High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril by Juan Sanchez, Joshua Pierson, Collin Borcik, Chad Rienstra, Elizabeth Wright

“…This workflow should serve as a starting point for individuals new to the neurodegeneration and structural biology fields. …”
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Compreensão do nutricionista sobre o enfrentamento da obesidade em um município da Amazônia Legal by Bianca Dias Ferreira, Andreza Domingos da Silva, Kellen Cristine Silva, Lorenna Martins da Silva, Marta Azevedo dos Santos, Sônia Lopes Pinto

“…Já a prática profissional foi caracterizada pela ausência de planejamento de ações, associada a práticas educativas com foco individual e caráter preventivo. Destaca-se a necessidade de qualificação profissional de forma conjunta com a estruturação de um modelo de atenção adequado a condições crônicas como a obesidade. …”
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Interpretation of indoor air surveillance for respiratory infections: a prospective longitudinal observational study in a childcare settingResearch in context by Caspar Geenen, Steven Traets, Sarah Gorissen, Michiel Happaerts, Kurt Beuselinck, Lies Laenen, Jens Swinnen, Sien Ombelet, Joren Raymenants, Els Keyaerts, Emmanuel André

“…However, there is a lack of research comparing air sampling and individual sampling of attendees. Therefore, it remains unclear how air sampling results should be interpreted for the purpose of surveillance. …”
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Effectiveness of multicomponent interventions in primary healthcare settings to promote continuous smoking cessation in adults: a systematic review by Carlos Martín Cantera, Elisa Puigdomènech, Jose Luis Ballvé, Olga Lucía Arias, Lourdes Clemente, Ramon Casas, Lydia Roig, Santiago Pérez-Tortosa, Laura Díaz-Gete, Sílvia Granollers

“…Methodologies used were mainly individual or group sessions, telephone conversations, brochures or quit-smoking kits, medications and economic incentives for doctors and no-cost medications for smokers. …”
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Associations between brominated flame retardants exposure and non-alcoholic fatty liver disease: Mediation analysis in the NHANES by Yulan Cheng, Jingyi Su, Xiangdong Wang, Ruiyao Huang, Zixuan Zhao, Kai Tian, Tianxiang Gu, Xiaoke Wang, Lin Chen, Xinyuan Zhao

“…Results: Our study demonstrated that specific concentrations of BFRs are related to an increased risk of NAFLD, both individually and when combined. PBB153, PBDE28, PBDE209, and PBDE153 exhibited the highest importance for NAFLD and were potential risk factors worthy of concern. …”
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Associations between fear of COVID-19 and mental health in Ghana: A sequential mediation model by Jiajia Ye, Po-Ching Huang, Emma Sethina Adjaottor, Frimpong-Manso Addo, Mark D. Griffiths, Daniel Kwasi Ahorsu, Chung-Ying Lin

“…Introduction: Although the coronavirus disease 2019 (COVID-19) pandemic has ceased globally, individuals may still suffer from various psychological burdens in the post-COVID-19 era. …”
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A semantic strength and neural correlates in developmental dyslexia by Sladjana Lukic, Sladjana Lukic, Sladjana Lukic, Fei Jiang, Maria Luisa Mandelli, Maria Luisa Mandelli, Ting Qi, Sarah M. Inkelis, Sarah M. Inkelis, Emily Rosenthal, Emily Rosenthal, Zachary Miller, Zachary Miller, Emma Wellman, Emma Wellman, Silvia A. Bunge, Silvia A. Bunge, Silvia A. Bunge, Maria Luisa Gorno-Tempini, Maria Luisa Gorno-Tempini, Christa Watson Pereira, Christa Watson Pereira

“…This work highlights that inter-individual differences should be taken into account in dyslexia and reveals a cognitive area of strength for some children with dyslexia that could be leveraged for reading interventions.…”
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Burden of brain and other central nervous system cancer in China, 1990–2019: a systematic analysis of observational data from the global burden of disease study 2019 by Peng Yin, Maigeng Zhou, Fan Zhang, E Wang, Xinran Hou, Zongbin Song, Zhuoyi Liu, Wenyong Long, Zheng Long, Maoen Zhu

“…Objective To evaluate the trends in disease burden and the epidemiological features of central nervous system (CNS) cancer in China from 1990 to 2019.Design A population-based observational study.Setting The incidence, prevalence, death and disability-adjusted life years (DALYs) due to CNS cancer in China, stratified by sex, age and provincial region, were collected from the Global Burden of Disease Study 2019.Participants Data were publicly available and individuals were not involved.Results In 2019, the incident cases of CNS cancer in China were 347 992 (95% UI 262 084–388 896), and the age-standardised rate (ASR) of incidence was 5.69 (95% UI 4.36–6.78) per 100 000 person-years increased by 27.9% compared with that in 1990; meanwhile, CNS cancer caused 63 527 (95% UI 47 793–76 948) deaths in China in 2019, and the ASR of death was 3.5 (95% UI 2.62–4.21) per 100 000 person-years decreased by 9.6%. …”
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Unsupervised machine learning model for phenogroup-based stratification in acute type A aortic dissection to identify postoperative acute gastrointestinal injury by Yuhu Ma, Xiaofang Yang, Chenxiang Weng, Xiaoqing Wang, Baoping Zhang, Ying Liu, Rui Wang, Zhenxing Bao, Peining Yang, Hong Zhang, Yatao Liu

“…The areas under the curve (AUCs) for diagnosing postoperative AGI of phenogroup A, B, and C were 0.943 (0.854–0.992), 0.990 (0.966–1.000), and 0.964 (0.899–0.997) using the RF model, respectively.ConclusionPhenogroup stratification based on unsupervised learning can accurately identify high-risk populations for postoperative AGI in ATAAD, providing a new approach for implementing individualized preventive and therapeutic measures in clinical practice.…”
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Feasibility pilot of a novel coaching intervention to optimize cannabis use for chronic pain management among Veterans by Kevin F. Boehnke, Gabrielle Bowyer, Jenna McAfee, Tristin Smith, Catherine Klida, Vivian Kurtz, Evangelos Litinas, Poonam Purohit, Anne Arewasikporn, Dana Horowitz, Laura Thomas, Jennifer Eckersley, Mia Railing, David A. Williams, Daniel J. Clauw, Kelley M. Kidwell, Amy S. B. Bohnert, Rachel S. Bergmans

“…Participants received up to 4 individual coaching sessions via videoconference, spaced approximately 2 weeks apart. …”
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An EEG-based framework for automated discrimination of conversion to Alzheimer’s disease in patients with amnestic mild cognitive impairment: an 18-month longitudinal study by Yingfeng Ge, Jianan Yin, Caie Chen, Shuo Yang, Yuduan Han, Chonglong Ding, Jiaming Zheng, Yifan Zheng, Jinxin Zhang

“…During 18-month follow-up period, 42 individuals progressed to AD (PMCI), while 65 remained in the aMCI stage (SMCI). …”
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Global temporal trends and projections of hepatitis B-related cirrhosis among adolescents and young adults from 1990 to 2035: an analysis based on the global burden of disease stud... by Quanwei He, Quanwei He, Quanwei He, Xiujuan Chang, Ran Xu, Ran Xu, Wei Han, Wei Han, Sihao Wang, Sihao Wang, Shujuan Gong, Shujuan Gong, Jiagan Huang, Jiangtao Liu, Rugang Zhang, Yongping Yang, Yongping Yang, Yongping Yang

“…Nevertheless, there was a slight increase in the incidence number among individuals aged 30–39 years. The substantial burden and predicted rise in the numbers of incidences and deaths in low SDI areas underscore the need for sustained and targeted public health interventions.…”
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Children’s emerging concepts of resilience: insights from using body mapping in an East London cohort sample of 7-10-year-old children by Aisling Murray, Dominie Mahala Smith Scott, Milena Nikolajeva, Daniele Porricelli, Francois van Loggerenberg, Dennis Ougrin, Jennifer Y. F. Lau

“…We also identified socioecological factors that contributed to resilience, mainly at the individual and interpersonal levels. Boys more often depicted Sports whilst more girls depicted Engagement in the arts and Social networks. 11 worry categories emerged, including education, relationships and physical health. …”
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Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model by Tatiane M. Preisser, Vanessa P. da Cunha, Mariana P. Santana, Vanessa B. Pereira, Denise C. Cara, Bianca M. Souza, Anderson Miyoshi

“…The STZ-induced mice that were treated with combined bacterial strains carrying plasmids encoding IL-4 and IL-10 showed lower incidence of diabetes and more preserved pancreatic islets than the mice that received the individual bacterial strains. Combined administration of L. lactis MG1363 FnBPA+ (pValac::dts::IL-4) and L. lactis MG1363 FnBPA+ (pValac::IL-10) resulted in protection against diabetes in NOD mice. …”
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Insights from a codesigned dynamic modelling study of child and adolescent obesity in Australia by Alison Hayes, Rebecca Wyse, Anna Lene Seidler, Kylie E Hunter, Rebecca K Golley, Louise A Baur, Anthony D Okely, Kenny Lawson, Jo-An Occhipinti, Louise Freebairn, Simon Keith Chiu, Joseph Carrello, L Kurt Kreuger

“…The most promising individually implemented intervention scenario for reducing the prevalence of childhood and adolescent obesity was a sugar-sweetened beverage tax (0.57 percentage points and 0.61 percentage points, respectively) and government funding of organised sports (0.42 percentage points and 0.63 percentage points, respectively). …”
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Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2 by C.F. Pulliam, M.A. Fath, S. Sho, S.T. Johnson, B.A. Wagner, M. Singhania, A.L. Kalen, K. Bayanbold, S.R. Solst, B.G. Allen, B.N. George, J.M. Caster, G.R. Buettner, D.P. Riley, J.L. Keene, R.A. Beardsley, D.R. Spitz

“…Pentaazamacrocyclic Mn (II)-containing (MnPAM) superoxide dismutase (SOD) mimetics and pharmacological ascorbate given IV to achieve [mM] plasma levels (pharmacological ascorbate: P-AscH‾) have been shown to act individually as cancer cell radio- and chemosensitizers via the generation of H2O2 in vivo. …”
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Evaluation of oral cholera vaccine (Euvichol-Plus) effectiveness against Vibrio cholerae in Bangladesh: an interim analysis by Amanda Tiffany, Ashraful Islam Khan, Firdausi Qadri, John D Clemens, Faisal Ahmmed, Farhana Khanam, Tahmina Shirin, Fahima Chowdhury, Md. Taufiqul Islam, Md Nazmul Islam, Md Nazmul Hasan Rajib, Md Ismail Hossen, Md. Taufiqur Rahman Bhuiyan, Shahinur Haque, Prasanta Kumar Biswas, Amirul Islam Bhuiyan, Zahid Hasan Khan, Mohammad Ashraful Amin, Aninda Rahman, S M Shahriar Rizvi, Lucy Breakwell

“…Using this vaccine in a cholera epidemic in Dhaka, Bangladesh, provided the opportunity to evaluate the vaccine effectiveness (VE) using a test-negative design.Methods A two-dose regimen of Euvichol-Plus was administered to individuals aged >1 year in a population of ca. 900 000 in two campaign rounds between June and August 2022, with prospective registration of all persons who received at least one dose. …”
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Interrelationships between social exclusion, mental health and wellbeing in adolescents: insights from a national Youth Survey by K. Filia, S. M. Teo, N. Brennan, T. Freeburn, D. Baker, V. Browne, A. Watson, J. Menssink, A. Prasad, E. Killackey, P. D. McGorry, S. M. Cotton, C. X. Gao

“…Screening approaches are needed to identify individuals and groups of young people in need of support, and to facilitate care coordination across multiple providers. …”
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Gender differences of health literacy in persons with a migration background: a systematic review and meta-analysis by Elke Kalbe, Nicole Skoetz, Christiane Woopen, Digo Chakraverty, Annika Baumeister, Angela Aldin, Ümran Sema Seven, Ina Monsef

“…Objective To investigate gender differences of health literacy in individuals with a migration background.Design Systematic review and meta-analysis. …”
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Oral delivery of bovine tuberculosis vaccine to free-ranging white-tailed deer by Kurt VerCauteren, Abigail Feuka, Michael Lavelle, Michael Glow, Keely Kohen, Patrick Ryan, Tony Aderman, Anthony Duffiney, Mitchell Palmer, Paola M. Boggiatto, Carly Kanipe, Hayden Hamby, Emily Ruell, Melinda Cosgrove, Michael Vanderklok, Nathan Snow, Kim M. Pepin, Henry Campa

“…Deer learned to seek out and consume vaccine DU’s in just 1 to 3 days, with individuals often eating more than the 1 or 2 needed to vaccinate themselves. …”
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