Bulk and single-cell transcriptome revealed the metabolic heterogeneity in human glioma by Yong Xiao, Mengjie Zhao, Ran Wang, Liang Liu, Chong Xiang, Taiping Li, Chunfa Qian, Hong Xiao, Hongyi Liu, Yuanjie Zou, Xianglong Tang, Kun Yang

“…To advance therapies targeting metabolic processes, it is crucial to uncover metabolic differences and identify distinct metabolic subtypes. Therefore, we aimed to develop a classification system for gliomas based on the enrichment levels of four key metabolic pathways: glutaminolysis, glycolysis, the pentose phosphate pathway, and fatty acid oxidation. …”
Get full text

Polygonatum kingianum polysaccharide alleviated intestinal injuries by mediating antioxidant ability and microbiota by Reng Qiu, Chuangye Pan, Yuxi Qin, Qianfei Wei, Yue Yu, Ying Zhang, Xuehan Xie, Jianqin Li, Shouhai Chen, Kun Li, Dalia Fouad, Yi Wu, Qiu Zhong

“…There were 5 phyla and 20genera of remarkable bacteria found among mice groups including genera of Escherichia, Pseudomonas_E, Mailhella, Paramuribaculum, NM07-P-09, Odoribacter, Nanosyncoccus, SFM01, Onthenecus, Clostridium_Q, UBA6985, Ructibacterium, UBA946, Lachnoclostridium_B, Evtepia, CAG-269, Limivicinus, Formimonas, Dehalobacterium, Dwaynesavagella, and UBA6985. We revealed that Polygonatum kingianum polysaccharide could alleviate intestinal injuries by promoting oxidation resistance, decreasing inflammatory responses, and accommodating the intestinal microbiota of mice.DiscussionOur results suggest the possibility of developing novel therapies for intestinal diseases.…”
Get full text

The role of OCO-3 XCO₂ retrievals in estimating global terrestrial net ecosystem exchanges by X. Wang, F. Jiang, F. Jiang, F. Jiang, H. Wang, Z. Zhang, M. Wu, J. Wang, W. He, W. Ju, W. Ju, J. M. Chen, J. M. Chen

“…Here, using the Global Carbon Assimilation System, version 2, we investigate the impact of OCO-3 XCO<span class="inline-formula">₂</span> on the estimation of global NEE by assimilating the OCO-3 XCO<span class="inline-formula">₂</span> retrievals alone and in combination with the OCO-2 XCO<span class="inline-formula">₂</span> retrievals. …”
Get full text

MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses by Yupei Zhang, Songhui Zhai, Shugang Qin, Yuting Chen, Kepan Chen, Zhiying Huang, Xing Lan, Yaoyao Luo, Guohong Li, Hao Li, Xi He, Meiwan Chen, Zhongwei Zhang, Xingchen Peng, Xin Jiang, Hai Huang, Xiangrong Song

“…However, there was a lack of research investigating its efficacy in enhancing immune responses to RNA virus infections. Here, we have developed an innovative strategy for the formulation of mRNA vaccines. …”
Get full text

Short-Interval Self-Learning to Improve Retention of Resuscitation Skills: A Randomized Controlled Trial

“…The optimal interval and methods for cardiopulmonary resuscitation (CPR) retraining remain unclear. We evaluated the difference in CPR skills one year after a 45-minute chest compression-only CPR training among participants receiving short self-learning refresher training at 3-month intervals, those receiving this training at 6-month intervals, and those without the refresher training. …”
Get full text

Synergistically S/N self-doped biochar as a green bifunctional cathode catalyst in electrochemical degradation of organic pollutant by Xuechun Wang, Huizhong Wu, Jiana Jing, Ge Song, Xuyang Zhang, Minghua Zhou, Raf Dewil

“…Biomass-derived heteroatom self-doped cathode catalysts has attracted considerable interest for electrochemical advanced oxidation processes (EAOPs) due to its high performance and sustainable synthesis. Herein, we illustrated the morphological fates of waste leaf-derived graphitic carbon (WLGC) produced from waste ginkgo leaves via pyrolysis temperature regulation and used as bifunctional cathode catalyst for simultaneous H2O2 electrochemical generation and organic pollutant degradation, discovering S/N-self-doping shown to facilitate a synergistic effect on reactive oxygen species (ROS) generation. …”
Get full text

Flow Cytometric Assessment of FcγRIIIa-V158F Polymorphisms and NK Cell Mediated ADCC Revealed Reduced NK Cell Functionality in Colorectal Cancer Patients by Phillip Schiele, Stefan Kolling, Stanislav Rosnev, Charlotte Junkuhn, Anna Luzie Walter, Jobst Christian von Einem, Sebastian Stintzing, Wenzel Schöning, Igor Maximilian Sauer, Dominik Paul Modest, Kathrin Heinrich, Lena Weiss, Volker Heinemann, Lars Bullinger, Marco Frentsch, Il-Kang Na

“…Fc gamma receptor IIIa (FcγRIIIa) polymorphisms impact ADCC, yet their clinical relevance in NK cell functionality remains debated. We developed two complementary flow cytometry assays: one to predict the FcγRIIIa-V158F polymorphism using a machine learning model, and a 15-color flow cytometry panel to assess antibody-induced NK cell functionality and cancer-immune cell interactions. …”
Get full text

Non-coding RNAs secreted by renal cancer include piR_004153 that promotes migration of mesenchymal stromal cells by Joanna Bogusławska, Małgorzata Grzanka, Piotr Popławski, Weronika Zarychta-Wiśniewska, Anna Burdzinska, Karolina Hanusek, Helena Kossowska, Roksana Iwanicka-Nowicka, Alex Białas, Beata Rybicka, Anna Adamiok-Ostrowska, Joanna Życka-Krzesińska, Marta Koblowska, Leszek Pączek, Agnieszka Piekiełko-Witkowska

“…The impact of RCC-secreted small non-coding RNAs (sncRNAs) on TME is largely underexplored. Here, we comprehensively analysed the composition of exosomal sncRNAs secreted by RCC cells to identify those that influence MSCs. …”
Get full text

Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles by Yan Xiao, Lixia Yang, Yicong Wang, Yu Wang, Yuning Chen, Wenhan Lu, Zhenle Pei, Ruonan Zhang, Yao Ye, Xiaowei Ji, Suying Liu, Xi Dong, Yonghua Xu, Yi Feng

“…<italic>Results:</italic> We found a 50&#x0025; increase in ovarian weight and in the number of mature follicles on the ultrasound-stimulated side with pulsed LIFU and intraperitoneal injection of 10 IU PMSG in 10-day-old rats. …”
Get full text

Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis by Sandra M Herrmann, Riley Fadden, Ryan J Sullivan, Kerry L Reynolds, Harish Seethapathy, Meghan E Sise, Shruti Gupta, Alexandra-Chloe Villani, Qiyu Wang, Daiana Moreno, Destiny Harden, R Neal Smith, Ivy A Rosales, Robert B Colvin, Sarah Chute, Lynn D Cornell, Nancy J Yang, Sara Barmettler, Sophia Wells, Jocelyn Farmer

“…Because ICIs block immune checkpoint pathways that include cytotoxic T lymphocyte antigen 4 (CTLA4), we hypothesized that biomarkers of immune dysregulationpreviously defined in patients with congenital CTLA4 deficiency, including elevated soluble interleukin-2 receptor alpha (sIL-2R) and flow cytometric cell-based markers of B and T cell dysregulation in peripheral blood may aid the diagnosis of ICI-nephritis.Methods A retrospective cohort of patients diagnosed with ICI-nephritis was compared with three prospectively enrolled control cohorts: ICI-treated controls without immune-related adverse events, patients not on ICIs with hemodynamic acute kidney injury (hemodynamic AKI), and patients not on ICIs with biopsy proven acute interstitial nephritis from other causes (non-ICI-nephritis). sIL-2R level and flow cytometric parameters were compared between groups using Wilcoxon rank sum test or Kruskal-Wallis test. …”
Get full text

Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target by Cèlia Dobaño-López, Juan García Valero, Ferran Araujo-Ayala, Ferran Nadeu, Fabien Gava, Carla Faria, Marine Norlund, Renaud Morin, Pascale Bernes-Lasserre, Fabian Arenas, Marta Grau, Cristina López, Irene López-Oreja, Neus Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, Silvia Beà, Elías Campo, Jean-Michel Lagarde, Armando López-Guillermo, Laura Magnano, Dolors Colomer, Christine Bezombes, Patricia Pérez-Galán

“…Abstract Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease onset, progression, and heterogenous clinical outcome. Here we present the first FL-Patient Derived Lymphoma Spheroid (FL-PDLS), including fundamental immune actors and features of TME in FL lymph nodes (LNs). …”
Get full text

Psychometric properties of the Moroccan dialect versions of the Perceived Stress Scale and the Center for Epidemiologic Studies Depression Scale among Moroccan university students by Younes RAMI, Hicham KHABBACHE, Jamal AMRAOUI, Driss AIT ALI, Zakaria ABIDLI, Abdulmohsen MOHAMMED ABDULLAH ALKHULAYFI, Mahmood BAHRAMIZADEH, Hassan LAABOUB, Amelia RIZZO, Bouabid BADAOUI, Şeyhmus AKSOY, Lukasz SZARPAK, Murat YILDIRIM, Francesco CHIRICO

“…The objective is to evaluate the reliability and validity of these scales for assessing perceived stress and depressive symptoms among this population. Methods: We conducted a cross-sectional survey of 204 Moroccan university students. …”
Get full text

“A torch, a rope, a belly laugh”: engaging with the multiple voices of support groups for people living with rare dementia by Paul M. Camic, Emma Harding, Sam Rossi-Harries, Oliver S. Hayes, Mary Pat Sullivan, Lawrence Wilson, Nikki Zimmermann, Roberta McKee-Jackson, Joshua Stott, Nick C. Fox, Catherine J. Mummery, Jonathan D. Rohrer, Jason D. Warren, Rimona S. Weil, Sebastian James Crutch

“…Survey results revealed a varied but generally positive response to writing whilst reactions to the completed poems reflected strong emotional connections that resonated with personal experience.ConclusionThis is the first study that we are aware of to explore the use of co-constructed research poetry to better understand how in-person support groups provide support for people impacted by different rare dementias. …”
Get full text

Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers by Siyer Roohani, Felix Ehret, Marcus Beck, Danai P. Veltsista, Jacek Nadobny, Sebastian Zschaeck, Sultan Abdel-Rahman, Franziska Eckert, Anne Flörcken, Rolf D. Issels, Stephan Klöck, Robert Krempien, Lars H. Lindner, Markus Notter, Oliver J. Ott, Daniel Pink, Vlatko Potkrajcic, Peter Reichardt, Oliver Riesterer, Mateusz Jacek Spałek, Emanuel Stutz, Rüdiger Wessalowski, Thomas Zilli, Daniel Zips, Pirus Ghadjar, David Kaul

“…Purpose To analyze the current practice of regional hyperthermia (RHT) for soft tissue sarcoma (STS) at 12 European centers to provide an overview, find consensuses and identify controversies necessary for future guidelines and clinical trials.Methods In this cross-sectional survey study, a 27-item questionnaire assessing clinical subjects and procedural details on RHT for STS was distributed to 12 European cancer centers for RHT.Results We have identified seven controversies and five consensus points. …”
Get full text

Association between major depressive disorder or depressive symptoms and the risk of vascular complications among patients with type 2 diabetes, and the mediating role of metabolic... by Guochen Li, Yongfu Yu, Chunqing Lin, Shichen Zheng, Hong Tu, Wanghong Xu

“…Summary: Background: Depression is a severe mental disorder commonly co-morbid with diabetes, but it remains to elucidate whether depression is associated with the risks of a wide range of vascular complications in people with type 2 diabetes mellitus (T2DM) and whether metabolic biomarkers may mediate this pathway. Methods: We conducted this prospective analysis among the participants of the UK Biobank who were diagnosed with T2DM and free of vascular complications at baseline between March 13, 2006 and September 30, 2010. …”
Get full text

Renal function and clinical outcomes in survivors of out-of-hospital cardiac arrest by Hao-Wei Lee, Ming-Jen Kuo, Pai-Feng Hsu, I-Hsin Lee, Chih-Yu Yang, Teh-Fu Hsu, Chorng-Kuang How, Yenn-Jiang Lin, Chin-Chou Huang

“…Background: Comprehensive studies about renal-function changes in the context of out-of-hospital cardiac arrest (OHCA) have been lacking. Therefore, we investigated the impact of renal function on clinical outcomes among patients with OHCA. …”
Get full text

Conflict-related and sexual trauma in treatment-seeking Arabic-speaking men: a cross-sectional studyResearch in context by Max Vöhringer, Freya Specht, Christine Knaevelsrud, Birgit Wagner, Maria Böttche, Yuriy Nesterko

“…Although it has occurred throughout history, research data on this topic is scarce, especially regarding male survivors and Arabic-speaking countries. In the present study, we examined sexual and conflict-related trauma prevalence rates and those of other trauma types, as well as associations with sociodemographic and psychological characteristics among men from Arabic-speaking countries in the Middle East and North Africa (MENA) region seeking treatment via the internet. …”
Get full text

A novel nanomaterial baffle decrease aerosols and microbial aerosols during non-contact tonometry measurements by X. Shen, Y. Guo, X, X. Wang, Y. Ye, Q. Chi, W. Zhou, Y. Chen, C. Li

“…NCT measurements performed in Groups 1–3.We used Air quality detectors and Air Ideal® 3P to monitor and sample aerosols and microbial aerosols during NCT measurements. …”
Get full text

Beta-variant recombinant SARS CoV-2 vaccine induces durable cross-reactive antibodies against Omicron BA variants by Odile Launay, Rachna Gupta, Tifany Machabert, Eleine Konate, Alexandra Rousseau, Claire Vigne, Francois Beckers, Louis Devlin, Elisabeth Botelho-Nevers, Marine Cachanado, Christian Chidiac, Dominique Deplanque, Bertrand Dussol, Inès Ben Ghezala, Marie Lachatre, Karine Lacombe, Fabrice Laine, Liem Binh Luong Nguyen, Patricia Pavese, Catherine Schmidt-Mutter, Marie-Pierre Tavolacci, Roman M. Chicz, Bogdana Coudsy, Saranya Sridhar, Amel Touati, Eric Tartour, Tabassome Simon

“…Abstract Background We previously reported the safety and immunogenicity data from a randomized trial comparing the booster responses of vaccinees who received monovalent (MV) recombinant protein Beta-variant (MVB.1.351) and MV ancestral protein (MVD614) vaccines with AS03 adjuvant (Sanofi/GSK) to booster response of vaccinees who received mRNA MV ancestral strain BNT162b2 vaccine (Pfizer-BioNTech). …”
Get full text

Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil by Lina Tao, Panpan Wang, Ting Zhang, Mengzhen Ding, Lijie Liu, Ningping Tao, Xichang Wang, Jian Zhong

“…Specific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug delivery. In this work, we reported a monoaxial dispersion electrospraying-ionotropic gelation technique to prepare multicore millimeter-sized spherical capsules for specific and sustained release of fish oil. …”
Get full text