The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) by Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall, Techung Lee

“…The finding may offer an innovative strategy for gene-based regeneration of the pulp-dentin complex.…”
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From cellular senescence towards age-related macular degeneration: the role of telomeres by L.K. Moshetova, O.I. Abramova, K.I. Turkina, O.P. Dmitrenko, N.S. Karpova

“…The understanding of molecular mechanisms involved in aging may provide innovative therapeutic and preventive strategies for AMD. …”
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GC/MS Fatty Acid Profile of Marine-Derived Actinomycetes from Extreme Environments: Chemotaxonomic Insights and Biotechnological Potential by Marlene B. Cunha, André F. Jorge, Maria João Nunes, Joana R. Sousa, Maria João Lança, Marco Gomes da Silva, Susana P. Gaudêncio

“…Furthermore, these results underline the diversity and biotechnological potential of FAs in actinomycetes, uncovering their potential to be used as microbial cell factories, and paving the way for innovations in biofuels, pharmaceuticals, and eco-friendly industrial products.…”
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Supporting rotational grazing systems with virtual fencing: paddock transitions, beef heifer performance, and stress response by N.A. Grinnell, D. Hamidi, M. Komainda, F. Riesch, J. Horn, I. Traulsen, R. Palme, J. Isselstein

“…Virtual fencing (VF) is an innovative technology for simplified, less laborious grazing management and remote animal monitoring, potentially facilitating the expansion of sustainable livestock production. …”
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Principles, barriers and enablers to agroecological animal production systems: a qualitative approach based on five case studies by B. Dumont, C. Barlagne, P. Cassart, J.E. Duval, A. Fanchone, J-L. Gourdine, O. Huguenin-Elie, Y. Kazakova, J. Klötzli, A. Lüscher, E. Oteros-Rozas, D. Pomies, M.G. Rivera Ferre, W.A.H. Rossing, V. Stefanova, A. Swartebroeckx, C. Zagaria

“…Following a multilevel perspective, we propose a new eight-category framework to categorise barriers and enablers in these different socioecological contexts, and discuss the implications of these results for scaling out and scaling up agroecological niche innovations in animal production areas. Though we could observe activities related to each agroecological principle in each case study, the relative importance of each principle differed. …”
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Application of organoids in drug screening of gynecological malignant tumors by JIANG Yuanyuan, WEI Wenfei, WU Jingya, LI Huawen

“…Organoid models have been extensively studied as an innovative drug screening tool and personalized medicine for treating gynecologic malignancies. …”
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Life cycle assessment of agricultural waste recycling for sustainable environmental impact by S. Sumiyati, B.P. Samadikun, A. Widiyanti, M.A. Budihardjo, S. Al Qadar, A.S. Puspita

“…Life cycle assessment has emerged as an innovative and comprehensive viewpoint that considers the entire recycling process to evaluate the potential and true implications of agricultural waste recycling. …”
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The Application of Three-dimensional Shear Wave Elastography in the Detection of Inguinal Lymph Node Metastasis in Gynecological Malignancies by Yuping Shen, Jiulong Dai, Jiami Li, Man Lu

“…This study implements three-dimensional shear wave elastography (3D-SWE), an innovative technique that quantifies the stiffness of inguinal lymph nodes (ILN) in patients with gynecological cancers. …”
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LightweightUNet: Multimodal Deep Learning with GAN-Augmented Imaging Data for Efficient Breast Cancer Detection by Hari Mohan Rai, Joon Yoo, Saurabh Agarwal, Neha Agarwal

“…Hence, to overcome this challenge, we have presented the innovative LightweightUNet hybrid deep learning (DL) classifier for the accurate classification of breast cancer. …”
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Public acceptance of microbiome management strategy in dairy calves: a European survey on colostrum, probiotic provision and prolonged cow-calf contact by A. Ait Sidhoum, A. Stygar, F. Bedoin, J.K. Niemi

“…The aim of this study was to investigate the public acceptance of innovative microbiome management practices aimed at improving the health and welfare of calves and to assess the factors influencing these levels of acceptance. …”
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Optimization of SiC reinforced Al7039/Cu composites for enhanced thermal conductivity and hardness via response surface methodology by Fetene Teshome Teferi, Kishor Purushottam Kolhe, Assefa Asmare Tsegaw, Samuel Olawale Fatoba

“…This study emphasizes the potential of optimized MMCs to efficiently and cost-effectively fulfill advanced engineering requirements, promoting their adoption in innovative technologies.…”
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Presenting the Model of Eco-Leadership in Elementary Schools with an Interpretive Phenomenological Approach by Adel Zahed babolan, Seyyedmohammad Seyyedkalan

“…The findings of this research have innovatively defined environmental leadership within educational management, identified and analyzed environmental challenges specific to elementary schools, and proposed solutions. …”
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Application of the DEB-TKTD model with multi-omics data: Prediction of life history traits of Chinese mitten crab (Eriocheir sinensis) under different salinities by Hanzun Zhang, Shipeng Dong, Hongwei Shan, Chao Yang, Fang Wang

“…This approach provides an innovative tool for ecological toxicological research in the aquaculture environment.…”
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Post-therapeutic support and rehabilitation for breast cancer women in complete remission in a thermal resort: study protocol for the PACThe Real-Life conditions observational tria... by Mélanie Godiveau, Judith Passildas, Emilie Thivat, Mélanie Casile, Céleste Pinard, Alexia Giro, Marie-Ange Mouret-Reynier, Ioana Molnar, Catherine Abrial, Claude-Eugène Bouvier, Yves-Jean Bignon, Xavier Durando

“…It combines institutional quality and security with the freedom of real life and the dynamics of a group formed under innovative conditions. This rehabilitation procedure was tested with the program PACThe (Program of Accompanying women after breast Cancer treatment completion in Thermal resorts) which was evaluated at one year in a randomized controlled trial involving 251 patients [1] and at five years in another study [2]. …”
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HOTSED: A new integrated model for assessing potential hotspots of sediment sources and related sediment dynamics at watershed scale by Manuel La Licata, Alberto Bosino, Seyed Hamidreza Sadeghi, Mattia De Amicis, Andrea Mandarino, Andrea Terret, Michael Maerker

“…In this paper we introduce HOTSED, a novel, innovative GIS-based model designed for assessing potential hotspots of sediment dynamics at watershed scale. …”
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A novel TID + IDN controller tuned with coatis optimization algorithm under deregulated hybrid power system by Geetanjali Dei, Deepak Kumar Gupta, Binod Kumar Sahu, Mohit Bajaj, Vojtech Blazek, Lukas Prokop

“…In summary, this paper presents an innovative TID + IDN controller optimized using a novel Coatis Optimization Algorithm within a three-area hybrid system operating in a deregulated context. …”
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La escritura borrada de las mujeres. Itinerarios lectores inclusivos y (re)construcción del canon poético / The erased writing of women. Inclusive reading itineraries and (re)const... by Remedios Sánchez-García, Pablo Aparicio-Durán

“…Once the research problem has been defined, the new situation is addressed as a result of the legal implementation of the LOMLOE in Andalucía, suggesting strategies to create original, relevant and innovative reading itineraries in order to work on the reality of 20th century poetry in a meaningful way, also favouring education in values such as respect for gender equality. …”
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Global regional and national burden of intracerebral hemorrhage between 1990 and 2021 by Zhao-wei Wang, Mei-ping Wan, Jia-hui Tai, Yong Wang, Min-yi Yin

“…Gender analysis identified distinct age-specific patterns, with males above 35 showing higher risk, particularly in Eastern Europe, while South Asia demonstrated minimal gender differences. Our innovative analysis during COVID-19 revealed healthcare system strength significantly impacted ICH outcomes, with well-resourced countries maintaining better outcomes. …”
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Historical education of primary school children: from theory to practice by Irina V. Verkhovykh, Natalya P. Shityakova, Inga V. Zabrodina

“…This requires teachers to understand the essence of this process, apply innovative teaching methods and approaches aimed at actively involving students in learning history. …”
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Comprehensive assessment of a nationwide simulation-based course for artificial life support. by Mateusz Puslecki, Marek Dabrowski, Marcin Ligowski, Bishoy Zakhary, Ahmed S Said, Kollengode Ramanathan, Elaine Cooley, Lukasz Puslecki, Sebastian Stefaniak, Piotr Ziemak, Ilona Kiel-Puslecka, Agata Dabrowska, Tomasz Klosiewicz, Maciej Sip, Radoslaw Zalewski, Malgorzata Ladzinska, Wojciech Mrowczynski, Piotr Ladzinski, Lidia Szlanga, Konrad Baumgart, Piotr Kupidlowski, Lukasz Szarpak, Marek Jemielity, Bartlomiej Perek

“…The implementation of the education program during COVID-19 pandemic may be helpful in founding specialized Advanced Life Support centers and teams including mobile ones. The dedicated R&D Innovation Ecosystem established in the "ECMO for Greater Poland" program, with developed National Education Center can play a crucial role in the knowledge and know-how transfer but future research is needed.…”
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