Associations between local COVID-19 policies and anxiety in the USA: a longitudinal digital cohort study by Jeffrey E Olgin, Gregory M Marcus, Rita Hamad, John Kornak, Carmen R Isasi, Ana Sanchez-Birkhead, Mark Pletcher, Soo Park, Natasha Williams, Thomas Carton, Aaron E Cozen, Madelaine Faulkner Modrow, Amy Chiang, Matthew Brandner, Jaime H Orozco, Kristen Azar, Sylvia E K Sudat, Pelin Ozluk, Heather Kitzman, Sara J Knight

“…Local government policies may have contributed to increases in anxiety and mental health disparities during the COVID-19 pandemic.Methods We analysed associations between composite policy scores for containment and closure, public health or economic support from the US COVID-19 County Policy Database and self-reported anxiety scores (Generalised Anxiety Disorder-7) from COVID-19 Citizen Science participants between 22 April 2020 and 31 December 2021.Results In 188 976 surveys from 36 711 participants in 100 counties across 28 states, associations between anxiety and containment and closure policy differed by employment (p<0.0001), with elevated anxiety under maximal policy for people working in hospitality and food services (+1.05 vs no policy; 95% CI: 0.45, 1.64) or arts and entertainment (+0.56; 95% CI 0.15, 0.97) and lower anxiety for people working in healthcare (−0.43; 95% CI −0.66 to –0.20) after adjusting for calendar time, county-specific effects and COVID-19 case rates and death rates. …”
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Identification of positive selection signatures associated with milk and composition traits in Murciano-Granadina and Barki by Hossein Mohammadi, amir hossien khaltabadi farahani, Mohammad Hossein Moradi

“…GeneCards (http://www.genecards.org) and UniProtKB (http://www.uniprot.org) databases were also used to interpret the function of the obtained genes.Results and Discussion Using FST approach, we identified seven genomic regions on chromosomes 4, 6, 14, 15 (two regions per chromosome), 17, and 23 chromosomes. …”
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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

“…To identify novel, better-tolerated anticancer combinations, we screened a collection of plant extracts and found two natural compounds from the plant, Psoralea corylifolia, that synergistically inhibit cancer cell proliferation. …”
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A new multi-grid bathymetric dataset of the Gulf of Naples (Italy) from complementary multi-beam echo sounders by F. Foglini, M. Rovere, R. Tonielli, G. Castellan, G. Castellan, M. Prampolini, M. Prampolini, F. Budillon, M. Cuffaro, G. Di Martino, V. Grande, S. Innangi, M. F. Loreto, L. Langone, F. Madricardo, A. Mercorella, P. Montagna, C. Palmiotto, C. Pellegrini, A. Petrizzo, L. Petracchini, A. Remia, M. Sacchi, D. Sanchez Galvez, A. N. Tassetti, F. Trincardi

“…The digital bathymetric data previously available are restricted to the shallow highly dynamic area of the Gulf of Naples and appear fragmented as they were acquired in successive years, with different goals thereby using a variety of devices, with markedly different spatial resolutions. In this paper, we present bathymetric maps of the Gulf of Naples and adjacent slope basins at unprecedented resolution using three state-of-the-art multi-beam echo sounders. …”
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A study of relationship between cardiac exposure dose-volume and cardiovascular autonomic dysfunction in radiotherapy by CHEN Hongyu, SU Pengyu, LUO Wenzi, PANG Dequan, WANG Feiran

“…This study aimed to explore the impact of thoracic radiotherapy on the cardiac autonomic function of patients with malignant tumors by comparing the differences in heart rate variability (HRV) analysis parameters before and after radiotherapy, and to explore the dosimetric risk factors for the occurrence of AD by comparing the dosimetry between the case group and the control group, providing a theoretical basis for optimizing the dose distribution of radiotherapy regimens in order to improve patient prognosis and reduce the occurrence of complications. Methods: We prospectively collected data of patients with malignant tumors who underwent thoracic radiotherapy in the Radiotherapy Department of the Affiliated Hospital of North China University of Science and Technology from February 2023 to December 2023. …”
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Case Report: Combination of focal vibration therapy and botulinum toxin injections to treat equinus gait in a child with unilateral spastic cerebral palsy by Christophe Boulay, Christophe Boulay, Christophe Boulay, Jacques-Olivier Coq, Morgan Sangeux, Morgan Sangeux, Guillaume Authier, Guillaume Authier, Alexis Ulian, Alexis Ulian, Maud Pradines, Maud Pradines, Marjolaine Baude, Marjolaine Baude, Béatrice Desnous, Jean-Luc Jouve, Jean-Luc Jouve, Bernard Parratte, Emilie Peltier, Sébastien Pesenti, Jean-Michel Gracies, Jean-Michel Gracies

“…In children with spastic cerebral palsy (CP), FVT has also been suggested to reduce spasticity, increase torque production and improve gait function, but evidence is limited.MethodsWe report the case of a child with unilateral spastic CP (USCP) and equinus gait (GFMCS II level) with (i) ankle dorsiflexor paresis, (ii) ankle plantar flexor overactivity, especially in gastrosoleus complex and peroneus longus, (iii) spastic myopathy, affecting gastrosoleus complex in particular, and (iv) calf pain seemingly related to muscle overactivity. …”
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THE RIGHT TO GOOD ADMINISTRATION AS A CONSTITUTIONAL RIGHT OF THE PERSON: EU EXPERIENCE by Tetyana Kaganovska, Vitalii Serohin

“…The functioning of the administration (first of all, the executive power and its subsystems, as well as local self-government bodies) is fundamental for determining the quality of the democratic system as a whole. In general, we can say that the quality of administrative functioning is achieved by proper administrative practice (which includes the observance of fundamental rights) or, conversely, by the presence of improper management. …”
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Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges by Weigao Zhang, Hu Liu, Danyang Zhang, Yuguo Yi, Liang Tao, Yunfeng Zhu, Shuxian Huang, Xunan Zhao, Qianchao Shao, Peiqi Li, Yiwen Weng, Wei Lu, Jianfa Zhang, Haibing Zhang, Yuxin Chen, Dan Weng

“…However, the mechanisms governing this resilience remain incompletely understood. In this study, we identified Receptor interacting protein kinase 1 (RIPK1) in hepatocytes as a critical regulator in preserving hepatic homeostasis during metabolic challenges, such as short-term fasting or high-fat dieting. …”
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Prospective Single-Arm Study of Remifentanil-Propofol Anesthesia with Manual Right Hypochondrial Compression for Painless Gastroscopy in Obese Patients by Wang M, Tang J, Pan Z, Jiang H, Hu D, Zhu B, Liang Z, Zhao X, Li Y

“…Furthermore, our findings contribute to the understanding of the lowest SpO2 values that obese patients can tolerate during such procedures, establishing Nadir SpO2 as the cut-off point. We also identified severe OSA and diabetes as independent predictive risk factors for hypoxemia. …”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…However, the mechanism how VSIG4+ TAMs mediate immune evasion in aggressive cancers have not been fully elucidated. In our study, we found targeting VSIG4+ TAMs by VSIG4 deficiency or blockade remarkably limited tumor growth and metastasis, especially those derived from anaplastic thyroid cancer (ATC) and pancreatic cancer, two extremely aggressive types. …”
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An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…This study aimed to explore potential biomarkers associated with gemcitabine chemoresistance in pancreatic cancer by utilizing gemcitabine-resistant cell lines and pathological pancreatic cancer tissues, in conjunction with data from online databases. Additionally, we analyzed follow-up data from pancreatic cancer patients to assess the impact of relevant targets on patient prognosis. …”
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Relationship Between Adenoma Detection Rate and Respective Withdrawal Time in Different Colon Segments: A Retrospective, Single‐Center Study by Xujin Chen, Bingxin Xu, Bingni Wei, Lin Ji, Cheng Yang, Qiang Zhan

“…The adenomas in the rectosigmoid colon are more likely to be detected and do not take longer withdrawal times. We need to choose the appropriate time according to different colon segments.…”
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Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC by Domenico Lo Tartaro, Beatrice Aramini, Valentina Masciale, Nikolaos Paschalidis, Francesco Demetrio Lofaro, Anita Neroni, Rebecca Borella, Elena Santacroce, Alin Liviu Ciobanu, Anna Valeria Samarelli, Federica Boraldi, Daniela Quaglino, Alessandra Dubini, Michele Gaudio, Gloria Manzotti, Francesca Reggiani, Federica Torricelli, Alessia Ciarrocchi, Antonino Neri, Federica Bertolini, Massimo Dominici, Pier Luigi Filosso, Franco Stella, Lara Gibellini, Sara De Biasi, Andrea Cossarizza

“…In this study, using polychromatic flow cytometry, mass cytometry, and spatial transcriptomics we explored the intricate landscape of B cell phenotypes, bioenergetics, and their interaction with T cells in NSCLC. …”
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Chinese patent medicine tongxinluo capsule as a supplement to treat chronic coronary syndromes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials by Shi-Bing Liang, Shi-Bing Liang, Shi-Bing Liang, Yi-Fei Wang, Yi-Fei Wang, Yi-Fei Wang, Zhen-Chao Niu, Zhen-Chao Niu, Yu-Fei Li, Hui-Min Zheng, Hui-Min Zheng, Jia-Ming Huan, Jie Yuan, Nicola Robinson, Nicola Robinson, Jian-Ping Liu, Yun-Lun Li, Yun-Lun Li, Yun-Lun Li

“…Tongxinluo capsules (TXL) are widely used in China for treating CCS.ObjectivesTo systematically evaluate the therapeutic effects and safety of adding TXL to Western medical treatment (WM) for CCS.MethodsWe searched PubMed, Cochrane Library, CNKI, VIP, and Wanfang databases up to August 2024 for randomized controlled trials (RCTs) investigating the therapeutic effects and safety of combining TXL with WM compared to WM alone for CCS. …”
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Modulating the sulfurization procedure to decrease by-product formation for one-step catalytic synthesis of sulfur-containing chemicals by ZhiZhi Xu, Jian Fang, Min Luo, Dedong He, Dingkai Chen, Jichang Lu, Yongming Luo

“…However, directionally regulating the reaction pathway for synthesizing target sulfur-containing chemicals remain challenging owing to the presence of multiple reactants and the following various competitive side reactions. Herein, we propose a facile and simple sulfurization procedure-dependent strategies to regulate the Mo-S(O) bond strength of K-MoS2 catalysts for highly selective CO-to-CH3SH catalysis. …”
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Predictive marker for response to trifluridine/tipiracil plus bevacizumab in metastatic colorectal cancer patients by Toshiaki Takahashi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Sho Takeda, Hibiki Umeda, Kazuya Moriwake, Masashi Kayano, Yuya Sakurai, Shunsuke Nakamura, Masafumi Takahashi, Kaori Nitta, Kazuhiro Yoshida, Yuki Matsumi, Hiroyuki Michiue, Hideki Yamamoto, Hiroyuki Kishimoto, Fuminori Teraishi, Ryohei Shoji, Nobuhiko Kanaya, Hajime Kashima, Yoshihiko Kakiuchi, Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara

“…Methods To assess the effectiveness of FTD/TPI in CRC patients, we retrospectively analyzed 72 CRC patients at Okayama University Hospital from 2014 to 2022. …”
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Arbovirus vectors of epidemiological concern in the Americas: A scoping review of entomological studies on Zika, dengue and chikungunya virus vectors. by Reilly Jones, Manisha A Kulkarni, Thomas M V Davidson, RADAM-LAC Research Team, Benoit Talbot

“…<h4>Results</h4>A total of 96 studies were included in the scoping review after initial screening and subsequent exclusion of out-of-scope studies, secondary data publications, and studies unavailable in English language.<h4>Key findings</h4>We observed a steady increase in number of publications, from 2013 to 2018, with half of all studies published from January 2017 to March 2018. …”
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Sex-specific associations between body composition and depression among U.S. adults: a cross-sectional study by Yijing Li, Juan Li, Tianning Sun, Zhigang He, Cheng Liu, Zhixiao Li, Yanqiong Wu, Hongbing Xiang

“…After accounting for confounding variables, the associations between fat mass index (FMI), appendicular skeletal muscle mass index (ASMI), body fat percentage (BFP), body composition phenotypes, and depression risk were assessed using restricted cubic spline (RCS) curves and multivariable logistic regression models. We further conducted interaction analyses for ASMI and FMI in females. …”
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Re-evaluating large for gestational age: differential effects on perinatal outcomes in term and premature births by Chun-Heng Kuo, Chun-Heng Kuo, Chun-Heng Kuo, Yi-Ling Wu, Chi-Nien Chen, Chi-Nien Chen, Yu-Ru Lo, I-Weng Yen, Kang-Chih Fan, Yi-Yun Tai, Ming-Wei Lin, Chih-Cheng Hsu, Chih-Cheng Hsu, Chih-Cheng Hsu, Chih-Cheng Hsu, Hung-Yuan Li

“…This study aims to explore the risks of adverse maternal and neonatal perinatal outcomes associated with LGA in term neonates and neonates with different degrees of prematurity, compared to appropriate-for-gestational-age (AGA) neonates.MethodsUsing the Birth Reporting Databases (2007–2018) linked to Taiwan's National Health Insurance Research Database, we conducted a retrospective nationwide cohort study of singleton neonates delivered between 24 and 42 weeks of gestation. …”
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A multicountry evaluation of the Xpert MTB/RIF assay for the diagnosis of intrathoracic tuberculosis in children using alternative specimens (nasopharyngeal aspirate and stool): A... by Rindra Vatosoa Randremanana, Mathurin Tejiokem, Niaina Rakotosamimanana, Valérie Donkeng Donfack, Verlaine Bolyse Mbouchong, Mirella Randrianarisoa, Aina Harimanana, Jean Voisin Taguebue, Suzie Tetang Ndiang, Valère Itchy, Annick Robinson, Lovaniaina Ravelomanana, Mbola Rakotomahefa, Dina Ranoharison, Man-Koumba Soumahoro, Brigitte Gicquel, Raymond N'Guessan, Sara Eyangoh, Voahangy Rasolofo, Emery Flavien Akpafi, Marius Irie Bi Irie, Anabelle Bai-Orsot, Jaudel Francis Yuya Septoh, Serge Abogo, Mamy Serge Raherison, Andrianantenaina Rakotoson, Vaomalala Raharimanga, Patrice Piola, Paulo Ranaivomanana, Jean-Marc Collard, Gabrielle Prisca Emmylou Andrianah, Turibio Razafindranaivo, Reziky Tiandraza Mangahasimbola, Kathleen Victoir

“…Samples for analysis included standard specimens (gastric aspirate or sputum), NPA, stools, with additional HIV serology, tuberculin skin test tests, and chest X-rays. We used a composite reference standard to estimate the accuracy of the Xpert MTB/RIF test with alternative samples. …”
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