Alteration in Oxidative Stress Enzymes and Proteins by Datura metel Stramonium Hydroethanolic Root Extract Promotes Hippocampus and Cerebral Cortex Neurons Damage in Adult Sprague... by oboma YI, Eberechukwu GC

“…Yibala Ibor oboma,1,2 God’sman C Eberechukwu1,3 1Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University Wilberforce Island Bayelsa State, Amassoma, Nigeria; 2Department of Medical Laboratory Science, School of Allied Health Sciences, Kampala International University, Ishaka Municipal, Uganda; 3Department of Histopathology and Cytopathology, Faculty of Medical Laboratory Science, Federal University, Otuoke, Bayelsa State, NigeriaCorrespondence: Yibala Ibor oboma, Department of Medical Laboratory Science, School of Allied Health Sciences, Kampala International University, Western Campus, Bushenyi District, Ishaka Municipal, Uganda, Tel +256740059020, Email yibaaoboma@kiu.ac.ugBackground: Datura metel is reported to induce hallucinations and mental disorders.Objective: This study investigates the neurotoxic effects of Datura metel stramonium hydroethanolic root extract on the hippocampus and cerebral cortex of adult rats using biochemical, histological and immunohistochemical techniques.Methodology: Twenty five adult rats were assigned to 5 groups (n = 5 each). …”
Get full text

Expression of osteogenic proteins in kidneys of cats with nephrocalcinosis by Nuttha Hengtrakul, Eva Furrow, Michael Borofsky, Ferenc Toth, Jody P. Lulich

“…Microradiography and histopathology (modified von Kossa stain) were used to confirm parenchymal mineralization. …”
Get full text

Bone Marrow Mesenchymal Stem Cells Decrease the Expression of RANKL in Collagen-Induced Arthritis Rats via Reducing the Levels of IL-22 by Fang Li, Xin Li, Guiyan Liu, Chong Gao, Xiaofeng Li

“…The transplantation of MSCs into CIA rats relieved the destruction of joints, measured by AI score, X-ray, and histopathology. MSCs also reduced the expression of IL-22 and RANKL in serum by ELISA (P<0.001) and similarly in FLSs by immunohistochemical staining. …”
Get full text

Does bladder outflow obstruction obfuscate the traditional clinical factors that are used to assess the risk of prostate cancer at rapid‐access diagnostic clinics? by Thomas Philip Cahill, Samuel Joseph Withey, Steve Hazell, Declan Cahill, Netty Kinsella

Get full text

SMYD3 drives cell cycle and epithelial-mesenchymal transition pathways through dual gene transcriptional repression and activation in HPV-negative head and neck cancer by Madhavi Murali, Abbas Saeed, Sohyoung Kim, Kyunghee Burkitt, Hui Cheng, Arfa Moshiri, Jawad Akhtar, Daniel Tsai, Marie Luff, Baktiar Karim, Vassiliki Saloura

Get full text

Melittin ameliorates schistosomiasis-induced liver fibrosis by suppressing signal transducer and activator of transcription 3 and nuclear factor kappa B by Ola I. Rozik, Manal M. Hussein, Ahmed S. El-elebiarie, Soad Nady

“…Additionally, expressions of signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappa B (NF-κB) were assessed in splenocytes. Moreover, histopathology of the liver and spleen were also investigated. …”
Get full text

Exploring the efficacy of AMACR, ERG, and AR immunostains in prostatic adenocarcinoma and their association with novel grade groups by Mohamed O. Andarawi, Hassan Otifi, Hesham Hassan, Adil A. Yousif, Saadalnour A. Mustafa, Shawgi A. Elsiddig, Asad Ma Babker, Elryah I. Ali, Omer Osman Elhag

Get full text

Atypical conjunctival sporotrichosis secondary to Mooren’s ulcer: a case report by Qing Su, He Dong, Lin Cui, Lijun Zhang

“…After partial tumor resection, histopathology and immunofluorescence staining suggested fungal infection with squamous epithelial hyperplasia. …”
Get full text

Visualization of Small Vessels by Micro–Computed Tomography Using Titanium Dioxide Nanoparticles as a Novel Contrast Agent by Taku Goto, Ruriko Tanabe, Hirotoshi Shibuya, Masaru Tamura, Shintaro Nomura

“…To establish a connection between m-CT images and genuine histopathology findings, we developed two novel titanium dioxide nanoparticle (TiO2-NP)–based perfusion contrast agents: TiNpCA-1 and TiNpCA-2. …”
Get full text

Systemic and immunotoxicity induced by topical application of perfluoroheptane sulfonic acid (PFHpS) or perfluorooctane sulfonic acid (PFOS) in a murine model by Lisa M. Weatherly, Hillary L. Shane, Laurel G. Jackson, Ewa Lukomska, Rachel Baur, Madison P. Cooper, Stacey E. Anderson

“…PFHpS induced significantly increased relative liver weight, significantly decreased relative spleen and thymus weight, altered serum chemistries, and altered histopathology. Additionally, PFHpS significantly reduced the humoral immune response and altered immune subsets in the spleen, suggesting immunosuppression. …”
Get full text

Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and 18F-FDG-PET/CT by Alessandro Stecco, Francesco Buemi, Martina Quagliozzi, Mariangela Lombardi, Alberto Santagostino, Gian Mauro Sacchetti, Alessandro Carriero

“…All patients underwent 18F-FDG-PET/CT and WB-DW-MRI. Histopathology findings or at least 6 months of clinical and radiological follow-up was the gold standard. …”
Get full text

Recovery from Liver Failure and Fibrosis in a Rat Portacaval Anastomosis Model after Neurointermediate Pituitary Lobectomy by Martín Muñoz-Ortega, Noé Macías-Segura, Javier Ventura-Juárez, Manuel Enrique Ávila-Blanco, Leonardo D. Ponce-Damian, Daniel González-Blas, Esperanza Sánchez-Alemán, Andrés Quintanar-Stephano

“…NIL in the PCA animals also decreased the gene expression levels of IL-1 and COLL-I, while increasing those of IL-10, TGF-β, and MMP-13. Histopathology of this group also showed significantly decreased signs of liver damage with lower extent of collagen deposition and fibrosis. …”
Get full text

Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice by Jin Zhang, Jin Zheng, Haitao Chen, Xinrong Li, Chenxiao Ye, Fan Zhang, Zewei Zhang, Qinghua Yao, Yong Guo

“…The therapeutic effect of curcumin on breast cancer cachexia was characterized by tumor growth, changes in body mass and gastrocnemius mass, muscle function test, histopathology, and serum nutrition indexes. Mitochondrial function in muscle tissue was observed by transmission electron microscopy and ATP detection, muscle inflammatory factors were detected by ELISA, muscle differential metabolites were detected by 1HNMR metabolomics, and the muscle tissue ubiquitination levels and NF-KB expression were also analyzed by RT-qPCR and Western blot. …”
Get full text

Effects of Curcumin on Parameters of Myocardial Oxidative Stress and of Mitochondrial Glutathione Turnover in Reoxygenation after 60 Minutes of Hypoxia in Isolated Perfused Working... by Ermita I. Ibrahim Ilyas, Busjra M. Nur, Sonny P. Laksono, Anton Bahtiar, Ari Estuningtyas, Caecilia Vitasyana, Dede Kusmana, Frans D. Suyatna, Muhammad Kamil Tadjudin, Hans-Joachim Freisleben

“…In the myocardium histopathology and AST in the perfusate indicated cell damage after hypoxia and malondialdehyde (MDA) levels increased to 232.5% of controls during reoxygenation. …”
Get full text

Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment by Hanan Seddiek, Mira Hanna, Amany Elsayed Mohamed Hamoud, Marawan Abd Elbaset, Ahmed M. A. Akabawy, Mohamed Zakaria Kotb, Mohamed Mansour Khalifa

“…In addition to significant deterioration in the histopathological and immunological nerve tissue assessment using silver stain and PNCA. …”
Get full text

Assessing waste separation behaviour in Nigeria: implications for post-Covid-19 pandemic waste management strategies by Tolulope B Olaiya, Shuliang Zhao, Oyewale D Abioye, Uzoamaka P Mgbachi, Oluwabunmi A Falebita

Get full text

Near-Complete Avipoxvirus Genome Assembled from Skin Lesions of Dead Eurasian Crane (<i>Grus grus</i>) by Eszter Kaszab, Endre Sós, Krisztina Bali, Viktória Sós-Koroknai, Edina Perge, Krisztina Ursu, Szilvia Marton, Márton Hoitsy, Gábor Kemenesi, Krisztián Bányai

“…In this study, gross pathological examination and histopathological examination of skin lesions and several organs suggested acute poxvirus infection of a Eurasian crane (<i>Grus grus</i>, Linnaeus, 1758). …”
Get full text

An Unusual Presentation of Glandular Fever by Dominic Worku, Li Hui Chang, Ian Blyth

“…Repeat EBV serology now showed equivocal EBV VCA IgG (0.77 OD) and positive VCA IgM (9.04 OD) with concurrent new hepatitis. Histopathology of the core biopsy revealed Sternberg-reed cells and a mixed immunoblastic reaction in keeping with resolving IM. …”
Get full text

Orbital Desmoid-Type Fibromatosis: A Case Report and Literature Review by Alessandro Moro, Paolo De Angelis, Giulio Gasparini, Sandro Pelo, Gianluigi Petrone, Emanuela Lucci Cordisco, Umberto Garagiola, Giuseppe D’Amato, Gianmarco Saponaro

Get full text

Clinical Characteristics and Prognosis of Gastrointestinal Metastases in Solid Tumor Patients: A Retrospective Study and Review of Literatures by Li Lin, Xiangyi Wang, Chuanhao Tang, Jun Liang

“…The diagnosis of gastrointestinal tract metastases was based on histopathology. Results. 30 patients (median age 56 years, 56.7% female) were included. …”
Get full text