Case report: Multiple cryotherapy sessions in localized Darier's disease: a rare clinical presentation and literature review by Yansi Lyu, Bin Wang, Lyuxin Guan, Li Ma, Hao Li

“…The diagnosis of localized keratosis follicularis was confirmed through dermatoscopic examination and histopathological assessment of the skin lesion. After repeated applications of cryotherapy combined with the use of emollients, while avoiding physical friction and sun exposure, the rash gradually subsided. …”
Get full text

Hamster and Murine Models of Severe Destructive Lyme Arthritis by Erik Munson, Dean T. Nardelli, Brian K. Du Chateau, Steven M. Callister, Ronald F. Schell

“…Weeks to months following the onset of Lyme borreliosis, a histopathological reaction characteristic of synovitis including bone, joint, muscle, or tendon pain may occur. …”
Get full text

Clinical and morphological features of salmonellosis in cows and calves affected by heat stress by L. I. Drozdova, E. N. Shilova, I. A. Shkuratova, M. V. Ryaposova

“…In calves, the disease was accompanied by septic signs, severein toxication, hyperthermia (40.5–41.0 °C), severed ehydration (morethan 7%) and death. Histopathological examination of bovineparenchymal organs revealed changes typical for salmonellos is pathological process: specific salmonella granulomas were foundin parenchymalorgans (liver, spleen). …”
Get full text

Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations by Huilai Tian, Eliot Davidowitz, Patricia Lopez, Sharareh Emadi, James Moe, Michael Sierks

“…In Alzheimer’s disease (AD), tau aggregates into fibrils and higher order neurofibrillary tangles, a key histopathological feature of AD. However, soluble oligomeric tau species may play a more critical role in AD progression since these tau species correlate better with neuronal loss and cognitive dysfunction. …”
Get full text

Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy by Myung-Whan Suh, Jaihwan Hyun, Ah-Ra Lyu, Dong Woon Kim, Sung Jae Park, Jin Woong Choi, Gang Min Hur, Yong-Ho Park

“…Loss of vestibular function was observed during the early stages, but function recovered partially over time. Histopathological findings demonstrated a mild decrease in vestibular hair cells numbers. …”
Get full text

Effects of the Rho-Kinase Inhibitor Y-27632 on Extraocular Muscle Surgery in Rabbits by Ji‐Sun Moon, Hyun Kyung Kim, Sun Young Shin

“…To assess acute and late inflammatory changes, Ki-67, CD11β+, and F4/80 were evaluated and the sites of muscle reattachment were evaluated for a postoperative adhesion score and histopathologically for collagen formation. Results. F4/80 antibody expression was significantly different in the Rho-kinase inhibitor-injected group at both postoperative day 3 and week 4 (p=0.038, 0.031). …”
Get full text

Right Testicular Artery Occlusion and Acute Appendicitis by Angiostrongylus costaricensis by Luis Enrique Sánchez-Sierra, Roberto Antonio Martínez-Quiroz, Héctor S. Antúnez, Humberto Cabrera-Interiano, Fernando Josué Barrientos-Melara

“…The diagnosis is complex, because the clinical manifestations are similar to an orchitis or acute abdomen, therefore, the definitive diagnosis is made during the surgical intervention and histopathological study.…”
Get full text

Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats by Pavle Randjelovic, Slavimir Veljkovic, Nenad Stojiljkovic, Ljubinka Jankovic-Velickovic, Dusan Sokolovic, Milan Stoiljkovic, Ivan Ilic

“…Quantitative evaluation of gentamicin-induced structural alterations and degree of functional alterations in the kidneys were performed by histopathological and biochemical analyses in order to determine potential beneficial effects of SA coadministration with gentamicin. …”
Get full text

Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis by Aljuhani Naif, Ismail Raed S., El-Awady Mohammed S., Hassan Memy H.

“…In conclusion, perindopril may be safely used with cisplatin in mice since it ameliorated cisplatin-induced histopathological changes, inflammation and apoptosis without affecting renal biomarkers or oxidative stress.…”
Get full text

Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPARα by Bianca Knoch, Matthew P. G. Barnett, Janine Cooney, Warren C. McNabb, Diane Barraclough, William Laing, Shuotun Zhu, Zaneta A. Park, Paul MacLean, Scott O. Knowles, Nicole C. Roy

“…The aims were to (1) characterize colitis onset and progression using a histopathological, transcriptomic, and proteomic approach and (2) investigate links between PPARα and IL10 using gene network analysis. …”
Get full text

Ectopic Thyroid at the Base of the Tongue of a Young Patient by Paulo Henrique de Souza Castro, Luiz Evaristo Ricci Volpato, Julia Tramujas, Alvaro Henrique Borges

“…The proposed treatment was complete resection of the lesion. The histopathological diagnosis was lingual thyroid. After the diagnosis was established, the patient was referred to an endocrinologist for exams and medical follow-up. …”
Get full text

Integrating network analysis and experimental validation to reveal the mechanism of Cuscuta chinensis lam. Extract in the treatment of IgA nephropathy by Xianlong Zhang, Mingjie Liang, Ziyang Lin, Minyi Li, Tingting Duan, Yun Han, Lanqing Meng, Mengqiu Li, Guixuan Lin, Tao Xia, Ying Lai, Boen Liang, Bingqiong Li, Minhua Li, Fengxin Kang, Quan Zhu, Zhenghai Li, Junzheng Yang

“…Results: The results demonstrated that a significant decrease in the glomerular filtration rate, accompanied by a notable elevation in biochemical indexes in rats in model group, including the ratio of total protein to creatinine in urine, sCr, BUN, TG, AST, ALT, IL-1β and TNF-α; additionally, the rats in the model group exhibited substantial histopathological alterations, characterized by the presence of many IgA deposits; CCLE has been demonstrated to enhance the glomerular filtration rate, downregulate the levels of sCr, BUN, TG, AST, ALT, IL-1β and TNF-α, reduce the IgA deposition, and ameliorate the histopathological changes in IgA nephropathy rats; Western blotting demonstrated CCLE can suppress the expressions of p-PI3K, p-AKT, p-IKK, p-NF-κB, and p-IκB in IgA nephropathy rats. …”
Get full text

Effect of Ginkgolide B on Non-Alcoholic Fatty Liver Disease based on Notch Signaling Pathway by Hong YU, Junzi WU, Bo SONG, Jun LI

“…After intervention for four weeks, some indexs such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were compared; the differences of transforming growth factor-β1(TGF-β1) and tumor necrosis factor-α(TNF-α) in liver and plasma were compared; HE staining method was used to observe liver histopathological changes; Real-time fluorescent quantitative PCR method and Western blot method were used to detect the protein and mRNA expression of Notch-3, Hes-1. …”
Get full text

Seventy-Day Toxicity Study in Juvenile Sprague-Dawley Rats with Semicarbazide (SEM) from Weaning to Sexual Maturity by Vijaykumar Malashetty, Raghunandan Deshpande, Somnathreddy Patil

“…Semicarbazide caused significant changes in sperm motility, sperm count, and sperm abnormality. Histopathologically, semicarbazide caused cortical hypertrophy in adrenals and increased extramedullary hematopoiesis in the spleen; hepatocellular hypertrophy, follicular epithelial hypertrophy in the thyroid, and degeneration of seminiferous tubules in the testis were observed at 60 mg/kg/day when compared to control. …”
Get full text

Adult-onset spinal teratoma: a case report and review by K. Blank, G. Terbetas, L. Neverauskienė, J. Ušinskienė

“…The main spinal teratoma symptoms are pain, weakness and numbness of the legs, sphincter and/or gait dysfunction; intramedullary teratomas present early with increased reflexes and loss of vesical and rectal control. Histopathologic examination is the gold standard for definite diagnosis. …”
Get full text

Changes in Mobility of the Golden Hamster with Induction of an IL-1-Induced Arthritis by I. G. Otterness, M. L. Bliven, A. J. Milici

“…These results suggest a lack of correlation between inhibition of mobility and histopathological changes in cartilage and soft tissue.…”
Get full text

Antidiabetic Potential of Mushroom-Based Herbal Formulation in Streptozotocin-Induced Diabetic Rats by Bisma Saleem, Ghulam Hussain, Azhar Rasul, Haseeb Anwar, Mudassir Hassan

“…The study outcomes revealed that the administration of MHF to diabetic rats resulted in remarkable (p<0.001) improvements in fasting blood glucose (FBG) levels and glycated hemoglobin along with other biochemical markers. The histopathological examination also showed the protective effect of MHF against diabetic-induced damage in the pancreas, kidney, and liver. …”
Get full text

Reactive Lymphoid Hyperplasia of the Liver Incidentally Found in a 55-Year-Old Woman with a History of Ulcerative Colitis by Noritoshi Mizuta, Takuya Kikuchi, Shunsuke Kusano, Nobuya Sano

“…Laparoscopic partial hepatectomy was performed. Histopathological findings revealed a conglomerate hyperplasia of lymphoid follicles with germinal centers. …”
Get full text

Can Purple Sweet Potato Water Extract (Ipomoea batatas L.) Induce Steatosis at Toxic Doses in Rat? by Gemila Hikmatussalam, Yuktiana Kharisma, Nurul Romadhona

“…The liver organ was harvested after 24 hours, and then slides were made at the Pathology Anatomy Laboratory of Padjajaran University. Results: The histopathological view did not find any steatosis either in macrovesicular or microvesicular, but other features were found in ballooning degeneration, sinusoidal dilation, and inflammation. …”
Get full text

Double-Expressor Appendiceal Burkitt’s Lymphoma: A Case Report and Literature Review by Osama N. Dukmak, Hamzeh M. I. Abugharbieh, Mohammad Farid Emar, Iman Khamayseh, Salem M. Tos, Rafiq Salhab

“…Appendectomy was performed. Histopathological examination of the appendectomy specimen revealed a double-expressor non-Hodgkin diffuse large cell lymphoma with Burkitt’s-like morphology. …”
Get full text