Published 2019-06-01
“…The results of the HE staining showed that the structure of gray matter and white matter of the spinal cord tissue in the sham-operated group were normal at the perilesional area, the structure of the neurons was also clear, and no significant spinal cord injured was found; compared with the sham-operated group, the spinal cord structure was severely damaged in the model group: the gray matter of the central part of the spinal cord and the white matter of the surrounding part of the spinal cord turned into blur because of injury and a large number of neurons degenerated, a number of nerve cells even appeared necrosis, and the cell structure was seriously destroyed at the same time, and in addition, the nuclear turned into shrinkage or dissolution and passed away, accompanying with varying degrees of neutrophil infiltration and a large number of microglia proliferation; compared with the model group, the spinal cord structure of the treatment group with iridoid-rich fraction from <italic>Valeriana jatamansi</italic> Jones significantly improved, and there were only small areas presenting a neuronal necrosis, a small amount of eosinophils increasing and a small number of eosinophils microglia infiltration in the spinal cord tissue at the perilesional area, and at the same time, the
histopathological scores in tissue sections were lower(<italic>P</italic>< 0.05). …”
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