Does pregabalin offer potential as a first-line therapy for generalized anxiety disorder? A meta-analysis of efficacy, safety, and cost-effectiveness by Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Luis Gutiérrez-Rojas, Luis Gutiérrez-Rojas, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, María Pérez-Páramo

“…GAD is often underdiagnosed, leading to negative consequences for individuals, healthcare systems, and society. The economic burden and impaired quality of life associated with GAD underscores the need for effective treatment. …”
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Effect of a prepartum and postpartum, complex interdisciplinary lifestyle and psychosocial intervention on metabolic and mental health outcomes in women with gestational diabetes m... by Umberto Simeoni, Antje Horsch, Arnaud Chiolero, Yvan Vial, Nicole Sekarski, Jardena J Puder, Pascal Bovet, Yvan Mivelaz, Adina Mihaela Epure, Bobby Stuijfzand, Leah Gilbert, Stefano Lanzi, Justine Gross, Didier Hans, Stefano Di Bernardo, Elena Gonzalez-rodriguez, Alain Lacroix, Jean-Benoît Rossel, Dan Yedu Quansah, Amar Arhab, Sandrine Estoppey Younes, Seyda Mayerat

“…Objective To test the effect of a complex, interdisciplinary, lifestyle and psychosocial intervention on metabolic and mental health outcomes in women with gestational diabetes mellitus during pregnancy and in the post partum.Design Single centred, single blinded, randomised, controlled trial (the MySweetheart trial).Setting Lausanne University Hospital, Switzerland, from 2 September 2016 to 25 October 2021.Participants 211 women aged at least 18 years with a diagnosis of gestational diabetes mellitus at 24-32 gestational weeks were randomly assigned (1:1) to the intervention (n=105) or to usual care (n=106).Interventions In addition to a comparator based on active guidelines for prepartum and postpartum usual care, the intervention consisted of four individual lifestyle visits during pregnancy and four interdisciplinary visits in the postpartum group, a peer support group workshop in pregnancy and post partum, and a bimonthly lifestyle coach support through telemedicine. …”
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Prevalence and determinants of post-neonatal mortality in East Africa: a multilevel analysis of the recent demographic and health survey by Alebachew Ferede Zegeye, Desale Bihonegn Asmamaw, Wubshet D. Negash, Wubshet D. Negash, Tadele Biresaw Belachew, Elsa Awoke Fentie, Atitegeb Abera Kidie, Tsegaw Amare Baykeda, Samrawit Mihret Fetene, Banchlay Addis, Sisay Maru Wubante, Abel Endawkie, Tadesse Tarik Tamir

“…It was discovered that factors at the individual and community levels associated with post-neonatal mortality. …”
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Definitional differences in “outpatient” surgery can influence study outcomes related to total shoulder arthroplasty by Junho Song, MD, Jennifer Yu, BS, Avanish Yendluri, BS, William A. Ranson, MD, Nikan K. Namiri, MD, John J. Corvi, MD, David E. Kantrowitz, MD, Thomas Boucher, MD, Leesa M. Galatz, MD, Paul J. Cagle, MD, Bradford O. Parsons, MD, Robert L. Parisien, MD

“…After controlling for potential confounders, inpatient TSA was associated with increased risk of 30-day readmission and reoperation compared with HDO cases, while morbidity and individual complication rates were similar. However, compared with SDD patients, inpatient TSA was associated with higher rates of readmission, reoperation, morbidity, pneumonia, pulmonary embolism, myocardial infarction, and deep venous thrombosis. …”
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Whole blood ratio of CDK1/CX3CR1 mRNA expression combined to lactate refines the prediction of ICU mortality in septic patients in the Sepsis-3 era: a proof-of-concept study by Marie-Angélique Cazalis, Marie-Angélique Cazalis, Louis Kreitmann, Louis Kreitmann, Guillaume Monneret, Guillaume Monneret, Alexandre Pachot, Alexandre Pachot, Karen Brengel-Pesce, Karen Brengel-Pesce, Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos

“…This performance was better than that of each individual mRNA biomarker. In the external validation cohort, the predictive performance of the CDK1/CX3CR1 ratio, measured using RT-qPCR, was similar to that of lactate when measure at day 1, and higher when measured at days 2–3. …”
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The Importance of Dose Escalation in the Treatment of Pulmonary Arterial Hypertension with Treprostinil by Piotr Kędzierski, Marta Banaszkiewicz, Michał Florczyk, Michał Piłka, Rafał Mańczak, Maria Wieteska-Miłek, Piotr Szwed, Krzysztof Kasperowicz, Katarzyna Wrona, Szymon Darocha, Adam Torbicki, Marcin Kurzyna

“…The dose of treprostinil is adjusted on an individual basis for each patient. A number of factors determine how well patients respond to treatment. …”
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A comparative analysis of autograft choices of anterior cruciate ligament reconstruction and their effects on muscle strength and joint biomechanics by Wiem Issaoui, Wiem Issaoui, Ismail Dergaa, Ismail Dergaa, Ismail Dergaa, Hatem Ghouili, Abdelfatteh El Omri, Noomen Guelmami, Philippe Chomier, Mourad Ghrairi, Helmi Ben Saad, Helmi Ben Saad, Helmi Ben Saad, Wassim Moalla, Wassim Moalla

“…IntroductionAnterior cruciate ligament reconstruction (ACLR) is crucial to restore knee stability and function after ACL injuries, especially in physically active individuals. Despite advances in surgical techniques and rehabilitation protocols, the choice of autograft has a significant impact on postoperative recovery, particularly on muscle strength and joint biomechanics. …”
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Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators by Michael Hecker, Brit Fitzner, Isis Ludwig-Portugall, Friederike Bohne, Edmar Heyland, Juliane Klehmet, Matthias Grothe, Matthias Schwab, Alexander Winkelmann, Stefanie Meister, Ales Dudesek, Hannah Wurm, Ilya Ayzenberg, Ingo Kleiter, Ingo Kleiter, Corinna Trebst, Martin W. Hümmert, Bernhard Neumann, Bernhard Neumann, Klaus Eulitz, Dirk Koczan, Uwe K. Zettl

“…Further studies are required to verify whether anti-EBNA1 (391-410) antibody reactivities and the expression of CD4-CTL-related genes may be indicative of the individual clinical response to this therapy.…”
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Single-cell RNA sequencing highlights the role of distinct natural killer subsets in sporadic amyotrophic lateral sclerosis by Esther Álvarez-Sánchez, Álvaro Carbayo, Natalia Valle-Tamayo, Laia Muñoz, Joaquim Aumatell, Soraya Torres, Sara Rubio-Guerra, Jesús García-Castro, Judit Selma-González, Daniel Alcolea, Janina Turon-Sans, Alberto Lleó, Ignacio Illán-Gala, Juan Fortea, Ricard Rojas-García, Oriol Dols-Icardo

“…For this purpose, peripheral blood mononuclear cells (PBMC) were isolated from 14 ALS patients and 14 cognitively unimpaired healthy individuals (HC), matched by age and gender, and cryopreserved until library preparation and scRNAseq. …”
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Fact-finding and risk factor analysis of chemotherapy-induced nausea and vomiting in children with solid tumors: a prospective observational study by Miaomiao Shao, Ying Li, Jing Qin, Yuchen Zhou, Yixin Sun, Peiyi Yang, Xisi Wang, Cheng Huang, Yan Su, Wen Zhao

“…Receipt of 5HT3RA plus dexamethasone had a higher likelihood of acute phase complete CIV control versus 5HT3RA. In the future, individualized management of nausea and vomiting, based on existing CINV guidelines and the unique characteristics of children, will be necessary to reduce the incidence of CINV and improve the quality of life for these children.…”
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Post-acute sequelae of hospitalised COVID-19 re-infection compared with hospitalised first-time infection: a population-based retrospective cohort study in Hong Kong by Yin Zhang, Francisco T T Lai, Shirley Chiu Wai Chan, Chak Sing Lau, Xue Li, Eric Yuk Fai Wan, Lung Yi Mak, Celine S L Chui, Ivan F N Hung, Esther Wai Yin Chan, Vincent Ka Chun Yan, Deliang Yang, Carlos Wong, Ian Chi-Kei Wong

“…Adults hospitalised with COVID-19 between 1 January and 30 November 2022, who survived the first 28 days after infection and was discharged, were categorised into re-infection and first-time infection groups. Individuals with reinfection were compared with those with first-time infection for all-cause mortality, all-cause hospital readmission, attendance to the emergency department and complications during the post-acute period using propensity-score-weighted Cox regression. …”
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Productivity of water and heat resources and cotton yield response to cropping pattern and planting density in cotton fields in arid area by Zhenlin Dong, Sumei Wan, Yunzhen Ma, Jinbin Wang, Lu Feng, Yunlong Zhai, Tiantian Li, Zhengjun Cui, Jian Wang, Beifang Yang, Ze Yang, Zhan Zhao, Fei Yan, Shiwu Xiong, Yabing Li, Guodong Chen

“…The individual effects of cropping patterns and planting densities on cotton yield formation and resource utilization have been extensively studied in the arid regions of western China, but research on their combined impacts remains limited. …”
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Sex differences in murine MASH induced by a fructose-palmitate-cholesterol-enriched diet by Lakshmi Arivazhagan, Sofie Delbare, Robin A. Wilson, Michaele B. Manigrasso, Boyan Zhou, Henry H. Ruiz, Kaamashri Mangar, Ryoko Higa, Emily Brown, Huilin Li, Michael J. Garabedian, Ravichandran Ramasamy, Kathryn J. Moore, Edward A. Fisher, Neil D. Theise, Ann Marie Schmidt

“…The identification of intrinsic, within-sex, diet-dependent disparities underscores the critical need to include both male and female individuals in MAFLD/MASH studies and clinical trials. …”
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Factors associated with physical fitness and disparities in population segments among older adults: A cross-sectional study by Yuqin Rao, Jingjing Wang, Kai Li, Fanhui Zheng, Ying Chen, Bo Zhai, Jintao Hong, Chen Wang, Bao Liu, Dao Wang

“…Furthermore, greater marginal effects on achieving higher physical fitness test scores were observed among individuals classified as inactive when engaging in more moderate-to-vigorous activities and exercise. …”
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Artificial intelligence-based, non-invasive assessment of the central aortic pressure in adults after operative or interventional treatment of aortic coarctation by Renate Oberhoffer, Peter Ewert, Harald Kaemmerer, Nicole Nagdyman, Oliver Dewald, Frank Klawonn, Michael Huntgeburth, Andreas Eicken, Christian Meierhofer, Sebastian Freilinger, Martin Middeke, Pinar Bambul Heck, Annika Freiberger, Frank Harig, Manuel Lösch, Fritz Mellert, Fabian von Scheidt, Elsa Ury, Nicole Wolfrum, Ann-Sophie Kaemmerer-Suleiman, Mathieu N. Suleiman

“…Conventional blood pressure (BP) measurement methods lack precision for individual diagnoses and therapeutic decisions. This study evaluated the use of artificial intelligence-based pulse wave analysis (AI-PWA) to assess central aortic blood pressure (CABP) and related parameters in post-treatment CoA patients.Methods This exploratory, cross-sectional study enrolled 47 adults with CoA, between June 2023 and May 2024. …”
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Development of a framework to structure decision-making in environmental and occupational health: A systematic review and Delphi study by Emily Senerth, Paul Whaley, Elie Akl, Brandy Beverly, Pablo Alonso-Coello, Ezza Jalil, Jayati Khattar, Nicole R. Palmer, Andrew Rooney, Holger J. Schünemann, Kristina A. Thayer, Katya Tsaioun, Rebecca L. Morgan

“…We identified another 16 frameworks in a search of gray literature, totaling 38 source frameworks. We abstracted 560 individual decision considerations from these frameworks, 104 of which may contribute additional information to the guidance, scope, context, or assessment criteria of the GRADE EtD framework. …”
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Phase IV adaptive randomised clinical trials evaluating efficacy and cost-efficacy of pre-emptive pharmacogenetic genotyping strategies in the Spanish National Health System: iPHAR... by Xandra García-González, Alberto M Borobia, Antonio J Carcas, Miriam Estébanez, Montserrat Carmona, Irene García García, Francisco Abad-Santos, Luis A López-Fernández, Esther Cubo, Iñaki Imaz-Iglesia, Alicia Marín-Candón, Miriam Saiz-Rodríguez, Irene Taladriz-Sender, Pedro Arias, Rocío Rosas-Alonso, Enrique Seco-Meseguer, Stefan Stewart, Elena Diago-Sempere, María del Mar García Saiz, Emilio J Laserna-Mendieta, Ana M Peiró, Magí Farré, Consuelo Rodriguez-Jimenez, Judith Sanabria-Cabrera, Lucia Pedrosa, Ignacio Bernardino, Javier Guiijarro-Eguinoa, Arturo Gómez López De Las Huertas, Susana Martín-López, Olga Hladun Alvaro, Vicente Arrate, Ana Fries, Daniel Rodriguez Díaz, Fernando Marqués García, Núria Alonso Pedrol, Modesto M Maestre Muñiz, Leticia Rodríguez Alcolado, Carlos Ortiz-Bautista, Angela Remesal-Doblado, María Isabel Lucena, Zaida Salmón González, Inmaculada Coca-Prieto

“…Randomisation will be conducted on an individual basis with a centralised approach and stratification by centre. …”
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Production of giant gourami Osphronemus goramy Lac. juvenile with different rate of water exchange by Tatag Budiardi, Rona Albrettico Nemanita Ginting, Yani Hadiroseyani

“…The financial benefits resulted of the process were worth of IDR.351,903.00; IDR.402,302.00; and IDR.464,715.00; whereas R/C ratio of 1.71; 1.80; dan 1.90; BEP of 1,845 unit, 1,645 unit, and 1,517 unit; payback period (PP) of 0.97 years, 0.85 years, and 0.74 years; and the cost production as much as IDR.79.90; IDR.82.70; and IDR.82.90/individual, respectively. The treatments were significantly different on several parameters, such as specific growth rate, length of growth rate, feed efficiency at p<0.05. …”
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Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…Despite advancements in therapeutic strategies, the 5-year survival rate for individuals undergoing curative resection remains between 10% and 15%. …”
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The role of smell in medical and psychological disorders: An interdisciplinary approach by Giuseppe Riva

“…Anosmia leads to some disturbances in food enjoyment, detecting harmful food and smoke, and to some extent in social situations and working life. The majority of individuals deal well and manage those restrictions with appropriate coping strategies. …”