Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

“…Mechanistic studies were performed using single-cell RNA-sequencing.Results Applying stringent in vitro assays and orthotopic in vivo NB models, we demonstrated that our single-chain variable fragment, CT3, integrated into a CAR vector with a CD28 hinge, CD28 transmembrane, and 4-1BB co-stimulatory domain (CT3.28H.BBζ) elicits the best preclinical anti-NB activity compared with other tested CAR constructs. …”
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SOCIAL AND ECONOMIC DEVELOPMENT OF MAGADAN: FROM A PLANNED ECONOMY TO A MARKET ECONOMY (1960–2020) by Natalya V. Galtseva, Oksana S. Favstritskaya, Olga A. Sharypova

“…The findings reveal that during the planned economy era, Magadan experienced major growth, with integrated development across industries, population increase, and economic appeal driven by northern benefits provided by the government. …”

Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma by Wen-Yan Wang, Yue Chen, Qian Chen, Hong-Wei Sun, Nuo-Xuan Niu, Hong-Hui Li, Yu-Dan Cao, Yan-Xia Bai, Xiang Li, Xiang Li

“…Validated as an independent prognostic factor in both cohorts, the SIIN score showed strong correlation with adverse clinicopathological outcomes.ConclusionThe SIIN score is a promising prognostic tool that integrates immune, inflammatory, and nutritional factors for predicting clinical outcomes in HNSCC patients. …”
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MultiTax-human: an extensive and high-resolution human-related full-length 16S rRNA reference database and taxonomy by Zhiwei Bao, Bin Zhang, Jianhua Yao, Ming D. Li

“…Our study presents the MultiTax-human database, a high-resolution reference tool specifically designed for human microbiome research. By integrating data from multiple sources and employing advanced classification techniques, this database offers an accurate and detailed map of the human microbiome. …”
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Breastfeeding Practices and Food Consumption of Socially Vulnerable Children by Natália A. Oliveira, Nathalia Pizato, Érika S. O. Patriota, Ariene S. do Carmo, Gabriela Buccini, Vivian S. S. Gonçalves

“…The associations observed revealed the need to integrate family food choices and nutritional education into public policies for early childhood.…”
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Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (IMMENSE study): study protocol for a randomised controlled trial by Liv Mathiesen, Jeanette Schultz Johansen, Kjerstin Havnes, Kjell H. Halvorsen, Stine Haustreis, Lillann Wilsgård Skaue, Elena Kamycheva, Kirsten K. Viktil, Anne Gerd Granås, Beate H. Garcia

“…Introduction Drug-related problems (DRPs) are common in the elderly, leading to suboptimal therapy, hospitalisations and increased mortality. The integrated medicines management (IMM) model is a multifactorial interdisciplinary methodology aiming to optimise individual medication therapy throughout the hospital stay. …”
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Imaging and Spectral Fitting of Bright Gamma-Ray Sources with the COSI Balloon Payload by Jarred M. Roberts, Steven Boggs, Thomas Siegert, John A. Tomsick, Marco Ajello, Peter von Ballmoos, Jacqueline Beechert, Floriane Cangemi, Savitri Gallego, Pierre Jean, Chris Karwin, Carolyn Kierans, Hadar Lazar, Alex Lowell, Israel Martinez Castellanos, Sean Pike, Clio Sleator, Yong Sheng, Hiroki Yoneda, Andreas Zoglauer

“…Cygnus X-1 was also observed during this flight, and we obtain a measured flux of (1.4 ± 0.2) × 10 ^3 ph cm ^−2 s ^−1 in the same energy band and a best-fit result (including data from NuSTAR, Swift-BAT, and INTEGRAL/IBIS) was a cutoff power law with a high-energy cutoff energy of 138.3 ± 1.0 keV and a photon index of Γ = 1.358 ± 0.002. …”
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Subacromial Pain Syndrome in Breast Cancer Survivors—Are Structural Shoulder Changes Verified by Ultrasound Clinically Relevant? by Ivana Klarić-Kukuz, Jure Aljinović, Blaž Barun, Marko Roki, Benjamin Benzon, Danijela Budimir Mršić, Maja Marinović Guić, Ana Poljičanin

“…Ultrasound is valuable but requires integration with clinics for accurate diagnosis of the underlying causes of shoulder pain.…”
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Ethnopharmocology, phytochemistry and pharmacology of the genus Orthosiphon: A review by Rui Wang, Ling Qiu, Qing-wen Zhang, Ligen Lin

“…Method: Orthosiphon-related information was collected from the online databases, such as Google Scholar, SciFinder, Web of Science, Elsevier, PubMed and China Knowledge Resource Integrated (CNKI). Results: Plants of the genus Orthosiphon are widely distributed in African, Australia, South Asian, and Southeast Asian, and in China. …”
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Produção de um curso de especialização em Medicina de Família e Comunidade by Alysson Feliciano Lemos, Paula Zeni Miessa Lawall, Rodrigo Luciano Bandeira de Lima, Sara Shirley Belo Lança, Edinalva Neves Nascimento

“…Para enfrentá-lo, é fundamental qualificar profissionais em saúde pública, com ênfase na saúde da família, por meio de uma abordagem reflexiva e problematizadora que integre teoria e prática e utilize tecnologias de informação e comunicação. …”
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Multi-task aquatic toxicity prediction model based on multi-level features fusion by Xin Yang, Jianqiang Sun, Bingyu Jin, Yuer Lu, Jinyan Cheng, Jiaju Jiang, Qi Zhao, Jianwei Shuai

“…Methods: The model integrates molecular fingerprints and molecule graphs to characterize molecules, enabling the simultaneous prediction of acute toxicity for the same organic compound across four distinct fish species. …”
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Expert evaluation of large language models for clinical dialogue summarization by David Fraile Navarro, Enrico Coiera, Thomas W. Hambly, Zoe Triplett, Nahyan Asif, Anindya Susanto, Anamika Chowdhury, Amaya Azcoaga Lorenzo, Mark Dras, Shlomo Berkovsky

“…Privacy concerns and the restricted nature of health records remain challenges for its integration. Further evaluations using diverse clinical dialogues and multiple initialization seeds are needed to verify the reliability and generalizability of automatically generated summaries.…”
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Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth by Li-Yan Zhang, Tian-Tian Li, Hong-Xin Liao, Jin-Rui Wen, Hong-Yan Nie, Fu-Rong Xu, Xiao-Yun Liu, Xian Dong

“…Chromatin immunoprecipitation sequencing (ChIP-seq) analysis revealed that menthone inhibited the growth of F. proliferatum by decreasing H3K27ac levels and interfering with the transcription of energy metabolism-related genes. By integrating the RNA-seq data with the ChIP-seq results, we identified 110 DEGs associated with reduced H3K27ac modification primarily associated with ribosome biogenesis. …”
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Water use in the industrial sector based on the IPAC model under the carbon-neutral transformation path in China by Yu-Jie Jiao, Ke-Jun Jiang, Sha Chen, Pian-Pian Xiang, Chen-Min He

“…By 2050, the chemical industry is projected to reduce water stress by transitioning from traditional water-saving technologies to the integration of automation and hydrogen-based solutions.…”
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Needle tracking and segmentation in breast ultrasound imaging based on spatio-temporal memory network by Qiyun Zhang, Jiawei Chen, Jinhong Wang, Haolin Wang, Yi He, Yi He, Bin Li, Zhemin Zhuang, Huancheng Zeng

“…The proposed network integrates a hybrid encoder that employs CNN-Transformer architectures, along with an optical flow estimation method. …”
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Evaluation of learning from Practical Obstetric Multi-Professional Training and its impact on patient outcomes in Australia using Kirkpatrick’s framework: a mixed methods study by Philip DeKoninck, Euan M Wallace, Debra Nestel, Arunaz Kumar, Sam Sturrock, Donna Lucey, Sally Stoyles, Jenny Morgan, Peter Neil, Michelle Schlipalius

“…We explored participants’ acquisition of knowledge and skills, its impact on clinical outcomes and organisational change to integrate the PROMPT programme as a credentialing tool. …”
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Sustainable aquaculture and sea ranching with the use of vaccines: a review by Alma Alfatat, Kwaku Amoah, Kwaku Amoah, Kwaku Amoah, Kwaku Amoah, Kwaku Amoah, Jia Cai, Jia Cai, Jia Cai, Jia Cai, Jia Cai, Yu Huang, Yu Huang, Yu Huang, Yu Huang, Yu Huang, Muhammad Fachri, Hagai Nsobi Lauden, Shaoliang Lyu, Xuefeng Wang, Sahya Maulu, Berchie Asiedu, Syaifiuddin Syaifiuddin

“…Vaccines also improve the survival rates of hatchery-reared fish in natural habitats, supporting long-term sustainability. By integrating vaccination with selective breeding for disease resistance, aquaculture can achieve enhanced productivity and reduced environmental impact. …”
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Voices from the Amazon: exploring implementor and user perceptions of non-invasive malaria diagnostics in Peru by Lauren Nussbaum, Emma Ortega, E. Jennifer Ríos López, Alfonso Simoné Vizcarra, Jhonny J. Córdova López, Serafina Calarco, Elena Marbán-Castro, Kevin Tetteh, Sonjelle Shilton, Amy C. Morrison, Vanessa Fargnoli, Valerie A. Paz-Soldán

“…As manufacturers evaluate the efficacy and effectiveness of these non-invasive diagnostic tools, international recommendations should be created to ensure their agile integration into national malaria programmes.…”
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Image depth estimation assisted by multi-view projection by Liman Liu, Jinshan Tian, Guansheng Luo, Siyuan Xu, Chen Zhang, Huaifei Hu, Wenbing Tao

“…To address this problem, a multi-view projection-assisted image depth estimation network is proposed, which integrates multi-view stereo vision into a deep learning-based encoding-decoding image depth estimation framework without pre-estimation of view bitmap. …”
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Body composition as an indicator of metabolic changes in mice obtained by <i>in vitro</i> fertilization by M. V. Anisimova, Yanli Gon, G. V. Kontsevaya, A. V. Romashchenko, N. V. Khotskin, A. K. Stanova, L. A. Gerlinskaya, M. P. Moshkin

“…One of the consequences of reduced utilization of IVF energy substrates by offspring is a decrease in their tolerance to glucose loading. The integral criterion for the effectiveness of restoring the initial glucose level is the area under the curve (AUC), the value of which was 2.5 (males) and 3.2 (females) times higher in IVF offspring compared to the corresponding control. …”
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