Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) by Liliana Ferreira, Edite Teixeira-de-Lemos, Filipa Pinto, Belmiro Parada, Cristina Mega, Helena Vala, Rui Pinto, Patrícia Garrido, José Sereno, Rosa Fernandes, Paulo Santos, Isabel Velada, Andreia Melo, Sara Nunes, Frederico Teixeira, Flávio Reis

“…In conclusion, chronic sitagliptin treatment corrected the glycaemic dysmetabolism, hypertriglyceridaemia, inflammation, and hypertension, reduced the severity of the histopathological lesions of pancreatic endocrine and exocrine tissues, together with a favourable redox status, which might be a further advantage in the management of diabetes and its proatherogenic comorbidities.…”
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Murine model evaluation of biochemical and tissue-damage induced by Bothrops asper (Nauyaca) snake venom by Dr. Carlos Gallardo-Casas Ángel Gallardo-Casas, María Teresa Valadez-Omaña, Emmanuel Correa Solís, María del Carmen Castillo-Hernández, Rocio Ortiz-Butron

“…Results: Results: Animals treated with poison (LD25 of 1 mg of protein/kg) had greater activity of AST, ALT and LDH enzymes, structural damage in the cortex and renal medulla, as well as in the liver after 24 hours of administration in the experimental group Conclusion: B. asper venom causes an increase in LDH and transaminase enzymes, as well as renal and hepatic histopathological alterations. …”
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Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature by Durga Paudel, Michiko Nishimura, Bhoj Raj Adhikari, Daichi Hiraki, Aya Onishi, Tetsuro Morikawa, Puja Neopane, Sarita Giri, Koki Yoshida, Jun Sato, Masayuki Ono, Yoshitaka Kamino, Hiroki Nagayasu, Yoshihiro Abiko

“…Herein, we present a case of SC of buccal mucosa, which appeared clinically as a benign lesion in a 54-year-old Japanese female patient. Histopathologically, the tumor cells presented with an eosinophilic cytoplasm with microcytic structure along with eosinophilic secretory material and hemosiderin deposit. …”
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Recent advances of photodiagnosis and treatment for head and neck squamous cell carcinoma by Yining Zhang, Zhenfang Li, Chengchi Zhang, Chengying Shao, Yanting Duan, Guowan Zheng, Yu Cai, Minghua Ge, Jiajie Xu

“…The diagnosis of HNSCC currently relies on biopsy and histopathological examination of suspicious lesions. However, the early mucosal changes are subtle and difficult to detect by conventional oral examination. …”
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Squamous Cell Carcinoma Developing in a Cutaneous Lichen Planus Lesion: A Rare Case by Saptarshi Ghosh, Sivasankar Kotne, P. B. Ananda Rao, S. P. V. Turlapati, Dillip Kumar Soren

“…The patient underwent wide local excision with superficial skin grafting. Postoperative histopathological examination revealed verrucous squamous cell carcinoma complicating lichen planus. …”
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Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway by Li Wang, Chaofan Zhang, Muhammad Azhar Memon, Qianting Shi, Le Lu, Xishuai Tong, Yonggang Ma, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan

“…The results showed that in vivo, CGA reduced the Cd level and alleviated Cd-induced histopathological and ultrastructural damages in the chicken cerebral cortex. …”
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A Case of a Spinal Extradural Arachnoid Cyst by Yousuke Kojimahara, Shintaro Tsuge, Keiji Hasegawa, Katsunori Fukutake, Kazumasa Nakamura, Akihito Wada, Hiroshi Takahashi

“…This pathway was ligated and the cyst was excised. The histopathological diagnosis was an arachnoid cyst. Pain improved after surgery, and as of 10 months after surgery, the cystic lesion has not recurred. …”
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Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities by de Lima Vazquez Vinicius, Cristovam Scapulatempo, Natalia Martins Perpetuo, Faheez Mohamed, Teóclito Sachetto de Carvalho, Antônio Talvane Torres de Oliveira, José Getúlio Martins Segalla, André Lopes Carvalho

“…A Tissue Microarray was constructed using immunohistochemistry to quantify expression of the HER family, E-cadherins, and podoplanin. Clinical and histopathological factors related to lymph node metastasis and prognosis were also established. …”
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Rapidly Growing Chondroid Syringoma of the External Auditory Canal: Report of a Rare Case by Ioannis Vasileiadis, Stylianos Kapetanakis, Aristotelis Petousis, Euthimios Karakostas, Christos Simantirakis

“…The diagnosis was confirmed by histopathologic examination. Conclusion. Although chondroid syringoma is extremely rare, it should always be considered in the differential diagnosis of an aural polyp. …”
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Prognostic Factors for Cancer-Specific Survival and Disease-Free Interval of Dogs with Mammary Carcinomas by Elaine da Silva Soares, Fabrício Luciani Valente, Carolina Camargos Rocha, Carlos Eduardo Real Pereira, Thaís Barroso Sarandy, Fabiano Luiz Dulce de Oliveira, Sabrina Loise de Morais Calado, Andréa Pacheco Batista Borges

“…Canine mammary tumors (CMTs) are the most diagnosed neoplasms in dogs; however, there are few studies analyzing the influence of epidemiological, clinicopathological, and histopathological data on cancer-specific survival (CSS), disease-free interval (DFI), and overall survival (OS) in a large cohort. …”
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Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth by Chu-Wen Li, Xiao-Li Wu, Xiao-Ning Zhao, Zu-Qing Su, Hai-Ming Chen, Xiu-Fen Wang, Xiao-Jun Zhang, Hui-Fang Zeng, Jian-Nan Chen, Yu-Cui Li, Zi-Ren Su

“…Results indicated that oral administration of ERP (120, 240, and 480 mg/kg) significantly attenuated xylene-induced ear edema, decreased acetic acid-induced capillary permeability, inhibited carrageenan-induced neutrophils recruitment, and reduced carrageenan-induced paw edema, in a dose-dependent manner. Histopathologically, ERP (480 mg/kg) abated inflammatory response of the edema paw. …”
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Hypoglossal Schwannoma Masquerading as a Carotid Body Tumor by Matthew K. Lee, Douglas R. Sidell, Abie H. Mendelsohn, Keith E. Blackwell

“…Intraoperatively, the mass was noted to arise from the hypoglossal nerve, remaining independent of the carotid artery. On histopathologic analysis, the mass was determined to be consistent with hypoglossal schwannoma. …”
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Heavy metal contamination (Cd, Cu) in the gills and flesh of mullet (Planiliza subviridis) in Cilincing Coastal Waters, Jakarta Bay by Susilowati Dwi Indah, Sulistiono Sulistiono, Riani Etty, Wildan Dudi M., Sinaga Jessica

“…For copper, the concentrations in the gills and flesh varied from 0.62 ppm to 2.195 ppm and from 0.12 ppm to 1.62 ppm, respectively. Histopathological examinations revealed signs of hyperplasia, infiltration inflammatory cells, hemorrhage in the basal cells of the gills, and inflammatory cell infiltration in the flesh. …”
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A 23-Year-Old Female with a Mixed Germ Cell Tumor of the Pituitary Infundibulum: The Challenge of Differentiating Neoplasm from Lymphocytic Infundibuloneurohypophysitis—A Case Repo... by Sann Yu Mon, Hussain Mahmud, Munira Abbasi, Geoff Murdoch, Juan C. Fernandez-Miranda, Paul A. Gardner, Sue M. Challinor

“…The two diagnoses are difficult to distinguish based on MRI imaging, CSF findings, and histopathological examination. Our case demonstrates the need for close follow-up of patients with isolated lesions of the pituitary infundibulum and reinforces the need for biopsy of an infundibular lesion when progression of disease is demonstrated. …”
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Diabetic Muscle Infarction of the Tibialis Anterior and Extensor Hallucis Longus Muscles Mimicking the Malignant Soft-Tissue Tumor by Yoshikuni Mimata, Kotaro Sato, Karen Tokunaga, Itsuko Tsukimura, Hiroshi Tada, Minoru Doita

“…Magnetic resonance imaging (MRI) revealed that the mass exhibited heterogeneous signals on T1- and T2-weighted images and slight heterogeneous enhancement within the muscles on fat suppressed T1-weighted images. Because histopathological analysis revealed mostly necrotic muscle tissues but no neoplastic cells, we resected the affected muscles. …”
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Cooccurrence of Metastatic Papillary Thyroid Carcinoma and Salmonella Induced Neck Abscess in a Cervical Lymph Node by Jae-Myung Kim, Ju-Yeon Kim, Eun Jung Jung, Eun Jin Song, Dong Chul Kim, Chi-Young Jeong, Young-Tae Ju, Young-Joon Lee, Soon-Chan Hong, Sang-Kyung Choi, Woo-Song Ha

“…The cystic mass was suspected of being a metastatic lymph node; modified radical neck dissection was performed. Histopathological examination confirmed the presence of PTC in the resected node and laboratory examination of the combined abscess cavity confirmed the presence of Salmonella Typhi. …”
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Intraosseous angioleiomyoma of the mandible- Report of a rare case by K.S. Gamal Abdul Nasser, S.G. Wasim Ahamed, Madhu Narayan

“…On immunohistochemical analysis, it was S100 negative but smooth muscle actin positive which led to the histopathological diagnosis of “LM.” The microscopic picture of the excised specimen showed spindle cells in an amorphous eosinophilic stroma, spicules of vital bone, dilated capillaries, and extravasated red blood cells. …”
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Monostotic Fibrous Dysplasia of the Rib: A Case Report by Asha Mahadevappa, Sapna Patel, Sunila Ravishankar, Gubbanna V. Manjunath

“…The resected lesion was a firm, well-defined solid, grey-white expansile mass replacing the medullary cavity. Histopathologically, benign fibrous spindle areas with disorganized irregular bony trabeculae were seen. …”
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Decompression of a Large Periapical Lesion: A Case Report of 4-Year Follow-Up by Claudio Maniglia-Ferreira, Fabio de Almeida Gomes, Marcelo de Morais Vitoriano, Francisco de Assis Silva Lima

“…Due to persistent discharge from the root canal system during endodontic procedures despite application of intracanal medicament (calcium hydroxide paste), the decision was made to biopsy and decompress the lesion and conclude endodontic treatment. Histopathologic examination revealed a periapical granuloma. …”
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Rationality of the FIGO2023 staging for early-stage endometrial cancer, compared with the FIGO2009 staging by Yiqin Wang, Jianliu Wang, Xingchen Li, Aoxuan Zhu, Yangyang Dong

“…Objective The International Federation of Gynecology and Obstetrics (FIGO) released a new staging for endometrial cancer (EC), which revised the FIGO2009 staging to include histopathological and molecular features. The purpose of this study was to validate the prognostic accuracy of the new staging and discuss its clinical applicability.Methods In this single-centre retrospective study, 540 patients with primary surgically treated early-stage EC were enrolled and staged according to FIGO2009/2023. …”
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