Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007... by Leo Anthony Celi, Jonathan Shaffer, Marie-Laure Charpignon, Liam G McCoy, Luis Filipe Nakayama, Jack Gallifant, Urvish Jain, Joao Matos, Pia Gabrielle I Alfonso, Marisa Cobanaj, Amelia Morel Fiske, Alexander J Gates, Frances Dominique V Ho, Mohammad Kashkooli, Naira Link

“…In addition, our findings offer a first step towards understanding the composition of teams conducting medical research globally and an opportunity for individual authors to reflect on their own collaborative research practices and possibilities to cultivate more diverse partnerships in their work.…”
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FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis by Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini, Joshua R. Schultz, Pedro Berraondo, Matias A. Avila

“…Discussion This proof-of-concept study demonstrates the potential of mRNA-based therapies delivering FGF21 and APOA1 in experimental AP. While individual treatments effectively reduced pancreatic injury, the APOA1-FGF21 fusion molecule did not exhibit superior activity. …”
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Étude archéozoologique du quartier portuaire romain de Saint-Lupien à Rezé/Ratiatum (Loire-Atlantique) : les vestiges fauniques en pied de berge by Aurélia Borvon

“…These are probably made in the form of garum-type fish sauce as indicated by the species identified and by the small estimated sizes of the individuals. The association with shrimp remains in some samples attests to the possible incorporation of these animals into this type of food preparation. …”
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Laffer Curve and Taxable Revenue Elasticity: The Impact of Tax Deductions on a Dynamic General Equilibrium Model by Nahid Gohartash, Rouhollah shahnazi, Ahmad Sadraei javaheri, Mahboubeh Jafari, Parviz Rostamzadeh

“…Discussion and Conclusion One of the important results of this research is the changes in the government tax income and the reaction of individuals in the form of taxable income, caused by the consideration and non-consideration of deductions and tax exemptions on the household and corporate sectors. …”
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Fatty Acids of Erythrocyte Membranes and Blood Serum as Possible Predictors of Exacerbation in Patients with Inflammatory Bowel Diseases by M. V. Kruchinina, M. F. Osipenko, A. I. Valuyskikh, E. Yu. Valuiskikh, I. O. Svetlova

“…In the acute stage, patients with IBD have a higher total content of saturated fatty acids (SFAs) in erythrocyte membranes compared to the control group (p = 0.006), and, on the contrary, lower levels of unsaturated fatty acids (UFAs) (p = 0.005), mainly due to polyunsaturated FAs (PUFAs) (p = 0.026), namely omega-6 PUFAs (p = 0.011).Remission of IBD is associated with an increase in the level of a number of SFAs in the blood serum — margaric C17:0 (p = 0.024), arachidic acid (C20:0) — in erythrocyte membranes and serum (p = 0.0001 and p = 0.019, respectively), with a decrease in the total content of monounsaturated FAs in erythrocyte membranes (p = 0.022), an increase in the total concentration of PUFAs due to both omega-3 PUFAs (p = 0.0008) and omega-6 PUFAs (p = 0.033) in erythrocyte membranes compared with a group of healthy individuals.The exacerbation stage in patients with IBD examined over time is associated with higher levels of stearic FA C18:0 (p = 0.005), SFA/UFA (p = 0.034) and SFA/PUFA (p = 0.039) ratios in erythrocyte membranes, serum level of arachidic FA C20:0 (p = 0.008), and, on the contrary, lower content of UFAs in erythrocyte membranes — eicosapentaenoic C20:5n-3 (p = 0.0023), eicosadienoic C20:2n-6 (p = 0.0027), hexadecadienoic C16:2n-6 (p = 0.006), docosatetraenoic C22:4n-6 (p = 0.008) and alpha-linolenic C18:3n-3 (p = 0.039).A combined “panel” of fatty acids, including the levels of C20:2n-6, C18:0 in erythrocyte membranes and the content of C20:0 in blood serum, provided an AUC of 0.683 (95 % CI: 0.500–0.844), sensitivity 91.4 %, specificity 68.3 %.Levels of C20:5n-3, C20:2n-6, C18:0, C16:2n-6, C22:4n-6, C18:3n-3 fatty acids, SFA/UFA and SFA/PUFA ratios in erythrocyte membranes and content C20:0 in blood serum, used as biomarkers — predictors of the development of exacerbation in patients with IBD who were in remission, predicted the development of exacerbation of IBD after 2–4 months in the case of maximally changed levels of FAs, after 6–8 months — with moderately changed levels FAs, maintaining remission for 12 months — with minimally changed FAs levels.Conclusion. …”
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Editorial by Daniel Halliday

“…Again, such hierarchies might not be so profound in a society where all incomes were due to individuals’ own efforts. On the other hand, there are reasons to defend intergenerational wealth transfers as a means through which families can retain important assets, like a cherished home, and so that parents can exercise a degree of partiality towards their offspring or other chosen recipients. …”
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Development and Validation of a Diagnostic Model for Stanford Type B Aortic Dissection Based on Proteomic Profiling by Zhao Z, Chen T, Liu Q, Hu J, Ling T, Tong Y, Han Y, Zhu Z, Duan J, Jin Y, Fu D, Wang Y, Pan C, Keyoumu R, Sun L, Li W, Gao X, Shi Y, Dou H, Liu Z

“…Crucially, the combined models outperformed individual biomarkers and clinical models, demonstrating superior efficacy.Conclusion: Using proteomic profiling, we identified serum IL-6, GDF-15, CD58, LY9, and Siglec-7 as TBAD biomarkers. …”
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Pharmacogenetic and pharmacokinetic factors for dexmedetomidine-associated hemodynamic instability in pediatric patients by Yanping Guan, Bilian Li, Yiyu Zhang, Hao Luo, Xueding Wang, Xue Bai, Zhuoling Zheng, Yaying Huang, Wei Wei, Min Huang, Xingrong Song, Guoping Zhong

“…PurposeThe incidence of hemodynamic instability associated with dexmedetomidine (DEX) sedation has been reported to exceed 50%, with substantial inter-individual variability in response. Genetic factors have been suggested to contribute significantly to such variation. …”
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Barriers and Facilitators to Adherence to a Healthy Diet Across the Spectrum of Chronic Kidney Disease by Trigueros-Flores XB, Luna-Hernández G, Santos-Lopez MF, Pérez-Galván L, Flores-Camacho KJ, Díaz-Canchola LM, Cueto-Manzano AM, Chávez-Chávez HE, Cerrillos-Gutiérrez JI, Rojas-Campos E, Martín-del-Campo F

“…Lack of time, work, economy, food preferences and cravings were the main barriers in people with CKD stage 3b-5 and transplant, while low willingness to eat healthy foods and dietary restrictions were the main barriers in people receiving dialysis.Conclusion: Personal, environmental, health professional-related, CKD related as well as feelings and emotions aspects that people with CKD face in a daily basis, act as barriers or facilitators when trying to follow a healthy diet. Individualizing nutritional treatment taking into account people with CKD perspectives and situations is of utmost importance to improve adherence to nutritional treatment.Plain summary: In this article, the authors discuss the main barriers and facilitators that people with kidney disease face when trying to follow a healthy diet (from the people with CKD perspective). …”
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Serum biomarkers in the metabolic dysfunction-associated steatotic liver fibrosis diagnosis in children by Yu.M. Stepanov, N.Yu. Zavhorodnia, I.A. Klenina, O.M. Tatarchuk, O.P. Petishko

“…One of the unresolved problems associated with MASLD is the identification of individuals at risk of rapid disease progression and development of irreversible liver changes. …”
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Splenic artery aneurysms – a systematic review of the literature by Marta Machado, Andreia Coelho, João Peixoto, Luís Fernandes, Roberto Boal, Francisco Basílio, Patrícia Carvalho, Beatriz Guimarães, Pedro Brandão, Alexandra Canedo

“…CONCLUSION: SAAs rupture is associated with high mortality, so timely diagnosis and management are essential to attain a satisfactory outcome. A detailed and individualized analysis of each case and a sufficient understanding of the anatomy and hemodynamics of a particular aneurysm should guide the therapeutic decision. …”
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Large errors in soil carbon measurements attributed to inconsistent sample processing by R. J. Even, M. B. Machmuller, M. B. Machmuller, J. M. Lavallee, J. M. Lavallee, T. J. Zelikova, T. J. Zelikova, M. F. Cotrufo, M. F. Cotrufo

“…Further, to better understand how soil processing procedures and quantification methods commonly used in soil testing laboratories affect soil C concentration measurements, we designed an internal experiment assessing the individual effect of several alternative procedures (i.e., sieving, fine grinding, and drying) and quantification methods on total (TC), inorganic (SIC), and organic (SOC) soil C concentration estimates. …”
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L’habituation des bonobos de la forêt de Manzano dans le Territoire de Bolobo (Province du Bandundu, RDC) : évolution du processus au regard du socio-écosystème by Victor Narat, Jean Christophe Bokika Ngawolo, Blanchard Bongwana, Sabrina Krief

“…Les bonobos étant plus cohésifs que les chimpanzés, le taux de rencontre du même individu est plus grand, facilitant l’habituation. …”
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Growth of green catfish seed fed on sludge worm and artificial feed combination by Netti Aryani, Niken Ayu Pamungkas, . Adelina

“…Average body length of juvenile was 12 mm and weight 2.8±0.0 mg, maintained at a density of 30 individuals/aquarium. The treatment in this research was T10PB30 (8–18 days old juvenile were fed with sludge worm and 18–48 days old fish were fed with artificial diet), T20PB20 (8–28 days old juvenile were fed with sludge worm and 28–48 days old were fed with artificial diet), T30PB10 (8–38 days old juvenile were fed with sludge worm and 38–48 days old were given artificial diet), PB40 (8–48 days old juvenile were fed artificial diet), T40 (8–48 days old juvenile were fed with sludge worm). …”
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Recurrent adenoid cystic carcinoma of the left upper palate accompanied by massive maxillary hemorrhage: a case report and literature review by ZHANG Wangru, CHEN Yuanyuan, LI Zhiping, MENG Jian

“…Following an urgent consultation with the vascular interventional surgery department, super-selective embolization was promptly employed to effectively halt the bleeding and achieve rapid vascular occlusion. An individualized treatment plan was developed under MDT, incorporating postoperative radiotherapy, targeted therapies, and immunotherapy to manage the tumor. …”
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Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease St... by Chengzhi Yang, Yuhe Jia, Changlin Zhang, Zening Jin, Yue Ma, Xuanye Bi, Aiju Tian

“…Among three age groups, the largest increase in HF prevalence from 1990 to 2021 was found in individuals aged 20–24 years (AAPC = 0.61 [0.6–0.61]). …”
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Differentiation of Early Sacroiliitis Using Machine-Learning- Supported Texture Analysis by Qingqing Zhu, Qi Wang, Xi Hu, Xin Dang, Xiaojing Yu, Liye Chen, Hongjie Hu

“…A control group of healthy individuals matched in terms of age and sex to the patients was included in this study. …”
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Reinfección por sífilis gestacional: reporte de caso y revisión sistemática de la literatura by Harold Villamizar, Natalia Vergara, Daniela Martínez-Barreto, Jaime Moreno-Chaparro, Hernando Gaitán-Duarte

“…Conclusiones: la vigilancia activa e individual de los casos de SG tratada es importante porque permite no solo identificar la reinfección, sino también garantizar el tratamiento de los compañeros sexuales para prevenirla. …”
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Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, I. . A.s. Trukhmanov, Ye. K. Baranskaya, O. B. Dronova, O. V. Zayratyants, R. G. Sayfutdinov, A. A. Sheptulin, T. L. Lapina, S. S. Pirogov, Yu. A. Kucheryavy, O. A. Storonova, D. N. Andreyev

“…The treatment of GERD has to be individualized according to the pattern and severity of clinical symptoms. …”
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Association of accelerated phenotypic aging, genetic risk, and lifestyle with progression of type 2 diabetes: a prospective study using multi-state model by Lulu Pan, Yahang Liu, Chen Huang, Yifang Huang, Ruilang Lin, Kecheng Wei, Ye Yao, Guoyou Qin, Yongfu Yu

“…Abstract Background Aging is a major risk factor for type 2 diabetes (T2D), but individuals of the same chronological age may vary in their biological aging rate. …”
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