Low-Dose Anti-PD(L)1 for the Treatment of Solid Malignancies by Iza Andrade de A. Souza, Beatriz de M. Dobbert, Barbara G. Sao Jose, Joao Pedro Homse-Netto, Larissa L. Furlan, Maira S. Abreu, Camila Ferrari, Bruno Uchoa, Kathia Abdallah, Stephano N. Lucio, Joao A. Soler, Fabio L.C. Fernandez, Luiza Ferreira, Joao D. Guedes, Aline F. Fares, Daniel V. Araujo

“…PURPOSEMounting data suggest that lower doses of anti-PD(L)1 agents can be as efficacious as label-approved doses at a fraction of its cost. We compare the outcomes of patients treated with low-dose (LD) and with conventional-dose (CD) anti-PD(L)1 agents.METHODSThis observational study evaluates the outcomes of patients with solid malignancies treated with anti-PD(L)1 agents (LD or CD) at Hospital de Base, Brazil. …”
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A multimodal transformer system for noninvasive diabetic nephropathy diagnosis via retinal imaging by Zheyi Dong, Xiaofei Wang, Sai Pan, Taohan Weng, Xiaoniao Chen, Shuangshuang Jiang, Ying Li, Zonghua Wang, Xueying Cao, Qian Wang, Pu Chen, Lai Jiang, Guangyan Cai, Li Zhang, Yong Wang, Jinkui Yang, Yani He, Hongli Lin, Jie Wu, Li Tang, Jianhui Zhou, Shengxi Li, Zhaohui Li, Yibing Fu, Xinyue Yu, Yanqiu Geng, Yingjie Zhang, Liqiang Wang, Mai Xu, Xiangmei Chen

“…To reform the traditional biopsy-all diagnostic paradigm and avoid unnecessary biopsy, we developed a transformer-based deep learning (DL) system for detecting DN and NDRD upon non-invasive multi-modal data of fundus images and clinical characteristics. …”
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Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis by Xiaoming Li, Xiaoming Li, Rui Xu, Rui Xu, Dan Zhang, Ji Cai, Ji Cai, He Zhou, He Zhou, Tao Song, Tao Song, Xianyao Wang, Xianyao Wang, Qinghong Kong, Liujin Li, Zhaohui Liu, Zhixu He, Zhengzhen Tang, Jun Tan, Jidong Zhang, Jidong Zhang, Jidong Zhang

“…Baicalin’s therapeutic effects are achieved through various pathways, including antioxidant, anti-inflammatory, antifibrosis, and regulation of apoptosis and cell proliferation. Besides, we also hope this review may give some enlightenment for treating AKI and renal fibrosis in clinical practice.…”
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Realizing low voltage-driven bright and stable quantum dot light-emitting diodes through energy landscape flattening by Yiting Liu, Yingying Sun, Xiaohan Yan, Bo Li, Lei Wang, Jianshun Li, Jiahui Sun, Yaqi Guo, Weipeng Liu, Binbin Hu, Qingli Lin, Fengjia Fan, Huaibin Shen

“…However, the serious energy disorder between the quantum dots (QDs) and hole transport layer (HTL) makes it challenging to achieve high-performance devices at lower voltage ranges. Here, we introduce “giant” fully alloy CdZnSe/ZnSeS core/shell QDs (size ~ 19 nm) as the emitting layer to build high-efficient and stable QLEDs. …”
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Enhancing immunotherapy through PD‐L1 upregulation: the promising combination of anti‐PD‐L1 plus mTOR inhibitors by Anna Hernández‐Prat, Alejo Rodriguez‐Vida, Laura Cardona, Mengjuan Qin, Oriol Arpí‐Llucià, Luis Soria‐Jiménez, Sílvia Menendez, Fabricio Gerel Quimis, Miguel Galindo, Edurne Arriola, Marta Salido, Nuria Juanpere‐Rodero, Federico Rojo, Aura Muntasell, Joan Albanell, Ana Rovira, Joaquim Bellmunt

“…The potential interaction between mTOR inhibitors and PD‐L1 expression in UC has not been well characterized. In our study, we investigated how phosphoinositide 3‐kinase (PI3K)/AKT/mTOR pathway inhibitors (TAK‐228, everolimus and TAK‐117) affect PD‐L1 expression and function in preclinical bladder cancer cell models. …”
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An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants by Bruce Nmezi, Guillermo Rodriguez Bey, Talia DeFrancesco Oranburg, Kseniia Dudnyk, Santana M. Lardo, Nathan Herdman, Anastasia Jacko, Sandy Rubio, Emanuel Loeza-Alcocer, Julia Kofler, Dongkyeong Kim, Julia Rankin, Emma Kivuva, Nicholas Gutowski, Katherine Schon, Jelle van den Ameele, Patrick F. Chinnery, Sérgio B. Sousa, Filipe Palavra, Camilo Toro, Filippo Pinto e Vairo, Jonas Saute, Lisa Pan, Murad Alturkustani, Robert Hammond, Francois Gros-Louis, Michael S. Gold, Yungki Park, Geneviève Bernard, Raili Raininko, Jian Zhou, Sarah J. Hainer, Quasar S. Padiath

“…Utilizing data from recently identified families that carry LMNB1 gene duplications but do not exhibit demyelination, ADLD patient tissues, CRISPR edited cell lines and mouse models, we have identified a silencer element that is lost in ADLD patients and that specifically targets expression to oligodendrocytes. …”
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Measurable residual disease as predictor of post–day +100 relapses after allografting in adult AML by Naveed Ali, Megan Othus, Eduardo Rodríguez-Arbolí, Corentin Orvain, Filippo Milano, Brenda M. Sandmaier, Chris Davis, Ryan S. Basom, Frederick R. Appelbaum, Roland B. Walter

“…To examine the role of MFC MRD testing to predict later relapses, we examined 935 adults with AML or myelodysplastic neoplasm/AML transplanted in first or second morphologic remission who underwent bone marrow restaging studies between day 70 and 100 after HCT and were alive and without relapse by day +100. …”
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CHROMOGRANIN-A IN THE DIAGNOSIS OF PROSTATE CANCER by A. V. Sivkov, N. G. Keshishev, G. D. Efremov, G. A. Kovchenko, A. A. Trudov, L. M. Nikonova, F. D. Romikh

“…Defining the relationship between HGA and stage of prostate cancer (LPC, LAPC and CRPC), we also found a correlation (r = 0,31, p <0,005) among these groups of patients.Conclusions. …”
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Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer... by Dong-Dong Wang, Ming-Qian Jia, He-Li Xu, Yu Li, Jia-Xin Liu, Jia-Cheng Liu, Jia-Nan Sun, Fan Cao, Lang Wu, Fang-Hua Liu, Yi-Zi Li, Yi-Fan Wei, Xiao-Ying Li, Qian Xiao, Song Gao, Dong-Hui Huang, Tao Zhang, Ting-Ting Gong, Qi-Jun Wu

“…Dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) were calculated based on specific antioxidant nutrients. We examined the associations of pre-diagnosis, post-diagnosis, and changes from pre-diagnosis to post-diagnosis in TAC, CDAI, and representative antioxidant nutrients with overall survival (OS) among patients with OC. …”
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Solvent-dripping modulated 3D/2D heterostructures for high-performance perovskite solar cells by Xiaoming Chang, Randi Azmi, Tinghuan Yang, Nan Wu, Sang Young Jeong, Herui Xi, Drajad Satrio Utomo, Badri Vishal, Furkan H. Isikgor, Hendrik Faber, Zhaoheng Ling, Mingjie He, Marco Marengo, Pia Dally, Adi Prasetio, Yu-Ying Yang, Chuanxiao Xiao, Han Young Woo, Kui Zhao, Martin Heeney, Stefaan De Wolf, Leonidas Tsetseris, Thomas D. Anthopoulos

“…Unfortunately, the random orientation of the spontaneously formed 2D phase atop the pre-deposited 3D perovskite film can deteriorate charge extraction owing to energetic disorder, limiting the maximum attainable efficiency and long-term stability of the PSCs. Here, we introduce a meta-amidinopyridine ligand and the solvent post-dripping step to generate a highly ordered 2D perovskite phase on the surface of a 3D perovskite film. …”
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Leptin decreases Th17/Treg ratio to facilitate neuroblastoma via inhibiting long-chain fatty acid catabolism in tumor cells by Meng Li, Di Li, Hai-Yun Wang, Weixin Zhang, Zhenjian Zhuo, Huiqin Guo, Jiabin Liu, Yue Zhuo, Jue Tang, Jing He, Lei Miao

“…Based on metabolomic and transcriptomic data in mediastinal NB tissues, we found that the content of long-chain acylcarnitine (LCAC) was increased and positively associated with leptin expression in advanced NB. …”
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Clinical utility and predictive value of cerebrospinal fluid cell-free DNA profiling in non-small cell lung cancer patients with leptomeningeal metastasis by Sheng-Kai Liang, Wei-Yu Liao, Jin-Yuan Shih, Chia-Lin Hsu, Ching-Yao Yang, Shang-Gin Wu, Yen-Ting Lin, Yueh-Feng Wen, Lun-Che Chen, Yen-Fu Chen, Ya-Fang Chen, Yen-Heng Lin, Chong-Jen Yu

“…Cerebrospinal fluid (CSF) cell-free DNA (cfDNA) analysis using next-generation sequencing (NGS) offers insights into resistance mechanisms and potential treatment strategies. We conducted a study from February 2022 to April 2023 involving patients from five hospitals in Taiwan who had recurrent or advanced NSCLC with LM. …”
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Baseline Serum Cholesterol Is Associated with a Response to Pegylated Interferon Alfa-2b and Ribavirin Therapy for Chronic Hepatitis C Genotype 2 by Naota Taura, Tatsuki Ichikawa, Hisamitsu Miyaaki, Yoshiko Kadokawa, Takuya Tsutsumi, Shotaro Tsuruta, Yuji Kato, Osami Inoue, Noboru Kinoshita, Kazuo Ohba, Hiroyuki Kato, Kazuyuki Ohata, Junichi Masuda, Keisuke Hamasaki, Hiroshi Yatsuhashi, Kazuhiko Nakao

“…However, most of these studies involved patients infected with HCV genotype 1. Thus, we performed a multi-institutional clinical study to evaluate the impact of lipid profiles on SVR rates in patients with HCV genotype 2. …”
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Lutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy by Myrna Luna-Gutiérrez, Erika Azorín-Vega, Rigoberto Oros-Pantoja, Blanca Ocampo-García, Pedro Cruz-Nova, Nallely Jiménez-Mancilla, Gerardo Bravo-Villegas, Clara Santos-Cuevas, Laura Meléndez-Alafort, Guillermina Ferro-Flores

“…Peptides that target specific pathways and cells involved in immunomodulation can potentially improve the efficacy of cancer therapy. Recently, we reported iPD-L1 as a novel inhibitor peptide that specifically targets the cancer cell ligand PD-L1 (programmed death ligand 1). …”
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Multicenter Evaluation of Morbidity and Predictors of Response to Imiquimod Treatment for Penile Intraepithelial Neoplasia by Ofir Avitan, Laura Elst, Manon Vreeburg, Tynisha Rafael, Katja Jordanova, Niels Graafland, Kees Hendricksen, Bas W.G. van Rhijn, Henk G. van der Poel, Maarten Albersen, Oscar Brouwer

“…The primary objective of our study was to assess the response to IQ treatment, associated SEs, and potential predictors of response in the largest reported cohort to date. Methods: We conducted a collaborative retrospective study involving patients diagnosed with PeIN and treated with IQ between 2010 and 2022 in two high-volume centers in the Netherlands and Belgium. …”
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Increased Early‐Mortality in Children With Solid Tumors During the COVID‐19 Pandemic in a Middle‐Income Country by Oscar Ramirez, Vivian Piedrahita, Santiago Bolivar, Karina Grillo, Adriana Linares, Carlos Pardo, Martha Piña, Amaranto Suarez, Carlos A. Portilla, Jesus Ardila, Viviana Lotero, Luz A. Urcuqui, Angela Trujillo, Patricia Montenegro, Luis E. Bravo, Paula Aristizabal, VIGICANCER Working Group

“…In the EC, the adjusted odds ratio (aOR) for metastatic solid tumors vs. nonmetastatic was 1.4 (95% CI, 1.0–1.8) and in children with retinoblastoma and public insurance the 24‐month mortality aHR was 4.9 (95% CI, 1.1–21.7). Conclusions We observed increased early‐mortality for solid tumors, particularly bone tumors and retinoblastoma, likely attributed to more advanced‐stage presentation and loss of treatment effectiveness due to healthcare disruptions. …”
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Vertical gradients of neutral winds observed by ICON and estimated by the Horizontal Wind Model during the geomagnetic storm on August 26−28, 2021 by JiaWei Wu, Chao Xiong, YuYang Huang, YunLiang Zhou

“…The Michelson Interferometer for Global High-resolution Thermospheric Imaging (MIGHTI) onboard the Ionospheric Connection Explorer (ICON) satellite offers the opportunity to investigate the altitude profile of thermospheric winds. In this study, we used the red-line measurements of MIGHTI to compare with the results estimated by Horizontal Wind Model 14 (HWM14). …”
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Gene networks for use in metabolomic data analysis of blood plasma from patients with postoperative delirium by V. A. Ivanisenko, N. V. Basov, A. A. Makarova, A. S. Venzel, A. D. Rogachev, P. S. Demenkov, T.  V. Ivanisenko, M. A. Kleshchev, E. V. Gaisler, G. B. Moroz, V. V. Plesko, Y. S. Sotnikova, Y. V. Patrushev, V. V. Lomivorotov, N. A. Kolchanov, A. G. Pokrovsky

“…Employing gene network reconstruction, we perceived a set of 82 regulatory enzymes affiliated with the genetic coordination of the sphingolipid metabolism pathway. …”
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Survival feature and trend of female breast cancer: A comprehensive review of survival analysis from cancer registration data by Dan-Dan Tang, Zhuo-Jun Ye, Wan-Wan Liu, Jing Wu, Jing-Yu Tan, Yan Zhang, Qun Xu, Yong-Bing Xiang

“…To better understand global patterns, chronological changes, and international comparisons of female breast cancer survival, we reviewed published data from population-based cancer registries worldwide. …”
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Factors Affecting Influenza and Pneumococcal Vaccination Rates in Hemodialysis Patients: A Multicenter Study by Selen T, Merhametsiz Ö, Öneç K, Ercan Z, İslam M, Altun G, Pınar M, Demir ME

“…In the multivariate logistic regression analysis, dialysis duration and education level were identified as independent factors predicting a higher level of knowledge about the pneumococcal vaccine (p=0.038, 0.040, and p=0.010).Conclusion: It was observed that awareness and vaccination rates regarding influenza and pneumococcal vaccines were lower in our patients than recommended. We believe that educating patients about vaccines and increasing the sensitivity of hemodialysis physicians, nurses and nephrologists on this issue will increase vaccination rates.Keywords: hemodialysis, influenza, pneumococcal pneumonia, vaccine…”
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