In vitro and in silico Anti-diabetes mechanism of phytochemicals from Curculigo pilosa and its pharmacokinetic profiling via α-amylase inhibition by Damilola A. Omoboyowa, Temitope C. Aribigbola, Simbo T. Akinsulure, Damilola S. Bodun, Ezekiel A. Olugbogi, Ebenezer A. Oni

“…The ethylacetate, n-butanol and methanol extracts of C. pilosa were subjected to in vitro α-amylase inhibitory assay, followed by identification of the bioactive compounds from the most potent extract using HPLC. Integrated computational analyses were performed on ten (10) active compounds against α-amylase using Maestro Schrodinger (v2). …”
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Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines by Alexandra Razumovskaya, Mariia Silkina, Mariia Silkina, Mariia Silkina, Andrey Poloznikov, Timur Kulagin, Maria Raigorodskaya, Nina Gorban, Anna Kudryavtseva, Maria Fedorova, Boris Alekseev, Alexander Tonevitsky, Alexander Tonevitsky, Alexander Tonevitsky, Sergey Nikulin, Sergey Nikulin, Sergey Nikulin

“…The resulting gene expression signatures successfully stratified Stage II/III and Stage IV CRC patients, with potential clinical utility for improving treatment outcomes after further validation.DiscussionThis study highlights the advantages of integrating diverse experimental models, such as organoids and cell lines, to identify novel prognostic biomarkers and enhance the understanding of chemotherapy resistance in CRC.…”
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Optimization of performance under off-design conditions for dual-pressure organic Rankine cycle with hot source splitting by Shiqi Wang, Zhongyuan Yuan, Kim Tiow Ooi, Xiangyu Chang, Nanyang Yu

“…The Dual-Pressure Organic Rankine Cycle system, integrated with Hot Source Splitting (DORC-HSS), demonstrates enhanced performance by optimizing heat matching. …”
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PreciPalm: An Intelligent System for Calculating Macronutrient Status and Fertilizer Recommendations for Oil Palm on Mineral Soils Based on a Precision Agriculture Approach by Kudang Boro Seminar, Harry Imantho, null Sudradjat, Sudirman Yahya, Sirojul Munir, Indra Kaliana, Fajar Mei Haryadi, Awalia Noor Baroroh, null Supriyanto, Gani Cahyo Handoyo, Arif Kurnia Wijayanto, Cecep Ijang Wahyudin, null Liyantono, Rhavif Budiman, Achmad Bakir Pasaman, Dwi Rusiawan, null Sulastri

“…This research aims to determine macronutrients, specifically nitrogen (N), phosphorus (P), and potassium (K) contents in oil palm leaves based on PA principles using the integration of remote sensing technology and machine learning to quickly obtain the macronutrient status from oil palm plantation areas. …”
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A comparative study on disinfection effect of three different disinfectants for oral dental chair water lines (三种不同消毒剂对口腔综合治疗台水路消毒效果的比较)... by WANG Wenjuan (王文娟), LI Yajuan (李雅娟), LI Pei (李培), KONG Li (孔莉), WANG Ting (王婷)

“…Methods Selection of seven independent water source integrated treatment tables in the Stomatology Department of Beijing No. 2 Hospital before opening of the clinic in 2019, divided into 4 groups (3 experimental + 1 control). …”
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Computational Modeling and Experimental Investigation of CO₂-Hydrocarbon System Within Cross-Scale Porous Media by Feiyu Chen, Linghui Sun, Bowen Li, Xiuxiu Pan, Boyu Jiang, Xu Huo, Zhirong Zhang, Chun Feng

“…Additionally, adsorption effects in micro- and nano-scale pores are explicitly integrated to enhance model reliability. A multi-scale thermodynamic model for CO₂-hydrocarbon systems is developed and validated through physical simulations. …”
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The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP by Zigmunds Orlovskis, Archana Singh, Adi Kliot, Weijie Huang, Saskia A Hogenhout

“…Our research underscores the dual role of the phytoplasma effector SAP54 in host development alteration and vector attraction - integral to the phytoplasma life cycle. Importantly, we clarify how SAP54, by targeting SVP, heightens leaf vulnerability to leafhopper males, thus facilitating female attraction and subsequent plant colonization by the insects. …”
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MCPA: multi-scale cross perceptron attention network for 2D medical image segmentation by Liang Xu, Mingxiao Chen, Yi Cheng, Pengwu Song, Pengfei Shao, Shuwei Shen, Peng Yao, Ronald X. Xu

“…Recently, numerous transformer-based techniques have been incorporated into the UNet architecture to overcome this limitation by effectively capturing global feature correlations. However, the integration of the Transformer modules may result in the loss of local contextual information during the global feature fusion process. …”
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The impact of biofeedback in enhancing chronic pain rehabilitation: A systematic review of mechanisms and outcomes by Andrea Calderone, Vincenza Maura Mazzurco Masi, Rosaria De Luca, Antonio Gangemi, Mirjam Bonanno, Daniela Floridia, Francesco Corallo, Giovanni Morone, Angelo Quartarone, Maria Grazia Maggio, Rocco Salvatore Calabrò

“…Furthermore, it aimed to evaluate the impact of BFB on key outcomes, including pain severity, functional capabilities, and quality of life, with the goal of guiding its integration into contemporary rehabilitation practices. …”
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Minimizing Power Consumption and Interference Mitigation of Downlink NOMA HetNets by IRS-Supported Aerial Base Stations by Osamah Thamer Hassan Alzubaidi, Mhd Nour Hindia, Kaharudin Dimyati, Kamarul Ariffin Noordin, Faizan Qamar, Atef Abdrabou

“…Moreover, the results demonstrate that integrating IRS into multi-ABS HetNets significantly improves the total performance by enhancing the quality of the channel between ABSs and their corresponding GUs while minimizing inter-ABS interference. …”
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Evidence that the domesticated fungus Leucoagaricus gongylophorus recycles its cytoplasmic contents as nutritional rewards to feed its leafcutter ant farmers by Caio Ambrosio Leal-Dutra, Lok Man Yuen, Bruno Augusto Maciel Guedes, Marta Contreras-Serrano, Pedro Elias Marques, Jonathan Zvi Shik

“…While autophagy is a ubiquitous and often highly derived process across the tree of life, our study reveals a new role for autophagy as a mechanism of functional integration between ant farmers and their fungal crop, and potentially as a signifier of higher-level homeostasis between uniquely life-time committed ectosymbionts.…”
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From resources to resilience: Understanding the impact of standard of living and energy consumption on natural resource rent in Asia by Muhammad Imran, Muhammad Tufail, Chen Mo, Salman Wahab, Muhammad Kamran Khan, Wong Chee Hoo, Zhu Ling

“…With increasing energy demands, escalating CO₂ emissions, and widening income inequality, an integrated approach to managing natural resources has never been more critical. …”
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A Study on Lower Limb Movement Intention Recognition Based on Multi-Source Information Fusion by Siyu Zong, Wei Li, Dawen Sun, Xiaojie Wei, Junjie Chen, Zhengwei Yue, Daxue Sun

“…The multivariate flow-limited sliding time window BPGN reduced the mean knee error by 11.2° and the mean ankle angle error by 7.4° compared to Radial Basis Function (RBF) Neural-network intent recognition. By integrating the sEMG signal and lower limb joint angle information, the system can more accurately capture the patient’s movement intention and realize more precise lower limb rehabilitation training.…”
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Quantifying intratumoral heterogeneity within sub-regions to predict high-grade patterns in clinical stage I solid lung adenocarcinoma by Zhichao Zuo, Jinqiu Deng, Wu Ge, Yinjun Zhou, Haibo Liu, Wei Zhang, Ying Zeng

“…Subsequently, a hybrid model which presented as a nomogram was developed, integrating the Clin-Rad classification and ITH score. …”
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Model development of isopropanol dehydration from binary and ternary mixtures with pervaporation: Comparison and environmental evaluation of hybrid separation methods by Huyen Trang Do Thi, Eniko Haaz, Andras Jozsef Toth

“…This study investigates the separation of isopropanol (IPA) from water and ethanol (EtOH) using hybrid distillation-hydrophilic pervaporation (D+HPV), distillation-hydrophilic pervaporation-distillation (D+HPV+D), and distillation-hydrophilic pervaporation-distillation-heat integration (D+HPV+D+HI) systems. The pervaporation performance of PERVAP™ 1510 and PERVAP™ 4100 hydrophilic membranes is evaluated for ternary (IPA-EtOH-Water) and binary (IPA-Water) mixtures at varying feed compositions and temperatures. …”
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Knowledge and Use of Caries Detection Methods among Dental Students and Dental Practitioners in Riyadh, Saudi Arabia by Waseem Radwan, Abeer A. AlNasser, Hesah Aloqab, Khalid Al-Saggaf, Nora A. Almuhtab, Bothinah Alnasyan

“…Accurate detection and diagnosis of dental caries is an integral part of achieving adequate comprehensive dental care. …”
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FedDrip: Federated Learning With Diffusion-Generated Synthetic Image by Karin Huangsuwan, Timothy Liu, Simon See, Aik Beng Ng, Peerapon Vateekul

“…Moreover, we demonstrate that this virtual-client strategy can be integrated into any federated learning framework, including foundational algorithms such as FedAvg and advanced algorithms such as FedDyn and FedProx. …”
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Spatially explicit assessment of water stress and potential mitigating solutions in a large water-limited basin: the Yellow River basin in China by W. Zhang, W. Zhang, X. Zhao, X. Zhao, X. Gao, W. Liang, J. Li, B. Zhang

“…However, the roles of water withdrawal and water availability components in determining water stress and potential mitigating measures in large water-scarce basins are poorly understood. Here, an integrated analytical framework was applied to the Yellow River basin (YRB), where the water crisis has been a core issue for sustainable development. …”
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Human_SNP_TATAdb: a database of SNPs that statistically significantly change the affinity of the TATA-binding protein to human gene promoters: genome-wide analysis and use cases by S. V. Filonov, N. L. Podkolodnyy, O. A. Podkolodnaya, N. N. Tverdokhleb, P. M. Ponomarenko, D. A. Rasskazov, A. G. Bogomolov, M. P. Ponomarenko

“…This model served as a base for other ICG web services, SNP_TATA_Z-tester and SNP_TATA_Comparator, which make a statistical assessment of the SNP-induced change in the affinity of TBP binding to the human gene promoter and help predict changes in expression that may be associated with a genetic predisposition to diseases or phenotypic features of the organism. In this work, we integrated into a single database information about SNPs in human gene promoters obtained by automatic extraction from various heterogeneous data sources, as well as the estimates of TBP affinity for the promoter obtained using the three-step binding model and predicting their effect on gene expression for wild-type promoters and promoters with SNPs. …”
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Phytoplankton growth and succession driven by topography and hydrodynamics in seasonal ice-covered lakes by Ziyue Zhao, Yanfeng Wu, Y. Jun Xu, Yexiang Yu, Guangxin Zhang, Dehua Mao, Xuemei Liu, Changlei Dai

“…A typical seasonally ice-covered lake, Lake Chagan, was selected, and 164 water column and plankton samples were collected in 2023. An integrated underwater topographic-hydrodynamic model was constructed based on topographic data from 597 exploration points and long-term hydrological and meteorological observational data. …”
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