistochemical assessment of CD68+ macrophages, CD4+ T-lymphocytes, CD8+ T-lymphocytes, mucosal addressin cell adhesion molecule-1 (MAdCAM-1), tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), and nuclear factor-κB (NFκB) expression. …”
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The Initial Vascular Access Type Contributes to Inflammation in Incident Hemodialysis Patients by Mala Sachdeva, Adriana Hung, Oleksandr Kovalchuk, Markus Bitzer, Michele H. Mokrzycki

“…C-reactive protein (CRP), interleukin-6 (IL-6), and interferon-γ-induced protein (IP-10) were measured before and at 6-time points after access placement for 1 year. …”
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Infection after Acute Ischemic Stroke: Risk Factors, Biomarkers, and Outcome by Katja E. Wartenberg, Anett Stoll, Andreas Funk, Andreas Meyer, J. Michael Schmidt, Joerg Berrouschot

“…The maximum temperature on days 1 and 3, leukocytes, interleukin-6, lipopolysaccharide-binding protein on days 1, 3, and 5, C-reactive protein on days 3 and 5, and procalcitonin on day 5 were higher and HLA-DR-expression on monocytes on days 1, 3, and 5 lower in patients with infection. …”
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Coronary artery disease-associated genetic variants and biomarkers of inflammation. by Morten Krogh Christiansen, Sanne Bøjet Larsen, Mette Nyegaard, Søs Neergaard-Petersen, Ramzi Ajjan, Morten Würtz, Erik Lerkevang Grove, Anne-Mette Hvas, Henrik Kjærulf Jensen, Steen Dalby Kristensen

“…<h4>Methods</h4>We genotyped 45 CAD-associated SNPs in 701 stable CAD patients in whom levels of high-sensitivity C-reactive protein (hsRCP), interleukin-6, calprotectin, fibrinogen and complement component 3 levels had previously been measured. …”
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Unveiling promising sepsis biomarkers: a clinical perspective by Hong Zhang, Junpeng Zhao, Zhiping Wang, Mengxiang Huang, Zhonghua Tan, Feng Jiang, Yuhong Zhou, Linhua Wang, Mingbing Xiao

“…In recent years, new biomarkers, such as neutrophil extracellular traps, interleukin-6, histones, cell-free DNA and composite indicators, such as the systemic immune inflammation index,have been identified. …”
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Plasminogen Activator Inhibitor-1 Level Correlates with Lipoprotein Subfractions in Obese Nondiabetic Subjects by Sándor Somodi, Ildikó Seres, Hajnalka Lőrincz, Mariann Harangi, Péter Fülöp, György Paragh

“…Plasma PAI-1, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and myeloperoxidase (MPO) concentrations were determined with enzyme-linked immunosorbent assay (ELISA), while serum paraoxonase-1 (PON1) activities were measured by spectrophotometry. …”
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Profiling Pro‐Inflammatory Proteases as Biomolecular Signatures of Material‐Induced Subcutaneous Host Response in Immuno‐Competent Mice by Nam M.P. Tran, Anh T.H. Truong, Dang T. Nguyen, Tram T. Dang

“…Protease activity exhibits positive correlations with protein expression of pro‐inflammatory cytokines tumor necrosis factor α and interleukin 6 but negative correlation with pro‐fibrotic cytokine transforming growth factor β1. …”
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Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood by Tanja Eichhorn, Alexander E. Ivanov, Maria B. Dainiak, André Leistner, Ingrid Linsberger, Hans Jungvid, Sergey V. Mikhalovsky, Viktoria Weber

“…Plain PS-DVB microparticles showed efficient adsorption of albumin-bound toxins related to liver failure (bilirubin and cholic acid) and of cytokines (tumor necrosis factor-alpha and interleukin-6). The rates of adsorption and the amount of adsorbed factors were lower for the embedded microparticles as compared to the parent PS-DVB microparticles, indicating the importance of the accessibility of the adsorbent pores. …”
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The Anti-Cytokine Storm Activity of Quercetin Zinc and Vitamin C Complex by Hayder B. Sahib, Omer Abid Kathum, Rafal Shakeeb Alanee, Rehab A. M Jawad, Ahmed Majeed Al-Shammari

“…Then, levels of interleukin 1 and interleukin 6 were measured in the serum, and lung and kidney tissues were investigated for any changes that may have happened. …”
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The Potential Role of Korean Mistletoe Extract as an Anti-Inflammatory Supplementation by Soo-Min Ha, Ji-Hyeon Kim, Jong-Won Kim, Do-Yeon Kim, Min-Seong Ha

“…Blood samples were collected for measurement of serum cytokine levels at baseline, immediately after exercise, and following 30 minutes of recovery. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) were used as markers for inflammation. …”
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Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1 by Mardi M. Algandaby

“…AM guarded against Pb-induced enhanced the protein expression of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), cyclooxygenase-2 (COX-2), and nuclear factor-kappa B (NF-κB). …”
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Investigation of the Proliferation, Apoptosis/Necrosis, and Cell Cycle Phases in Several Human Multiple Myeloma Cell Lines. Comparison of Viscum album QuFrF Extract with Vincristin... by Eva Kovacs

“…Multiple myeloma is a haematological disorder of malignant plasma cells. Interleukin-6 (IL-6) is a potent growth factor for the proliferation of these cells. …”
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Association between extracellular DNA levels, markers of inflammation and left ventricular mass index in children with chronic kidney disease by Ylva Tranæus Lindblad, Ľubomíra Tóthová, Peter Celec, Karolina Kublickiene, Peter Bárány, Milan Chromek

“…In univariate analysis, levels of interleukin-6 (IL-6), antimicrobial peptide cathelicidin (LL-37), soluble vascular cell adhesion molecule-1 (VCAM-1) and left ventricular mass index (LVMI) were positively correlated with total exDNA and nc_exDNA concentrations. …”
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Il-6 and MSH3 in colorectal carcinoma: Expression, relationship, and prognostic significance in 171 colorectal carcinoma cases by Elif Kolay Bayram, Betul Ogut, Mehmet Arda Inan, Ayse Dursun

“…In cell lines, the proinflammatory cytokine interleukin-6 (IL-6) causes a cytosolic shift in the mismatch repair protein MSH3, accompanied by functional loss. …”
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