Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy by Qingchao Shang, Qingchao Shang, Pei Zhang, Xiao Lei, Lehui Du, Baolin Qu

“…Furthermore, inhibition of CSF-1/CSF-1R signaling combined with radiotherapy has been extensively studied to reduce immunosuppression and promote abscopal effect. In addition, cumulative evidence demonstrated that M2 phenotype macrophage is dominant in tissue fibrosis and the inhibition of CSF-1/CSF-1R signaling pathway ameliorated pulmonary fibrosis, including radiation-induced lung fibrosis. …”
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Cytokine Patterns in Brain Tumour Progression by Radu Albulescu, Elena Codrici, Ionela Daniela Popescu, Simona Mihai, Laura Georgiana Necula, Daniel Petrescu, Mihaela Teodoru, Cristiana Pistol Tanase

“…The body’s response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute to tumour growth, progression, and immunosuppression, rather than in building an effective antitumour defence. …”
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Prophylactic intravenous immunoglobulin use in allogeneic stem cell transplantation; does intravenous immunoglobulin affect survival, sepsis, and engraftment time? by Ahmet Kaya, İlhami Berber, İrfan Kuku, Emin Kaya, Mehmet Ali Erkurt, Soykan Biçim, Süleyman Arslan, Fatma Hilal Yağin

“…BACKGROUND: Stem cell transplant recipients have an increase in various infections depending on the immunosuppression. The purpose is to explore the effect of the use of proflactıc intravenous immunoglobulin (IVIG) on transplant recıpıents. …”
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The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma by Mircea Tampa, Cristina Iulia Mitran, Madalina Irina Mitran, Ilinca Nicolae, Adrian Dumitru, Clara Matei, Loredana Manolescu, Gabriela Loredana Popa, Constantin Caruntu, Simona Roxana Georgescu

“…Dysregulation of the immune system (chronic inflammation and immunosuppression), environmental factors (ultraviolet radiation), and genetic factors are the most important cofactors involved in beta HPV-related carcinogenesis. …”
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A Very Rare Case: HPV-Negative Vulvar Cancer in an Adolescent by Ilker Kahramanoglu, Hasan Turan, Yahya Ozgun Oner, Tugan Bese, Sennur Ilvan, Macit Arvas, Fuat Demirkiran

“…These patients have usually risk factors such as human papillomavirus (HPV) infection and immunosuppression. Herein, we present a case of invasive squamous vulvar cancer in an 18-year-old patient without any risk factor. …”
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The Challenges of Distinguishing Different Causes of TMA in a Pregnant Kidney Transplant Recipient by A. Krelle, S. Price, M. M. Law, S. Kranz, P. Shamdasani, S. Kane, J. Unterscheider, P. Champion de Crespigny

“…TMA disorders are well-recognised in kidney transplant recipients, often due to an underlying genetic predisposition related to complement dysregulation, or de novo due to infection, immunosuppression toxicity, or antibody-mediated rejection. …”
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Lymphomatoid Granulomatosis Treated Successfully with Rituximab in a Renal Transplant Patient by Cindy Castrale, Wael El Haggan, Françoise Chapon, Oumedaly Reman, Thierry Lobbedez, Jean Philippe Ryckelynck, Bruno Hurault de Ligny

“…Here, we describe LYG in a 70-year-old renal allograft recipient who, 4 years after transplantation, on tacrolimus and mycophenolate mofetil and prednisone maintenance immunosuppression, complained of low-grade fever, persistent headache and gait disturbance. …”
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Current trends in antimicrobial use and the role of antimicrobial stewardship in palliative oncology: a narrative review by Bassem Awada, Aref Zribi, Ahmad Al Ghoche, Souha S. Kanj

“…This overutilization stems from recurrent infections due to immunosuppression, malnutrition, and frequent hospitalizations, as well as difficulty differentiating infection-related symptoms from cancer-related complications. …”
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Transplantation and Pregnancy by Pinar Erkan Uc, Sermet Sagol

“…Specific criteria such as pre-pregnancy serum creatinine levels and blood pressure control, as well as adherence to immunosuppressive therapy, significantly influence pregnancy success in transplant patients. …”
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Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study by Sanjeevan Sriskandarajah, Leif Bostad, Tor Åge Myklebust, Bjørn Møller, Steinar Skrede, Rune Bjørneklett

“…Background. Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. …”
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Successful Antiviral Treatment with Direct-Acting Antivirals for Hepatitis C Virus Infection during Peritransplant Period in a Kidney Transplant Recipient by Giovanni Varotti, Ferdinando Dodi, Ernesto Paoletti, Andrea Bruno, Iris Fontana

“…A standard straightforward kidney transplant was performed. Immunosuppression included thymoglobulin and prednisone for induction and tacrolimus and mycophenolate for maintenance. …”
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A fulminant case of JC virus encephalopathy supporting a novel syndrome associated with JC virus infection of cortical neurons by Matteo Ciocca, Marta Pirovano, Monica Lodi, Antonino Romeo, Vincenza Fetoni

“…PML almost exclusively affects immunosuppressed patients, whereas it is rare in immunocompetent subjects. …”
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Plasma mcfDNA Sequencing May Improve Usual Care Diagnostics to Detect HHV-8 Among Outpatient People with Advanced HIV by Sarah Park, Brian Epling, Morgan Richey, Daniel Lupu, Mona Mughar, Irini Sereti

“…Background: Human herpesvirus-8 (HHV-8), or Kaposi sarcoma (KS)-associated herpesvirus (KSHV), causes severe disease in people with profound immunosuppression. Yet, diagnosing KS can be challenging given the diverse manifestations and current limited usual care diagnostic methods (UC; polymerase chain reaction, histopathology). …”
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Severe invasive streptococcal infection in a patient with COVID-19: A case report by Yuki Matsuura, Mone Murashita, Takayoshi Oyasu, Akira Kodate, Yoshihiro Sadamoto, Akio Endo, Hisako Sageshima, Takumi Tsuchida

“…This case suggests the possibility of immunosuppression due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. …”
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Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review by Siddharth Shah, Hadeel M. Mansour, Brandon Lucke-Wold

“…Although preclinical trials in HD models have shown promise in improving cognitive and motor functions, stem cell therapy still faces many challenges and disadvantages including immunosuppression and immunorejection as well as ethical, technical, and safety concerns. …”
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Advancements in cellular immunotherapy: overcoming resistance in lung and colorectal cancer by Lijuan Qin, Yuan Li, Juan Liu, Xiaoqin An

“…Tumor resistance mechanisms—ranging from immune evasion, antigen loss, and immune checkpoint upregulation, to tumor microenvironment immunosuppression—remain major obstacles. This mini-review highlights the latest advancements in tumor immunotherapy, with a focus on cellular therapies, and addresses the resistance mechanisms that hinder their effectiveness in lung and colorectal cancers. …”
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Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in Levels of Treg-Related Cytokines by Lifang Sun, Yu Liu

“…Elevated HLA antibody II and CD4 + CD25 + Treg are the main clinical risk factors for TRALI, and CD4 + CD25 + Treg may be involved in immunosuppression by increasing the expression levels of IL-10 and TGF-β. …”
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Spontaneous Complete Regression of Colon Cancer Liver Metastases in a Lung Transplant Patient: A Case Report by Koen Zwart, Dieuwertje Ruigrok, Magda de Graaf-Bos, Roel Goldschmeding, Miriam Koopman, Guus M. Bol

“…The cause of malignancies in patients with solid organ transplants is multifactorial, but the use of intensive immunosuppression is regarded as an important factor. We describe the spontaneous, complete regression of colon cancer liver metastases, without initiation of antitumor therapy, in a solid organ transplant patient after modulation of immunosuppressants. …”
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The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function by Christian Kuhn, Bernd Jänigen, Laura Matuschik, Max J. Rieger, Daniel Sidler, Stefan Zschiedrich

“…Abstract Background Despite advances in kidney transplant surgery and immunosuppression, lymphoceles remain a frequent complication in the early postoperative period following kidney transplantation, often requiring reintervention. …”
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Mast Cells Exert Anti-Inflammatory Effects in an IL10−/− Model of Spontaneous Colitis by E. M. Lennon, L. B. Borst, L. L. Edwards, A. J. Moeser

“…Mast cells are well established as divergent modulators of inflammation and immunosuppression, but their role in inflammatory bowel disease (IBD) remains to be fully defined. …”
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