Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer’s disease: a bioinformatics and experimental study by Shengjie Zhang, Ruqiu Zhang, Zhaoqin Chen, Zihan Shao, An Li, Fan Li, Fang Huang

“…Gene-inflammation association analysis shows that the hub gene AREL1 is related to inflammatory response, while the protein-inflammation association analysis shows that the hub proteins AKT1 and MAPK14 are related to inflammatory response.ConclusionThis study provides new insights into the shared molecular mechanisms between AD and nHIBD. …”
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Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods by Marina Ramal-Sanchez, Chiara Bravo-Trippetta, Veronica D’Antonio, Elena Corvaglia, Angela A. M. Kämpfer, Roel P. F. Schins, Mauro Serafini, Donato Angelino

“…The integrity and stability of the epithelial barrier were monitored and the inflammatory response of the model was assessed using various stressors at different concentrations, both individually and in combination (phorbol-12- myristate-13-acetate or PMA, and lipopolysaccharide or LPS), in terms of cytokines production. …”
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Single Exposure to Low-Intensity Focused Ultrasound Causes Biphasic Opening of the Blood-Brain Barrier Through Secondary Mechanisms by Tasneem A. Arsiwala, Kathryn E. Blethen, Cullen P. Wolford, Geoffrey L. Pecar, Dhruvi M. Panchal, Brooke N. Kielkowski, Peng Wang, Manish Ranjan, Jeffrey S. Carpenter, Victor Finomore, Ali Rezai, Paul R. Lockman

“…This study aimed to characterize the time-dependent changes in BBB permeability, transporter function, and inflammatory responses in both sonicated and non-sonicated brain tissues following LiFUS treatment. …”
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Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study by Wei Zheng, Wei Zheng, Chuanzan Zhou, Jia Miao, Yunkai Yang, Xuanhan Hu, Heng Wang, Xinyu Zhang, Qi Zhang, Yifan Wang

“…The influence of inflammatory response and cognitive function on the interaction between GNRI and OAB was also examined by mediation analysis.ResultsGNRI in the OAB group was significantly lower than that in the non-OAB group. …”
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Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy by Jianyao Zeng, Yan Sun, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian, Qijun Qian, Qijun Qian

“…Nonetheless, non-methylated CpG sequences within plasmid DNA can elicit an inflammatory response via Toll-like receptor 9 (TLR9) during CAR-T cell preparation, adversely affecting transgene expression. …”
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Role and interactions of organelle stress in septic cardiomyopathy by Wei Wei, Zhang Jinbo, Zhang Zhaocai

“…The excessive inflammatory response, immune dysfunction, and dysregulation of homeostasis induced by sepsis can trigger abnormal stress responses in organelles such as endoplasmic reticulum, mitochondria, and Golgi apparatus, regulating the pathophysiological progression of SCM. …”
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Systemic and Local CC Chemokines Production in a Murine Model of <emph>Listeria monocytogenes</emph> Infection

“…The liver-to-serum ratio was more pronounced in the case of macrophage inflammatory protein 1<mml:math> <mml:mi>&#x03B1;</mml:mi> </mml:math> (MIP-1<mml:math> <mml:mi>&#x03B1;</mml:mi> </mml:math> ), suggesting its role in the inflammatory response in the liver. The ratio of brain-to-serum concentration of monocyte chemoattractant protein 1 (MCP-1) remained the same as in the control animals, while it was lower in the infected mice, both in the case MIP-1<mml:math> <mml:mi>&#x03B1;</mml:mi> </mml:math> and in the case of regulated on activation, normal T cell expressed and secreted (RANTES). …”
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Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation by Alejandro Pablo Adam

“…Tyrosine kinase signaling has emerged as a central regulator of the inflammatory response, partly through direct phosphorylation and dephosphorylation of the adherens junction components. …”
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Cyclooxygenase Inhibition in Sepsis: Is There Life after Death? by David M. Aronoff

“…Prostaglandins are important mediators and modulators of the inflammatory response to infection. The prostaglandins participate in the pathogenesis of hemodynamic collapse, organ failure, and overwhelming inflammation that characterize severe sepsis and shock. …”
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Piezosurgery-Assisted Surgical Treatment in Impacted Canine Transmigration by Matheus Francisco Barros Rodrigues, Layla Louise de Amorim Rocha, Rodrigo da Franca Acioly, Cristofe Coelho Lopes da Rocha, Daniel do Carmo Carvalho

“…The surgical treatment established for this case was satisfactory, and full recovery of the patient was achieved without complications such as an intense postoperative inflammatory response.…”
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Inflammasomes in Mycobacterium tuberculosis-Driven Immunity by Sebastian Wawrocki, Magdalena Druszczynska

“…Inflammasome activation, which triggers the multifaceted activity of these two proinflammatory cytokines, is a prerequisite for developing an efficient inflammatory response against pathogenic Mycobacterium tuberculosis (M.tb). …”
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The role of inflammation in pathogenesis and treatment of colorectal cancer by T. N. Garmanova, M. I. Bredikhin, I. A. Tulina, P. V. Tsarkov

“…The paper makes an attempt to present a unified concept of the impact of postoperative complications on tumor recurrence in the light of the inflammatory response to surgical intervention.…”
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Intestinal inflammation in TNBS sensitized rats as a model of chronic inflammatory bowel disease by N. Selve, T. Wöhrmann

“…Histologically, the inflammatory response included mucosal and submucosal cell infiltration by lymphocytes and histiocytes, transmural granulomatous inflammation with multinucleated cells and activated mesenteric lymph nodes. …”
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Periodontal Disease and its Relationship with Diabetes by Jennifer Dayana Cárdenas Velastegui, Danna Mabel Castro Freire, Leslie Fernanda Dávila Alemán, Oswaldo Miranda Rosero

“…The severity of periodontal disease is affected by the inflammatory response. Cells such as IL-1β, IL-6, and TNF-α are chronically and persistently elevated. …”
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The role of NF-κB in diabetic cardiomyopathy by Huang-Jun Liu, Le-Kun Gui, Han Wei, Xing-Yu Zhou, Zhen-Lan Liu, Li-Jun Jin

“…Among these, nuclear factor kappa B (NF-κB), a pleiotropic transcription factor, assumes a crucial role in regulating oxidative stress, inflammatory response, endothelial dysfunction, myocardial fibrosis and hypertrophy, and cardiomyocyte apoptosis in DCM. …”
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Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia by Michael Huang, Erin Owen, Scott Myers, Ashok Raj

“…Pulmonary leukostasis and systemic inflammatory response syndrome (SIRS) following leukemia cell lysis are the likely etiologies. …”
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The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi) by Paul T. King, Roleen Sharma

“…NTHi induces a strong inflammatory response in the respiratory tract with activation of immune responses, which often fail to clear the bacteria from the lung. …”
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Pien Tze Huang Attenuates Neuro-inflammatory Injury in BV2 Microglial Cells Induced by Lipopolysaccharide via Inhibition of TLR4/MAPK Signaling Pathway by Zhenwei HUANG, Qing ZHANG, Lili HUANG, Xiaoqin ZHANG, Mingqing HUANG

“…BV2 microglial cells were seeded at a density of 5×10⁴cells/mL in 96-well plate. The inflammatory response in BV2 microglial cells was induced by LPS(100 ng/mL), while the cells were treated with different concentrations of PZH(0.05, 0.10 and 0.15 mg/mL) for 12 h. …”
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The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer by Ross D. Dolan, Kathryn Pennel, Joshua Thompson, Molly McKenzie, Peter Alexander, Colin Richards, Douglas Black, Tanvir Abbass, Noori Maka, Josh McGovern, Antonia Roseweir, Stephen T. McSorley, Paul G. Horgan, Campbell Roxburgh, Donald C. McMillan, Joanne Edwards

“…Abstract Background In cancer cachexia the relationship between the tumour, its environment and the systemic inflammatory response is not clear. This study aims to examine this relationship in greater detail. …”
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Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis by Zheng D, Chen T, Yang K, Yin G, Chen Y, Gui J, Xu C, Lv S

“…The dual luciferase experiment demonstrated that ZEB2 was the target gene of miR-200c-3p.Conclusion: The synergistic effect of AgPEI and miR-200c-3p can inhibit the inflammatory response, apoptosis, and matrix degradation of chondrocytes. …”
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