Effects of stress hyperglycemia ratio upon long-lasting prognosis in coronary artery disease patients with or lacking chronic renal impairment: findings from a Chinese multi-center... by Jielan Wu, Jin Liu, Ziyao Yuan, Shangyi Tang, Weipeng Zhang, Yulong Xiang, Jinming Chen, Qiqiang Lin, Wei Guo, Yibo He, Haozhang Huang, Xiaozhao Lu, Jingru Deng, Huangtao Ruan, Rengui Jiang, Shiqun Chen, Yong Liu

“…The present study was designed to elucidate the relation of SHR with prolonged prognosis and the value of SHR in predicting the long-term all-cause and cardiovascular death of CAD patients with CKD or non-CKD. Methods We assessed 45,780 adults with CAD from a Chinese multi-center registry. …”
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Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and l... by Li Chen, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry Kok Yen Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Markus R. Wenk, Sartaj Ahmad Mir

“…Higher maternal ApoC-I and ApoC-III concentrations at preconception were significantly associated with shorter gestational age of the offspring. Interpretation: We describe the longitudinal landscape of maternal circulating apolipoproteins from preconception to postpartum and their associations with maternal metabolic risk factors and offspring birth outcomes. …”
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A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions by Jun Sun, Masanori Aikawa, Hassan Ashktorab, Noam D. Beckmann, Noam D. Beckmann, Michael L. Enger, Joaquin M. Espinosa, Xiaowu Gai, Xiaowu Gai, Benjamin D. Horne, Benjamin D. Horne, Paul Keim, Paul Keim, Paul Keim, Jessica Lasky-Su, Rebecca Letts, Cheryl L. Maier, Meisha Mandal, Lauren Nichols, Nadia R. Roan, Nadia R. Roan, Mark W. Russell, Jacqueline Rutter, George R. Saade, George R. Saade, Kumar Sharma, Kumar Sharma, Stephanie Shiau, Stephen N. Thibodeau, Samuel Yang, Lucio Miele, NIH Researching COVID to Enhance Recovery (RECOVER) Consortium

“…Many of our recommendations have already been considered by the NIH through the peer-review process, resulting in the creation of a systems biology panel that is currently designing the studies we proposed. This system biology strategy, coupled with modern data science approaches, will dramatically improve our prospects for accurate disease subtype identification, biomarker discovery and therapeutic target identification for precision treatment. …”
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Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation by Oana Hangiu, Oana Hangiu, Oana Hangiu, Rocío Navarro, Susana Frago, Laura Rubio-Pérez, Laura Rubio-Pérez, Laura Rubio-Pérez, Antonio Tapia-Galisteo, Antonio Tapia-Galisteo, Antonio Tapia-Galisteo, Laura Díez-Alonso, Laura Díez-Alonso, Laura Díez-Alonso, Marina Gómez-Rosel, Marina Gómez-Rosel, Marina Gómez-Rosel, Noelia Silva-Pilipich, Noelia Silva-Pilipich, Lucía Vanrell, Cristian Smerdou, Cristian Smerdou, Kenneth A. Howard, Laura Sanz, Luis Álvarez-Vallina, Luis Álvarez-Vallina, Luis Álvarez-Vallina, Marta Compte

“…The in vivo efficacy of the mRNA-encoded bispecific antibodies was evaluated in xenograft tumor models expressing EGFR.ResultsWe investigated the combined effect of two mRNA-encoded Fc-free bispecific antibodies with complementary mechanisms of action: an EGFR-targeting TCE and a half-life extended PD-L1 x 4-1BB costimulatory antibody. …”
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A Conversation with Toyin Falola on the future of Yoruba Language by Oyesina Fadare

“…Wọn gbagb ́ ọ pe ti ọmọ bá ti mọ e ̀dè Gẹẹ̀ si, o ́ ́ ti kogo ja; ko ́ ̀ sí ipò ti ́ kò le ̀ dé ni aye ́ . Ile ́ í we to n ko ̀ ọmọ ni ede Gẹẹ̀ si ni ́ ̀kan ni won ma n fẹ ra ́ n a ́ ẁ ọn ọmọ wọn lo. …”
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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

“…Each new or modified checklist item is accompanied by a detailed description, its rationale with supportive evidence, and examples of good reporting curated from EPDF trial protocols covering a range of therapeutic areas and interventions. We recommend utilising this paper alongside the SPIRIT statement, and any relevant extensions, to enhance the development and review of EPDF trial protocols.By facilitating adoption of the SPIRIT-DEFINE statement for EPDF trials, this E&E document can promote enhancement of methodological rigour, patient safety, transparency, and facilitate the generation of high-quality, reproducible evidence that will strengthen the foundation of early phase research and ultimately improve patient outcomes. …”
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A randomized trial of blended first aid education for the public

“…The effectiveness of learning was measured through pre- and post-learning evaluation forms using 0-10 Likert scales and questions on first aid knowledge for both face-to-face and blended groups, and additionally, post-online (blended learners only).Results: We found comparable results between face-to-face and blended learning for improving learner knowledge of first aid. …”
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Steady-state mixing state of black carbon aerosols from a particle-resolved model by Z. Zhang, Z. Zhang, J. Wang, J. Wang, J. Wang, J. Wang, N. Riemer, C. Liu, C. Liu, Y. Jin, Y. Jin, Z. Tian, Z. Tian, J. Cai, J. Cai, Y. Cheng, Y. Cheng, G. Chen, G. Chen, B. Wang, B. Wang, S. Wang, A. Ding, A. Ding

“…However, due to computational constraints, the mixing state is challenging to accurately represent in large-scale models. In this study, we employ a particle-resolved model to simulate the evolution of BC mixing state based on field observation. …”
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Clinical, genomic, and histopathologic diversity in cerebral cavernous malformations by Jian Ren, Daochao Wang, Leiming Wang, Chendan Jiang, An Tian, Ziwei Cui, Yeqing Ren, Lisong Bian, Gao Zeng, Guolu Meng, Yongzhi Shan, Jiantao Liang, Xinru Xiao, Jie Tang, Yukui Wei, Chuan He, Liyong Sun, Yongjie Ma, Jiaxing Yu, Guilin Li, Ming Ye, Peng Hu, Jingwei Li, Ye Li, Lijian Niu, Qianwen Li, Feng Ling, Jan-Karl Burkhardt, Hongqi Zhang, Tao Hong

“…This study aimed to clarify the clinical, genetic, and pathological features of CCMs using a multicenter cohort across three Chinese centers. We analyzed 290 surgical specimens from symptomatic CCM patients, utilizing whole-exome sequencing, droplet digital PCR, and targeted panel sequencing, alongside immunohistology to examine genotypic and phenotypic differences. …”
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Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding by Yinghao Li, Dongling Xiao, Weixi Yan, Meilin Jiang, Ju Tan, Zhongliang Qin, Jingting Zhou, Yue Sun, Mingcan Yang, Guanyuan Yang, Yawei Gu, Yong Liu, Chuhong Zhu

“…Here, inspired by the principle of chromatin assembly, we present a tissue-conformable tough matrix for robust sealing of severe bleeding. …”
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Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study by Sandra Dos Santos, Anne-Sophie Valentin, Mathilde Farizon, Manon Charbonneau, Mohamed Riadh Boukhris, Roselyne Brat, Fabiana Cazzorla, Jennifer Chauvel, Fabrice Cneude, Pauline Coutable, Maryvonne Demasure, Emeline Duminil, Vénonique Faraut-Derouin, Maud Gits Muselli, Valérie Gorin, Rosemary Goujon, Melinda Guillouche-Puissant, Nadine Hacinlioglu, Caroline Landelle, Annick Lefebvre, Elise Leroy-Terquem, Aurore Martinet, Camille Massebeuf, Nadia Mazille Orfanos, Guillaume Menard, Laure Menvielle, Vanessa Monin, Virginie Morange, Juliana Patkai, Nathalie Perrault, Emilie Prat, Nathalie van der Mee-Marquet

“…The incidence of S. haemolyticus-associated CLABSIs in French neonates is increasing, but the mechanisms underlying this trend remain unclear.MethodsWe examined microorganisms in 108 central line infusion sets used in preterm infants across 12 neonatal intensive care units, and collected at the time of removal.ResultsThe infusion sets varied widely in type (28 types; 1-6 parts) and length (10-180 cm, mean 52.9 cm). …”
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Jiedu Xiaozheng Decoction Augments 5-fluorouracil Induced Anti-hepatic Carcinoma Effect <italic>in Vitro</italic> and <italic>in Vivo</italic> by Zhiyun CAO, Liangpu ZHENG, Wei LIN, Xuzheng CHEN, Xiaoqin ZHU, Jiumao LIN, Wei LIN, Jian DU

“…The previous studies found that JXD inhibited tumor growth by inducing apoptosis, blocking cell cycle and anti-angiogenesis. In this study, we evaluated anti-cancer effects of JXD ethyl acetate extract(EE-JXD)combined with 5-FU <italic>in vitro</italic> and <italic>in vivo</italic> in order to explore the biological mechanism and provide more experimental basis for clinical application of JXD.Methods：EE-JXD was prepared according to the describe in the previous study. …”
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Association of exposure to second-hand smoke during childhood with blood DNA methylation by Marta Cosin-Tomas, Thanh Hoang, Cancan Qi, Giulietta S. Monasso, Ryan Langdon, Simon Kebede Merid, Lucinda Calas, Paula de Prado-Bert, Rebecca Richmond, Vincent VW Jaddoe, Liesbeth Duijts, John Wright, Isabella Annesi-Maesano, Regina Grazuleviciene, Marianna Karachaliou, Gerard H. Koppelman, Erik Melén, Olena Gruzieva, Martine Vrijheid, Paul Yousefi, Janine F. Felix, Stephanie J. London, Mariona Bustamante

“…While numerous studies have linked maternal smoking during pregnancy (MSDP) to widespread differences in child blood DNA methylation (DNAm), research specifically examining postnatal SHS exposure remains sparse. To address this gap, we conducted epigenome-wide meta-analyses to identify associations of postnatal SHS and child blood DNAm. …”
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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

“…For each new or modified checklist item, we provide a detailed description and its rationale with supporting evidence, and present examples from EPDF trial reports published in peer-reviewed scientific journals. …”
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Coronary plaque characteristics quantified by artificial intelligence-enabled plaque analysis: Insights from a multi-ethnic asymptomatic US population by Guadalupe Flores Tomasino, Caroline Park, Kajetan Grodecki, Jolien Geers, Donghee Han, Andrew Lin, Keiichiro Kuronuma, Nipun Manral, Emily Xing, Heidi Gransar, Sebastien Cadet, Alan Rozanski, Piotr J. Slomka, Michelle Williams, Daniel S. Berman, Damini Dey

“…Background: Ethnic differences in coronary atherosclerosis remain to be fully elucidated. We aimed to assess quantitative plaque characteristics from coronary CT Angiography (CCTA) in relation to ethnicity and cardiovascular risk factors in a multi-ethnic asymptomatic US population. …”
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Trivalent recombinant protein vaccine induces cross-neutralization against XBB lineage and JN.1 subvariants: preclinical and phase 1 clinical trials by Jingyun Yang, Weiqi Hong, Huashan Shi, Cai He, Hong Lei, Yanan Zhou, Hao Yang, Aqu Alu, Zimin Chen, Yun Yang, Wenhai Yu, Cong Tang, Junbin Wang, Bai Li, Qing Huang, Jiong Li, Li Yang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Zhaoming Su, Yuquan Wei, Qiangming Sun, Shuaiyao Lu, Zhenling Wang, Youchun Wang, Guangwen Lu, Weimin Li, Xiawei Wei

“…Abstract The immune escape capacities of XBB variants necessitate the authorization of vaccines with these antigens. In this study, we produce three recombinant trimeric proteins from the RBD sequences of Delta, BA.5, and XBB.1.5, formulating a trivalent vaccine (Tri-Vac) with an MF59-like adjuvant at a 1:1:4 ratio. …”
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Implementing a nurse-enabled, integrated, shared-care model involving specialists and general practitioners in early breast cancer post-treatment follow-up (EMINENT): a single-cent... by Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel McKavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma McKinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. McPhail, Katharine Cuff, Laisa Teleni, Jon Emery

“…Many breast cancer survivors face ongoing unmet needs that may benefit from a multidisciplinary, shared-care approach. We aimed to evaluate the feasibility and preliminary effectiveness of implementing nurse-enabled, shared-follow-up care between the acute and primary care setting for early-stage breast cancer. …”
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Life satisfaction around the world: Measurement invariance of the Satisfaction With Life Scale (SWLS) across 65 nations, 40 languages, gender identities, and age groups. by Viren Swami, Stefan Stieger, Martin Voracek, Toivo Aavik, Hamed Abdollahpour Ranjbar, Sulaiman Olanrewaju Adebayo, Reza Afhami, Oli Ahmed, Annie Aimé, Marwan Akel, Hussam Al Halbusi, George Alexias, Khawla F Ali, Nursel Alp-Dal, Anas B Alsalhani, Sara Álvarez-Solas, Ana Carolina Soares Amaral, Sonny Andrianto, Trefor Aspden, Marios Argyrides, John Jamir Benzon R Aruta, Stephen Atkin, Olusola Ayandele, Migle Baceviciene, Radvan Bahbouh, Andrea Ballesio, David Barron, Ashleigh Bellard, Sóley Sesselja Bender, Kerime Derya Beydaǧ, Gorana Birovljević, Marie-Ève Blackburn, Teresita Borja-Alvarez, Joanna Borowiec, Miroslava Bozogáňová, Solfrid Bratland-Sanda, Matthew H E M Browning, Anna Brytek-Matera, Marina Burakova, Yeliz Çakır-Koçak, Pablo Camacho, Vittorio Emanuele Camilleri, Valentina Cazzato, Silvia Cerea, Apitchaya Chaiwutikornwanich, Trawin Chaleeraktrakoon, Tim Chambers, Qing-Wei Chen, Xin Chen, Chin-Lung Chien, Phatthanakit Chobthamkit, Bovornpot Choompunuch, Emilio J Compte, Jennifer Corrigan, Getrude Cosmas, Richard G Cowden, Kamila Czepczor-Bernat, Marcin Czub, Wanderson Roberto da Silva, Mahboubeh Dadfar, Simon E Dalley, Lionel Dany, Jesus Alfonso D Datu, Pedro Henrique Berbert de Carvalho, Gabriel Lins de Holanda Coelho, Avila Odia S De Jesus, Sonia Harzallah Debbabi, Sandesh Dhakal, Francesca Di Bernardo, Donka D Dimitrova, Jacinthe Dion, Barnaby Dixson, Stacey M Donofrio, Marius Drysch, Hongfei Du, Angel M Dzhambov, Claire El-Jor, Violeta Enea, Mehmet Eskin, Farinaz Farbod, Lorleen Farrugia, Leonie Fian, Maryanne L Fisher, Michał Folwarczny, David A Frederick, Matthew Fuller-Tyszkiewicz, Adrian Furnham, Antonio Alías García, Shulamit Geller, Marta Ghisi, Alireza Ghorbani, Maria Angeles Gomez Martinez, Sarah Gradidge, Sylvie Graf, Caterina Grano, Gyöngyvér Gyene, Souheil Hallit, Motasem Hamdan, Jonathan E Handelzalts, Paul H P Hanel, Steven R Hawks, Issa Hekmati, Mai Helmy, Tetiana Hill, Farah Hina, Geraldine Holenweger, Martina Hřebíčková, Olasupo Augustine Ijabadeniyi, Asma Imam, Başak İnce, Natalia Irrazabal, Rasa Jankauskiene, Ding-Yu Jiang, Micaela Jiménez-Borja, Verónica Jiménez-Borja, Evan M Johnson, Veljko Jovanović, Marija Jović, Marko Jović, Alessandra Costa Pereira Junqueira, Lisa-Marie Kahle, Adam Kantanista, Ahmet Karakiraz, Ayşe Nur Karkin, Erich Kasten, Salam Khatib, Nuannut Khieowan, Patricia Joseph Kimong, Litza Kiropoulos, Joshua Knittel, Neena Kohli, Mirjam Koprivnik, Aituar Kospakov, Magdalena Król-Zielińska, Isabel Krug, Garry Kuan, Yee Cheng Kueh, Omar Kujan, Miljana Kukić, Sanjay Kumar, Vipul Kumar, Nishtha Lamba, Mary Anne Lauri, Maria Fernanda Laus, Liza April LeBlanc, Hyejoo J Lee, Małgorzata Lipowska, Mariusz Lipowski, Caterina Lombardo, Andrea Lukács, Christophe Maïano, Sadia Malik, Mandar Manjary, Lidia Márquez Baldó, Martha Martinez-Banfi, Karlijn Massar, Camilla Matera, Olivia McAnirlin, Moisés Roberto Mebarak, Anwar Mechri, Juliana Fernandes Filgueiras Meireles, Norbert Mesko, Jacqueline Mills, Maya Miyairi, Ritu Modi, Adriana Modrzejewska, Justyna Modrzejewska, Kate E Mulgrew, Taryn A Myers, Hikari Namatame, Mohammad Zakaria Nassani, Amanda Nerini, Félix Neto, Joana Neto, Angela Nogueira Neves, Siu-Kuen Ng, Devi Nithiya, Jiaqing O, Sahar Obeid, Camila Oda-Montecinos, Peter Olamakinde Olapegba, Tosin Tunrayo Olonisakin, Salma Samir Omar, Brynja Örlygsdóttir, Emrah Özsoy, Tobias Otterbring, Sabine Pahl, Maria Serena Panasiti, Yonguk Park, Muhammad Mainuddin Patwary, Tatiana Pethö, Nadezhda Petrova, Jakob Pietschnig, Sadaf Pourmahmoud, Vishnunarayan Girishan Prabhu, Vita Poštuvan, Pavol Prokop, Virginia L Ramseyer Winter, Magdalena Razmus, Taotao Ru, Mirjana Rupar, Reza N Sahlan, Mohammad Salah Hassan, Anđela Šalov, Saphal Sapkota, Jacob Owusu Sarfo, Yoko Sawamiya, Katrin Schaefer, Michael Schulte-Mecklenbeck, Veya Seekis, Kerim Selvi, Mehdi Sharifi, Anita Shrivastava, Rumana Ferdousi Siddique, Valdimar Sigurdsson, Vineta Silkane, Ana Šimunić, Govind Singh, Alena Slezáčková, Christine Sundgot-Borgen, Gill Ten Hoor, Passagorn Tevichapong, Arun Tipandjan, Jennifer Todd, Constantinos Togas, Fernando Tonini, Juan Camilo Tovar-Castro, Lise Katrine Jepsen Trangsrud, Pankaj Tripathi, Otilia Tudorel, Tracy L Tylka, Anar Uyzbayeva, Zahir Vally, Edmunds Vanags, Luis Diego Vega, Aitor Vicente-Arruebarrena, Jose Vidal-Mollón, Roosevelt Vilar, Hyxia Villegas, Mona Vintilă, Christoph Wallner, Mathew P White, Simon Whitebridge, Sonja Windhager, Kah Yan Wong, Eric Kenson Yau, Yuko Yamamiya, Victoria Wai Lan Yeung, Marcelo Callegari Zanetti, Magdalena Zawisza, Nadine Zeeni, Martina Zvaríková, Ulrich S Tran

“…The Satisfaction With Life Scale (SWLS) is a widely used self-report measure of subjective well-being, but studies of its measurement invariance across a large number of nations remain limited. Here, we utilised the Body Image in Nature (BINS) dataset-with data collected between 2020 and 2022 -to assess measurement invariance of the SWLS across 65 nations, 40 languages, gender identities, and age groups (N = 56,968). …”
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The effect of climate change on the simulated streamflow of six Canadian rivers based on the CanRCM4 regional climate model by V. K. Arora, A. Lima, R. Shrestha

“…The simulated streamflow regime for the Fraser and Columbia rivers shifts from a snow-dominated to a hybrid or rainfall-dominated regime towards the end of this century in the RCP 8.5 scenario. While we expect the climate change signal from CanRCM4 to be higher than that from other climate models, owing to the higher-than-average climate sensitivity of its parent global climate model, the results presented here provide a consistent overview of hydrological changes across six major Canadian river basins in response to a warmer climate.…”
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Integrated microbiome, transcriptome and metabolome insight into the alleviating mechanisms of sheep milk in a DSS-induced colitis mouse model by Wenna Yao, Ruilin Du, Shuo Yan, Teligun Bao, Huimin Zhang, Fang Yang, Yue Xue, Yulong Zhao, Siqin Bao, Xihe Li, Yongli Song

“…In the DSS group, LGR5, KI67, and MUC2 were significantly lower than in the CON group, but the SM treatment increased these protein expression levels. We also found that the tight junction proteins expression level was elevated in the SM group compared to the DSS group. …”
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