Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo... by Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

“…However, real-world data on its long-term efficacy remains sparse.Methods This study assessed 5-year outcomes of first-line pembrolizumab monotherapy in a large, multicenter, real-world cohort of patients with advanced NSCLC and PD-L1 TPS≥50%, referred to as Pembro-real 5Y. Individual patient-level data (IPD) from the experimental arm of the KEYNOTE-024 trial were extracted (KN024 IPD cohort) to compare the long-term outcomes between the two cohorts. …”
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Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging by Lukas Hingerl, Bernhard Strasser, Simon Schmidt, Korbinian Eckstein, Guglielmo Genovese, Edward J. Auerbach, Andrea Grant, Matt Waks, Andrew Wright, Philipp Lazen, Alireza Sadeghi-Tarakameh, Gilbert Hangel, Fabian Niess, Yigitcan Eryaman, Gregor Adriany, Gregory Metzger, Wolfgang Bogner, Małgorzata Marjańska

“…Maps of 13 metabolic compounds (aspartate, choline compounds and creatine + phosphocreatine, γ-aminobutyric acid (GABA), glucose, glutamine, glutamate, glutathione, myo-inositol, scyllo-inositol, N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), taurine) and macromolecules were obtained individually. The spectral quality was outstanding in the parietal and occipital lobes, but lower in other brain regions such as the temporal and frontal lobes. …”
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Comparative Study of the Chemical Composition Disparities Between Fast-twitch and Slow-twitch Muscles in Marine Teleost Fishes by Huan WANG, Shufang LIU

“…Renowned for its flexibility, diversity, and efficiency, this mode of movement is significant for the individual survival and reproductive success of animals. …”
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Comparación de un hemoglobinómetro portátil (Verio Q Red) con los resultados del laboratorio clínico en la práctica clínica habitual by Boris Trenado-Luengo, Rosa García-Sierra, Verónica Moreno Gómez, Marina Montenegro Calvo, Jordi Anguita Lapido, Pere Torán-Monserrat

“…Venous blood is drawn, and simultaneously, capillary blood is collected. Results: 120 individuals are included, with an average age of 58.9 years. …”
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Exploring the role of methylation-driven gene IFFO1 in pancreatic adenocarcinoma diagnosis, prognosis and cellular functions by XU Ziqi, HU Ruizhi, LI Junjian, WANG Hongxia, SANG Youzhou

“…Methods: mRNA expression data (TCGA-PAAD-mRNA), DNA methylation data (TCGA-PAAD-meth, GSE53051, PACA-AU) of PAAD and adjacent normal tissues, as well as DNA methylation data of healthy individuals’ blood (GSE69270), were obtained from the The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC) and Gene Expression Omnibus (GEO) databases. …”
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A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients by M.-C. Boll, M. Alcaraz-Zubeldia, C. Rios, D. González-Esquivel, S. Montes

“…Results: Out of 42 patients enrolled, 20 individuals receiving VPA-Li and 18 on placebo treatment were included in the final analysis. …”
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Editorial by Lindsay B. Flynn

“…Those at the bottom often experience the opposite, because wealth is sticky and prone to transfer within families, not across. of course, there is cross-national and individual-level variation, but the on average increases in rent and house prices, as well as the risk factors associated with placing household assets in global financial markets, combine to create an explosive situation. …”
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Estimating Suitable Areas for Dry Almond (Amygdalus communis L.) Cultivation Development in Fars Province using Geographic Information System (GIS) by Ayatollah Karami, Alireza Salehi, Vida Aliyari

“…The results of this study can be valuable to all individuals and organizations active in the field of agricultural development and land resource management (including farmers and horticulturists in Fars province, officials and policymakers related to agriculture and rural development, researchers, and academics in geology, agriculture, and sustainable natural resource development in Fars province) and assist them in decision making regarding almond cultivation development.AcknowledgementsThe authors of the present study would like to express their gratitude to the collaboration of the National Meteorological Organization for providing the necessary data for this research.…”
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Characteristics of the Volunteer Service Management System for National Parks in the United Kingdom by Tianyi REN, Chuanbo HONG, Yinglin WANG

“…Therefore, relevant management agencies must recognize that the volunteer service in China’s national parks is of a public welfare nature, so no enterprises, institutions, or individuals related to the volunteer service management system shall have selfish intentions or seek personal gain in the management process. …”
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A Comparative Study of Health Efficacy Indicators in Subjects with T2DM Applying Power Cycling to 12 Weeks of Low-Volume High-Intensity Interval Training and Moderate-Intensity Con... by Jun Li, Wei Cheng, Haifeng Ma

“…The effect of power cycling on FI has the advantages of both aerobic and resistance exercise, which may optimize the type, intensity, and time of exercise prescription according to the individual or the type of exercise program. Our results provide a reference for the personalization of exercise prescription for patients with T2DM.…”
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A qualitative study of symptoms and psychological experience of patients with delayed resolution after microvascular decompression for hemifacial spasm (面肌痉挛行微血管减压术后延迟治愈患者症状体验和心理感受... by JING Dan (井丹), LYU Yan (吕燕), XU Zai (徐再)

“…Medical staff should take a comprehensive dynamic evaluation on disease awareness, physical issues, psychological issues and social support system, try to understand the symptoms and psychological experience of patients, and provide professional guidance and individualized nursing intervention, in order to relieve discomfort, improve the mental health, and improve the satisfaction and therapeutic experience of patients. …”
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Normative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case–Control Study by Lianne Mobbs, Vinuja Fernando, R. Dineth Fonseka, Pragadesh Natarajan, Monish Maharaj, Ralph J. Mobbs

“…Introduction: Gait analysis is a vital tool in the assessment of human movement and has been widely used in clinical settings to identify potential abnormalities in individuals. However, there is a lack of consensus on the normative values for gait metrics in large populations. …”
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Ophthalmological monitoring in patients with hypertension and coronary heart disease by L.K. Moshetova, I.V. Vorobyeva, A. Dgebuadze, O.D. Ostroumova, A.V. Arablinskiy, E.P. Delver, A.A. Belogurov

“…</i> </p> <p> <i><b>Conclusions</b>: in patients with hypertension and CHD with coronary artery stenosis, significant (p&lt;0.05) reduction in BCVA, MS, SCP VD, DCP VD, and choriocapillaris VD and increase in CMT and FAZ area were detected compared to healthy individuals. Additionally, strong correlations between ocular parameters (FAZ, SCP VD, DCP VD, and choriocapillaris VD) and EF (p&lt;0.05) were identified. …”
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A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients by M.-C. Boll, M. Alcaraz-Zubeldia, C. Rios, D. González-Esquivel, S. Montes

“…Results: Out of 42 patients enrolled, 20 individuals receiving VPA-Li and 18 on placebo treatment were included in the final analysis. …”
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Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“… - Intergenerational justice: This is justice between members of different generations, each generation represented by an average individual. The capacity of the atmosphere to serve as a sink for CO2e is non-renewable in a human time-scale. …”
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Altérations comportementales et fonctionnelles de la préhension au cours du vieillissement chez un primate non-humain : le microcèbe murin by Marie Le Brazidec, Emmanuelle Pouydebat, Anthony Herrel, Fabienne Aujard

“…Le vieillissement affectant ses capacités, un individu adapterait son comportement de façon à mettre en place des stratégies optimales telles que la diminution de l’utilisation des mains au profit de la bouche. …”
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Functionally important respiratory symptoms and continued cigarette use versus e-cigarette switching: population assessment of tobacco and health study waves 2-6Research in context by James D. Sargent, Kristin Lauten, Kathryn C. Edwards, Susanne E. Tanski, Todd A. MacKenzie, Laura M. Paulin, Mary F. Brunette, Maciej L. Goniewicz, Amanda Malasky, Debra Stark, Fernando B. de Moura, Holly Griffin, Kimberly H. Nguyen, Eric Backlund, Heather L. Kimmel, John H. Kingsbury, Jenny E. Ozga, K Michael Cummings, Andrew Hyland

“…The RRs for exclusive e-cigarette use with a cutoff of ≥3 for respiratory symptom worsening and improvement were not significant (0.74 [0.53, 1.05] and 1.20 [0.95, 1.51] respectively) but were significant in an unweighted analysis that included partial data for individuals lost to follow-up (0.74 [0.57, 0.95] and 1.21 [1.06, 1.39] respectively). …”
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Les orangs-outans aiment-ils peindre ? Étude préliminaire des variations du stress en captivité par dosage du cortisol et observation comportementale lors de l'enrichissement du mi... by Baptiste Sadoughi, Victor Narat, Morgane Debuigne, Michel Saint Jalme, Sabrina Krief

“…Les séances de dessin (7 à 8 par individu) se déroulent soit individuellement soit en groupe, entre 9 h 45 et 10 h 15. …”
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Systematic review and meta-analysis to examine intrapartum interventions, and maternal and neonatal outcomes following immersion in water during labour and waterbirth by Priscilla J Hall, Claire Feeley, Ethel Burns, Jennifer Vanderlaan

“…All calculations were conducted in Comprehensive Meta-Analysis V.3, using the inverse variance method. Results of individual studies were converted to log OR and SE for synthesis. …”
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Poverty Dynamics and the Fundamental Root Causes in Iran by Zahra Azari, Parviz Mohamadzadeh, Davoud Behboudi

“…Educational structure: in relation to the interaction between education and poverty, it can be acknowledged that without adequate education and appropriate for the society, the individual and the society are limited to a poor life. …”
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