Optimization of the extraction methods and evaluation of the hypoglycemic effect of Adhatoda Zeylanica extracts on artificially induced diabetic mice by Md Fahim Ahmed, Khalid Hasan Raby, Nishat Tasnim, Md Tariful Islam, Mahbub Chowdhury, Zarin Tasnim Juthi, Md Ashik Mia, Lubna Jahan, A.K.M. Zakir Hossain, Shoeb Ahmed

“…Synthetic antidiabetic drugs are often associated with various adverse side effects, including hypoglycemia, nausea, gastrointestinal disturbances, headaches, and even liver damage. …”
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Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus by Xu He, Xu He, Xu He, Wei Zhao, Wei Zhao, PeiHang Li, PeiHang Li, YinJiang Zhang, YinJiang Zhang, GuoHua Li, HongYu Su, BiNan Lu, BiNan Lu, ZongRan Pang, ZongRan Pang

“…Compared with other non-insulin hypoglycemic drugs, it can not only effectively reduce blood glucose and glycosylated hemoglobin (HbA1c), but also protect cardiovascular system, nervous system and kidney function without causing hypoglycemia and weight gain. Therefore, GLP-1RAs has good application prospects and potential for further development.…”
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Shorter Digestion Times of Donor Islets Is Associated With Better Islet Graft Function After Islet Transplantation by Chia-Hao Wang, Christopher Orr, Jeannette Hacker-Stratton, Mohamed El-Shahawy, Keiko Omori, Meirigeng Qi, Fouad Kandeel

“…Although islet transplantation is effective in reducing severe hypoglycemia events and controlling blood glucose in patients with type 1 diabetes, maintaining islet graft function long-term is a significant challenge. …”
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Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a protocol for a systematic review with meta-analysis and Trial Seque... by Johanne Juul Petersen, Sophie Juul, Caroline Barkholt Kamp, Pascal Faltermeier, Christina Dam Bjerregaard Sillassen, Tiago Jeronimo Dos Santos, Janus Christian Jakobsen

“…Primary outcomes will be severe hypoglycemia, ketoacidosis, and serious adverse events. …”
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Strategic Infectious Diseases in Beef Cattle in Balongpanggang during 2023 by Wiwik Misaco Yuniarti, Bambang Sektiari Lukiswanto, Boedi Setiawan, Ira Sari Yudaniayanti, Nusdianto Triakoso, Mirza Atikah Madarina Hisyam, Lina Susanti, Apriliwiyani Niken Hastuti, Budi Santoso Sudjono

“…In addition to BEF, official veterinary services reported a total case of 1546 throughout 2023 that comprises; diarrhea (99), limping (24), helminthiasis (91), ectoparasite (11), hematochezia (3), wound (3), mastitis (4), allergy (1), dystocia (28), vaginal prolapse (11), dermatitis (45), enteritis (27), tympani (11), scabiosis (122), arthritis (67), ophthalmic problem (11), endometritis (1), uterine retention (13), indigestion (2), pneumonia (21), hypoglycemia (5), abscess (21), ovariohysterectomy (1), orchitis (1), intoxication (1), and papilloma (1). …”
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Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs by Jocelyn Mott, Arnon Gal, Antonio Maria Tardo, Alisa Berg, Riley Claude, Alexis Hoelmer, Mei Lun Mui, Avin Arjoonsingh, Chen Gilor

“…Eighty‐four percent (28/33) of dogs responded to once daily dose of IDeg100 with low frequency of clinical hypoglycemia.…”
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Efficacy and safety of glucagon-like peptide-1 receptor agonists in the elderly versus non-elderly patients with type 2 diabetes mellitus: insights from a systematic review by Yao Wang, Jiangling Wang, Qian Gong, Haoming Wu, Shuhao Yang, Jufeng He, Xulin Hu, Tianfang Huang

“…However, no significant differences were observed in weight loss (SMD = 0.03, 95% CI –0.12 to 0.19, p = 0.686), HbA1c% (SMD = –0.02, 95% CI –0.11 to 0.08, p = 0.715), FBG levels (SMD = –0.03, 95% CI –0.11 to 0.06, p = 0.537), and the incidence of overall AEs (OR = 0.85, 95% CI 0.71 to 1.01, p = 0.072), serious AEs (OR = 0.68, 95% CI 0.45 to 1.04, p = 0.077), nausea (OR = 0.91, 95% CI 0.81 to 1.03, p = 0.140), vomiting (OR = 0.95, 95% CI 0.79 to 1.13, p = 0.532), diarrhea (OR = 0.86, 95% CI 0.72 to 1.02, p = 0.081), and hypoglycemia (OR = 1.22, 95% CI 0.90 to 1.65, p = 0.193). …”
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Real-World Life Analysis of a Continuous Glucose Monitoring and Smart Insulin Pen System in Type 1 Diabetes: A Cohort Study by Paola Pantanetti, Giovanni Cangelosi, Sara Morales Palomares, Gaetano Ferrara, Federico Biondini, Stefano Mancin, Gabriele Caggianelli, Mauro Parozzi, Marco Sguanci, Fabio Petrelli

“…These findings highlight its efficacy in improving hyperglycemia management while maintaining a stable risk of hypoglycemia.…”
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A Randomized Trial of Insulin Glargine plus Oral Hypoglycemic Agents versus Continuous Subcutaneous Insulin Infusion to Treat Newly Diagnosed Type 2 Diabetes by Shuo Lin, Mu Chen, Wanling Chen, Keyi Lin, Panwei Mu, Bilian Zhu, Wen Xu, Manman Wang, Jianping Weng, Longyi Zeng

“…The primary outcome measure was the mean amplitude of glycemic excursions (MAGE), and secondary endpoints included time to reach glycemic control target (FPG < 7 mmol/L and 2-hour postprandial plasma glucose < 10 mmol/L), markers of β-cell function, and hypoglycemia. Results. Subjects in the CSII (n=35) and basal insulin plus OHA (n=33) groups had a similar significant reduction from baseline to end of treatment in glycated albumin (−6.44 ± 3.23% and− 6.42 ± 3.56%, P=0.970). …”
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Implementasi Algoritma Naïve Bayes untuk Mendeteksi Resiko Tinggi Diabetes Melitus Pada Ibu Hamil (Studi Kasus : Puskesmas Kabupaten Malang) by Fatmawati Fatmawati, Satrio Agung Wicaksono, Satrio Hadi Wijoyo

“…Occurrence of congenital malformations, miscarriage, risk of preeclampsia, CPD (Cepalo Pelvic Disproportion), premature birth, position abnormalities, placenta previa and neonatal hypoglycemia. Therefore, attention and comprehensive treatment for pregnant women with diabetes. …”
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Characteristics and Outcomes of 79 Patients with an Insulinoma: A Nationwide Retrospective Study in Finland by Elina Peltola, Päivi Hannula, Heini Huhtala, Saara Metso, Ulla Kiviniemi, Martine Vornanen, Juhani Sand, Johanna Laukkarinen, Mirja Tiikkainen, Camilla Schalin-Jäntti, Johanna Arola, Jukka Sirén, Antti Piiroinen, Minna Soinio, Pirjo Nuutila, Mirva Söderström, Hanna Hämäläinen, Leena Moilanen, David Laaksonen, Elina Pirinen, Fia Sundelin, Tapani Ebeling, Pasi Salmela, Markus J. Mäkinen, Pia Jaatinen

“…To shorten the delay, clinicians should be informed and alert to consider the possibility of hypoglycemia and insulinoma, when symptomatic attacks are investigated in different sectors of the healthcare system. …”
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Prevalence and factors associated with potential clinically significant drug-drug interactions in patients with cardiovascular diseases at hospital admission by Marović Iva, Udovičić Mario, Rudan Diana, Manola Šime, Samardžić Ivana, Vrca Vesna Bačić, Hadžiabdić Maja Ortner, Marinović Ivana

“…The most common interventions regarding identified DDIs included exclusion one of the drugs, dose adjustment, increased monitoring of signs of bleeding, cardiac disorders, hypoglycemia, CNS depression and rhabdomyolysis, blood pressure, markers of renal function and electrolyte status. …”
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[18F]FB(ePEG12)12-exendin-4 noninvasive imaging of insulinoma negative for insulin immunostaining on specimen from endoscopic ultrasonography-guided fine needle aspiration: a case... by Daisuke Otani, Takaaki Murakami, Saeko Murakami, Ikuko Hanaoka, Hiroyuki Fujimoto, Yoichi Shimizu, Kanae Kawai Miyake, Kentaro Sakaki, Yohei Ueda, Daisuke Tanaka, Tsuyoshi Ohno, Hironori Shimizu, Naoki Uyama, Norishige Iizuka, Daisuke Yabe, Yuji Nakamoto, Nobuya Inagaki

“…Insulinomas are the most common functional pancreatic neuroendocrine neoplasm; when treatment is delayed, they induce hyperinsulinemic hypoglycemia, which is life-threatening. As surgical resection is the only curative treatment for insulinoma, preoperative localization is crucial; however, localization based on conventional imaging modalities such as computed tomography (CT) and magnetic resonance imaging is often inconclusive. …”
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Real world efficacy and safety of the advanced hybrid closed-loop system MiniMed 780G (SmartGuard) in children under 7 years of age by Sara López-López, Cristina Díaz-Martín, Inés García-de Pablo, María Teresa Ovejero-Garcia, María Beatriz Garnier-Rodríguez, Ruth Molina-Suárez, Cristina Ontoria-Betancort, Blanca Sáez-Gallego, Ángela Domínguez-García, Sofía Quinteiro-González, Lourdes Travieso-Suárez, María Fátima Cabrera-Guedes, Yeray Nóvoa-Medina, Yeray Nóvoa-Medina, Yeray Nóvoa-Medina

“…No events of severe hypoglycemia or diabetic ketoacidosis occurred. Efficacy and safety were maintained in children with a TDD &lt;8 units/day.ConclusionThe use of the Medtronic 780G™ SmartGuard™ system in children under 7 years of age with T1D is effective and safe, with benefits persisting for up to 6–12 months. …”
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Effectiveness and Safety of the TRIO Optimal Health Management Program in Patients With Type 2 Diabetes Mellitus Initiating Basal Insulin Therapy: Prospective Observational Real-Wo... by Chenxi Li, Lixin Guo, Lixin Shi, Li Chen, Liming Chen, Yaoming Xue, Hong Li, Yuzhen Liang, Jing Yang, Weimin Wang, Dalong Zhu

“…The presence of complications, shorter diabetes duration, and higher baseline HbA1c were significantly associated with increased hypoglycemia incidence risk (all P<.05). …”
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Early systemic insults following severe sepsis-associated encephalopathy of critically ill patients: association with mortality and awakening—an analysis of the OUTCOMEREA database... by Michael Thy, Romain Sonneville, Stéphane Ruckly, Bruno Mourvillier, Carole Schwebel, Yves Cohen, Maité Garrouste-Orgeas, Shidasp Siami, Cédric Bruel, Jean Reignier, Elie Azoulay, Laurent Argaud, Dany Goldgran-Toledano, Virginie Laurent, Claire Dupuis, Julien Poujade, Lila Bouadma, Etienne de Montmollin, Jean-François Timsit, on the behalf of the OUTCOME R. E. A. network

“…Compared to non-survivors, survivors had significantly less early systemic insults (hypoglycemia, hypotension, hypothermia, and anemia) within the first 48 h of ICU admission. …”
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Ginsenoside F1 administration promotes UCP1-dependent fat browning and ameliorates obesity-associated insulin resistance by Yuhan Meng, Weili Li, Chenxing Hu, Si Chen, Haiyang Li, Feifei Bai, Lujuan Zheng, Ye Yuan, Yuying Fan, Yifa Zhou

“…Increasing thermogenesis is regarded as an effective strategy for hypolipidemia and hypoglycemia. Ginsenoside is a natural active component in Panax ginseng C.A. …”
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Re-evaluating large for gestational age: differential effects on perinatal outcomes in term and premature births by Chun-Heng Kuo, Chun-Heng Kuo, Chun-Heng Kuo, Yi-Ling Wu, Chi-Nien Chen, Chi-Nien Chen, Yu-Ru Lo, I-Weng Yen, Kang-Chih Fan, Yi-Yun Tai, Ming-Wei Lin, Chih-Cheng Hsu, Chih-Cheng Hsu, Chih-Cheng Hsu, Chih-Cheng Hsu, Hung-Yuan Li

“…Compared to AGA neonates, LGA neonates in term and late preterm groups exhibited higher risks of primary cesarean section, prolonged labor, neonatal hypoglycemia, birth trauma, hypoxic ischemic encephalopathy, jaundice needing phototherapy, respiratory distress, neonatal intensive care unit (NICU) admission, newborn sepsis, and fetal death. …”
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Gastrointestinal complications of hepatic glycogen storage disease: a national survey questionnaire study in China by Xiaoyan Zhang, Zexiong Su, Jiaxing Wu, Hanshi Zeng, Xun Jiang, Ying Wang, Huiqing Shen, Xiaoli Xie, Yuan Xiao, Qing Tang, Xiaoping Luo, Xuemei Zhong, Huan Chen, Jiaoli Lan, Yongxin Chen, Xiaolu Zeng, Huiqiong Zhang, Zhiling Li, Yuxin Zhang, Min Yang

“…The common characteristics of these GSDs were hypoglycemia, lactic acidosis, anemia, liver enlargement, hyperlipidemia, hyperuricemia, and weakness. …”
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Comparison of Insulin Lispro Protamine Suspension with NPH Insulin in Pregnant Women with Type 2 and Gestational Diabetes Mellitus: Maternal and Perinatal Outcomes by Antonietta Colatrella, Natalia Visalli, Santina Abbruzzese, Sergio Leotta, Marzia Bongiovanni, Angela Napoli

“…In this retrospective study, for maternal outcome we recorded time and mode of delivery, hypertension, glycaemic control (fasting blood glucose and HbA1c), hypoglycemias, weight increase, and insulin need. For neonatal outcome birth weight and weight class, congenital malformations was recorded and main neonatal complications. …”
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