Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7 by Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie, Min Jin, Huanbai Xu

“…In inflammatory sites, high molecular weight hyaluronan fragments are degraded into lower molecular weight hyaluronan fragments (LMW-HA) to regulate immune responses. However, the function of LMW-HA in PTC progression remains to be elucidated. …”
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Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology by Chauveau, Carine, Roby, Dominique

“…Identification of RKS1 protein interactors and complexes was a first step, systems biology and reconstruction of protein networks were then used to decipher the molecular roadmap to the immune responses controlled by RKS1. Finally, exploration of the potential impact of key components of the RKS1-dependent gene network on leaf microbiota offers interesting and challenging perspectives to decipher how the plant immune systems interact with the microbial communities’ systems.…”
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Autologous Cytokine-Induced Killer Cell Immunotherapy Enhances Chemotherapy Efficacy against Multidrug-Resistant Tuberculosis by Peijun Tang, Xingnian Chen, Junchi Xu, Yunlong Hu, Zhijian Ye, Xiafang Wang, Yumei Xiao, Xinghua Shen, Jianping Zhang, Yanjun Feng, Cuilin Shi, Xin Yu, Lixian Yi, Xinchun Chen, Binfeng Lu, Ping Xu, Zhongwen Sun, Meiying Wu

“…T cell-mediated immunity plays a critical role in controlling Mycobacterium tuberculosis (Mtb) infection, and therefore, enhancing Mtb-specific T cell immune responses represents a promising therapeutic strategy against TB. …”
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Transcriptional Targeting of Mature Dendritic Cells with Adenoviral Vectors via a Modular Promoter System for Antigen Expression and Functional Manipulation by Ilka Knippertz, Andrea Deinzer, Jan Dörrie, Niels Schaft, Dirk M. Nettelbeck, Alexander Steinkasserer

“…To specifically target dendritic cells (DCs) to simultaneously express different therapeutic transgenes for inducing immune responses against tumors, we used a combined promoter system of adenoviral vectors. …”
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Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia by Federica Tonon, Stefano Di Bella, Fabiola Giudici, Verena Zerbato, Ludovica Segat, Raffaella Koncan, Andrea Misin, Barbara Toffoli, Pierlanfranco D’Agaro, Roberto Luzzati, Bruno Fabris, Stella Bernardi

“…Circulating adipokines have been associated with inflammatory burden and amplified or dysregulated immune responses. This study aimed to evaluate the discriminatory ability of adipokines to identify COVID-19 pneumonia and to assess disease severity. …”
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TRIM8 inhibits porcine epidemic diarrhoea virus replication by targeting and ubiquitinately degrading the nucleocapsid protein by Zhenbin Bi, Wei Wang, Shanshen Gu, Yajing Zhou, Zhengchang Wu, Wenbin Bao, Haifei Wang

“…This suggests that TRIM8 plays a crucial role in boosting antiviral immune responses against PEDV infection. Our findings provide new insights into the functions and mechanisms of TRIM8 in regulating PEDV infection and highlight its potential as a molecular target for the prevention and control of this virus.…”
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Gut mycobiome and neuropsychiatric disorders: insights and therapeutic potential by Ines Hadrich, Mariem Turki, Mariem Turki, Imen Chaari, Imen Chaari, Balkiss Abdelmoula, Rahma Gargouri, Nahed Khemakhem, Dhawia Elatoui, Fatma Abid, Sonda Kammoun, Sonda Kammoun, Mona Rekik, Mona Rekik, Samir Aloulou, Samir Aloulou, Mariem Sehli, Mariem Sehli, Aymen Ben Mrad, Aymen Ben Mrad, Sourour Neji, Fabian M. Feiguin, Jihene Aloulou, Jihene Aloulou, Nouha Bouayed Abdelmoula, Hayet Sellami, Hayet Sellami

“…Studies indicate that specific fungal populations, such as Candida and Saccharomyces, may influence neuroinflammation, gut permeability and immune responses, thereby affecting mental health outcomes.ConclusionUnderstanding the gut mycobiome’s role in neuropsychiatric disorders opens new avenues for therapeutic interventions, including antifungal treatments, probiotics, and dietary modifications. …”
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Cryo-thermal therapy reshaped the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy by Shicheng Wang, Peng Peng, Junjun Wang, Zelu Zhang, Ping Liu, Lisa X. Xu

“…Conclusions Our results suggest that CTT can significantly reshape the tumor immunosuppressive microenvironment and convert “cold tumors” into “hot tumors,” thereby enhancing ACT-induced immune responses and maximizing the therapeutic effect of ACT.…”
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Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex by Xiaotong Diao, Qinghong Shang, Mengqi Guo, Yubin Huang, Meina Zhang, Xiaoyu Chen, Yinping Liang, Xiangnan Sun, Fan Zhou, Jingjing Zhuang, Shuang-Jiang Liu, Christoph F. A. Vogel, Fraydoon Rastinejad, Dalei Wu

“…Upon ligand binding, AHR translocates from the cytoplasm to nucleus, forming a transcriptionally active complex with aryl hydrocarbon receptor nuclear translocator (ARNT), for DNA binding and initiation of gene expression programs that include cellular detoxification pathways and immune responses. Here, we examine the molecular mechanisms governing AHR’s high-affinity binding and activation by a diverse group of ligands. …”
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MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway by Pei Huang, Guangli Yang, Pingping Zhang, Yin Zhu, Yaning Guan, Jian Sun, Qian Li, Yang An, Xiaoqi Shi, Juanjuan Zhao, Chaohong Liu, Zhixu He, Yan Chen, Zuochen Du

“…Furthermore, MAPK4 KO mice exhibit impaired T cell-independent humoral immune responses. Mechanistically, MAPK4 inhibits the activation of the PI3K signaling pathway in B cells by activating the IRF4-SHIP1 pathway. …”
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Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advan... by Shigeru Yutani, Kazuomi Ueshima, Kazumichi Abe, Atsushi Ishiguro, Junichi Eguchi, Satoko Matsueda, Nobukazu Komatsu, Shigeki Shichijo, Akira Yamada, Kyogo Itoh, Tetsuro Sasada, Masatoshi Kudo, Masanori Noguchi

“…To evaluate safety and immune responses of personalized peptide vaccination (PPV) for hepatitis C virus- (HCV-) positive advanced hepatocellular carcinoma (HCC). …”
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Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy by Zhihui Zhang, Haifeng Wang, Li Zhang, Rebecca Crew, Nan Zhang, Xiaolei Liu, Yanfang Jiang

“…The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. …”
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Genetic Comparison of Stemness of Human Umbilical Cord and Dental Pulp by Chung-Min Kang, Hyunok Kim, Je Seon Song, Byung-Jai Choi, Seong-Oh Kim, Han-Sung Jung, Seok-Jun Moon, Hyung-Jun Choi

“…Genes related to cell proliferation, angiogenesis, and immune responses were expressed at higher levels in UC, whereas genes related to growth factor and receptor activity and signal transduction were more highly expressed in DP. …”
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Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency by Jungnam Lee, Naweed Mohammad, Kyudong Han, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban, Karina A. Serban

“…Despite the antimicrobial activities of α-defensins by direct bacterial killing and by modulation of immune responses, AATD individuals are paradoxically burdened by recurrent exacerbation triggered by bacterial infections, frequently with nontypeable Haemophilus influenzae (NTHi). …”
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Phenotypic Characterization of Circulating CD4+ T Cells in ANCA-Associated Vasculitis by Sandra Lilliebladh, Åsa Johansson, Åsa Pettersson, Sophie Ohlsson, Thomas Hellmark

“…T cell-mediated immune responses are thought to play an important role in the pathogenesis of anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitides (AAV). …”
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Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine by Izadiyan Z, Misran M, Kalantari K, Webster TJ, Kia P, Basrowi NA, Rasouli E, Shameli K

“…The integration of immunotherapeutic agents within liposomes marks a paradigm shift, enabling the design of ‘immuno-modulatory hubs’ capable of orchestrating precise immune responses while facilitating theranostic applications. …”
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Examining alternative approaches to antibiotic utilisation: A critical evaluation of phage therapy and antimicrobial peptides combination as potential alternatives by Chibuzo Vincent Alisigwe, Chibuzor Stanley Ikpa, Uchenna Joseph Otuonye

“…However, concerns about phage evolution potentially eliciting human immune responses necessitate additional investigation to enhance phage therapy. …”
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Association between changes in genital immune markers and vaginal microbiome transitions in bacterial vaginosis by Philipp Foessleitner, Briah Cooley Demidkina, Wafae El-Arar, Miles Goldenberg, Meena Murthy, Agnes Bergerat, Ofri Bar, Douglas S. Kwon, Caroline M. Mitchell

“…This prospective study aimed to assess associations between microbial changes and mucosal immune responses in BV patients. Therefore, samples from 20 premenopausal women with BV and treated with metronidazole were analyzed. …”
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Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori. by Md Nahian, Md Rasel Khan, Fabiha Rahman, Hossain Mohammed Reza, Imren Bayil, Tanjum Ahmed Nodee, Tabassum Basher, Mostafizur Rahaman Sany, Rabeya Najnin Munmun, S M Ariful Habib, Lincon Mazumder, Mrityunjoy Acharjee

“…These analyses suggest that the proposed vaccines may elicit potent immune responses against H. pylori, but laboratory validation is needed to verify their safety and immunogenicity.…”
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Exploring Antibacterial Activity of Fish Protein Hydrolysate In Vitro Against Vibrio Strains and Disease Resistance to V. harveyi in Turbot (Scophthalmus maximus) by Yuliang Wei, Lu Wang, Yanlu Li, Qiang Ma, Mengqing Liang, Houguo Xu

“…Results of the feeding trial showed that FPH enhanced antioxidant and immune responses before V. harveyi challenge as modulating immunoglobulin M (IgM), catalase (CAT), and myeloperoxidase (MPO) activities in serum, as well as the number of goblet cells in the intestine. …”
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