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  1. 2861

    Influence of Training on Employees' Performance: A Case Study of Rukiga SACCO. by Manige, Alexander

    Published 2025
    “…The study objectives included; establishing the influence of induction on employee performance in Rukiga SACCO, examining the influence of on-the-job training on employee performance in Rukiga SACCO, and determining the influence of off-the-job training and employee performance in Rukiga SACCO. …”
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    Thesis
  2. 2862
  3. 2863

    Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan by MIREILLE YAYO- AYE, Adia Eusèbe Adjambri, Boidy Kouakou, Rebecca N'guessan-Blao, Louis Missa Adjé, Taïratou Kamagaté, Vincent Yapo, Duni Sawadogo

    Published 2024-02-01
    “…Biochemical parameters within normal ranges, except for a moderate treatment-related increase in transaminases. Conclusion: The induction of fetal hemoglobin (Hb F) production through hydroxyurea intake is the primary mechanism by which hydroxyurea modifies the pathogenesis of sickle cell disease …”
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    Article
  4. 2864

    Trials and tribulations: a qualitative exploration of researcher perspectives on navigating the challenges of health system implementation research by Natalie Taylor, April Morrow, Julia Steinberg, Emily Hogden, Deborah Debono, Elijah Tyedmers, Priscilla Chan, Gabriella Tiernan

    Published 2025-01-01
    “…Focus groups were transcribed verbatim and analysed using an inductive thematic approach. Barriers and facilitators identified within themes were deductively coded to domains of the updated Consolidated Framework for Implementation Research.Setting Participants were recruited from a research organisation based in Sydney, Australia.Participants A total of seven researcher and administering institution participants took part in four focus groups.Results Analysis highlighted the following themes: navigating bureaucracy, distinguishing implementation trials from clinical trials, the impact of COVID-19, balancing rigour and pragmatism in implementation trials, data access and complexity of analysis, and key learnings and future directions (subthemes: building relationships with ethics committees, communicating implementation concepts, streamlining of the implementation and research approach).Conclusions Findings highlight the need for streamlining current administrative and ethical review processes, as well as procedures that allow greater flexibility for researchers to respond to challenges as they arise. …”
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    Article
  5. 2865

    Perspectives of Pharmacists Towards Patient-Centred Mental Health Pharmacy Services: A Focus Group Study by Nurul Aziera A Rahim, Norny Syafinaz Ab Rahman, Khairul Azrul Abdul Rahman, Jia Yi Cheong, Nur Fazlin Abd Ghafar, Yasmin Ibrahim, Aida Roziana Ramlan, Syahrir Zaini

    Published 2025-01-01
    “…Thematic analysis was performed inductively to analyse the data. Results: This study involved 14 focus group sessions with all 63 pharmacists participating. …”
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    Article
  6. 2866

    Stigma reduction in a disability and mental health programme in Ghana: Lessons in participation by Maria Zuurmond, Augustina Naami, Lyla Adwan-Kamara, Cathy Stephen, Sapana Basnet, Caroline Vanderick, Mohammed Chantimah, Abigail Nana Asamoah, Daisy Macdonald, Crick Lund

    Published 2025-01-01
    “…We conducted thematic analysis using deductive and inductive approaches. Results: The programme adopted several approaches to participation at design and implementation stages, with a focus on the leadership of people with disabilities and people with mental health conditions. …”
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    Article
  7. 2867

    <i>Agrobacterium rhizogenes</i>-Mediated Hairy Root Transformation in <i>Rosa</i> by Jun Lu, Yuwen Huang, Yuhan Guo, Chunguo Fan, Guozhen Yuan, Rui Zhou, Jingjing Sun, Mengjuan Bai, Kun Wang, Jinyi Liu, Changquan Wang

    Published 2025-01-01
    “…We explored the factors affecting the induction and transformation of hairy root cultures in rose by screening different types of explants, <i>Rosa</i> genotypes, <i>Agrobacterium</i> strains, media, and infection and co-cultivation times for genetic transformation under aseptic conditions. …”
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    Article
  8. 2868

    Mineral composition and ratios in aortic valves, serum, and epicardial fat among patients with aortic stenosis undergoing aortic valve replacement by Barbara Poniedziałek, Bartłomiej Perek, Aleksandra Proch, Anna Komosa, Przemysław Niedzielski, Piotr Buczkowski, Marek Jemielity, Piotr Rzymski

    Published 2025-01-01
    “…Elemental composition was determined using inductively coupled plasma mass spectrometry. Analyses revealed a distinct accumulation of Ca and P in aortic valve tissues, not correlated to and exceeding that in epicardial adipose tissue, suggesting localized mineralization. …”
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    Article
  9. 2869

    Preventive Effect of Cocoa Flavonoids via Suppression of Oxidative Stress-Induced Apoptosis in Auditory Senescent Cells by Luz del Mar Rivas-Chacón, Joaquín Yanes-Díaz, Beatriz de Lucas, Juan Ignacio Riestra-Ayora, Raquel Madrid-García, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez

    Published 2022-07-01
    “…Each cell line was divided into a control group (CTR) and an H<sub>2</sub>O<sub>2</sub> group (induction of senescence by an oxygen radical). Additionally, every group of every cell line was treated with the cocoa polyphenolic extract (CPE), measuring different markers of apoptosis, viability, the activity of antioxidant enzymes, and oxidative/nitrosative stress. …”
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    Article
  10. 2870

    Caffeic acid phenethyl ester restores mitochondrial homeostasis against peritoneal fibrosis induced by peritoneal dialysis through the AMPK/SIRT1 pathway by Ying Lu, Luyan Gao, Wenwen Zhang, Ying Zeng, Ji Hu, Kai Song

    Published 2024-12-01
    “…In vitro, peritoneal mesothelial cells (PMCs) treated with PDF showed inhibition of the AMPK/SIRT1 pathway, mitochondrial membrane potential depolarization, overproduction of mitochondrial reactive oxygen species (ROS), decreased ATP synthesis, and induction of mesothelial-mesenchymal transition (MMT). …”
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    Article
  11. 2871

    Comparative Analysis of Preoperative Sedation Modalities: Oral Midazolam and Ketamine Versus Chloral Hydrate and Meperidine in Pediatric Tonsillectomy - A Randomized Clinical Trial by Nima Naderi, Soodabeh Emami, Mahsa Banifatemi, Maryam Ghadimi, Ensieh Shahriari, Mohammad Ali Sahmeddini

    Published 2024-09-01
    “…Objective: A pre-anesthetic medication that is ideal for pediatric patients undergoing tonsillectomy should alleviate pediatric anxiety, facilitate the smooth induction of anesthesia, and have an analgesic effect for postoperative care. …”
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    Article
  12. 2872

    Small RNA sequencing highlights potential functions of tsRNAs in regulating pyroptosis in trigeminal neuralgia by Mizhen Qiu, Fei Zeng, Yi Yan, Mu Xu, Xuexue Zhang, Zhijian Wang, Yutong Wang, Daying Zhang, Shibiao Chen

    Published 2024-12-01
    “…The expression of caspase-1, IL-1β, and IL-18 was significantly boosted after TN induction. CoPP + H2O2 exposure induced cell injury and pyroptosis of rat Schwann RSC96 cells, but reversed by VX-765 (a caspase-1 inhibitor). …”
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    Article
  13. 2873

    Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival by Monika Komza, Jesminara Khatun, Jesse D. Gelles, Andrew P. Trotta, Ioana Abraham-Enachescu, Juan Henao, Ahmed Elsaadi, Andriana G. Kotini, Cara Clementelli, JoAnn Arandela, Sebastian El Ghaity-Beckley, Agneesh Barua, Yiyang Chen, Mirela Berisa, Bridget K. Marcellino, Eirini P. Papapetrou, Masha V. Poyurovsky, Jerry Edward Chipuk

    Published 2025-01-01
    “…When wild-type and oncogenic RAS patient-derived induced pluripotent stem cell acute myeloid leukemia (AML) models were examined, KL-11743 mediated induction of mitochondrial respiration and dependency for survival associated with oncogenic RAS. …”
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    Article
  14. 2874

    A microfluidics platform for simultaneous evaluation of sensitivity and side effects of anti-cancer drugs using a three-dimensional culture method by Yuki Kobayashi, Honoka Hashizume, Sotaro Takiguchi, Jiajue Ji, Ryuji Kawano, Keiichiro Koiwai, Haru Yamamoto, Mohamed Elbadawy, Tsutomu Omatsu, Amira Abugomaa, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki

    Published 2025-01-01
    “…Perfusion of MI organoids with toceranib also reduced viability, as observed in FMT organoids; however, this was due to the induction of necrosis rather than apoptosis. In conclusion, our established multi-organoid-on-chip system could be used to evaluate anti-cancer drug sensitivity and side effects in vitro, which might contribute to developing personalized medicine for cancer patients.…”
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    Article
  15. 2875

    Use of digital data from open sources during the investigation of criminal offenses: certain aspects by Basysta I., Havrylyuk L., Hutnyk A., Khytra A.

    Published 2024-06-01
    “…An analysis of national legislation, national judicial practice, the Berkeley protocol for conducting an investigation using open digital data (hereinafter referred to as the Berkeley Protocol), the practice of the European Court of Human Rights, the International Criminal Court and scientific research, based on which, by means of a synthesis, the basis of the problem was identified. Induction and deduction were used to form authors’ conclusions. …”
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    Article
  16. 2876

    Promoting ER stress in a plasmacytoid dendritic cell line drives fibroblast activation by Beatriz H. Ferreira, Inês S. Silva, Andreia Mendes, Fátima Leite-Pinheiro, Adrienne W. Paton, James C. Paton, Iola F. Duarte, Philippe Pierre, Catarina R. Almeida

    Published 2025-02-01
    “…Conclusions Overall, our data suggest that ER stress induction in pDCs promotes fibroblast activation, which may contribute to the development of fibrosis in SSc.…”
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    Article
  17. 2877

    Reflecting on partnerships established and sustained over four cycles of a federally funded cancer prevention and control research program: lessons learned for community-academic n... by Swann Arp Adams, Swann Arp Adams, Lauren Workman, Lauren Workman, Mayank Sakhuja, Brooks Yelton, Karen E. Wickersham, Ciaran Fairman, Jan Eberth, Sue Heiney, James R. Hebert, James R. Hebert, Jaron H. King, Freda Allyson Hucek, Lauren Schaurer, Daniela B. Friedman

    Published 2025-01-01
    “…As community-based participatory research is a core value of our center, we examined the development and continued engagement of our community partners using a qualitative, inductive approach to identify emergent themes from focus group sessions with current and past investigators.ResultsSeveral key themes were identified from our analysis including long-term commitment to community partnerships and interconnectedness with other work, authentic approach, valuing our community as experts, and mutual benefits.DiscussionWith our results, we provide evidence of common community-based participatory research (CBPR) principles which have supported the sustained engagement with those racial minorities who are most vulnerable in our community. …”
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    Article
  18. 2878

    Phenolic Compounds from Water-Ethanol Extracts of Tetrapleura tetraptera Produced in Cameroon, as Potential Protectors against In Vivo CCl4-Induced Liver Injuries by Peter William Kemewele Saague, Bruno Moukette Moukette, Jacques Romain Njimou, Prosper Cabral Nya Biapa, Francine Nzufo Tankeu, Vicky Joseline Ama Moor, Constant Anatole Pieme, Jeanne Yonkeu Ngogang

    Published 2019-01-01
    “…The extract of T. tetraptera was administered at doses of 50 mg/kg and 100 mg/kg for 07 per os to rats before the induction of hepatotoxicity with of 2 ml/kg of 1:1 (v/v) carbon tetrachloride (CCl4) and olive oil through intraperitoneal route. …”
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  19. 2879

    Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells by Jiangyi Wang, Guoqing Li, Lei Hu, Fei Yan, Bin Zhao, Xiaoshan Wu, Chunmei Zhang, Jinsong Wang, Juan Du, Songlin Wang

    Published 2020-01-01
    “…Human DPSCs were isolated and cultured in osteogenic induction medium with or without RA or BMS 493, an inverse agonist of the pan-retinoic acid receptors (pan-RARs). …”
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    Article
  20. 2880

    EFFORTS IN CONTROLLING COAL DUST HAZARDS IN THE STOCKPILE AREA OF A STEAM POWER PLANT (PLTU) by Alifiah Rizky Rosydah, Y. Denny Ardyanto Wahyudiono, Ahmad Imaduddin, Dani Nasirul Haqi, Meirina Ernawati

    Published 2022-11-01
    “…POMI included the installation of a spray gun, a dust suppression system, reforestation, and ventilation setting. Further, OHS induction was conducted, together with safety talk, working hour regulations, toolbox meeting, training on the use of PPE, Medical Check Up (MCU), person authorization, preventive maintenance, and the use of PPE by workers. …”
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    Article