The effect of continuous positive airway pressure therapy on atrial fibrillation in patients with obstructive sleep apnea by Jiancheng Hu, Siyuan Zuo, Jiahui Qian, Fangfang Cheng, Dengji Wang, Yanyan Deng, Dasheng Lu, Dasheng Lu

“…The intricate pathophysiological pathways linking OSA to AF encompass chronic intermittent hypoxia, disruptions in the autonomic nervous system, inflammatory responses, and alterations in ion channel function. …”
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Traffic Control of Bacteria-Derived Molecules: A New System of Host-Bacterial Crosstalk by Hiroaki Konishi, Mikihiro Fujiya, Yutaka Kohgo

“…Virulent microorganisms, such as pathogenic bacteria and viruses, are recognized by pattern recognition receptors (PRRs), including toll-like receptors (TLRs) and nucleotide-binding oligomerization-domain proteins (NODs), and induce inflammatory responses in mammalian hosts. Conversely, commensal bacteria and probiotics, which symbiotically confer health benefits on the host organisms, can lodge in the host intestinal tract without inducing intestinal inflammation. …”
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Colon-targeted engineered postbiotics nanoparticles alleviate osteoporosis through the gut-bone axis by Tingting Yu, Rushui Bai, Zeming Wang, Yuting Qin, Jingwei Wang, Yaohua Wei, Ruifang Zhao, Guangjun Nie, Bing Han

“…These engineered postbiotics nanoparticles can effectively suppress macrophage inflammatory activation, modulate the redox balance, and regulate the composition of the gut microbiota, thereby restoring epithelial barriers, inhibiting bacterial invasion, and down-regulating pro-inflammatory responses. As a result, the remission of systemic inflammation is accompanied by a rebalancing of osteoblast and osteoclast activity, alleviating inflammatory bowel disease-related and post-menopausal bone loss. …”
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BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets by Jaehwi Lee, Man Hee Rhee, Eunji Kim, Jae Youl Cho

“…These data strongly suggest that BAY is an inhibitor with multiple targets and could serve as a lead compound in developing strong anti-inflammatory drugs with multiple targets in inflammatory responses.…”
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Glutathione: A Key Regulator of Extracellular Matrix and Cell Death in Intervertebral Disc Degeneration by Fudong Li, Shaofei Li, Yangyang Shi, Feng Lin, Lining Rui, Jiangang Shi, Kaiqiang Sun

“…The ECM and various types of cell death in IVDD are regulated by multiple factors, such as inflammatory responses and oxidative stress. The glutathione (GSH) redox system is the most important antioxidant defense system in cells. …”
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Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications by Mehrdad Afarid, Ehsan Namvar, Fatemeh Sanie-Jahromi

“…In contrast, higher concentrations of brain-derived neurotrophic factor might induce inflammatory responses. Damage to the retinal cells due to metabolic alterations associated with diabetes and its consequence vasculopathy may also lead to changes in the ocular microenvironment and cytokines. …”
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Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery by Chananya Karunasumetta, Chotika Chatgasem, Suriya Punchai, Kittisak Sawanyawisuth

“…These DEMs were associated with protein and energy production, oxidative stress, and inflammatory responses. Key differential metabolites between the groups included histidine and alanine, which notably impacted the histidine metabolism pathway. …”
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Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation. by Gastón F Alfaro, Valentino Palombo, Mariasilvia D'Andrea, Wenqi Cao, Yue Zhang, Jonathan Beever, Russell B Muntifering, Wilmer J Pacheco, Soren P Rodning, Xu Wang, Sonia J Moisá

“…Several metabolic pathways revealed potential positive effects to the animal's liver metabolism due to administration of rumen-protected niacin; for example, a decrease in lipolysis, apoptosis, inflammatory responses, atherosclerosis, oxidative stress, fibrosis, and vasodilation-related pathways. …”
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The Role of IL-33 in Gut Mucosal Inflammation by Luca Pastorelli, Carlo De Salvo, Maurizio Vecchi, Theresa T. Pizarro

“…Indeed, data generated from these studies suggest that IL-33 may possess dichotomous functions, enhancing inflammatory responses on one hand and promoting epithelial integrity on the other. …”
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Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation by Adam Aguirre, Carola J. Maturana, Paloma A. Harcha, Juan C. Sáez

“…The corticotropin-releasing hormone and glucocorticoids are critical players in stress-induced mastocyte degranulation and potentiation of glial inflammatory responses, respectively. Mastocytes and glial cells express different toll-like receptor (TLR) family members, and their activation via proinflammatory molecules can increase the expression of connexin hemichannels and pannexin channels in glial cells. …”
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Research Progress on Biomaterials for Spinal Cord Repair by Liao Z, Bao Q, Saijilahu, Chimedtseren C, Tumurbaatar K, Saijilafu

“…In addition, the glial scars and inflammatory responses around the lesion site are another major obstacle for successful axon regeneration after SCI. …”
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Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes by Jordan Greaves, Giordano Pula

“…Multiple reports describe the hyperactivity of platelets in DM and their participation in inflammatory responses. The understanding of the mechanisms underlying the contribution of platelets to cardiovascular pathologies in DM will help the development of targeted therapeutic strategies able to reduce cardiovascular risk in these patients. …”
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Immunomodulatory insights of monoterpene glycosides in endometriosis: immune infiltration and target pathways analysis by Jin Zhan, Jiajie Wu

“…Enrichment analysis highlighted pathways involved in immune and inflammatory responses. Machine learning identified SSTR5, CASP3, FABP2, and SYK as critical targets, contributing to a nomogram that demonstrated good predictive performance for endometriosis risk. …”
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Relationship between hospitalization from cannabis usage and pulmonary tuberculosis in Thailand from 2017 to 2022. by Kemmapon Chumchuen, Wit Wichaidit, Virasakdi Chongsuvivatwong

“…Cannabis usage can increase inflammatory responses in the respiratory tract. Sharing of cannabis waterpipes has been linked to increased tuberculosis risks. …”
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Mitochondrial Dysfunction in Diabetic Periodontitis: Mechanisms and Therapeutic Potential by Meng L, Wen W

“…We further delve into the connections between mitochondrial dysfunction and the pathogenic mechanisms of diabetic periodontitis, such as exacerbated inflammatory responses, decreased tissue repair capacity, and autophagy dysregulation. …”
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Adipokines as Drug Targets in Diabetes and Underlying Disturbances by Vinícius Andrade-Oliveira, Niels O.S. Câmara, Pedro M. Moraes-Vieira

“…Multiple roles in metabolic and inflammatory responses have been assigned to these molecules. …”
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Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells by Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki

“…In conclusion, these findings suggest that nobiletin can inhibit inflammatory responses in TNF-stimulated HPDLCs by inhibiting NF-κB and AKT1 activations and upregulating the NFE2L2 and HMOX1 expression.…”
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Inhibition of Angiogenic Factor Production from Murine Mast Cells by an Antiallergic Agent (Epinastine Hydrochloride) In Vitro by K. Asano, A. Furuta, K. Kanai, S. Sakaue, H. Suzaki, T. Hisamitsu

“…Angiogenesis is an important event both in the development of allergic inflammatory responses and in the pathophysiology of tissue remodeling in allergic diseases. …”
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HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure by Runkuan Yang, Xiaoping Zou, Jyrki Tenhunen, Tor Inge Tønnessen

“…BT triggers/induces systemic inflammatory responses syndrome (SIRS), which can lead to MOF in ALF. …”
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Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection by Chandran Ramakrishna, Mari S. Golub, Abby Chiang, Teresa Hong, Markus Kalkum, Edouard M. Cantin

“…We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses. We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone. …”
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