Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder by Yilu Zhao, Zhao Fu, Eric J. Barnett, Ning Wang, Kangfuxi Zhang, Xuping Gao, Xiangyu Zheng, Junbin Tian, Hui Zhang, XueTong Ding, Shaoxian Li, Shuyu Li, Qingjiu Cao, Suhua Chang, Yufeng Wang, Stephen V. Faraone, Li Yang

“…Notably, the variant that contributed most to the CNN model was NKAIN2, an ADHD-related gene, which is also associated with metabolic processes. To conclude, the integration of GWAS and DL methods revealed new genes contribute to ADHD pharmacological treatment responses, and underscored the interplay between neural systems and metabolic processes, potentially providing critical insights into precision treatment. …”
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Socioeconomic disparity in stage at cancer diagnosis among patients with type 2 diabetes in Dutch primary care: a cross-sectional study by Geertruida H De Bock, Gijs W D Landman, Nanne Kleefstra, Bert van der Vegt, Sabine Siesling, Klaas H Groenier, Jing de Haan-Du

“…We evaluated the association of SES and cancer stage among patients with type 2 diabetes (T2DM) treated in primary care.Research design and methods This cross-sectional study linked data from the primary care Zwolle Outpatient Diabetes Project Integrating Available Care database for T2DM (n=71 648, 1998–2019) to a cancer registry and personal records database in the Netherlands. …”
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An MRI radiomics model for predicting a prostate-specific antigen response following abiraterone treatment in patients with metastatic castration-resistant prostate cancer by Yi Wu, Xiang Liu, Shaoxian Chen, Fen Fang, Feng Shi, Yuwei Xia, Zehong Yang, Daiying Lin

“…Univariate and multivariate analyses were performed using Cox regression to identify significant predictors of the efficacy of abiraterone treatment in patients with mCRPC.ResultsThe integrated model was constructed from seven radiomics features extracted from the T2WI, DWI, and ADC sequence images of the training data. …”
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Assessing microbial biodiversity in oil palm seedlings using oil palm waste compost mixed media by Siti Suliza Salamat, Mohd Zulkhairi Mohd Yusoff, Mohd Ali Hassan Hassan, Mohd Huzairi Mohd Zainuddin, Yoshihito Shirai, Ahmad Husni Mohd Hanif, Mohd Shahkhirat Norizan, Fatini Mat Arisah, Mohammed Abdillah Ahmad Farid, Toshinari Maeda, Mohd Noor Mat Isa, Mohd Faizal Abu Bakar

“…The co-occurrence of Bacteroidetes and Acidobacteria in compost-treated soils suggested pH stability that supports plant growth and ecosystem resilience. Conclusion: Integrating compost into nursery media significantly enhances microbial biodiversity and dynamics, particularly favoring beneficial nutrient-cycling bacteria. …”
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High Data-Rate Hilbert-Curved-Shaped MIMO Antenna With Improved Bandwidth and Circular Polarization for Wireless Capsule Endoscopy by Syed Misbah Un Noor, Syed Ahson Ali Shah, Shahid Khan, Izaz Ali Shah, Jamal Nasir, Salahuddin Khan, Slawomir Koziel

“…Comprehensive simulation analysis of antenna-integrated WCE systems in homogeneous and hetrogenous environments is conducted in the stomach, small intestine, and large intestine. …”
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Single-cell RNA-sequencing and genome-wide Mendelian randomisation along with abundant machine learning methods identify a novel B cells signature in gastric cancer by Qi Ma, Jie Gao, Yuan Hui, Zhi-Ming Zhang, Yu-Jie Qiao, Bin-Feng Yang, Ting Gong, Duo-Ming Zhao, Bang-Rong Huang

“…Utilising bulk RNA sequencing data, we employed machine learning integration methods to train specific biomarkers for the development of novel diagnostic combinations. …”
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Quality of life in people with syndromic heritable thoracic aortic disease and their relatives: a qualitative interview based study by Gry Velvin, Heidi Johansen, Gunnbjørg Aune, Kerstin Fugl-Meyer, Amy Østertun Geirdal

“…Conclusion Based on our findings, to improve QoL in patients with sHTAD we should more effectively integrate the patient`s perspectives and voice on the elements crucial to QoL. …”
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Healthcare Practitioners’ perspectives on paediatric burns management at Korle Bu Teaching Hospital, Ghana by Alberta A. Rockson, Natalie Benjamin-Damons, Sonti Imogene Pilusa

“…A move towards more integrated care, the development of locally adapted protocols, better financial support, and enhanced caregiver education are essential next steps in elevating the quality of paediatric burn management in Ghana.…”
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A novel gene signature for predicting outcome in colorectal cancer patients based on tumor cell-endothelial cell interaction via single-cell sequencing and machine learning by Lina Pang, Qingxia Sun, Wenyue Wang, Mingjie Song, Ying Wu, Xin Shi, Xiaonan Shi

“…Methods: We conducted an in silico study integrating single-cell RNA sequencing and bulk transcriptome data to characterize the cellular heterogeneity of CRC. …”
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Correlation between selenium levels and selenoproteins expression in idiopathic generalized epilepsy: a study from Karachi by Hareem Nisar, Rafat Amin, Sadaf Khan, Tehseen Fatima, Qamar-Un-Nisa, Jawwad-Us-Salam

“…Selenium, in the form of selenoproteins is an integral part of the human antioxidant defense system. …”
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Time Zero for Net Zero: A Coal Mine Baseline for Decarbonising Heat by Alison A. Monaghan, Luke Bateson, Adrian J. Boyce, Neil M. Burnside, Rebecca Chambers, Julia R. de Rezende, Eilidh Dunnet, Paul A. Everett, Stuart M. V. Gilfillan, Muhammad S. Jibrin, Gareth Johnson, Richard Luckett, Donald John MacAllister, Alan M. MacDonald, John W. Moreau, Laura Newsome, Alessandro Novellino, Barbara Palumbo-Roe, Ryan Pereira, Douglas Smith, Mike J. Spence, Vanessa Starcher, Helen Taylor-Curran, Christopher H. Vane, Thomas Wagner, David B. Walls

“…Biogeochemical interactions of sulphur, carbon and iron, plus indications of microbially-mediated mineral oxidation/reduction reactions require further investigation for long term operation. Integration of the wide array of time zero observations and understanding of coupled subsurface processes has significant potential to inform development of efficient and resilient geothermal infrastructure and to inform the design of fit-for-purpose monitoring approaches in the quest towards meeting Net Zero targets.…”
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Magnitude, Severity, and Associated Factors of Anemia among Under-Five Children Attending Hawassa University Teaching and Referral Hospital, Hawassa, Southern Ethiopia, 2016 by Yeshimebet Gebereselassie, Mesganaw BirhanSelassie, Tadesse Menjetta, Jemal Alemu, Aster Tsegaye

“…It clearly indicates that there should be well integrated public health interventions to improve the health status that needs to be prioritized to prevent anemia among children under five years of age.…”
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Network characteristics of referrals for chronic disease patients: results from hierarchical medical reform in Shenzhen, China by Fangfang Gong, Junxia Luo, Zhihong Wang, Ping Tang, Guangyu Hu, Ying Zhou, Hanqun Lin

“…Conclusions The referral network has a vertical flow pattern conducive to the division of labour, cooperation, and resource integration of medical institutions in the region, and a hierarchical medical order is taking shape. …”
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A Study on Canopy Volume Measurement Model for Fruit Tree Application Based on LiDAR Point Cloud by Na Guo, Ning Xu, Jianming Kang, Guohai Zhang, Qingshan Meng, Mengmeng Niu, Wenxuan Wu, Xingguo Zhang

“…Additionally, improvements to the mesh integral volume method incorporate the effects of canopy gaps in height difference calculations, significantly enhancing the accuracy of canopy volume estimation. …”
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Revisiting teacher educators' training in Ethiopia: Implications for a new approach to curriculum development by Haftu Hindeya Gebremeskel, Ahmed Yibrie Ahmed, Dawit Asrat Getahun, Meskerem Lechissa Debele, Dawit Tibebu, Dereje Taye Wondem

“…The obtained results in general show a clear gap in the general pedagogical knowledge and skills, pedagogical content knowledge, and instructional technology that demanded the need of following the framework that integrates technology, pedagogy, and content knowledge for the development of new curricula. …”
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A Collision-Free Path-Planning Method for an Articulated Mobile Robot by P. Quintero-Alvarez, G. Ramirez, S. Zeghloul

“…The proposed approach, compared to other methods, has the main advantage of integrating anti-collision constraints between the articulated robot itself and the environment, in order to avoid and resolve dead-lock situations. …”
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Trends, outcomes and knowledge gaps in mobile apps for reproductive endocrinology and infertility: a scoping review protocol by Alba Regina de Abreu Lima, Emerson Roberto dos Santos, Aline Russomano de Gouvêa, Natália Almeida de Arnaldo Silva Rodriguez Castro, João Daniel de Souza Menezes, Matheus Querino da Silva, Helena Landin Gonçalves Cristóvão, Cíntia Canato Martins, Jéssica Gisleine de Oliveira, Patrícia da Silva Fucuta, Alexandre Lins Werneck, Gerardo Maria de Araújo Filho, Heloisa Cristina Caldas, Vânia Maria Sabadoto Brienze, Júlio César André, Antônio Hélio Oliani

“…Despite promising advancements such as the development of apps with sophisticated algorithms for ovulation prediction and comprehensive platforms offering integrated fertility education and emotional support, there remain gaps in the literature regarding the comprehensive evaluation of mobile apps for reproductive endocrinology and infertility. …”
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A systematic review and meta-analysis of the effectiveness of perineural dextrose injection in peripheral compression neuropathies of the upper limbs by Fatemeh Azizi, Faezeh Saber Gharesoo, Fereshteh Eidy, Sama Heidari, Nastaran Maghbouli, Shirin Djalalinia, Amir Kasaeian

“…Healthcare providers should consider integrating dextrose injection into their treatment strategies for patients with entrapment neuropathies.…”
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Evaluation of Competency-Based Medical Education (CBME) curriculum implementation for Phase II Medical undergraduates: A qualitative study by KRISHNAMURTHY SOUNDARIYA, ANANDABASKAR NISHANTHI, RAJALAKSHMI MAHENDRAN, MOUROUGUESSINE VIMAL

“…The faculty members have adopted various strategies for curriculum implementation such as preparing departmental planners, framing lesson plans, using interactive teaching-learning methods and e-learning, conducting self-directed learning sessions, ensuring alignment and integration, incorporating skill modules, ensuring student logbook maintenance, using appropriate assessment methods and implementing AETCOM modules. …”
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Does interprofessional simulation increase self-efficacy: a comparative study by Peter Jaye, Gabriel Reedy, Alastair Ross, Colm Watters, Nicola J Morgan, Rhodri Handslip

“…Simulation education attempts to create an environment for healthcare professionals to learn, without potential safety risks for patients. Integrating simulation and interprofessional education can provide benefits to individual learners.Setting The intervention took place in a high-fidelity simulation facility located on the campus of a large urban hospital. …”
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