New Horizons In The Treatment Of Metastatic Castrate Resistant Prostate Cancer by Zein El Amir

“…The speciality that benefits the most from this subject in clinical practice is surgery while the rest of the specialities rely on anatomy during physical exams, symptom interpretation, patient education, and interpretation of radiological images.   If we talk specifically about the undergraduate medical curriculum, anatomy is a vital component of the basic sciences taught during the first one or two years of medical or dental school. …”
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Severe obesity, high inflammation, insulin resistance with risks of all-cause mortality and all-site cancers, and potential modification by healthy lifestyles by Qianyun Jin, Siwen Liu, Yunmeng Zhang, Yuting Ji, Jie Wu, Hongyuan Duan, Xiaomin Liu, Jingjing Li, Yacong Zhang, Zhangyan Lyu, Fangfang Song, Fengju Song, Hua Li, Yubei Huang

“…During a median follow-up of 11.0 years, we identified 8844 deaths and 20,944 cancer cases. …”
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HnRNPR-mediated UPF3B mRNA splicing drives hepatocellular carcinoma metastasis by Hong Wang, Dong Qian, Jiabei Wang, Yao Liu, Wenguang Luo, Hongyan Zhang, Jingjing Cheng, Heng Li, Yang Wu, Wuhan Li, Jing Wang, Xia Yang, Tianzhi Zhang, Dong Han, Qinyao Wang, Chris Zhiyi Zhang, Lianxin Liu

“…RNA immunoprecipitation, and in vitro and in vivo models were used to explore the role of UPF3B-S and the underlying mechanisms. Results: We show that splicing factor HnRNPR binds to the pre-mRNA of UPF3B via its RRM2 domain to generate an exon 8 exclusion truncated splice variant UPF3B-S. …”
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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials by Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F. Kelley, Sarah Kabbani, Srilatha Edupuganti, Allison Beck, Florence Kaltovich, Tamar Murray, Susanna Tsukerman, Derick Carr, Carl Ashman, Daphne A. Stanley, Aurélie Ploquin, Robert T. Bailer, Richard Schwartz, Fatim Cham, Allan Tindikahwa, Zonghui Hu, Ingelise J. Gordon, Nadine Rouphael, Katherine V. Houser, Emily E. Coates, Barney S. Graham, Richard A. Koup, John R. Mascola, Nancy J. Sullivan, Merlin L. Robb, Julie A. Ake, Kirsten E. Lyke, Mark J. Mulligan, Julie E. Ledgerwood, Hannah Kibuuka, the VRC 208 and RV 422 study team

“…Abstract Ebola virus disease (EVD) is a filoviral infection caused by virus species of the Ebolavirus genus including Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV). We investigated the safety and immunogenicity of a heterologous prime-boost regimen involving a chimpanzee adenovirus 3 vectored Ebola vaccine [either monovalent (cAd3-EBOZ) or bivalent (cAd3-EBO)] prime followed by a recombinant modified vaccinia virus Ankara EBOV vaccine (MVA-EbolaZ) boost in two phase 1/1b randomized open-label clinical trials in healthy adults in the United States (US) and Uganda (UG). …”
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A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings by Steven P. Treon, Camille N. Kotton, David J. Park, Giorgia Moranzoni, Camilla K. Lemvigh, Joseph C. Gathe, Tilly A. Varughese, Christopher F. Barnett, Johnny M. Belenchia, Nina M. Clark, Charles M. Farber, Muhammad Bilal Abid, Gulrayz Ahmed, Christopher J. Patterson, Maria L. Guerrera, Jacob D. Soumerai, Vipheaviny A. Chea, Isabel P. Carulli, Jackson Southard, Shuqiang Li, Catherine J. Wu, Kenneth J. Livak, Eric Holmgren, Pil Kim, Carrie Shi, Holly Lin, Vanitha Ramakrishnan, Ying Ou, Scott Olszewski, Lars Rønn Olsen, Derin B. Keskin, Derin B. Keskin, Zachary R. Hunter, Christopher Tankersley, Todd Zimmerman, Binod Dhakal

“…Bruton tyrosine kinase (BTK) is involved in innate immunity, and BTK inhibitors block cytokine release. We assessed the next-generation BTK inhibitor zanubrutinib in SARS-CoV-2–infected patients with respiratory distress.MethodCohort 1 had a prospective, randomized, double-blind, placebo-controlled design; cohort 2 had a single-arm design. …”
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Anatomy In The Undergraduate Medical Curriculum; Blending The Old And New by Ayesha Yousaf

“…[iv] The specialty that benefits the most from this subject in clinical practice is surgery while the rest of the specialties rely on anatomy while during physical exams, symptom interpretation, patient education and interpretation of radiological images.[v]  If we talk specifically about the undergraduate medical curriculum, anatomy is a vital component of the basic sciences taught during the first one or two years of medical or dental school. …”
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Left ventricular global longitudinal strain is associated with filling pressure and cardiac output in an outpatient setting: Insights from CardioMEMS™ by Francisco Barbas de Albuquerque, Rita Teixeira, Tiago Pereira-da-Silva, Vera Ferreira, António Valentim Gonçalves, Rita Ilhão Moreira, Ana Teresa Timóteo, Ana Galrinho, Luísa Branco, Pedro Rio, João Alves, Sofia Barquinha, Duarte Cacela, Rui Cruz Ferreira

“…Nevertheless, it is not clear whether LVGLS correlates with filling pressures and cardiac output (CO) in an ambulatory setting. We aimed to assess whether LVGLS is associated with invasive pulmonary artery pressures (PAP) and CO in outpatients using the invasive remote monitoring CardioMEMS™ system. …”
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Intestine-derived fibroblast growth factor 19 alleviates lipopolysaccharide-induced liver injury by regulating bile acid homeostasis and directly improving oxidative stress by Xiaomeng Tang, Jingjing Ning, Yilin Zhao, Shuyun Feng, Lujing Shao, Tiantian Liu, Huijie Miao, Yucai Zhang, Chunxia Wang

“…However, the roles and underlying mechanisms of FGF19 in SALI are still unclear. Methods: We conducted a case–control study that included 58 pediatric patients aged from 1 month to 14-years-old diagnosed with sepsis at Shanghai Children's Hospital from January to December 2018 and 30 healthy individuals. …”
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Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells by Simon N. Chu, Eric Soupene, Devesh Sharma, Roshani Sinha, Travis McCreary, Britney Hernandez, Huifeng Shen, Beeke Wienert, Chance Bowman, Han Yin, Benjamin J. Lesch, Kun Jia, Kathleen A. Romero, Zachary Kostamo, Yankai Zhang, Tammy Tran, Marco Cordero, Shota Homma, Jessica P. Hampton, James M. Gardner, Bruce R. Conklin, Tippi C. MacKenzie, Vivien A. Sheehan, Matthew H. Porteus, M. Kyle Cromer

“…Despite progress in genome editing treatments for β-thalassemia, there is no analogous curative option for α-thalassemia. To address this, we designed a Cas9/AAV6-mediated genome editing strategy that integrates a functional α-globin gene into the β-globin locus in α-thalassemia patient-derived hematopoietic stem and progenitor cells (HSPCs). …”
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The ratio of transverse to longitudinal turbulent velocity statistics for aircraft measurements by J. L. Nowak, M. Lothon, D. H. Lenschow, S. P. Malinowski

“…The goal of this study is to document the statistics of those ratios and exponents derived from aircraft observations, quantify their departures from theoretical predictions, and point out the differences among the aircraft.</p> <p>We estimate the transverse-to-longitudinal ratios and the scaling exponents from in situ high-rate turbulence measurements collected by three research aircraft during four field experiments in two regimes of the marine atmospheric boundary layer: shallow trade-wind convection and subtropical stratocumulus. …”
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Supercharged nanoadhesive through co-assembly of recombinant protein and tetrahedral DNA for corneal transplantation by Jing Zhao, Feng Zhang, Zhe Zhang, Zhenhua Li, Yanze Yu, Bingqing Sun, Binghong Yu, Yong Ma, Xuan Ding, Liyin Wang, Lifei Zheng, Wenguo Cui, Xingtao Zhou

“…A major challenge is achieving rapid adhesion without introducing polymer barriers or chemical toxicity from cross-linking. To address this, we developed a novel cornea-specific nanoadhesive constructed through protein-DNA co-assembly and applied it to corneal transplantation. …”
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Karel Janeček − a leading figure in Czech Music Theory and Pedagogy: his theoretical writings from the 1930s and 1940s by Miloš Hons

“…At this time, he also devoted himself to the analysis of Bedřich Smetana’s music. In these analyses we find the beginnings of his completely original concept of musical tectonics. …”
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A phase II double-blind multicentre, placebo-controlled trial to assess the efficacy and safety of alpelisib (BYL719) in paediatric and adult patients with Megalencephaly-CApillary... by Jean-Marc Treluyer, Benedicte Demeer, Laurence Faivre, Marc Bardou, Nathalie Boddaert, Paul Kuentz, Florence Petit, Christine Francannet, Pierre Vabres, Nadia Bahi-Buisson, Estelle Colin, Laurent Guibaud, Romaric Loffroy, Maxime Luu, Caroline Racine, Aurore Garde, Philippe Khau Van Kien, Aurore Curie, Nawale Hadouiri, Aurélie Espitalier, Agnès Maurer, Maud Carpentier, Adélaide Rega, Mouna Chebbi, Julie Charligny, Guillaume Canaud, Camille Fleck, Amelie Cransac, Elise Boucher-Brischoux, Adélaïde Brosseau-Beauvir, Florian Cherik, Alice Phan, Michaela Semeraro, Marion Nys, Charles Joris Roux, Alinoë Lavillaureix, Isabelle Maruani

“…Inclusions were completed by April 2024, with the end of follow-up in November 2026.Given the efficacy of alpelisib in patients with PROS, if the drug crosses the blood-brain barrier, we can expect a clinical benefit for patients with neurocognitive disorders.Ethics and dissemination Ethical approval was given by CPP Sud-Ouest et Outre-Mer I (reference: 2022-500197-34-01). …”
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Le sanctuaire romain du Vigneau à Pussigny (Indre-et-Loire) : un lieu de mémoire, de vie et d’accueil by Arnaud Coutelas, Sébastien Lepetz

“…In front of the double portico, a pit (FS1252) contained a large slab, likely from a megalithic building and hollowed out of a cupula, which we have interpreted as a possible altar buried on the ground, in the image of certain Chthonian cults.Although the data is incomplete for the eastern portion of the sanctuary, all evidence points to it facing west: interruption in the gallery walls, presence of the double portico, absence of structures in the axis of the cella, and installation of the slab in the FS1252 pit. …”
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Identification of a novel SPTB gene splicing mutation in hereditary spherocytosis: a case report and diagnostic insights by Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Xuemei Li, Li Wang, Li Wang, Li Wang, Li Wang, Qian Li, Qian Li, Qian Li, Qian Li, Qianqian Liu, Qianqian Liu, Qianqian Liu, Qianqian Liu, Chengyin He, Li Zhang, Li Zhang, Li Zhang, Li Zhang, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Junling Tang, Junling Tang, Junling Tang, Junling Tang

“…Mutations in key genes, including SPTB, ANK1, SLC4A1, SPTA1, and EPB42, are commonly implicated in HS.Case PresentationWe report the case of a 22-year-old female presenting with anemia, jaundice, and a family history of splenectomy. …”
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GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancer by Yujing Xuan, Wenyi Yan, Ruimin Wang, Xibin Wang, Yu Guo, Huilin Dun, Ziyan Huan, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang, Pengju Wang

“…Oncolytic viruses armed with immunoregulatory molecules are promising strategies to overcome limited efficacy and target inaccessible and metastatic tumors. In this study, we constructed a tumor-selective vaccinia virus (VV) with deletions of the TK and A49 genes (VVLΔTKΔA49, VVL-DD) using CRISPR-Cas9-based homologous recombination. …”
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Bug off or bug out: mapping flight secrets of Triatoma garciabesi (Hemiptera: Reduviidae) through climate, geography, and greenery by Thaiane Verly, Thaiane Verly, Federico G. Fiad, Ana Laura Carbajal-de-la-Fuente, Ana Laura Carbajal-de-la-Fuente, Sebastián Pita, Romina V. Piccinali, Romina V. Piccinali, Patricia A. Lobbia, Paz Sánchez-Casaccia, Paz Sánchez-Casaccia, Paz Sánchez-Casaccia, Antonieta Rojas de Arias, María José Cavallo, Gisel V. Gigena, Claudia S. Rodríguez, María C. Vega-Gómez, Miriam Rolón, Julieta Nattero, Julieta Nattero, Julieta Nattero

“…These lineages occur across the species distribution range and coincide with different ecological regions. Here, we aim to examine how phenotypic variation in flight-related traits is structured, determine the association between these traits and geographic distance, and identify the climatic, geographic, and/or vegetation cover variables that best explain the morphometric variation in flight-related traits.MethodsA total of 198 males of T. garciabesi from 24 populations in Argentina and Paraguay were included in this study, covering almost the entire T. garciabesi distribution range. …”
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Impacts on and damage to European forests from the 2018–2022 heat and drought events by F. Knutzen, P. Averbeck, C. Barrasso, C. Barrasso, L. M. Bouwer, L. M. Bouwer, B. Gardiner, J. M. Grünzweig, S. Hänel, K. Haustein, K. Haustein, M. R. Johannessen, S. Kollet, M. M. Müller, J.-P. Pietikäinen, K. Pietras-Couffignal, K. Pietras-Couffignal, J. G. Pinto, D. Rechid, E. Rousi, A. Russo, A. Russo, L. Suarez-Gutierrez, L. Suarez-Gutierrez, S. Veit, S. Veit, J. Wendler, E. Xoplaki, D. Gliksman, D. Gliksman

“…</p> <p>Based on this assessment, we conclude that (i) European forests are highly vulnerable to drought and heat, with even resilient ecosystems at risk of severe damage; (ii) tailored strategies are essential to mitigate climate change impacts on European forests, incorporating regional differences in forest damage and resilience; and (iii) effective management requires harmonised data collection and enhanced monitoring to address future challenges comprehensively.…”
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Benchmarking data-driven inversion methods for the estimation of local CO₂ emissions from synthetic satellite images of XCO₂ and NO₂ by D. Santaren, J. Hakkarainen, G. Kuhlmann, E. Koene, F. Chevallier, I. Ialongo, H. Lindqvist, J. Nurmela, J. Tamminen, L. Amorós, D. Brunner, G. Broquet

“…., computationally light inversion methods that directly process information from satellite images, local winds, and meteorological data, without resorting to computationally expensive dynamical atmospheric transport models. We designed an objective benchmarking exercise to analyze and compare the performance of five different data-driven inversion methods: two implementations with different complexities for the cross-sectional flux approach (CSF and LCSF), as well as one implementation each for the integrated mass enhancement (IME), divergence (Div), and Gaussian plume (GP) model inversion approaches. …”
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Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors by Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu

“…The biological evaluation of compound 8 was performed by transwell, flow cytometry, laser scanning confocal microscopy, Western blot, CTESA and immunohistochemistry. Results: Here, we employed molecular hybridization methods to construct a series of quinazoline-2-indolinone derivatives as PI3Kα selective inhibitors. …”
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