Impact of Methotrexate and 7‐Hydroxymethotrexate Exposure on Renal Toxicity in Pediatric Non‐Hodgkin Lymphoma by Hao Bing, Yi Ma, Jiamin Xu, Qixian Ling, Yanlong Duan, Libo Zhao

“…Moreover, the Cmax of MTX and 7‐OHMTX showed significant differences (p < 0.0001, p = 0.0472, respectively) among patients with or without nephrotoxicity. Similarly, individuals with nephrotoxicity also exhibited substantially higher ratio of 7‐OHMTX to MTX peak concentration and the sum of MTX + 2.25 times the concentration of 7‐OHMTX (p < 0.0001, p = 0.0426, respectively). …”
Get full text

The effects of contralateral limb cross-education training on post-surgical rehabilitation outcomes in patients with anterior cruciate ligament reconstruction: a randomized control... by Chao Liu, ShiJia Li, JianPing Li, HongHao Zhang, GuQiang Li, XiangZhan Jiang

“…Nonetheless, the fundamental mechanics of its effects remain ambiguous, and variables such as individual differences and neuromuscular adaptation processes may affect training results. …”
Get full text

Reflexões após 3 anos: relatando o desabrochar de reumatologistas através de atividades profissionais confiabilizadoras. by Rafael Mendonça da Silva Chakr, Charles Lubianca Kohem elaboração do manuscrito, Claiton Viegas Brenol, Ricardo Machado Xavier, Odirlei André Monticielo

“…Reuniões de feedback com uma agenda para os residentes e para o supervisor do programa contribuíram para o aprimoramento individual e a qualificação da formação. Discussão: A implementação de EPA na residência de reumatologia foi uma oportunidade para aumentar os feedbacks e qualificar o programa. …”
Get full text

Determinants of healthcare utilization under the Indonesian national health insurance system – a cross-sectional study by Qinglu Cheng, Rifqi Abdul Fattah, Dwidjo Susilo, Aryana Satrya, Manon Haemmerli, Soewarta Kosen, Danty Novitasari, Gemala Chairunnisa Puteri, Eviati Adawiyah, Andrew Hayen, Anne Mills, Viroj Tangcharoensathien, Stephen Jan, Hasbullah Thabrany, Augustine Asante, Virginia Wiseman

“…Results Of the 31,864 individuals included in the ENHANCE survey, around 14% had used outpatient services in the past month. …”
Get full text

Healthcare provision for displaced people in transit: Analyses of routinely collected data from INTERSOS clinics at the Ukrainian border with Moldova and Poland by Saleh Aljadeeah, Seyed-Moeen Hosseinalipour, Nataliia Khanyk, Eszter Szocs, Aliki Traianou, Ana Tomas, Chrysanthi Tatsi, Elżbieta Czapka, Alessandro Verona, Tessa van Boekholt, Ion Chesov, Apostolos Veizis

“…The majority of the adult population seeking healthcare were females (76.5 %), 26.1 % were children and 18.7 % were older individuals. Noncommunicable diseases (NCDs) were the primary reason for seeking healthcare at these clinics, with 23.3 % of the study population being diagnosed with at least one chronic disease, and 3.4 % of people having multimorbidity. …”
Get full text

Machine learning for predicting severe dengue in Puerto Rico by Zachary J. Madewell, Dania M. Rodriguez, Maile B. Thayer, Vanessa Rivera-Amill, Gabriela Paz-Bailey, Laura E. Adams, Joshua M. Wong

“…When excluding hemoconcentration and leukopenia, the CatBoost AUC-ROC was 96.7% (95% CI: 95.5–98.0%), demonstrating minimal reduction in performance. Individual warning signs like abdominal pain and restlessness had sensitivities of 79.0% and 64.6%, but lower specificities of 48.4% and 59.1%, respectively. …”
Get full text

Toward Understanding of Quiet Human Resource Management Theory in Iranian Organizations: Theoretical Origins, Conceptual Narration and its Consequences by Abbas Nargesian, Sajjad Sadpoor

“…These practices often stem from individual factors such as superior employee skills and performance, job-related factors like stress and burnout, and organizational factors including cost-saving measures and workforce restructuring. …”
Get full text

Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis by David P Carbone, David Spigel, Jeffrey S Ross, Karthikeyan Murugesan, Gerald Li, Richard S P Huang, Ryon P Graf, Geoffrey R Oxnard, Alexa Schrock, Liangliang Zhang, Khaled Tolba, Jacob Sands

“…Background For patients with advanced non-small cell lung carcinoma (NSCLC), immune checkpoint inhibitor (ICPI) and chemotherapy (chemo) ICPI represent two distinct first-line standard-of-care regimens without clear and established biomarkers to inform the optimal choice for individual patients. Here, we examined the complementary roles of tumor mutational burden (TMB) and programmed death ligand-1 (PD-L1) immunohistochemistry (IHC) to inform first-line therapy using a large real-world (rw) data set.Materials and methods The study included patients with NSCLC from an rw de-identified clinico-genomic database. …”
Get full text

Profiles of innovative behavior and associated predictors among clinical nurses: a multicenter study using latent profile analysis by Husheng Li, Yue Qiao, Tianxiang Wan, Chun Hua Shao, Fule Wen, Xiaoxin Liu

“…Results Among the respondents, individuals aged 25 to 35 accounted for 55.9%, and females comprised 94.6%. …”
Get full text

The utilization of seagrass and macroalgae substrate for settlement of sandfish Holothuria scabra larvae by Lisa Fajar Indriana, , Marjuky, Sitti Hilyana

“…Wadah pemeliharaan berupa wadah plastik dengan volume air laut 10 L, kepadatan awal 1.000 individu/wadah. Perhitungan akhir STS dilakukan pada hari ke-13 masa pemeliharaan. …”
Get full text

Plasma S100β is a predictor for pathology and cognitive decline in Alzheimer’s disease by Geetika Nehra, Bryan J. Maloney, Rebecca R. Smith, Wijitra Chumboatong, Erin L. Abner, Peter T. Nelson, Björn Bauer, Anika M. S. Hartz

“…The goal of this study was to assess markers for barrier dysfunction in postmortem tissue samples from research participants who were either cognitively normal individuals (CNI) or diagnosed with AD at the time of autopsy and determine to what extent these markers are associated with AD neuropathologic changes (ADNC) and cognitive impairment. …”
Get full text

不一樣的人生道路？STEM科系畢業生的薪資發展軌跡 Different Life Pathway: Earning Trajectory of the Graduates in STEM Majors by 張宜君 Yi-Chun Chang

“…This study systematically investigates the influence of majoring in STEM fields on individual earning trajectory. Merging the Panel Study of Family Dynamics from 2009 to 2020 and using the growth curve model to estimate the effects of STEM education on earning trajectory, the findings show that the earnings of workers trained in STEM majors are significantly higher than those of workers in non-STEM majors, and their advantages increase with the accumulation of work experience. …”
Get full text

Exploring the barriers to cervical screening and perspectives on new self-sampling methods amongst under-served groups by Stephanie Gillibrand, Helen Gibson, Kelly Howells, Sean Urwin, Jennifer C. Davies, Emma J. Crosbie, Caroline Sanders

“…Addressing this research gap, the study aims to understand experiences during and barriers to attending cervical screening for under-screened groups and; explore the views of individuals eligible for screening towards self-sampling (vaginal swabbing and urine sampling) as alternative screening methods and how this may address existing barriers to screening. …”
Get full text

Modern approaches to monitoring the ecological condition of lake ecosystem waters by Yu. S. Tuchkovenko, V. А. Ovcharuk, М. О. Martyniuk, Ye. І. Gazyetov, О. V. Zotova, V. M. Khokhlov, D. Jiang, A. N. Tyler

“…Presentation of the results of the implementation of new approaches to monitoring indicators of the ecological state of water in lake ecosystems using the example of the Danube lakes with the use of modern express methods of determining individual ecological parameters and satellite information of the water bodies' water bodies.                …”
Get full text

Patterns of general and abdominal obesity and their association with hypertension control in the iranian hypertensive population: insights from a nationwide study by Fataneh Esmaeili, Keyvan Karimi, Samaneh Akbarpour, Mohammadreza Naderian, Shirin Djalalinia, Ozra Tabatabaei-Malazy, Ali Golestani, Nazila Rezaei

“…This study targeted the association between uncontrolled HTN—defined according to the JNC8 guidelines— and different obesity patterns (general and abdominal) among adult hypertensive individuals. Methods Data for the present investigation were obtained from the 2021 STEPwise Approach to NCD Risk Factor Surveillance (STEPS) national survey in Iran. …”
Get full text

Short-term effects of combined environmental factors on respiratory disease mortality in Qingdao city: A time-series investigation. by Xin Zhang, Zijian Xi, Min Yang, Xiuqin Zhang, Ruikai Wu, Shuang Li, Lu Pan, Yuan Fang, Peng Lv, Yan Ma, Haiping Duan, Bingling Wang, Kunzheng Lv

“…Subgroup analysis showed that females, elderly individuals, and those exposed during warm seasons demonstrated greater susceptibility to PM exposure.…”
Get full text

Prevalence of pulmonary tuberculosis and associated factors among adults living with HIV/AIDS in Ethiopia, systematic review and meta-analysis by Amlaku Nigusie Yirsaw, Berihun Agegn Mengistie, Eyob Getachew, Gebrehiwot Berie Mekonnen, Adamu Ambachew Shibabaw, Alex Ayenew Chereka, Gemeda Wakgari Kitil, Wubet Tazeb Wondie, Gebeyehu Lakew

“…The prevalence was notably higher in individuals with lower CD4 counts, advanced HIV stages (III and IV), and in smokers. …”
Get full text

Spatial, temporal, and spatiotemporal cluster detection of malaria incidence in Southwest Ethiopia by Lidetu Demoze, Fetlework Gubena, Eyob Akalewold, Helen Brhan, Tigist Kifle, Gelila Yitageasu

“…To better understand the factors contributing to these high-risk areas, further research is needed to explore individual, household, geographical, and climatic factors. …”
Get full text

Comparative- and Cost-Effectiveness Research Determining the Optimal Intervention for Advancing Transgender Women With HIV to Full Viral Suppression (Text Me, Alexis!): Protocol fo... by Cathy J Reback, Thomas Blue, Ali Jalali, Raphael Landovitz, Michael J Li, Raymond P Mata, Danielle Ryan, Philip J Jeng, Sean M Murphy

“…Findings have the potential to improve individual and population health outcomes by generating significant improvements in viral suppression among transgender women and guiding service provision and public policy. …”
Get full text

Healthcare practitioners as accomplices: a qualitative study of gender affirmation in a context of ambiguous regulation in Indonesia by Benjamin Hegarty, Alegra Wolter, Amalia Puri Handayani, Kevin Marian, Jamee Newland, Dede Oetomo, Ignatius Praptoraharjo, Angela Kelly-Hanku

“…Abstract Background The World Professional Association for Transgender Health guidelines Standards of Care 8 draw on ethical arguments based on individual autonomy, to argue that healthcare and other professionals should be advocates for trans people. …”
Get full text