Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism by Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen, Zhixi Hu

“…The pharmacodynamics of SMI were validated using the H-HF animal model, with analysis of fecal gut microbiota integrating metabolomics and 16S rRNA sequencing. Metorigin metabolite traceability analysis and the MetaboAnalyst platform were utilized to explore the action mechanism. …”
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Disturbed shear stress promotes atherosclerosis through TRIM21‐regulated MAPK6 degradation and consequent endothelial inflammation by Feng Wang, Shu‐Yu Wang, Yue Gu, Shuai Luo, Ai‐Qun Chen, Chao‐Hua Kong, Wen‐Ying Zhou, Li‐Guo Wang, Zhi‐Mei Wang, Guang‐Feng Zuo, Xiao‐Fei Gao, Jun‐Jie Zhang, Shao‐Liang Chen

“…Comprehensive RNA‐seq, integrated single‐cell mapping and further experiments unveiled the involvement of MAPK6 in inflammation through the EGR1/CXCL12 axis. …”
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Quantitative analysis of amino acid excretion by Methanothermobacter marburgensis under N2-fixing conditions by Barbara Reischl, Benjamin Schupp, Hayk Palabikyan, Barbara Steger-Mähnert, Christian Fink, Simon K.-M. R. Rittmann

“…The concomitant production of amino acids and CH4 could become of biotechnological relevance in an integrated approach coupling biomethanation and N2-fixation in a biorefinery concept.…”
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Unveiling the Cosmic Chemistry: Revisiting the Mass–Metallicity Relation with JWST/NIRSpec at 4 < z < 10 by Arnab Sarkar, Priyanka Chakraborty, Mark Vogelsberger, Michael McDonald, Paul Torrey, Alex M. Garcia, Gourav Khullar, Gary J. Ferland, William Forman, Scott Wolk, Benjamin Schneider, Mark Bautz, Eric Miller, Catherine Grant, John ZuHone

“…Beyond z = 8, we observe a significant deviation (∼0.27 dex) in FMR, consistent with recent JWST findings. We also integrate Cosmic Evolution Early Release Science (135 galaxies) and JADES (47 galaxies) samples with our data to study the metallicity evolution with redshift in a combined sample of 263 galaxies, revealing a decreasing metallicity trend with a slope of 0.067 ± 0.013, consistent with IllustrisTNG and EAGLE but contradicting the FIRE simulations. …”
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Prevalence of dengue and leptospirosis coinfection and associated mortality rates: a systematic review and meta-analysis by Suraj Tiwari, Mahalaqua Nazli Khatib, Rekha MM, Mandeep Kaur, Girish Chandra Sharma, Puneet Sudan, K. Satyam Naidu, Rajesh Singh, Teena Vishwakarma, Sonam Puri, Muhammed Shabil, Anuradha Yadav, Takveer Singh, Sahil Khurana, Rachana Mehta, Prakasini Satapathy, Renu Sah, Abhay M Gaidhane, Ganesh Bushi

“…Further research into the immunopathology and the implementation of integrated surveillance systems could enhance the effectiveness of diagnosis and treatment strategies in regions where these diseases are endemic.…”
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Errores innatos de la inmunidad en pacientes de Sancti Spíritus, Cuba. 2022. by María del Carmen Chávez Alfonso, José Luis Marcelo Pentón, Yralys Naranjo Herrera, Valia Concepción Ulloa, Dayana Monteagudo García, Ernesto Gabriel Caraballosa Yera

“…Objetivo: Determinar la frecuencia de aparición de errores innatos de la inmunidad en la provincia de Sancti Spíritus y actualizar el registro de pacientes diagnosticados hasta la fecha, para ofrecer una atención integral de estas enfermedades. Método: estudio observacional, descriptivo y transversal de 59 pacientes con diagnóstico de errores innatos de la inmunidad que se encuentran reportados en el registro provincial de Sancti Spíritus hasta el año 2022. …”
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Dimensions of suffering and the need for palliative care: experiences and expectations of patients living with cancer and diabetes and their caregivers in Mexico – a qualitative st... by Svetlana V Doubova, Ingrid Patricia Martinez-Vega, Felicia Knaul, Afsan Bhadelia, Diana Pérez-Moran, Nancy García-Cervantes

“…Policies to enhance access to palliative care should integrate it into primary care, redesigning services towards patient and caregiver biopsychosocial and spiritual needs and ensuring access to medicines and competent health personnel.…”
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Cardiac and respiratory activities induce temporal changes in cerebral blood volume, balanced by a mirror CSF volume displacement in the spinal canal by Pan Liu, Kimi Owashi, Heimiri Monnier, Serge Metanbou, Cyrille Capel, Olivier Balédent

“…We then obtained CBV and CSF volume displacement (CSFV) curves by integrating the flow rate signals. Cardiac and respiratory signals were recorded during acquisition to reconstruct cardiac-driven and breath-driven CBV and CSFV curves.During deep breathing, compared to free breathing, the total cerebral arterial flow rate decreased by 29 % (from 12.5 ml/s to 8.8 ml/s), and the duration of the cardiac cycle period shortened by 15 % (0.90 s to 0.77 s), leading to reductions of 37 % and 23 % in cardiac-driven CBV and CSFV amplitudes, respectively. …”
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Diagnoses of postpartum urinary retention using next-generation non-piezo ultrasound technology: assessing the accuracy and benefits by Ruben Plöger, Charlotte Behning, Adeline Walter, Ulrich Gembruch, Brigitte Strizek, Florian Recker

“…These findings affirm the high reliability of PUD for the diagnosis of postpartum urinary retention and supports their integration into daily clinical practice, thereby simplifying regular controls of the bladder by physicians during daily rounds on the ward. …”
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Factors affecting implementation of interventions for oral health, substance use, smoking and diet for people with severe and multiple disadvantage: a community-based qualitative s... by Sheena E Ramsay, Richard G Watt, Falko F Sniehotta, Eileen Kaner, Martha Paisi, Neha Jain, Martin Burrows, Emma A Adams, Gillian McLellan, Emma C Joyes, Laura J McGowan, David Landes, Lorenzo Iafrate

“…Environmental factors included funding and integrated services; organisational factors included inclusive services, health promotion, prevention and training healthcare providers; interpersonal factors included the presence of support workers and motivation among service providers.Conclusion The implementation and sustainability of health interventions for people experiencing SMD are influenced by factors across environmental, organisational and interpersonal levels that interact with the inherent challenges of disadvantaged groups. …”
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Exploring effects of a booster workshop on progression and retention of resuscitation skills of residents when added to regular low-dose simulation by Hui-Wen Chen, Hung-Wei Tsai, Yi-Chun Chen, Yu-Jui Chiu, Enoch Yi-No Kang, Yi-Ting Hsu, S. Barry Issenberg, Jen-Chieh Wu

“…Conclusions This study demonstrates the potential and advantages of integrating simulation-based training into the clinical training curriculum for residents to improve medical task performance and teamwork behaviors for handling in-hospital cardiac arrest scenarios. …”
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Assessment of Cellular Responses after Short- and Long-Term Exposure to Silver Nanoparticles in Human Neuroblastoma (SH-SY5Y) and Astrocytoma (D384) Cells by Teresa Coccini, Luigi Manzo, Vittorio Bellotti, Uliana De Simone

“…Silver nanoparticle (AgNP, 20 nm) neurotoxicity was evaluated by an integrated in vitro testing protocol employing human cerebral (SH-SY5Y and D384) cell lines. …”
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Cardiovascular function shows early impairment in asymptomatic adolescents diagnosed with type 1 diabetes mellitus: an ultrasound-derived myocardial work study by Martina Ghirardo, Martina Ghirardo, Irene Cattapan, Irene Cattapan, Jolanda Sabatino, Jolanda Sabatino, Alice Pozza, Alice Pozza, Jennifer Fumanelli, Jennifer Fumanelli, Martina Avesani, Joaquin Gutierrez De Rubalcava Doblas, Carlo Moretti, Biagio Castaldi, Giovanni Di Salvo

“…Therefore, these tools should be integrated into the cardiovascular assessment of diabetic adolescents, and preventive strategies should be implemented to maximize glycemic and pressure control effectiveness.…”
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Trends in palliative care utilization among older adult decedents with and without cancer in Taiwan: a population-based comparative studyResearch in context by Yu-Tai Lo, Tzu-Jung Chuang, Yu-Tung Huang, Yi-Lin Wu, Yi-Ching Yang, Chung-Yi Li

“…Interpretation: Efforts to ensure equitable access to palliative care for non-cancer individuals should focus on expanding services, enhancing provider education, and promoting cultural sensitivity to meet the growing need for palliative care integration. Funding: This study was supported in part by grants from the National Cheng Kung University Hospital (NCKUH-11305001, NCKUH-V101-10) and the National Health Research Institutes (NHRI-13A1-CG-CO-04-2225-1). …”
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Two-Dimensional Shear-Wave Elastography: Accuracy in Liver Fibrosis Staging Using Magnetic Resonance Elastography as the Reference Standard by Puwitch Charoenchue, Jiraporn Khorana, Taned Chitapanarux, Nakarin Inmutto, Wittanee Na Chiangmai, Amonlaya Amantakul, Suwalee Pojchamarnwiputh, Apichat Tantraworasin

“…In contrast, two-dimensional shear-wave elastography (2D-SWE) is more affordable, accessible, and widely integrated into routine ultrasound systems. <b>Objective:</b> Our aim was to determine the optimal 2D-SWE cut-offs for detecting significant fibrosis (≥F2) and evaluate its diagnostic performance across fibrosis stages. …”
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Approaches to implementing and financing primary health care in Kenya: a case of seven counties by Janette Karimi, Salim Hussien, Elizabeth Wangia, Mercy-Irene Kimani, Mohamud Mohamed, Melissa Wanda, Rosemarie Muganda, Rachel Ndirangu, Daniel Mwai, Mercy Wanjala, Fadhila Richter

“…BackgroundKenya has prioritized Primary Health Care as an indispensable foundation to realize UHC by 2022. Integral to this approach’s operationalization is the adoption of the primary health care networks (PCNs) model to strengthen service delivery efficiency and coordination. …”
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Exploration and characterization of lipid-degrading bacteria from palm oil mill effluent by P. Periadnadi, N. Nurmiati, F.W. Siregar, T.W. Edelwis

“…The results underscored the promising potential of specific bacteria isolates in mitigating lipid-rich effluents, advocating for the integration into sustainable wastewater management practices in palm oil industry. …”
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Simulation of slope soil erosion intensity with different vegetation patterns based on cellular automata model by Yan Sheng, Shangxuan Zhang, Long Li, Long Li, Zhiming Cao, Yu Zhang

“…This study focuses on the slopes of three planting patterns (uniform distribution, aggregation distribution, and random distribution), along with bare slopes, in the Baojiagou watershed of the Pisha Sandstone area, based on soil erosion intensity grade maps after rainfall from 2021 to 2023.MethodsA method combining Multi-Criteria Evaluation (MCE) and the CA-Markov model is used to analyze the spatial variation of soil erosion intensity types on different slopes. This approach integrates multiple influencing factors and generates a suitability map for the conversion of soil erosion intensity types. …”
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Alternative healthcare delivery arrangements in Nepal: a systematic review of comparative effectiveness, safety and cost-effectiveness studies by Rachelle Buchbinder, Shyam Sundar Budhathoki, Denise A O’Connor, Ilana Ackerman, Pramila Rai

“…Similarly, the use of a mobile phone call reminder may improve on-time medicine collection among patients with HIV compared with usual care (RR: 1.29, 95% CI: 1.12 to 1.48), while the integration of postpartum family planning and postpartum intrauterine contraceptive device (PPIUCD) insertion with maternity services may improve PPIUCD uptake compared with usual care (PP: 0.173, 95% CI: 0.098 to 0.246).Conclusion More evaluation is needed for alternative delivery arrangements due to limited low-certainty evidence from current trials. …”
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Effectiveness of ‘Tackle Your Tics’, a brief, intensive group-based exposure therapy programme for children with tic disorders: study protocol of a randomised controlled trial by Danielle Cath, Annet Heijerman-Holtgrefe, Chaim Huyser, Cara Verdellen, Jolande van de Griendt, Laura Beljaars, Kees-Jan Kan, Ramón Lindauer, Pieter Hoekstra, Lisbeth Utens

“…Patient representatives are fully integrated as part of the research team. If Tackle Your Tics proves to be effective, it can expand evidence-based treatment possibilities for children and adolescents with tic disorders. …”
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