Creation of body color mutants by CRISPR/Cas9 gene editing in largemouth bass, Micropterus salmoides by Lina Sun, Tian Gao, Zhiqiang Li, Xiaolong Yang, Zuliang Qin, Mingxiao Ye, Ying Li, Feilong Wang, Deshou Wang

“…The fertilized eggs were obtained through hormonal induction (5 μg/kg LHRH-A3, 600 IU/kg hCG and 2 mg/kg DOM) and artificial insemination, and the tyrb (tyrosinase b) or csf1ra (colony-stimulating factor 1 receptor a) gRNA and Cas9 mRNA were microinjected into the fertilized eggs at the one-cell stage for targeted gene editing. …”
Get full text

Health and tuberculosis systems resilience, the role of the private sector and pandemic preparedness: insights from a cross-country qualitative study with policy-makers in India, I... by Madhukar Pai, Poshan Thapa, Charity Oga-Omenka, Angelina Sassi, Vijayashree Yellappa, Petra Heitkamp, Bony Wiem Lestari, Surbhi Sheokand, Nathaly Aguilera Vasquez, Laura Jane Brubacher, Bolanle Olusola-Faleye, Joel Shyam Klinton

“…Data were analysed thematically using a hybrid inductive-deductive approach, informed by Haldane et al’s Determinants of Health Systems Resilience Framework.Results Policy-makers highlighted the crucial role of intersectoral collaboration, effective governance, innovative financing strategies, health workforce reallocation and technological advancements such as virtual consultations and mHealth in strengthening TB service delivery amid the COVID-19 pandemic. …”
Get full text

Initial treatment of steroid-sensitive idiopathic nephrotic syndrome in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre tr... by Burkhard Toenshoff, Martin Konrad, Steffen Luntz, Anja Sander, Peter F Hoyer, Rasmus Ehren, Marcus R Benz, Jorg Doetsch, Alexander Fichtner, Jutta Gellermann, Dieter Haffner, Britta Höcker, Bärbel Kästner, Markus J Kemper, Uwe Querfeld, Lutz T Weber

“…The treatment of the first episode implies two aspects: induction of remission and sustainment of remission. …”
Get full text

Hsp70/Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model by Guoxia Zhu, Yongxiang Wu, Yang Qiu, Keyong Tian, Wenjuan Mi, Xinqin Liu, Yuanyuan Chen, Jinwen Jia, Jiasheng Luo, Lianjun Lu, Jianhua Qiu

“…Collectively, these results suggested that the contribution of Bmi1 toward decreased sensitivity to noise-induced trauma following SC was triggered by Hsp70 induction and associated with enhancement of the antioxidant system and decreased mitochondrial superoxide accumulation. …”
Get full text

Heterogeneous integration of amorphous silicon carbide on thin film lithium niobate by Zizheng Li, Naresh Sharma, Bruno Lopez-Rodriguez, Roald van der Kolk, Thomas Scholte, Hugo Voncken, Jasper van der Boom, Simon Gröblacher, Iman Esmaeil Zadeh

“…Here, we show that amorphous silicon carbide (a-SiC), deposited using inductively coupled plasma enhanced chemical vapor deposition at low temperatures (<165 °C), can be conveniently integrated with LiNbO3 and processed to form high-performance photonics. …”
Get full text

A cell-based model to study mechanisms of endothelial-dependent thrombin generation in response to inflammation and its modulation by hydroxychloroquine by Deepa J. Arachchillage, Golzar Mobayen, Mike Laffan, Anna M. Randi, Josefin Ahnström, Charis Pericleous

“…Conclusion: We provide detailed optimization of a robust in vitro model to assess the induction of an inflammation-driven endothelial prothrombotic phenotype that is also sensitive to immunomodulatory therapies, providing a tool for investigating mechanisms of disease and new drugs.…”
Get full text

Anti-Inflammatory Effect of a Peptide Derived from the Synbiotics, Fermented Cudrania tricuspidata with Lactobacillus gasseri, on Inflammatory Bowel Disease by Jimyeong Ha, Hyemin Oh, Nam Su Oh, Yeongeun Seo, Joohyun Kang, Min Hee Park, Kyung Su Kim, Shin Ho Kang, Yohan Yoon

“…The mice in the IBD group were orally administered with PBS (IBD-PBS-positive control), Lactobacillus gasseri 505 (IBD-Pro), fermented powder of CT extract with L. gasseri 505 (IBD-Syn), β-casein: LSQSKVLPVPQKAVPYPQRDMP (IBD-Pep 1), or αs2-casein: VYQHQKAMKPWIQPKTKVIPYVRYL (IBD-Pep 2) (both peptides are present in the synbiotics) for four more days while inducing IBD. To confirm IBD induction, the weights of the animals and the disease activity index (DAI) scores were evaluated once every two days. …”
Get full text

“Holding on to Hope”: follow up qualitative findings of a tobacco treatment intervention for people experiencing mental health conditions by Tessa-May Zirnsak, Kristen McCarter, Melissa L. McKinlay, Ashleigh Guillaumier, Nadine Cocks, Catherine Brasier, Laura Hayes, Amanda L. Baker, Donita E. Baird, Billie Bonevski, Ron Borland, Ron Borland, David Castle, Erin Forbes, Peter J. Kelly, Catherine Segan, Catherine Segan, Rohan Sweeney, Alyna Turner, Alyna Turner, Jill M. Williams, Lisa Brophy, Lisa Brophy

“…Key themes were determined using inductive coding.ResultsSix key themes were identified. …”
Get full text

A cross-study analysis of the effect of a dual-strain probiotic applied via the waterline on the growth performance and gut health of broilers under a mild necrotic enteritis chall... by S.A.S. van der Klein, M. Bernardeau, Q. Wang, K. Gibbs

“…From d 1 to 42, CC birds exhibited reduced BW, BW gain (BWG), and feed intake (FI) (-9.2 %, -9.5 %, -5.0 %, respectively; P < 0.05), increased FCR and mortality (+8.5 points and 1.3 % points, respectively; P < 0.05) compared to C, and increased NE induction on d 28 (67.8 vs. 9.4 %, P <0.05). Compared to CC, CC+Probiotic birds exhibited increased BW, BWG and FI (d 42: +6.9 %, +7.1 %, +4.0 %; P < 0.05) and reduced FCR, mortality and d 28 NE lesion scores (-0.5 points, -1.4 % points and -57.1 %, respectively; P < 0.05). …”
Get full text

Portable X-ray fluorescence of zinc and selenium with nail clippings-Mother and Infant Nutrition Investigation (MINI). by David E B Fleming, Nelly Madani, Michaela G Kaiser, Jong Sung Kim, Erin Keltie, Natashia Drage, Ying Jin, Jane Coad, Louise Brough

“…Following this assessment of zinc and selenium with the non-destructive XRF method, clippings were measured for zinc and selenium concentration using a "gold standard" technique of inductively coupled plasma mass spectrometry (ICP-MS). …”
Get full text

The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response by Bush NJ, Cushnie AK, Boissoneault J, Aghabeigi S, Alexander C, Staud R, Robinson ME

“…Nicholas J Bush,1,2 Adriana K Cushnie,2 Jeff Boissoneault,1,2 Sharmagh Aghabeigi,1 Casey Alexander,1 Roland Staud,3 Michael E Robinson1 1Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; 2Department of Anesthesiology, University of Minnesota - Twin Cities, Minneapolis, MN, USA; 3Department of Medicine, University of Florida, Gainesville, FL, USACorrespondence: Nicholas J Bush, Department of Anesthesiology, University of Minnesota, Minneapolis, MN, 55414, USA, Tel +1 612-624-7357, Email bush0456@umn.eduBackground: Previous research has demonstrated that placebo induction manipulations can reduce an individual’s pain through non-specific mechanisms, such as expectancy manipulations. …”
Get full text

Impact of non-invasive oxygen reserve index versus standard SpO2 monitoring on peripheral oxygen saturation during endotracheal intubation in the intensive care unit: Protocol for... by Hugo Hille, Aurélie Le Thuaut, Pierre Asfar, Quentin Quelven, Emmanuelle Mercier, Anthony Le Meur, Jean-Pierre Quenot, Virginie Lemiale, Grégoire Muller, Martin Cour, Alexis Ferré, Asael Berge, Anaïs Curtiaud, Maxime Touron, Gaetan Plantefeve, Jean-Charles Chakarian, Jean-Damien Ricard, Gwenhael Colin, Arthur Orieux, Patrick Girardie, Mathieu Jozwiak, Manon Rouaud, Camille Juhel, Jean Reignier, Jean-Baptiste Lascarrou, CRICS-TRIGGERSEP Network

“…Baseline parameters, rapid-sequence induction medications, ETI devices, and physiological data are recorded. …”
Get full text

Attenuating susceptibility to ascites in cold‐stressed broiler chickens fed canola meal‐based diets by supplementing arginine or guanidinoacetic acid, either alone or in combinatio... by Negin Delfani, Mohsen Daneshyar, Parviz Farhoomand, Sina Payvastegan, Younes Ali Alijoo, Gholamreza Najafi

“…The groups experienced cold stress induction starting at 32°C on day one, with gradual reductions to 15°C on days 21. …”
Get full text

Trace element concentrations, multivariate analysis and health risk potential of soils from urban and peri-urban agriculture by K.M. Hawrami, A.K. Baset

“…The analysis was carried out using Inductively coupled plasma mass spectrophotometry, which operated in collision cell mode with 7 percent hydrogen in helium to minimize polyatomic interferences.FINDINGS: The study findings indicated that the soils, with a potential hydrogen range of 7.5 to 8.18, are mainly calcareous and have textures that vary from silty loam to sandy or silty clay. …”
Get full text

Y2O3NPs induce selective cytotoxicity, genomic instability, oxidative stress and ROS mediated mitochondrial apoptosis in human epidermoid skin A-431 Cancer cells by Hanan RH Mohamed, Shrouk H.A Hemdan, Ahmed A. El-Sherif

“…Cell viability and apoptosis induction were assessed using the Sulforhodamine B and chromatin diffusion assay, respectively. …”
Get full text

Electroacupuncture Alleviates Neuropathic Pain and Negative Emotion in Mice by Regulating Gut Microbiota by Feng C, Pan H, Zhang Y, Ye Z, Zhou Y, Zou H, Wang K

“…Starting from the 8th day post-CCI induction, the EA group underwent EA treatment once every two days, for a total of 20 sessions. …”
Get full text

Ultrafine industrial aerosol as an occupational risk factor for sintering industry workers by L. P. Sharavara, N. M. Dmytrukha, I. M. Andrusyshyna

“…The chemical composition of the suspended particulate matter was determined by the method of optical emission spectrometry with inductively coupled plasma (OES-IZP) using the device “Ortima 2100 DV” (PerkinElmer, USA). …”
Get full text

Can Underlying Co-Morbidities Affect Cerebral Oximetry in Cardiac Surgery Patients? by Kianoush Saberi, Shahnaz Sharifi, Amirhossein Orandi

“…Prior to anesthesia induction, cerebral oxygen saturation (rSO2) was continuously monitored using the INVOS 5100c cerebral oximeter. …”
Get full text

Effect of Co-Administration of Midazolam and Dexmedetomidine on Haemodynamics and Stress Response in Elderly Patients with Non-Small Cell Lung Cancer by Yanjun Zhao, Dongjiao An, Liang Bi

“…Significantly lower visual analog scale (VAS) scores were found one day after the surgery in patients given dexmedetomidine plus midazolam than those anesthetized administered with dexmedetomidine only, suggesting an enhanced pain mitigation effect after incorporating midazolam for anesthetic induction. Patients treated with dexmedetomidine plus midazolam presented with a more stable hemodynamic status than those treated with dexmedetomidine only, as evidenced by the significantly lower variability of mean arterial pressure (MAP), oxygen saturation (SpO2), and heart rate (HR). …”
Get full text

Barriers and facilitators of integrated hepatitis B, C, and HIV screening among pregnant mothers and newborns attending maternal and newborn clinics in Koboko District, Uganda: a q... by John Bosco Alege, John Paul Oyore, Rose Clarke Nanyonga, Philippa Musoke, Alloys S. S. Orago

“…Methods An exploratory qualitative descriptive study that used an inducted and deductive thematic analysis approach was used at Health Centre III (HC IIIs) level in an institutional setting. …”
Get full text