Genome-wide association studies with prolapsed gland of the third eyelid in dogs by Yu Zeng, Yu Zeng, Yu Zeng, Cundong Feng, Zheli Jiang, Zheli Jiang, Zheli Jiang, Weian Du, Shan He, Shan He, Shan He, Xingnuan Li, Xingnuan Li, Xingnuan Li, Yi Fan, Yi Fan, Yi Fan, Xiao Ouyang, Xiao Ouyang, Xiao Ouyang, Bixin Huang, Bixin Huang, Bixin Huang, Yan Su, Yan Su, Yan Su, Siyu Wang, Siyu Wang, Siyu Wang, Rongxing Wei, Zonghao Dai, Peng Jin, Jianyun Liu, Jianyun Liu, Jianyun Liu, Qianyong Yang, Qianyong Yang, Qianyong Yang

“…To explore the genes involved in cherry eyes, we performed GO functional enrichment analysis. …”
Get full text

Malate initiates a proton-sensing pathway essential for pH regulation of inflammation by Yu-jia-nan Chen, Rong-chen Shi, Yuan-cai Xiang, Li Fan, Hong Tang, Gang He, Mei Zhou, Xin-zhe Feng, Jin-dong Tan, Pan Huang, Xiao Ye, Kun Zhao, Wen-yu Fu, Liu-li Li, Xu-ting Bian, Huan Chen, Feng Wang, Teng Wang, Chen-ke Zhang, Bing-hua Zhou, Wan Chen, Tao-tao Liang, Jing-tong Lv, Xia Kang, You-xing Shi, Ellen Kim, Yin-hua Qin, Aubryanna Hettinghouse, Kai-di Wang, Xiang-li Zhao, Ming-yu Yang, Yu-zhen Tang, Hai-long Piao, Lin Guo, Chuan-ju Liu, Hong-ming Miao, Kang-lai Tang

“…Cytosolic pH is a regulator of inflammatory response in macrophages. Here, we found that L-malate exerts anti-inflammatory effect via BiP-IRF2BP2 signaling, which is a sensor of cytosolic pH in macrophages. …”
Get full text

Nécropoles multipolaires et élaboration d’un nouveau modèle socio-politique au premier âge du Fer : réflexions à partir des sites du Camp de l’Église Sud à Flaujac-Poujols (Lot) et... by Antoine Dumas

“…Firstly, it demonstrated that on a largescale, an initial period of occupation (800-725 BC) was characterized by a marked increase in the number of burials being installed, followed by a second period (725-550 BC) marked by a reversal of this tendency. We can therefore conclude, that the number of people important enough to access the necropolis varied through time, with a second much more selective period than the previous one. …”
Get full text

Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis by Ning Jin, Yi-yu Qian, Xiao-fei Jiao, Zhen Wang, Xin Li, Wen Pan, Jin-kai Jiang, Pu Huang, Si-yuan Wang, Ping Jin, Qing-lei Gao, Dan Liu, Yu Xia

“…Although niraparib holds a pivotal role in the maintenance treatment of OC, its effect on suppressing metastases during primary intervention remains enigmatic. Recently, we initiated a prospective clinical study (NCT04507841) in order to evaluate the therapeutic efficacy of neoadjuvant niraparib monotherapy for advanced OC with homologous recombination deficiency. …”
Get full text

First Detection of <i>Alphacoronavirus</i> in Bats from the World’s Largest Wetland, the Pantanal, Brazil by Tayane B. S. Magalhães, Amanda de O. Viana, Thiago B. F. Semedo, Juliane S. Saldanha, Nicole A. dos Reis, Nathalia de A. Pereira, Rachel V. P. de Barros, Hannah R. Miranda, Gabriella C. Almeida, Desyrée Y. S. R. Ozaki, Giovana S. Caleiro, Gustavo O. Fenner, Fernanda P. Vizu, Theo Kraiser, Thais P. Carvalho, Luciano M. Thomazelli, Erick G. Dorlass, Clarice W. Arns, Helena L. Ferreira, Erika Hingst-Zaher, Rogério Vieira Rossi, Guilherme S. T. Garbino, Edison L. Durigon, Jansen de Araujo, Daniel M. de Aguiar

“…Given the recent SARS-CoV-2 pandemic, we investigated the presence of CoV in bats captured in the Brazilian Pantanal. …”
Get full text

Weighted Gene Co-Expression Network of Growth Differentiation-Related lncRNAs and mRNAs in Plectropomus leopardus by Jin GAO, Jinye LIU, Fuxiao CHEN, Yongbo WANG, Shuyuan FU

“…Here, during the artificial breeding and intermediate rearing process of P. leopardus, early juveniles exhibited relatively minor susceptibility to non-genetic effects such as water temperature and quality changes, along with significantly differentiated growth and shorter intervals of divergence. Consequently, we selected muscle tissues of individuals exhibiting differential divergence within three consecutive time points of size screening for early juveniles (42, 70 and 91 days post-hatching) for whole transcriptome sequencing, aiming to elucidate genetic mechanisms. …”
Get full text

Convergent construct validity and test-retest reliability of both German versions of the original and the revised Niigata PPPD Questionnaire: NPQ and NPQ-R by Sarah Chételat, Sarah Chételat, Eve-Yaël Gerber, Eve-Yaël Gerber, Sarah El Khadlaoui, Frank Behrendt, Frank Behrendt, Michaela Stark, Michaela Stark, Stefan Schädler, Stefan Schädler, Maximilian Maywald, Lena Fabritius, Johannes Gerb, Johannes Gerb, Denis Grabova, Wiebke Trost, Andreas Zwergal, Andreas Zwergal, Ralf Strobl, Ralf Strobl, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Sandra Becker-Bense, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…The NPQ-R, with its additional subscales addressing associated symptoms and symptom behavior, represents both the patient and clinician perspective on PPPD-specific problems. Therefore, we recommend utilizing the NPQ-R for a comprehensive assessment of PPPD.…”
Get full text

ERBB4 selectively amplifies TGF-β pro-metastatic responses by Peihong Luo, Huanyu Hong, Baoling Zhang, Jie Li, Shuyi Zhang, Chaomin Yue, Jin Cao, Jia Wang, Yuhan Dai, Qingqing Liao, Pinglong Xu, Bing Yang, Xia Liu, Xia Lin, Yi Yu, Xin-Hua Feng

“…However, the underlying mechanisms of how TGF-β drives the opposing responses remain largely unknown. Here, we report that ERBB4, a member of the ERBB receptor tyrosine kinase family, specifically promotes TGF-β′s metastatic response but not its anti-growth response. …”
Get full text

Genetic evidence for the causal effects of air pollution on the risk of respiratory diseases by Yanjuan Wu, Yuting Zhang, Jingcun Wang, Qiming Gan, Xiaofen Su, Sun Zhang, Yutong Ding, Xinyan Yang, Nuofu Zhang, Kang Wu

“…In this study, Mendelian randomization (MR) analysis was used to explore the causal and epigenetic relationships between various air pollutants and common respiratory diseases. Methods: We utilized a two-sample Mendelian randomization (TSMR) approach to explore the impact of PM2.5, PM2.5–10, PM10, NO2, and NOX on the incidence of nine respiratory diseases using data from large-scale European GWAS datasets (N = 423,796–456,380 for exposures; N = 162,962–486,484 for outcomes). …”
Get full text

Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Abstract The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due to the lack of integration between the two processes, which limit real-time adjustments in treatment plans based on the patient’s condition and drive-up treatment costs. Here, we present a multifunctional pH-sensitive core-shell nanoparticle containing quercetin (QCT), termed AHA@MnP/QCT NPs, designed for the simultaneous diagnosis and treatment of non-small cell lung cancer. …”
Get full text

Subgenome asymmetry of gibberellins-related genes plays important roles in regulating rapid growth of bamboos by Ling Mao, Cen Guo, Liang-Zhong Niu, Yu-Jiao Wang, Guihua Jin, Yi-Zhou Yang, Ke-Cheng Qian, Yang Yang, Xuemei Zhang, Peng-Fei Ma, De-Zhu Li, Zhen-Hua Guo

“…Taking advantage of genomic resources of 11 representative bamboos at different ploidal levels, we integrated morphological, physiological, and transcriptomic datasets to investigate rapid growth. …”
Get full text

Jet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice by Denis N. Kisakov, Larisa I. Karpenko, Lyubov A. Kisakova, Sergey V. Sharabrin, Mariya B. Borgoyakova, Ekaterina V. Starostina, Oleg S. Taranov, Elena K. Ivleva, Oleg V. Pyankov, Anna V. Zaykovskaya, Elena V. Dmitrienko, Vladimir A. Yakovlev, Elena V. Tigeeva, Irina Alekseevna Bauer, Svetlana I. Krasnikova, Nadezhda B. Rudometova, Andrey P. Rudometov, Artemiy A. Sergeev, Alexander A. Ilyichev

“…<b>Methods:</b> In the first part of the study, the optimal conditions providing low traumatization and high expression of the model mRNA-GFP molecule in the tissues of laboratory animals were determined. Then, we used the selected protocol to immunize BALB/c mice with mRNA-RBD encoding the SARS-CoV-2 receptor-binding domain (RBD). …”
Get full text

High paracrine activity of hADSCs cartilage microtissues inhibits extracellular matrix degradation and promotes cartilage regeneration by Wei Liu, Hongyu Jiang, Jiajie Chen, Yue Tian, Ying He, Ying Jiao, Yanjun Guan, Zhibo Jia, Yanbin Wu, Cheng Huang, Yiben Ouyang, Wenjing Xu, Jianhong Qi, Jiang Peng, Aiyuan Wang

“…Autologous adipose-derived mesenchymal stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMSCs) are widely used in cartilage tissue engineering. In this study, we fabricated microcarriers and compared the behavior of two homologous cell types in the microcarrier environment. …”
Get full text

Alcohol intake exacerbates experimental autoimmune prostatitis through activating PI3K/AKT/mTOR pathway-mediated Th1 differentiation by Shun Xu, Shun Xu, Shun Xu, Jing Chen, Jing Chen, Jing Chen, Shaoyu Yue, Shaoyu Yue, Shaoyu Yue, Yifan Zhang, Yifan Zhang, Yifan Zhang, Shengyu Zhao, Shengyu Zhao, Shengyu Zhao, Yongtao Hu, Yongtao Hu, Yongtao Hu, Cheng Zhang, Cheng Zhang, Cheng Zhang, Wenrui Guan, Wenrui Guan, Wenrui Guan, Li Zhang, Li Zhang, Li Zhang, Ligang Zhang, Ligang Zhang, Ligang Zhang, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang

“…This research aimed to investigate the impact of alcohol on CP/CPPS using an animal model and to elucidate the underlying mechanisms.MethodsWe first established the widely used animal model for CP/CPPS, experimental autoimmune prostatitis (EAP). …”
Get full text

Applied pharmacogenetics to predict response to treatment of first psychotic episode: study protocol by Sergi Mas, Sergi Mas, Sergi Mas, Laura Julià, Manuel J. Cuesta, Manuel J. Cuesta, Manuel J. Cuesta, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Benedicto Crespo-Facorro, Javier Vázquez-Bourgon, Javier Vázquez-Bourgon, Javier Vázquez-Bourgon, Carlos Spuch, Carlos Spuch, Ana Gonzalez-Pinto, Ana Gonzalez-Pinto, Angela Ibañez, Angela Ibañez, Judith Usall, Judith Usall, Cristina Romero-López-Alberca, Cristina Romero-López-Alberca, Ana Catalan, Ana Catalan, Ana Catalan, Ana Catalan, Ana Catalan, Anna Mané, Anna Mané, Anna Mané, Anna Mané, Miquel Bernardo, Miquel Bernardo, Miquel Bernardo, Miquel Bernardo

“…However, several limitations have hindered its translation into clinical practice. Here, we describe the rationale, aims and methodology of Applied Pharmacogenetics to Predict Response to Treatment of First Psychotic Episode (the FarmaPRED-PEP project), which aims to develop and validate predictive algorithms to classify FEP patients according to their response to antipsychotics, thereby allowing the most appropriate treatment strategy to be selected. …”
Get full text

Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites by Ciying Qian, Jie Chen, Yurou Yang, Yihan Lu, Tianyu Ren, Yanan Jiang, Yang Huang, Xin Chi, Shuyue Zhang, Chengzong Zhang, Kewei Li, Jingjia Shen, Sibo Zhang, Daning Wang, Lizhi Zhou, Tingting Li, Qingbing Zheng, Hai Yu, Ying Gu, Ningshao Xia, Shaowei Li

“…Through strategic homologous loop swapping among HPV53, HPV56, and HPV66, we designed twenty double-type chimeric molecules. …”
Get full text

Post sleeve gastrectomy-enriched gut commensal Clostridia promotes secondary bile acid increase and weight loss by Shaoqian Zhao, Huibin Lin, Wen Li, Xiaoqiang Xu, Qihan Wu, Zhifeng Wang, Juan Shi, Yufei Chen, Lingxia Ye, Liuqing Xi, Lijia Chen, Mingyang Yuan, Junlei Su, Aibo Gao, Jiabin Jin, Xiayang Ying, Xiaolin Wang, Yaorui Ye, Yingkai Sun, Yifei Zhang, Xiaxing Deng, Baiyong Shen, Weiqiong Gu, Guang Ning, Weiqing Wang, Jie Hong, Jiqiu Wang, Ruixin Liu

“…However, the commensal bacteria involved and the underlying mechanism remain to be determined. We performed shotgun metagenomic sequencing in obese subjects before and longitudinally after sleeve gastrectomy (SG), and found a significant enrichment in microbial species in Clostridia and bile acid metabolizing genes after SG treatment. …”
Get full text

A Universal Break in Energy Functions of Three Hyperactive Repeating Fast Radio Bursts by Q. Wu, F. Y. Wang, Z. Y. Zhao, P. Wang, H. Xu, Y. K. Zhang, D. J. Zhou, J. R. Niu, W. Y. Wang, S. X. Yi, Z. Q. Hua, S. B. Zhang, J. L. Han, W. W. Zhu, K. J. Lee, D. Li, X. F. Wu, Z. G. Dai, B. Zhang

“…However, so far there has been no decisive evidence for this speculation. Here we report the energy functions of the three most active repeating FRBs, which show a universal break around 10 ^38 erg. …”
Get full text

Uvaol attenuates TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells by modulating expression and membrane localization of β-catenin by Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Mônica Silveira Wagner, Kayo Moreira Bagri, Erick Gabriel Alves Ferreira, Romulo Galvani, Romulo Galvani, Romulo Galvani, Romulo Galvani, Claudia Mermelstein, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Wilson Savino, Wilson Savino, Wilson Savino, Wilson Savino, Emiliano Barreto, Emiliano Barreto

“…Changes in cell shape were measured using phase-contrast and confocal microscopy, whereas protein expression levels were measured using immunofluorescence, flow cytometry, and Western blotting. We also performed wound scratch experiments to explore its effects on cell migration. …”
Get full text

Muzyka i wolnomularstwo warszawskie na początku XIX wieku. Kilka nowych informacji dotyczących wolnomularskiej działalności Józefa Elsnera (ze zbiorów archiwum masońskiego w AGAD)... by Małgorzata Sieradz

“…Wstąpił do loży wolnomularskiej już podczas pobytu we Lwowie, czyli jeszcze przed rokiem 1800. W Warszawie poczynając od roku 1805 należał do tutejszej loży Złoty Lichtarz, a w następnych latach osiągał kolejne stopnie w strukturach organizacyjnych i obarczany był odpowiedzialnymi funkcjami w swej loży macierzystej Zur Halle der Beständigkeit (Świątynia Stałości; do loży tej – choć nie w Warszawie – należał także jeden z synów Mozarta, Franz Xaver Wolfgang Mozart), oraz obdarzany członkostwem honorowym innych miejscowych lóż – Świątyni Minerwy, Świątyni Równości, Pochodni Północnej i Świątyni Izis. …”
Get full text