Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice by Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang

“…We further observed increased Th1 responses amplified by Tregs (regulatory T cells) and compromised Th17 responses, which alleviated the liver immunopathology. We speculated that these changes were related to polarization of Th1-like Tregs. …”
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Prevalence of dengue and leptospirosis coinfection and associated mortality rates: a systematic review and meta-analysis by Suraj Tiwari, Mahalaqua Nazli Khatib, Rekha MM, Mandeep Kaur, Girish Chandra Sharma, Puneet Sudan, K. Satyam Naidu, Rajesh Singh, Teena Vishwakarma, Sonam Puri, Muhammed Shabil, Anuradha Yadav, Takveer Singh, Sahil Khurana, Rachana Mehta, Prakasini Satapathy, Renu Sah, Abhay M Gaidhane, Ganesh Bushi

“…Further research into the immunopathology and the implementation of integrated surveillance systems could enhance the effectiveness of diagnosis and treatment strategies in regions where these diseases are endemic.…”
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Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study by Camille Windsor, Adrien Joseph, Stephanie Pons, Djamel Mokart, Frederic Pène, Achille Kouatchet, Alexandre Demoule, Fabrice Bruneel, Martine Nyunga, Edith Borcoman, Matthieu Legrand, Michael Darmon, Lara Zafrani, Elie Azoulay, Virginie Lemiale

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ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway by Xiaofei Huang, Xiaofei Huang, Yuqun Zeng, Jingru Lin, Huazhen Liu, Huazhen Liu, Chun-Ling Liang, Chun-Ling Liang, Yuchao Chen, Yuchao Chen, Feifei Qiu, Feifei Qiu, Jonathan S. Bromberg, Zhenhua Dai, Zhenhua Dai

“…Flow cytometric analyses were conducted to quantify CD4+Foxp3+ Tregs, while immunohistochemistry was carried out to observe allograft immunopathology. Western blotting was used to detect IĸBα/c-Rel signaling during Treg induction. …”
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A customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases by Hari Krishnan Krishnamurthy, Vasanth Jayaraman, Karthik Krishna, Tianhao Wang, Kang Bei, Chithra Changalath, Shiny Matilda, Alex J. Rai, Renata Welc-Falęciak, Agnieszka Pawełczyk, Lucas S. Blanton, Aleš Chrdle, Andrea Fořtová, Daniel Růžek, Gheyath K. Nasrallah, Laith J. Abu-Raddadi, Duaa W. Al-Sadeq, Marah Abed Alhakim Abdallah, Daniele Lilleri, Chiara Fornara, Piera D’Angelo, Milena Furione, Maria Söderlund-Venermo, Klaus Hedman, Dimosthenis Chochlakis, Eirini Makridaki, Artemis Ntoula, Anna Psaroulaki, Angélica Escárcega-Ávila, John J. Rajasekaran

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Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis by José Alberto Choreño-Parra, Luis Armando Jiménez-Álvarez, Ellis Daniela Maldonado-Díaz, Graciela Cárdenas, Luis Alejandro Fernández-Lopez, José Luis Soto-Hernandez, Marcela Muñoz-Torrico, Gustavo Ramírez-Martínez, Alfredo Cruz-Lagunas, Armando Vega-López, María Lilia Domínguez-López, Carlos Sánchez-Garibay, Parménides Guadarrama-Ortíz, Silvia Giono, Luis Antonio Jiménez-Zamudio, Shabaana A. Khader, Ethel A. García-Latorre, Citlaltepetl Salinas-Lara, Joaquín Zúñiga

“…The mechanisms underlying the immunopathology of tuberculous meningitis (TBM), the most severe clinical form of extrapulmonary tuberculosis (TB), are not understood. …”
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γδ T Cells’ Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models by Xavier Charmetant, Xavier Charmetant, Xavier Charmetant, Guillaume Rigault, Chien-Chia Chen, Hannah Kaminski, Hannah Kaminski, Jonathan Visentin, Jonathan Visentin, Benjamin Taton, Gabriel Marseres, Virginie Mathias, Alice Koenig, Alice Koenig, Alice Koenig, Thomas Barba, Thomas Barba, Thomas Barba, Pierre Merville, Pierre Merville, Stéphanie Graff-Dubois, Emmanuel Morelon, Emmanuel Morelon, Emmanuel Morelon, Julie Déchanet-Merville, Valérie Dubois, Jean-Paul Duong van Huyen, Lionel Couzi, Lionel Couzi, Olivier Thaunat, Olivier Thaunat, Olivier Thaunat

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Hepatitis D virus infection triggers CXCL9-11 upregulation in hepatocytes and liver infiltration of CXCR3+ CD4 T cells by Jan-Hendrik Bockmann, Lena Allweiss, Annika Volmari, David da Fonseca Araújo, Matin Kohsar, Anastasia Hyrina, Janine Kah, Zhijuan Song, Josolyn Chan, Katja Giersch, Tassilo Volz, Marc Lütgehetmann, Jeffrey J. Wallin, Dmitry Manuilov, Meghan M. Holdorf, Simon P. Fletcher, Ansgar W. Lohse, Antonio Bertoletti, Julian Schulze zur Wiesch, Maura Dandri

“…Impact and implications: Chronic hepatitis D (CHD) causes the most severe form of viral hepatitis, and treatment options are still limited; therefore, a more precise understanding of CHD immunopathology is needed. In this study, we demonstrated that HDV infection triggers CXCL9–11 expression in hepatocytes and liver infiltration of CXCR3-expressing CD4 T cells in preclinical models as well as patient biopsies. …”
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Granuloma Annulare, Autoimmune Thyroiditis, and Lichen Sclerosus in a Woman: Randomness or Significant Association? by Mariele De Paola, Anastasia Batsikosta, Luca Feci, Mattia Benedetti, Roberta Bilenchi

“…In our opinion this combination is not just coincidental but may share similar immunopathological mechanisms.…”
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Oral pemphigus vulgaris with one year follow-up and complete remission by Dineshkumar Thayalan, Rajkumar Krishnan, Rameshkumar Annasamy, Priyadharsini Nataraj, N. Indumathi

“…Correlations between clinical, histological, and immunopathological data are necessary for proper diagnosis and prompt therapy.…”
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Interferons and Interferon Regulatory Factors in Malaria by Sin Yee Gun, Carla Claser, Kevin Shyong Wei Tan, Laurent Rénia

“…Here, we review their roles and the signaling pathways involved in their production and protection against infection and induced immunopathologies.…”
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Adaptive Immune Responses in Primary Cutaneous Sarcoidosis by Matteo Bordignon, Paola Rottoli, Carlo Agostini, Mauro Alaibac

“…We will further explore the contributions of selected cytokines to the immunopathological process. The knowledge of the adaptive immunological mechanisms operative in cutaneous sarcoidosis may subsequently be useful for identifying prevention and treatment strategies of systemic sarcoidosis.…”
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Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis by Milan Buc

“…Principal cells of the immune system that drive the immunopathological processes are T cells, especially of TH1 and TH17 subsets. …”
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COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps by Leandro Borges, Tania Cristina Pithon-Curi, Rui Curi, Elaine Hatanaka

“…Coronavirus disease 2019 (COVID-19) is a virus-induced respiratory disease that may progress to acute respiratory distress syndrome (ARDS) and is triggered by immunopathological mechanisms that cause excessive inflammation and leukocyte dysfunction. …”
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Prospective Evaluation of Neutrophil Autoantibodies in 500 Consecutive Patients with Inflammatory Bowel Disease by Hugh Freeman, Brenda Roeck, Dana Devine, Cedric Carter

“…Results emphasize the immunopathological differences between ulcerative colitis and Crohn's disease, and indicate that both disorders are heterogeneous inflammatory disease processes.…”
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Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis by Yone Vila Nova Cavalcanti, Maria Carolina Accioly Brelaz, Juliana Kelle de Andrade Lemoine Neves, José Candido Ferraz, Valéria Rêgo Alves Pereira

“…Different from TNF-alpha and IFN-gamma, IL-10 is considered primarily an inhibitory cytokine, important to an adequate balance between inflammatory and immunopathologic responses. The increase in IL-10 levels seems to support the survival of mycobacteria in the host. …”
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Costimulatory Pathways: Physiology and Potential Therapeutic Manipulation in Systemic Lupus Erythematosus by Nien Yee Kow, Anselm Mak

“…Indeed, SLE is characterized by an orchestrated interplay amongst different types of immunopathologically important cells participating in both innate and adaptive immunity including the dendritic cells, macrophages, neutrophils and lymphocytes, as well as traditional nonimmune cells such as endothelial, epithelial, and renal tubular cells. …”
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MicroRNAs in Autoimmune Sjögren’s Syndrome by Seunghee Cha, Mahmoud Mona, Kyung Eun Lee, Dong Hee Kim, Kyudong Han

“…To facilitate the development of miRNA-targeted personalized therapy in the future, we urge more follow-up studies that confirm these findings and elucidate the immunopathological roles of differentially-expressed miRNAs. …”
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Differential Recruitment of Dendritic Cells Subsets to Lymph Nodes Correlates with a Protective or Permissive T-Cell Response during Leishmania (Viannia) Braziliensis or Leishmania... by A. K. Carvalho, K. Carvalho, L. F. D. Passero, M. G. T. Sousa, V. L. R. da Matta, C. M. C. Gomes, C. E. P. Corbett, G. E. Kallas, F. T. Silveira, M. D. Laurenti

“…(V.) braziliensis (Lb) are responsible for a large clinical and immunopathological spectrum in human disease; while La may be responsible for anergic disease, Lb infection leads to cellular hypersensitivity. …”
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Profile of Chlamydia vaccine research: A bibliometric analysis by Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang

“…The current research area has focused on protective immunity and immunopathological response. Major outer membrane protein (MOMP) is the most common target vaccine antigen. …”
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