Diospyros mespilifoemis hochst Modulates the Hippocampus and Prefrontal Cortex of Wistar Rat following Lithium chloride pilocarpine-induced Epilepsy by Sunday Yinka Olatunji, Oluwafemi Ezekiel Kale, Oluseyi Abimbola Ogunsola, John Afees Olanrewaju, Ijeoma Esiaba, Taiye Adelodun, Olubunmi Philip Ogunnaike

“….) + pilocarpine (30 mg/kg, i.p.) to induce seizure. Following induction, C, D, and E received 50 mg/kg, 200 mg/kg DM and 10 mg/kg sodium valproate respectively (p.o) while B was left untreated. …”
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Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemothera... by Michael Ghadimi, Uwe Pelzer, Marc G. Besselink, Jens Siveke, Ralph Telgmann, Rickmer Braren, Hanneke Wilmink, Marie Crede, Alexander Koenig, Ute Koenig, Sven Thorsten Liffers, Kai Antweiler, Bas Uijterwijk, Hanna Seppanen, Arno Nordin, Pauli Puolakkainen, Olav F. Dajani, Knut Jørgen Labori, Mia Johansson, Svein Olav Bratlie, Tim Friede, Peter Jo

“…This multicentre, randomized, controlled phase III trial is planned to evaluate whether resection of the primary tumor and liver metastases can improve overall survival in patients with PDAC with hepatic oligometastases in a multimodal treatment setting. Methods After an induction therapy with eight cyles of mFOLFIRINOX and a response assessment after four and eight cycles, patients will be randomized to either Arm 1 (perioperative mFOFIRINOX plus resection of the primary tumor with resection or ablation of all hepatic metastases) or Arm 2 (continuation of 4 cycles of the standard-of-care mFOLFIRINOX chemotherapy). …”
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Delta-Like-1 Changes the Immunomodulatory Property of OP9 Cells by Lei Zhang, Rui-Jie Dang, Yan-Mei Yang, Dian-Chao Cui, Ping Li, Yan-Li Ni, Tong Hao, Changyong Wang, Xiao-Xia Jiang, Nan-Zhu Fang

“…Compared with OP9, OP9DL1 displayed more osteogenesis and less adipogenesis when cultured in the respective induction media. Both OP9 and OP9DL1 inhibited mature B and T cell proliferation. …”
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Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens by Deepthi Kappala, Saravanan Ramakrishnan, Patel Nikunjkumar Prakashbhai, Abinaya Kaliappan, Prasad Thomas, Jörg Linde, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa

“…These results align with transcriptomic findings and highlight the upregulation of STAT1 and STAT3 as potential contributors to the induction of Th1 and Th2 immune responses by R-848 in chickens. …”
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3D printed magnesium silicate/β-tricalcium phosphate scaffolds promote coupled osteogenesis and angiogenesis by Lulu Wang, Mingkui Shen, Zhongxin Tang, Jun Tan, Kuankuan Li, Haijun Ma

“…In summary, 3D printed MS/β-TCP scaffolds with effectively osteogenic and angiogenic induction will be an ideal bone substitute applied in bone defect repair for clinical application in the future.…”
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Study on the Effects of Aluminum and Chromium on the Corrosion Resistance of Hot-Rolled Incoloy 800H Alloy in Molten Carbonate Salts by CAO Junjia, YU Haicun, GAO Yunteng, LI Haixiao, LI Yafeng, XU Shipeng, LA Peiqing

“…Metal alloys are subjected to molten salt corrosion in concentrating solar thermal power systems， leading to a reduction in their lifetime.In order to extend the service life of Incoloy 800H alloy in molten carbonate salt corrosion， Incoloy 800H alloys with varying aluminum(Al) and chromium (Cr) contents were prepared by vacuum induction melting.The corrosion mechanisms of Al and Cr elements on the resistance of 800H alloy to molten carbonate salt corrosion were investigated through analysis and testing methods such as X-ray diffraction (XRD)，scanning electron microscopy (SEM) and transmission electron microscopy (TEM).Results showed that the corrosion rate of Incoloy 800H alloy with 3%(mass fraction， the same below) Al content was 1 071.00 μm/a， while that with 2.75%Cr content was 359.56 μm/a after immersion in carbonate molten salt (32.1%Li2CO3＋33.4%Na2CO3＋34.5%K2CO3) at 650 ℃for 240 h.The corrosion products were mainly LiFeO2 and NiO.This was attributed to the fact that as the Al content increased， the oxide passivation film formed on the surface of the alloy became thicker and denser， providing better protection.The reduction of Cr content led to a decrease in the generation of soluble Cr oxides， an increase in the formation of other protective oxides， and a reduction in the precipitation of Fe elements in the substrate， thus improving the alloy’s corrosion resistance.…”
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Expression profile of Bcl‐2 family proteins in newly diagnosed multiple myeloma patients by Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Ignacio J. Cardona‐Benavides, Myriam Cuadrado, Isabel Isidro, María‐José Calasanz, Manuela Fernandez, Ramón García‐Sanz, Noemi Puig, M. Teresa Cedena, Bruno Paiva, Laura Rosiñol, Joaquín Martínez‐López, Joan Bladé, Juan J. Lahuerta, Jesús F. San Miguel, María V. Mateos, Luis A. Corchete, Norma C. Gutiérrez, GEM/PETHEMA cooperative study group

“…Bcl‐2 protein ratios predicting sensitivity to venetoclax in vitro were also able to distinguish patients with shorter time to progression after triplet‐based induction therapy and ASCT. This is the first study to assess the expression of the most important Bcl‐2 family proteins by a quantitative method in a large set of MM patients according to their cytogenetic abnormalities. …”
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Isolation and characterization of a novel highly efficient bacterium Lysinibacillus boronitolerans QD4 for quantum dot biosynthesis by Xingyu Gu, Xingyu Gu, Xiaoju Li, Ruijia Zhang, Ruijia Zhang, Ruoli Zheng, Ruoli Zheng, Mingrui Li, Mingrui Li, Rong Huang, Xin Pang

“…The distinctive yellow fluorescence from CdS quantum dots is visible after only a short induction time (a few hours). Moreover, the properties of the CdS quantum dots are characterized by fluorescence spectroscopy, UV-absorption spectroscopy, TEM, XRD, XPS, and infrared spectroscopy. …”
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High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy by Wei-jian Zeng, Hua-jing Yang, Ying-jie Gu, Meng-nan Yang, Meng-ru Sun, Sheng-kai Cheng, Yan-yan Hou, Wei Gu

“…In particular, HTR-8/SVneo cells with or without overexpressing FTH1 and HTR-8/SVneo cells with or without TCA induction were investigated to explore the relationship between FTH1 and ferroptosis during ICP in vitro, respectively. …”
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Analysis of Argonaute Complex Bound mRNAs in DU145 Prostate Carcinoma Cells Reveals New miRNA Target Genes by Jaroslaw Szczyrba, Volker Jung, Michaela Beitzinger, Elke Nolte, Sven Wach, Martin Hart, Sandra Sapich, Marc Wiesehöfer, Helge Taubert, Gunther Wennemuth, Norbert Eichner, Thomas Stempfl, Bernd Wullich, Gunter Meister, Friedrich A. Grässer

“…Posttranscriptional gene regulation by microRNAs (miRNAs) contributes to the induction and maintenance of prostate carcinoma (PCa). …”
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Stimulation of gonad maturation in mullet fish Mugil dussumieri using MT, E2, hCG, and Ovaprim hormone by Tatak Dwi Cahyono, Muhammad Zairin Junior, Odang Carman

“…The results showed that estradiol-17β and 17α-methyltestosterone induction in 9-14.7 cm body length mullet increase gonad maturity to stage II while hCG induction in 10-31 cm body length mullet increase gonad maturity to stage III.   …”
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Levels of Pathogenic Th17 and Th22 Cells in Patients with Rheumatoid Arthritis by Marlen Vitales-Noyola, Berenice Hernández-Castro, Diana Alvarado-Hernández, Lourdes Baranda, Sofía Bernal-Silva, Carlos Abud-Mendoza, Perla Niño-Moreno, Roberto González-Amaro

“…However, the in vitro induction/differentiation of pathogenic Th17 cells showed similar results in controls and patients with RA. …”
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From research to practice: bridging the implementation gap on the use of tranexamic acid in total knee arthroplasty by Robin M. Pfister, Benjamin F. Pfister, Ronald L. Hager, Nathan Sandholtz, Daniel Abulafia, David Bradshaw

“…Primary outcome measure was use of TXA at operative induction. Secondary outcome measures were post-operative blood transfusion, haemoglobin levels and in-hospital length of stay. …”
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Use of Minimal Residual Disease Status to Reduce Uncertainty in Estimating Long-term Survival Outcomes for Newly Diagnosed Multiple Myeloma Patients by Naomi van Hest, Peter Morten, Keith Stubbs, Nicola Trevor

“…**Methods:** Standard and response-based PSMs, estimating patient life-years (LYs) over a lifetime horizon, were developed for NDMM patients treated with bortezomib, thalidomide, and dexamethasone (BTd) with or without daratumumab as induction and consolidation therapy. In the standard PSM, LYs were determined by extrapolations from individual patient data from CASSIOPEIA. …”
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Anti-DENV-ED3 antibody cross-talks generate immune interference among the four DENVs by Md. Din Islam, Sanjida Yesmin, Tahmina Sharmin, Md. Ayoub Khan, Yutaka Kuroda, M. Monirul Islam

“…Conclusions: Although DENV1~4 ED3s share similar sequence homologies and structures, their immune induction potentials differ significantly in terms of immune magnitude, sero-specificity, and sero-cross-reactivity. …”
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Genes underlying cold acclimation in the tea plant (<i>Camellia sinensis</i> (L.) Kuntze) by L. S. Samarina, L. S. Malyukova, M. V. Gvasaliya, A. M. Efremov, V. I. Malyarovskaya, S. V. Loshkareva, M. T. Tuov

“…The accumulation of CBF transcripts occurs after 15 min of chilling induction, and longer cold stress leads to accumulation of CBF transcripts. …”
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Thrombin Induces COX-2 and PGE2 Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells by Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Chih-Kai Hsu, Chia-Yu Hu, Chuen-Mao Yang

“…The inflammation of the airway and lung could be triggered by upregulation cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) induced by various proinflammatory factors. COX-2 induction by thrombin has been shown to play a vital role in various inflammatory diseases. …”
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Narratives of change: how climate change narratives have evolved since the 1970s by Zarina Kulaeva

“…Semistructured interviews were conducted with a sample of 12 experts in the field using narrative analysis. We adopted an inductive approach, allowing climate narratives to emerge organically from the interview data, and facilitating the emergence of new topics and perspectives. …”
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Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice by Sorim Choung, Kyong Hye Joung, Bo Ram You, Sang Ki Park, Hyun Jin Kim, Bon Jeong Ku

“…Notably, the treatment of lobeglitazone increased the protein levels of PPARα and diminished levels of PPARγ phosphorylated at serine 273, which were increased by a HFD, suggesting that induction of PPARα and posttranslational modification of PPARγ in livers by lobeglitazone might be an underlying mechanism of the improvement seen in NAFLD. …”
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Selective Solid-Phase Extraction of Pb(II) Ions Using an Ion-Imprinted Functionalized Sodium Trititanate Whisker Adsorbent Prepared by a Surface-Imprinting Technique by Wanzhen Xu, Wenming Yang, Wei Zhou

“…A series of batch adsorption experiments was performed to evaluate the adsorption behaviour of the Pb(II)-IIPs/Na 2 Ti 3 O 7 materials towards Pb(II) ions, as assessed by inductively coupled plasma–atomic emission spectrometry (ICP–AES). …”
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