Cutin formation in tomato is controlled by a multipartite module of synergistic and antagonistic transcription factors by Yuan Shi, Changhao Deng, Xiangyin Lu, Yan Wang, Yaowen Pan, Deding Su, Wang Lu, Yuxiang Lin, Rui Li, Junnan Han, Yanwei Hao, Yi Chen, Ghassen Abid, Julien Pirrello, Mondher Bouzayen, Yudong Liu, Zhengguo Li, Baowen Huang

“…Summary: Cuticles protect plants from water loss and pathogen attack. We address here the functional significance of SlGRAS9, SlZHD17, and SlMBP3 in regulating cutin formation in tomato fruit. …”
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Comparative evaluation of multimarker algorithms for early-stage HCC detection in multicenter prospective studies by Jinlin Hou, Thomas Berg, Arndt Vogel, Teerha Piratvisuth, Jörg Trojan, Enrico N. De Toni, Masatoshi Kudo, Katarina Malinowsky, Peter Findeisen, Johannes Kolja Hegel, Wenzel Schöning, Kairat Madin, Konstantin Kroeniger, Henry Lik-Yuen Chan, Ashish Sharma

“…Background & Aims: We compared the clinical performance of the novel GAAD (gender [biological sex], age, alpha-fetoprotein [AFP], des-gamma carboxyprothrombin [DCP]) and GALAD (gender [biological sex], age, AFP, Lens culinaris agglutinin-reactive AFP [AFP-L3], DCP) algorithms to deduce the clinical utility of AFP-L3 for detecting early-stage hepatocellular carcinoma (HCC) from chronic liver disease (CLD). …”
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Newly identified c-di-GMP pathway putative EAL domain gene STM0343 regulates stress resistance and virulence in Salmonella enterica serovar Typhimurium by Kaifeng Chen, Lili Li, Nanwei Wang, Zhouping Zhou, Peng Pan, Chenggang Xu, Dage Sun, Jiayi Li, Changzhi Dai, Dai Kuang, Ming Liao, Jianmin Zhang

“…Therefore, identifying key regulatory elements is crucial for preventing and controlling S. Typhimurium. We performed transcriptomic analysis and screened for a c-di-GMP pathway key gene STM0343, a putative EAL domain protein with an unknown function. …”
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Stenotrophomonas maltophilia bacteremia in adult patients with hematological diseases: clinical characteristics and risk factors for 28-day mortality by Wenjing Guo, Qingsong Lin, Jia Li, Xiaomeng Feng, Sisi Zhen, Yingchang Mi, Yizhou Zheng, Fengkui Zhang, Zhijian Xiao, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Sizhou Feng

“…The preferred treatment is TMP/SMX rather than fluoroquinolones, with combination therapy of TMP/SMX and CSL considered a feasible treatment option.IMPORTANCEThis study, representing the largest cohort of adult hematological patients with SM bacteremia to date, strengthens the validity of existing findings and provides new insights into its clinical management. We identify risk factors for 28-day mortality, revealing that patients with two or more risk factors experience particularly high mortality rates. …”
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Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

“…In addition, a proportion of high-risk patients harbor amplification or activating mutations in anaplastic lymphoma kinase (ALK), and co-occurrence of ALK mutations and MYCN amplification have been associated with aggressive disease. In this study, we analyzed the efficacy of a Phase Ia-cleared, orally bioavailable dual ALK and focal adhesion kinase (FAK) inhibitor, ESK440, in multiple preclinical NB models. …”
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Impact of bedroom light exposure on glucose metabolic markers and the role of circadian-dependent meal timing: A population-based cross-sectional study by Qi Li, Yu-xiang Xu, Xiu-zhen Lu, Yu-ting Shen, Yu-hui Wan, Pu-yu Su, Fang-biao Tao, Xin Chen, Ying Sun

“…However, little is known about the effects of bedroom LAN exposure on glucose metabolism markers. We aimed to explore the association between intensity and duration of bedroom LAN exposure with glucose metabolism markers, and the role of circadian-dependent meal timing in these associations. …”
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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…In vivo antitumour activity was assessed by establishing humanized mice bearing human MSLN-expressing MC38 (MC38/hMSLN) or CT26 (CT26/hMSLN) cells, and safety was further evaluated in cynomolgus monkeys. Results We generated two humanized anti-MSLN×4-1BB bsAbs (HK013-G1/G4) by fusing an anti-4-1BB scFv to the C-terminus of an anti-MSLN VHH with an intact Fc fragment from human IgG1 or IgG4. …”
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Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial by Guoshuang Shen, Zhilin Liu, Miaozhou Wang, Yi Zhao, Xinlan Liu, Yujin Hou, Wenbiao Ma, Jingqi Han, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Zitao Li, Shifen Huang, Yongzhi Chen, Yingjian He, Yan Liu, Zijun Zhu, Yongxin Li, Jinming Li, Mengting Da, Hongnan Mo, Feng Du, Liang Cui, Jing Bai, Zhen Liu, Fei Ma, Jiuda Zhao

“…Abstract We aimed to evaluate the efficacy and safety of adding apatinib, to sintilimab and chemotherapy in the neoadjuvant treatment of early triple-negative breast cancer (TNBC). …”
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Neurotropic Tick-Borne Flavivirus in Alpine Chamois (<i>Rupicapra rupicapra rupicapra</i>), Austria, 2017, Italy, 2023 by Norbert Nowotny, Maria Lucia Mandola, Isabella Monne, Zoltán Bagó, Chiara Nogarol, Alice Fusaro, Katharina Dimmel, Barbara Moroni, Lisa Guardone, Jolanta Kolodziejek, Elisa Palumbo, Gabriela Stanclova, Adi Steinrigl, Gabriele Fidler, Cristina Bertasio, Irene Bertoletti, Alessandro Bianchi, Mattia Calzolari, Paola Prati, Nadia Vicari, Angela Salomoni, Maria Francesca Priore, Federica Gobbo, Aitor Garcia-Vozmediano, Tom Loney, Ahmad Abou Tayoun, Alawi Alsheikh-Ali, Paola De Benedictis, Jeremy V. Camp, Zdenek Hubalek, Ivo Rudolf, Davide Lelli, Ana Moreno

“…The European subtype of tick-borne encephalitis virus (TBEV-Eur; species <i>Orthoflavivirus encephalitidis</i>, family <i>Flaviviridae</i>) was the only tick-borne flavivirus present in central Europe known to cause neurologic disease in humans and several animal species. Here, we report a tick-borne flavivirus isolated from Alpine chamois (<i>Rupicapra rupicapra rupicapra</i>) with encephalitis and attached ticks, present over a wide area in the Alps. …”
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Generation of a USP9Y knockout human embryonic stem cell line with CRISPR-Cas9 technology by Sai Wei, Yuting Zhen, Chao Sun, Yanlin Ma, Qi Li, Luan Wen

“…Human embryonic stem cell (hESC) lines are vital tools for studying gene function, disease modeling, and therapy. We generated a USP9Y knockout hESC line using CRISPR-Cas9 in the male-derived H1 line. …”
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Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders by Jeffrey A Meyerhardt, Sunil Kumar, Jessica A Zerillo, Aparna Parikh, James M Cleary, Scott Rodig, Benjamin Schlechter, Kimmie Ng, Stephanie K Dougan, Nora Horick, Glenn J Hanna, Andrew L Coveler, Anuj K Patel, Nadine J McCleary, Douglas A Rubinson, Jeffrey W Clark, Kent Mouw, Kathleen Pfaff, Thomas A Abrams, Matthew B Yurgelun, Eliezer M Van Allen, S Jennifer Wang, Leah H Biller, Harshabad Singh, Emma L Welsh, Brandon M Huffman, Lestat R Ali, Megan T Hoffman, Katherine A Metayer, Shayla Murray, Alexandra Bird, Jennifer A Chan, Wolfram Goessling, Jeffrey S Wisch, Brendan Reardon, Robert J Mayer, Catherine Del Vecchio Fitz, Charlotte Kuperwasser

“…To characterize the clinical features of long-term responders, we combined data from our prospective trial with a retrospective cohort of patients with anal cancer treated with anti-PD-1 immunotherapy (n=18).Results In the phase II study, the ORR to pembrolizumab monotherapy was 9.4% and the median progression-free survival was 2.2 months. …”
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Graphene oxide scaffolds promote functional improvements mediated by scaffold-invading axons in thoracic transected rats by Marta Zaforas, Esther Benayas, Raquel Madroñero-Mariscal, Ana Domínguez-Bajo, Elena Fernández-López, Yasmina Hernández-Martín, Ankor González-Mayorga, Elena Alonso-Calviño, Eduardo R. Hernández, Elisa López-Dolado, Juliana M. Rosa, Juan Aguilar, María C. Serrano

“…Encouraged by previous findings in our laboratory on the exploration of 3D porous reduced graphene oxide (rGO) scaffolds in chronic cervical hemisected rats (C6), herein we report their neuro-reparative properties when chronically implanted in complete transected rats (T9-T10), in which no preserved contralateral neural networks can assist in any observed recovery. …”
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Quantifying the spatial patterns of retinal ganglion cell loss and progression in optic neuropathy by applying a deep learning variational autoencoder approach to optical coherence... by Jui-Kai Wang, Jui-Kai Wang, Brett A. Johnson, Zhi Chen, Zhi Chen, Honghai Zhang, Honghai Zhang, David Szanto, Brian Woods, Brian Woods, Michael Wall, Young H. Kwon, Young H. Kwon, Edward F. Linton, Edward F. Linton, Andrew Pouw, Mark J. Kupersmith, Mark J. Kupersmith, Mark J. Kupersmith, Mona K. Garvin, Mona K. Garvin, Mona K. Garvin, Mona K. Garvin, Randy H. Kardon, Randy H. Kardon

“…IntroductionGlaucoma, optic neuritis (ON), and non-arteritic anterior ischemic optic neuropathy (NAION) produce distinct patterns of retinal ganglion cell (RGC) damage. We propose a booster Variational Autoencoder (bVAE) to capture spatial variations in RGC loss and generate latent space (LS) montage maps that visualize different degrees and spatial patterns of optic nerve bundle injury. …”
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Effects of Mussel Peptides on Growth and Development and Microbial Community Structure of the Thick-Shelled Mussel Mytilus coruscus Plantigrades by Qian LIN, Zheng LI, Jinlong YANG, Fan MA, Xiao LIANG

“…Therefore, the optimal concentration of mussel peptide for the potential application of mussel peptides in the M. coruscus aquaculture industry must be determined. In this study, we focused on the effects of mussel peptides on the growth and development of the thick-shelled mussel M. coruscus and on the structural composition of microbial communities. …”
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Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort studyResearch in context by Jack L. Janetzki, Jung Ho Kim, Evan Minty, Jung Ah Lee, Daniel R. Morales, Rohan Khera, Chungsoo Kim, Thamir M. Alshammari, Scott L. DuVall, Michael E. Matheny, Thomas Falconer, Seonji Kim, Thanh-Phuc Phan, Phung-Anh Nguyen, Min-Huei Hsu, Jason C. Hsu, Rae Woong Park, Kenneth K.C. Man, Sarah Seager, Mui Van Zandt, James P. Gilbert, Patrick B. Ryan, Martijn J. Schuemie, Marc A. Suchard, George Hripcsak, Nicole Pratt, Seng Chan You

“…There was no increased risk of AA/AD associated with FQ compared to TMP or CPH in patients treated for UTI in the outpatient setting. As we only examined FQ used to treat UTIs in the outpatient setting, the results may not be generalisable to other indications with different severity. …”
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Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis by Ana Maria Vega-Letter, Cynthia García-Guerrero, Liliana Yantén-Fuentes, Carolina Pradenas, Yeimi Herrera-Luna, Eliana Lara-Barba, Felipe A. Bustamante-Barrientos, Masyelly Rojas, María Jesús Araya, Nicole Jeraldo, Constanza Aros, Francisca Troncoso, Daniela Poblete, Angela Court, Alexander Ortloff, Jose Barraza, Francesca Velarde, Carlos Farkas, Claudio Carril, Noymar Luque-Campos, Gonzalo Almarza, Maximiliano Barahona, Jose Matas, Lucas Cereceda, Rocío Lorca, Jorge Toledo, Karina Oyarce, Rolando Vernal, Andrés Caicedo, Andrea del Campo, Yessia Hidalgo, Roberto Elizondo-Vega, Farida Djouad, Maroun Khoury, Fernando E. Figueroa, Patricia Luz-Crawford

“…In recent years, it has been proposed that mesenchymal stromal cells (MSC) transfer their functional mitochondria to damaged cells in response to cellular stress, becoming one of the mechanisms underpinning their therapeutic effects. Therefore, we hypothesize that a novel cell-free treatment for OA could involve direct mitochondria transplantation, restoring both cellular and mitochondrial homeostasis. …”
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FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle by Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Fan Wang, Fan Wang, Fan Wang, Fan Wang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Fan Yao, Fan Yao, Fan Yao, Fan Yao, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Yongping Zhang, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun

“…Then, FGF21 was administered, and renal tissue examination and pathological observation were combined with an assessment of glomerular injury, inflammation, oxidative stress, and the fibrinogen system in mice following the administration of the intervention. Furthermore, we used db/db mice and FGF21 direct therapy for 8 weeks to investigate changes in fasting glucose and creatinine expression as well as pathological changes in glomeruli glycogen deposition, fibrosis, and nephrin expression. …”
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Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis by Qiang Ma, Jin-Lan Tian, Yao Lou, Ran Guo, Xiao-Ru Ma, Jian-Bin Wu, Jing Yang, Bing-Jie Tang, Shun Li, Mengsheng Qiu, Shumin Duan, Jing-Wei Zhao, Jing Zhang, Zhen-Zhong Xu

“…Recent studies have identified a striking association between oligodendrocytes and PD progression, yet how oligodendrocytes regulate the pathogenesis of PD is still unknown. Here, we show that G-protein-coupled receptor 37 (GPR37) is upregulated in oligodendrocytes of the substantia nigra and that prosaposin (PSAP) secretion is increased in parkinsonian mice. …”
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Initial clinical experience with [177Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer: dosimetry, safety, and efficacy from the lead-in cohort o... by Aaron R. Hansen, Stephan Probst, Jean-Mathieu Beauregard, Benjamin L. Viglianti, Jeff M. Michalski, Scott T. Tagawa, Oliver Sartor, Ronald F. Tutrone, Orhan K. Oz, Kevin D. Courtney, Ebrahim S. Delpassand, Luke T. Nordquist, Medhat M. Osman, Kim N. Chi, Richard Sparks, Noble George, Sara M. Hawley, Wenting Wu, Jessica D. Jensen, Neil E. Fleshner

“…This study leveraged a lead-in phase to assess tissue dosimetry and evaluate preliminary safety and efficacy, prior to expansion into a randomized phase. Here we report those results.MethodsEnrolled participants had mCRPC that progressed on one prior androgen receptor pathway inhibitor (ARPI), were prostate-specific membrane antigen (PSMA) PET–positive as determined by a central reader, were chemotherapy-naïve for mCRPC, and had adequate bone marrow and end-organ reserve. …”
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Regard rapproché, regard éloigné dans la critique d’art, de Diderot à Huysmans by Michel Delon

“…Our moral judgement, as well as our aesthetic judgement, depends on the distance from which we perceive that which touches us. The short-sighted person who draws near to the object and the long-sighted person who steps away cannot share the same perception. …”
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