Etoposide targets 2A protease to inhibit enterovirus 71 replication by Qinqin Liang, Sai Shi, Qingjie Zhang, Yaxin Wang, Sheng Ye, Binghong Xu

“…ABSTRACT Enterovirus 71 (EV71) is a major pathogen that causes hand, foot, and mouth disease (HFMD) in infants and children. Notably, no clinically approved drugs specifically target EV71. …”
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The Research Agenda for Perinatal Innovation and Digital Health Project: Human-Centered Approach to Multipartner Research Agenda Codevelopment by Haneen Amhaz, Sally Xuanping Chen, Amanee Elchehimi, Kylin Jialin Han, Jade Morales Gil, Lu Yao, Marianne Vidler, Kathryn Berry-Einarson, Kathryn Dewar, May Tuason, Nicole Prestley, Quynh Doan, Tibor van Rooij, Tina Costa, Gina Ogilvie, Beth A Payne

“… BackgroundDigital health innovations provide an opportunity to improve access to care, information, and quality of care during the perinatal period, a critical period of health for mothers and infants. However, research to develop perinatal digital health solutions needs to be informed by actual patient and health system needs in order to optimize implementation, adoption, and sustainability. …”
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Identification of a novel heterozygous GPD1 missense variant in a Chinese adult patient with recurrent HTG-AP consuming a high-fat diet and heavy smoking by Xiao-Yao Li, Bei-Yuan Zhang, Xin-Ran Liang, Yan-Yu Han, Min-Hua Cheng, Mei Wei, Ke Cao, Xian-Cheng Chen, Ming Chen, Jian-Feng Duan, Wen-Kui Yu

“…Abstract Background Glycerol-3-phosphate dehydrogenase 1 (GPD1) gene defect can cause hypertriglyceridemia (HTG), which usually occurs in infants. The gene defect has rarely been reported in adult HTG patients. …”
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Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suri... by Antoon W Grünberg, William Hawkins, Wilco Zijlmans, Jeffrey Wickliffe, Ashna Hindori-Mohangoo, Sigrid MacDonald-Ottevanger, Paul Ouboter, Gwendolyn Landburg, John Codrington, Jimmy Roosblad, Gaitree Baldewsingh, Radha Ramjatan, Anisma Gokoel, Firoz Abdoel Wahid, Lissa Fortes Soares, Cecilia Alcala, Esther Boedhoe, Arti Shankar, Emily Harville, S S Drury, Hannah Covert, Maureen Lichtveld

“…The study determines associations between levels of environmental elements and toxicants in pregnant women, and birth outcomes and neurodevelopment in their children.Participants Pregnant women (N=1143) were enrolled from December 2016 to July 2019 from three regions of Suriname: Paramaribo (N=738), Nickerie (N=204) and the tropical rainforest interior (N=201). Infants (N=992) were enrolled at birth. Follow-up will take place until children are 48 months old.Findings to date Biospecimens and questionnaire data on physiological and psychosocial health in pregnant women have been analysed. 39.1% had hair mercury (Hg) levels exceeding values considered safe by international standards. …”
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Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models by Wylie BJ, Kaali S, Duttweiler L, Ae-Ngibise KA, Mujtaba M, Tawiah C, Gibson E, Calafat AM, Ospina M, Jack DJ, Agyei O, Lee AG, Roberts DJ, Boamah-Kaali EA, Factor-Litvak P, Modest AM, Hauser R, Coull BA, Asante KP

“…We estimated associations of biomarker concentrations with newborn anthropometrics and gestational length, adjusting for confounders and exploring effect modification by infant sex and placental malaria. Results: 1,211 pregnant women contributed 3,786 gestational urinary samples. …”
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Poor sleep quality and associated factors among HIV-positive and negative postpartum women in Addis Ababa, Ethiopia: a comparative cross-sectional study by Milen Mihertabe, Alehegn Bishaw Geremew, Alehegn Bishaw Geremew, Elsa Awoke Fentie, Gidey Rtbey

“…BackgroundPoor sleep quality is common during the postpartum period due to nighttime feeding and frequent nocturnal awakenings of infants. In addition, the condition may worsen among postpartum women living with human immunodeficiency virus (HIV), affecting their capacity to care for their child. …”
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Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers by Daehwan Kim, Heekyung Chung, Wen Liu, Kangjin Jeong, Tugba Y. Ozmen, Furkan Ozmen, Matthew J. Rames, Sangyub Kim, Xiao Guo, Nathan Jameson, Petrus R. de Jong, Steven Yea, Laurie Harford, Jiali Li, Cara A. Mathews, Deborah B. Doroshow, Vincent J. Charles, Doris Kim, Kimberlee Fischer, Ahmed A. Samatar, Adrian Jubb, Kevin D. Bunker, Kimberly Blackwell, Fiona Simpkins, Funda Meric-Bernstam, Gordon B. Mills, Olivier Harismendy, Jianhui Ma, Mark R. Lackner

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Experiences of midwifery students and graduates in Somalia: evidence from qualitative data by Hawa Abdullahi, Asia Mohamed Mohamud, Maryan Abdulkadir Ahmed, Mohamed Ahmed Omar, Abdirisak A. Dalmar, Hannah Tappis, Shatha Elnakib

“…In terms of perceived preparedness, graduates felt well prepared for their role but identified gaps in abortion care, neonatal resuscitation, and usage of basic ultrasound.ConclusionThe challenges faced by midwifery students and newly graduated midwives have direct implications for the health outcomes of mothers and infants in conflict-affected settings. The recurring themes of inadequate training, security risks, and restrictive gender norms require holistic and systematic interventions that address these issues in order to improve motivation and workforce participation among this important health cadre.…”
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Obstetric outcomes in breastfeeding women in the first hour of delivery before and during the COVID-19 pandemic by Ana Paula Vieira Faria, Thales Philipe Rodrigues da Silva, Mery Natali Silva Abreu, Maria Albertina Canastra, Ana Clara Fernandes, Eunice Francisca Martins, Fernanda Marçal Ferreira, Fernanda Penido Matozinhos

“…Abstract Introduction Breastfeeding provides several benefits to the health of women and newborns and constituting a protective factor against infant morbidity and mortality in the short and long term. …”
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Intermittent auscultation fetal monitoring during labour: A systematic scoping review to identify methods, effects, and accuracy. by Ellen Blix, Robyn Maude, Elisabeth Hals, Sezer Kisa, Elisabeth Karlsen, Ellen Aagaard Nohr, Ank de Jonge, Helena Lindgren, Soo Downe, Liv Merete Reinar, Maralyn Foureur, Aase Serine Devold Pay, Anne Kaasen

“…Medline, EMBASE, Cinahl, Maternity & Infant Care, Cochrane Library, SveMed+, Web of Science, Scopus, Lilacs and African Journals Online were searched for publications up to January 2019. …”
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Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer by Anne Mills, Leisha A Emens, Mary L Disis, Kunle Odunsi, John B Liao, Tyler Curiel, Margaret Gatti-Mays, Amir Jazaeri, Emese Zsiros, Marcus O Butler, Jyoti Bajpai, Katherine C Kurnit, Haider Mahdi, Laura Doherty, Claire F Friedman, Melissa A Geller, Sarah F Adams, Shelley A Dodt, Veena S John

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Impact of Early-Life Microbiota on Immune System Development and Allergic Disorders by Norbert Dera, Katarzyna Kosińska-Kaczyńska, Natalia Żeber-Lubecka, Robert Brawura-Biskupski-Samaha, Diana Massalska, Iwona Szymusik, Kacper Dera, Michał Ciebiera

“…The literature data suggest that there is evidence to confirm that the intestinal microbiota of the infant plays an important role in regulating the immune response associated with the development of allergic diseases. …”
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Imaging and Clinical Characteristics of 8 Cases of COVID-19 Complicated with Pneumomediastinum in Children by FU Qiang, REN Zuolei, LIN Zhiqiang, GONG Jianfeng, WANG Changzheng, WANG Ting, HU Yalan, TAN Jufang

“…Conclusion Children with pneumomediastinum complicated by COVID-19 were mostly pre-school or school-age children, rare in infants. Pneumomediastinum can coexist with gas accumulation in the neck and chest wall. …”
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Kasus Persalinan Dengan Bekas Seksio Sesarea Menurut Keadaan Waktu Masuk di Bagian Obstetri dan Ginekologi RSUP Dr. M. Djamil Padang by Anggy Afriani, Desmiwarti Desmiwarti, Husnil Kadri

“…The women who has previous caesarean section in their pregnancy must come to the hospital before the date of planned birth, no labor, and no complications for the woman and her infants. However, there are many woman with caesarean section come to the hospital in partu. …”
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Trisomy 21 screening with αlpha software and the Fetal Medicine Foundation algorithm by L Pistorius, C A Cluver, I Bhorat, L Geerts

“…Despite the availability of these screening programmes, only a minority of infants with trisomy 21 are detected prenatally, raising questions about the effectiveness of screening. …”
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Determinants of prolonged exclusive breastfeeding among children aged 6–23 months in 21 sub-saharan African countries: evidence from nationally representative data by Enyew Getaneh Mekonen

“…Abstract Background Under-five mortality and malnutrition are more common in many low- and middle-income countries, highlighting the grave consequences of improper nutrition for children. Infants that continue to be exclusively breastfed after six months are considered to be engaging in prolonged exclusive breastfeeding. …”
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Newborn birth weight and its associated risk factors in Somalia using Somalia health and demographic survey by Denekew Bitew Belay, Nigussie Adam Birhan, Mahad Ibrahim Ali, Ding-Geng Chen

“…Background: Low birth weight is the result of fetal growth and it is a strong sign of infant morbidity and mortality. In sub-Saharan Africa, the number of low birth weight live births is estimated to have increased from 4.4 million in 2000 to 5 million in 2015. …”
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Anemia in pregnancy: a systematic review and meta-analysis of prevalence, determinants, and health impacts in Egypt by Ahmed Azzam, Heba Khaled, Alrefaey K. Alrefaey, Amar Basil, Sarah Ibrahim, Mohamed S. Elsayed, Muhammad Khattab, Nashwa Nabil, Esraa Abdalwanees, Hala Waheed Abdel Halim

“…For neonatal complications, infants born to anemic mothers had significantly lower Apgar scores, gestational ages, and birth weights (P < 0.05), with birth weight being the most adversely impacted (SMD = -1.3). …”
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Identifying the causes and consequences of pregnancy in Iranian Kurdish women under the age of 18: A grounded theory study by Javad Yoosefi lebni, Ahmad Ahmadi, Seyed Fahim Irandoost, Mandana Saki, Hossein Safari, Nafiul Mehedi

“…Background: Since teenage pregnancy is one of the major challenges for healthcare systems worldwide and can pose risks to the health of young mothers and their infants, the present study was conducted to identify the Identifying the causes and consequences of pregnancy in Iranian Kurdish women under the age of 18. …”
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Long-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT), a two-arm, randomized,... by Jan H. Driedger, Julian Schröter, PROTECT-Study Group, Steffen Syrbe, Afshin Saffari

“…The primary endpoint will be the neuropsychological outcome assessed by the cognitive scale of the Bayley Scales of Infant and Toddler Development III at 24 months of age compared to Standard of Care. …”
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