Epigenetic regulation of the inflammatory response in stroke by Jingyi Liang, Fei Yang, Zixiao Li, Qian Li

“…However, in clinical trials of anti-inflammatory agents, long-term immunosuppression has not demonstrated significant clinical benefits for patients. …”
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The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock by Gennaro De Pascale, Salvatore Lucio Cutuli, Mariano Alberto Pennisi, Massimo Antonelli

“…Increased risk of infection acquisition has been largely documented in MBL-deficient patients, but the real impact of this form of innate immunosuppression upon clinical outcome is not clear. In critically ill patients higher incidence and worse prognosis of severe sepsis/septic shock appear to be associated with low-producers haplotypes. …”
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Cytokine profiles in early rejection following OKT3 treatment in liver transplant patients by Sasan Roayaie, Patricia A. Sheiner, Sukru Emre, Steven Guy, Myron E. Schwartz, Peter Boros, Charles M. Miller

“…OKT3, a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFα and IL1β. …”
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Effects of Low Concentration of Glyphosate-Based Herbicide on Genotoxic, Oxidative, Inflammatory, and Behavioral Meters in Danio rerio (Teleostei and Cyprinidae) by Eduardo Bortolon Ribas, Gustavo Colombo Dal-Pont, Ariana Centa, Marcos Otávio Bueno, Ricardo Cervini, Rosana Claudio Silva Ogoshi, Claudriana Locatelli

“…The results showed that acute exposure to GBH promoted an inflammatory event, which reduced the efficiency of antioxidants, thus producing a disturbance in tissues, mainly in the liver, causing immunosuppression and generating genotoxicity.…”
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Anti-N-Methyl-D-Aspartate Encephalitis as Paraneoplastic Manifestation of Germ-Cells Tumours: A Cases Report and Literature Review by Claudia Geraldine Rita, Israel Nieto Gañan, Adriano Jimenez Escrig, Ángela Carrasco Sayalero

“…Management includes aggressive immunosuppression and surgical removal.…”
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PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis by A. Stravodimou, A. Cairoli, T. Rausch, R. Du Pasquier, P. Michel

“…With careful reduction of the immunosuppression after the first manifestation and with the use of chemotherapy combined with radiotherapy after the second manifestation, our patient showed complete disappearance of neurologic symptoms and she is clinically well with good kidney function. …”
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Lymphatic vessel network injury reduces local tumor control despite preservation of the tumor-draining lymph node by Lauren N. Liebman, Yang Shen, Zachary S. Buchwald, Zhanna Nepiyushchikh, Zhiming Qi, Andrés J. García, J. Brandon Dixon

“…Abstract The lymphatic system plays complex, often contradictory, roles in many cancers, including melanoma; these roles include contributions to tumor cell metastasis and immunosuppression in the tumor microenvironment as well as generation of antitumor immunity. …”
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Modulation of Immunity by Antiangiogenic Molecules in Cancer by Magali Terme, Orianne Colussi, Elie Marcheteau, Corinne Tanchot, Eric Tartour, Julien Taieb

“…Some antiangiogenic molecules inhibit the development of immunosuppressive mechanisms developed by the tumors to escape the immune system (such as regulatory T cells, myeloid-derived suppressor cells, and immunosuppressive cytokines). …”
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Gastric Mucormycosis in a Renal Transplant Patient Treated with Isavuconazole Monotherapy by Imran Gani, Atbin Doroodchi, Kristina Falkenstrom, Holly Berry, Won Lee, Laura Mulloy, Muhammad Saeed, Rajan Kapoor

“…Prompt diagnosis and modulation of immunosuppression are essential to decrease mortality and morbidity. …”
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Knowledge, Attitude, and Practice toward Skin Cancer Prevention and Detection among Jordanian Medical Students: A Cross-Sectional Study by Khaled Seetan, Almu’atasim Khamees, Afnan Migdadi, Mosab Abu Shqeer, Maram Jameel Hasan, Leen Ahmad Shatnawi, Tala Abu Bakr, Nada Zayed

“…The most prevalent skin cancer risk factors were sun exposure during the day (83.5%) and immunosuppression (71.2%). More than half of the students did not have any habits of skin examination (61.5%). 20% of the students never used sunscreen, while only 20% of them avoided sun exposure during day hours. …”
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Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activation by Fenglin Zhu, Miao Wang, Xuhong Zhang, Guoqing Zhao, Hongyan Gao, Lamei Zhou

“…Immunosuppressants are fundamental medications for the treatment of RA but carry the risk of inducing HBV reactivation. …”
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Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application by Mengyuan Wang, Quan Yuan, Liang Xie

“…In particular, their extensive immunosuppressive properties are being explored for promising therapeutic application in immune disorders. …”
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Identification of Molecular Subtypes and Prognostic Features of Breast Cancer Based on TGF-β Signaling-related Genes by Jia Qu, Mei-Huan Wang, Yue-Hua Gao, Hua-Wei Zhang

“…Objectives: The TGF-β signaling pathway is widely acknowledged for its role in various aspects of cancer progression, including cellular invasion, epithelial-mesenchymal transition, and immunosuppression. Immune checkpoint inhibitors (ICIs) and pharmacological agents that target TGF-β offer significant potential as therapeutic options for cancer. …”
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The impact of innate immune response on the efficacy of oncolytic viruses by Kirill N. Trachuk, Nikolai B. Pestov, Yulia K. Biryukova, Nadezhda M. Kolyasnikova

“…Thus, the success of the clinical application of the oncolytic viruses directly depends on the three key components: tumor immunosuppression, antiviral responses, and antitumor immune responses. …”
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Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia by Jing Wang, Terry W. Wright, Francis Gigliotti

“…Pneumocystis is an opportunistic fungal respiratory pathogen that causes life-threatening pneumonia (Pcp) in patients suffering from defects in cell-mediated immunity, including those with acquired immunodeficiency syndrome (AIDS) and immunosuppression secondary to chemotherapy or organ transplantation. …”
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Bilateral primary vitreoretinal lymphoma masquerading as fungal endophthalmitis- a case report by Manisha Agarwal, Alankrita Muralidhar, Tanya Jain, Prashant Katre, Arpan Gandhi, Priyanka Gupta, Charu Gupta, Shishir Narain

“…Conclusion Vitritis with sub-RPE yellowish deposits may be mistaken for infectious endophthalmitis specially in a patient with a history of intraocular surgery or immunosuppression. PVRL is a great masquerader and is to be kept in mind while diagnosing a middle-aged patient with infectious or non-infectious uveitis.…”
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Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren’s Syndrome by Hazlyna Baharuddin, Mohammad Hanafiah, Syazatul Syakirin Sirol Aflah, Mohd Arif Mohd Zim, Shereen Suyin Ch’Ng

“…The lessons from this case are (i) patients with LIP can be asymptomatic, (ii) LIP can precede symptoms of SS, and (iii) treatment decision for asymptomatic patients with abnormal imaging or patients with mild severity should be weighed between the risk of immunosuppression and risk of active disease.…”
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Incidental Finding of Nocardia: A Case Series from a Tertiary Care Centre in Uttarakhand by Aroop Mohanty, Suneeta Meena, Subodh Pandey Kumar, Puneet Kumar Gupta, Neelam Kaistha, Pratima Gupta, Mithilesh Kumar Jha, Sasi Rekha

“…The most common conditions causing immunosuppression were type II DM, COPD, and pulmonary tuberculosis.…”
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Hypnosis in the Perioperative Management of Breast Cancer Surgery: Clinical Benefits and Potential Implications by Arnaud Potié, Fabienne Roelants, Audrey Pospiech, Mona Momeni, Christine Watremez

“…During surgery, hypnosis may be applied to limit immunosuppression, while, in the postoperative period, it can reduce pain, anxiety, and fatigue and improve wound healing. …”
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Giant Condyloma Acuminatum of Vulva in an HIV-Infected Woman by Athanase Lilungulu, Bonaventura C. T. Mpondo, Abdallah Mlwati, Dismas Matovelo, Albert Kihunrwa, Balthazar Gumodoka

“…The most common risk factor is immunosuppression with HIV; however, any other cause of immunodeficiency can be a predisposing factor. …”
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