Efficacy and safety of PD-1 inhibitors as second-line treatment for advanced squamous esophageal cancer: a systematic review and network meta-analysis with a focus on PD-L1 express... by Fei Yang, Min Dan, Jindan Shi, Ling Fan, Haoluo Zhang, Tiantian Jian, Kelu Lei, Yue Wang, Juan Xin, Zhigang Yu, Wei Chen

“…To address this key issue in the second-line treatment of ESCC, we conducted a network meta-analysis (NMA) with a focus on OS benefits, particularly in patients with different levels of PD-L1 expression.MethodsA systematic search of relevant literature was conducted in Web of Science, Embase, PubMed, and Cochrane Library, covering publications from the inception of these database to June 2024. …”
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YafN-YafO toxin-antitoxin system contributes to stress resistance and virulence of avian pathogenic Escherichia coli by Qiubo Chen, Yunyan Sun, Qianlong Xing, Zhengliang Li, Song Gao, Qingqing Gao

“…Using bacterial two-hybrid and pull-down assays, we confirmed the interaction between YafN and YafO. …”
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The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration by Dragana Miloradovic, Dragica Miloradovic, Bojana Simovic Markovic, Aleksandar Acovic, Carl Randall Harrell, Valentin Djonov, Nebojsa Arsenijevic, Vladislav Volarevic

“…Although several possible explanations have been proposed, including different numbers of injected and engrafted MSCs, heterogeneity in phenotype, and function of tumor cells, the exact molecular mechanisms responsible for opposite effects of MSCs in modulation of antitumor immunity are still unknown. Herewith, we used a B16F10 murine melanoma model to investigate whether timing of MSC administration in tumor-bearing mice was crucially important for their effects on antitumor immunity. …”
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The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19 by Xuan Niu, Wenrui Bao, Zhaoyao Luo, Pang Du, Heping Zhou, Haiyang Liu, Baoqi Wang, Huawen Zhang, Bo Wang, Baoqin Guo, Hui Ma, Tao Lu, Yuchen Zhang, Junya Mu, Shaohui Ma, Jixin Liu, Ming Zhang

“…Crucially, the initial GMV in the right DLPFC can predict fatigue symptoms 3 months after infection. Conclusions: We provide novel evidence on the neuroanatomical basis of fatigue vulnerability and emphasize that acute fatigue is an important link between early GMV in the frontal-limbic regions and comorbid neuropsychiatric symptoms at baseline and 3 months after infection. …”
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Immunosuppressive therapy and nutritional diseases of patients after kidney transplantation: a systematic review by Aleksandra Anna Kajdas, Marcin Kleibert, Anne Katrine Normann, Krzysztof Krasuski, Ditte Søndergaard Linde, Dorota Szostak-Węgierek

“…Knowing that nutritional status plays a significant role in post-transplant results including graft survival, we conducted this systematic review with the aim to summarise the evidence of nutritional diseases following exposure to immunosuppressive therapy among patients after kTx. …”
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Mechanical Ventilator-Associated Pneumonia in the COVID-19 Pandemic Era: A Critical Challenge in the Intensive Care Units by Mircea Stoian, Adina Andone, Sergiu Rareș Bândilă, Danusia Onișor, Sergiu Ștefan Laszlo, Gabriela Lupu, Alina Danielescu, Dragoș-Florin Baba, Anca Meda Văsieșiu, Andrei Manea, Adina Stoian

“…<b>Background/Objectives:</b> Ventilator-associated pneumonia (VAP) is the most common nosocomial infection encountered in the intensive care unit (ICU) and is associated with prolonged hospitalization and increased mortality. We evaluated the causative pathogens involved and their resistance to the major classes of antibiotics in patients with VAP and assessed the differences between patients with and without coronavirus disease 2019 (COVID-19). …”
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The Existence and Uniqueness of Nonlinear Elliptic Equations with General Growth in the Gradient by Angelo Alvino, Vincenzo Ferone, Anna Mercaldo

“…In this paper, we prove the existence and uniqueness results for a weak solution to a class of Dirichlet boundary value problems whose prototype is <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>−</mo><msub><mo>Δ</mo><mi>p</mi></msub><mi>u</mi><mo>=</mo><mi>β</mi><msup><mrow><mo>|</mo><mo>∇</mo><mi>u</mi><mo>|</mo></mrow><mi>q</mi></msup><mo>+</mo><mi>f</mi><mo> </mo><mrow><mi mathvariant="normal">i</mi><mi mathvariant="normal">n</mi><mo> </mo><mo>Ω</mo></mrow><mspace width="0.166667em"></mspace><mo>,</mo><mo> </mo><mi>u</mi><mo>=</mo><mn>0</mn><mo> </mo><mrow><mi mathvariant="normal">o</mi><mi mathvariant="normal">n</mi><mo> </mo><mo>∂</mo><mo>Ω</mo></mrow><mspace width="0.166667em"></mspace><mo>,</mo><mspace width="4pt"></mspace></mrow></semantics></math></inline-formula> where <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mo>Ω</mo></semantics></math></inline-formula> is a bounded open subset of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mrow><mi mathvariant="double-struck">R</mi></mrow><mi>N</mi></msup></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>N</mi><mo>≥</mo><mn>2</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>1</mn><mo><</mo><mi>p</mi><mo><</mo><mi>N</mi></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mo>Δ</mo><mi>p</mi></msub><mi>u</mi><mo>=</mo><mi>div</mi><mfenced separators="" open="(" close=")"><msup><mrow><mo>|</mo><mo>∇</mo><mi>u</mi><mo>|</mo></mrow><mrow><mi>p</mi><mo>−</mo><mn>2</mn></mrow></msup><mo>∇</mo><mi>u</mi></mfenced></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>p</mi><mo>−</mo><mn>1</mn><mo><</mo><mi>q</mi><mo><</mo><mi>p</mi></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>β</mi></semantics></math></inline-formula> is a positive constant and <i>f</i> is a measurable function satisfying suitable summability conditions depending on <i>q</i> and a smallness condition.…”
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Increasing exposure of cotton growing areas to compound drought and heat events in a warming climate by Shengli Liu, Wei Zhang, Tongtong Shi, Tong Li, Hui Li, Guanyin Zhou, Zhanbiao Wang, Xiongfeng Ma

“…Despite this, a comprehensive assessment of global CDHE occurrence over cotton-growing areas and its potential impacts on cotton yields remains unresolved, hindering efforts to implement adaptive strategies to ensure global cotton productivity. To address this gap, we analyzed changes in mean temperature and soil moisture within global cotton-growing areas during their respective growing seasons, estimated the probability of CDHEs across multiple spatial scales via copula theorems, and examined the relationship between cotton yield anomalies and CDHEs in major cotton countries. …”
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Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor by Xin Xu, Hui Yu, Mingyi Yang, Jiale Xie, Ke Xu, Erliang Li, Xianjie Wan, Jiachen Wang, Guoqiang Wang, Ying Pan, Peng Xu, Junfei Guo

“…To exclude confounding effects of BMI, we also used a multivariate MR (MVMR). Results: After adjusting for BMI through MVMR, no significant causal relationship was identified between genetically predicted OSA and OA phenotypes, including knee (KOA) and hip osteoarthritis (HOA), suggesting that obesity largely drives the observed relationship between these conditions. …”
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Rehospitalization burden and morbidity risk in patients with heart failure with mid‐range ejection fraction by Enrique Santas, Rafael de laEspriella, Patricia Palau, Gema Miñana, Martina Amiguet, Juan Sanchis, Josep Lupón, Antoni Bayes‐Genís, Francisco Javier Chorro, Julio Núñez Villota

“…Abstract Aims Heart failure with mid‐range ejection fraction (HFmrEF) has been proposed as a distinct HF phenotype, but whether patients on this category fare worse, similarly, or better than those with HF with reduced EF (HFrEF) or preserved EF (HFpEF) in terms of rehospitalization risks over time remains unclear. Methods and results We prospectively included 2961 consecutive patients admitted for acute HF (AHF) in our institution. …”
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Chikungunya virus infection in the skin: histopathology and cutaneous immunological response by Natália Gedeão Salomão, Natália Gedeão Salomão, Luciana Araújo, Luiz José de Souza, Anna Luiza Young, Carlos Basílio-de-Oliveira, Rodrigo Panno Basílio-de-Oliveira, Jorge José de Carvalho, Priscilla Conrado Guerra Nunes, Juliana Fernandes da Silva Amorim, Douglas Valiati dos Santos Barbosa, Marciano Viana Paes, Kíssila Rabelo, Kíssila Rabelo, Flavia Dos Santos

“…Since the skin is the first line of defense against CHIKV infection, in this study, we aimed to investigate the immunohistopathological aspects of the skin of infected individuals during the acute phase of the disease by performing histopathological and ultrastructural analysis, detection and quantification of the viral genome, detection of viral antigen and immune cells, and cytokines/chemokines’ characterization. …”
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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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Universal antibacterial and anti-inflammatory treatment using chitosan-prussian blue nanozyme by Jian Wang, Jiayi Wang, Huayuan Zhou, Rui Ma, Zhou Fang, Jiawei Zhu, Zhejie Chen, Xinfeng Dai, Dali Wei, Jiabei Li, Yiting Jiang, Qian Xia, Xueliang Liu, Yu Yang

“…Bacterial infections are a growing global public health problem, exacerbated by the widespread and often inappropriate use of antibiotics, leading to the emergence of non-antibiotic pathogens. Herein, we synthesized a chitosan-Prussian blue nanozyme (CS@PB), a non-antibiotic agent, for universal antibacterial and anti-inflammatory treatment of bacterial infections. …”
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A gram-positive enhancer matrix particles vaccine displaying swine influenza virus hemagglutinin protects mice against lethal H1N1 viral challenge by Yufei Zhang, Yufei Zhang, Yufei Zhang, Pei Zhang, Pei Zhang, Pei Zhang, Xiaoyue Du, Xiaoyue Du, Xiaoyue Du, Xiaona Shi, Xiaona Shi, Xiaona Shi, Jinling Wang, Jinling Wang, Jinling Wang, Shuying Liu, Shuying Liu, Shuying Liu

“…Therefore, there is an urgent need to develop a potent vaccine against EA H1N1.MethodsIn this study, we report the effective intramuscular (i.m.) and/or intranasal (i.n.) vaccination of mice with a subunit influenza vaccine utilizing safe adjuvant gram-positive enhancer matrix (GEM) particles derived from the food-grade bacterium Lactococcus lactis. …”
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Relationship Between Diaphragm Function and Sarcopenia Assessed by Ultrasound: A Cross-Sectional Study by Takahiro Shinohara, Toru Yamada, Shuji Ouchi, Suguru Mabuchi, Ryoichi Hanazawa, Kazuharu Nakagawa, Kanako Yoshimi, Tatsuya Mayama, Ayane Horike, Kenji Toyoshima, Yoshiaki Tamura, Atsushi Araki, Haruka Tohara, Akihiro Hirakawa, Takuma Kimura, Takeshi Ishida, Masayoshi Hashimoto

“…<b>Background/Objectives</b>: The diaphragm is important for respiration, but the effects of age-related muscle loss and sarcopenia on diaphragm function are unclear. We evaluated the associations of sarcopenia and skeletal muscle mass (SMM) with diaphragm function. …”
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Real-world outcomes of the CROSS regimen in patients with resectable esophageal or gastro-esophageal junction adenocarcinoma: a nationwide cohort study in the NetherlandsResearch i... by Hanneke van Laarhoven, Rob Verhoeven, Mark van Berge Henegouwen, Nadia Haj Mohammad, Richard van Hillegersberg, Marije Slingerland, Christina T. Muijs, Bas Wijnhoven, Bianca Mostert, Laurens Beerepoot, Grard Nieuwenhuijzen, Sarah Derks, Peter S.N. van Rossum

“…To contextualize the findings from these studies using nCRT as a comparator, we aimed to investigate contemporary real-world outcomes of nCRT in patients with adenocarcinoma of the esophagus or GEJ. …”
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Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors by Hesham Abboud, Gencer Genc, Nicolas R. Thompson, Srivadee Oravivattanakul, Faisal Alsallom, Dennys Reyes, Kathy Wilson, Russell Cerejo, Xin Xin Yu, Darlene Floden, Anwar Ahmed, Michal Gostkowski, Ayman Ezzeldin, Hazem Marouf, Ossama Y. Mansour, Andre Machado, Hubert H. Fernandez

“…Postoperative UPDRS II and EQ-5D were analyzed using simple linear regression adjusting for preoperative score. For global outcomes, we utilized the Patient Global Impression of Change Scale (PGIS) and the Clinician Global Impression of Change Scale (CGIS). …”
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Detection Rate of Helicobacter Pylori Infection and Atrophic Gastritis Using Serological Markers “GastroPanel®” Among Employees of the National Medical Research Radiological Centre... by A. D. Kaprin, N. S. Sergeeva, S. S. Pirogov, I. I. Alentov, O. К. Yutsevich, V. I. Ryabtseva, G. F. Minibaeva, N. V. Marshutina, T. А. Karmakova

“…Regarding the occupational risks of infection among medical workers, we consider it advisable to conduct such screening without selecting an asymptomatic population.…”
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Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model by Wei Xu, Yang Zhou, Ling Lin, Dongyin Yuan, Yingqi Peng, Li Li, Wenjun Xiao, Zhihua Gong

“…However, the hypoglycemic effects of black brick tea are still unexplored. Here, we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice model. …”
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Aspergillus fumigatus extract modulates human eosinophils via NOD2 and oxidative stress by Hisashi Sasaki, Jun Miyata, Yusuke Kawashima, Ryo Konno, Masaki Ishikawa, Yoshinori Hasegawa, Ryuta Onozato, Yo Otsu, Emiko Matsuyama, Keeya Sunata, Katsunori Masaki, Hiroki Kabata, Yoshifumi Kimizuka, Tomoe Abe, Shigeharu Ueki, Koichiro Asano, Akihiko Kawana, Koichi Fukunaga

“…However, the precise mechanisms underlying airway inflammation remain unclear. In this study, we investigated the direct modulation of human eosinophils by A. fumigatus and identified the specific mechanism of airway inflammation. …”
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