Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats by Md. Yousuf Ali, Nur-E Noushin Rumpa, Sudip Paul, Md. Sakib Hossen, E. M. Tanvir, Tareq Hossan, Moumoni Saha, Nadia Alam, Nurul Karim, Md. Ibrahim Khalil, Siew Hua Gan

“…In addition, the highest dose (1000 mg/kg) caused a significant increase in iron (12.07%) and high-density lipoprotein cholesterol (8.87%) levels. Histopathological findings of the vital organs did not indicate any pathological changes indicating that pomelo is nontoxic, safe, and serves as an important source of natural antioxidants. …”
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Evaluation of sex-based differences in below-the-knee plaque histology in patients who underwent amputation for chronic limb-threatening ischemia by Fouzul Kansul, Deborah Vela, MD, Judit Csore, MD, Bright Benfor, MD, Sasha Suarez, MD, Anahita Dua, MD, MBA, MSC, Trisha L. Roy, MD, PhD

“…A significant sex-based difference was noted in the presence of luminal thrombus, which was more prevalent in females (38.7% vs 25.0%; P = .016). Histopathological differences were noted between popliteal and tibial lesions, with popliteal segments demonstrating increased chronic total occlusion presence and atherosclerosis, whereas severe calcification occurred more often in tibial segments. …”
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Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru by Juan Pedro Rojas-Armas, Jorge Luis Arroyo-Acevedo, José Manuel Ortiz-Sánchez, Miriam Palomino-Pacheco, Hugo Jesus Hilario-Vargas, Oscar Herrera-Calderón, Julio Hilario-Vargas

“…The serum levels of AST and ALT increased significantly and the histopathological study revealed chronic and acute inflammatory infiltrate in the lung; while in the liver was observed in 80% of the cases (24/30) mild chronic inflammatory infiltrate and in some of those cases there was vascular congestion and in one case cytoplasmic vacuolization. …”
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Ketogenic Diet‐Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice by Gabby Dyson, Montana Barrett, Leoni Schlupp, Emmaline Prinz, Nicholas Hannebut, Aleksander Szymczak, Cindy Miranda Brawner, Matlock A. Jeffries

“…Results KD mice had worse histopathologic OA after DMM (mean ± SEM Osteoarthritis Research Society International score: KD‐DMM: 4.0 ± 0.5 vs chow‐DMM: 2.7 ± 0.08; P = 0.02). …”
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A Morphological and Immunohistochemical Study of the Tumoral and Inflammatory Cells in Pancreatic Ductal Adenocarcinoma by Vlad Herlea, Elena Stoica Mustafa, Andreea Cristina Iorgescu, Nicolae Catalin Pechianu, Dragos Cretoiu, Maria Sajin, Simona Olimpia Dima, Catalin Vasilescu, Cezar Stroescu, Constantin Ungureanu, Traian Dumitrascu, Vladislav Brasoveanu, Minerva Ghinescu, Irinel Popescu

“…This study represents a multidisciplinary approach, and it is a result of teamwork; it presents histopathological methods of examination of this severe illness and describes only a part of the scientific effort to determine the main pathological mechanisms of this neoplasm.…”
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Paraoxonase and Arylesterase Activities, Lipid Profile, and Oxidative Damage in Experimental Ischemic Colitis Model by Ethem Unal, Cengiz Eris, Bülent Kaya, Hafize Uzun, Faruk Cavdar, Murat Yildar, Ali Riza Kiziler, Birsen Aydemir, Pembegul Gunes, Riza Kutanis, Izzet Titiz

“…Oxidative stress marker (malonyldialdehyde, MDA), lipid profile, and paraoxonase (PON-1) and arylesterase activities were determined. Histopathological evaluation was done under light microscopy, after sectioning and staining with hematoxyline and eosin. …”
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Two Cases of Composite Pheochromocytoma-Ganglioneuromas With Plasma Metanephrine Levels in the Subclinical Range Pheochromocytoma-Ganglioneuroma by Mayssam El Najjar, MD, Elie Naous, MD, Caroline Blake, Aysegul Bulut, MD, Alexander Perepletchikov, MD, Ann T. Sweeney, MD

“…The diagnosis relies on histopathological analysis. Treatment of pheochromocytoma-ganglioneuromas is complete surgical excision in a high-volume center with adrenal expertise and is associated with an overall excellent prognosis. …”
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Epicardially Placed Bioengineered Cardiomyocyte Xenograft in Immune-Competent Rat Model of Heart Failure by Ikeotunye Royal Chinyere, Pierce Bradley, Joshua Uhlorn, Joshua Eason, Saffie Mohran, Giuliana G. Repetti, Sherry Daugherty, Jen Watson Koevary, Steven Goldman, Jordan J. Lancaster

“…At the study endpoint, all cohorts underwent echocardiographic, hemodynamic, electrophysiologic, and histopathologic assessments. Results. The epicardially placed tissue graft therapy improved (p<0.05) in vivo and ex vivo cardiac function compared to the untreated CHF cohort. …”
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Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

“…Various parameters, including clinical and histopathological indicators, changes in body weight and organ weight, inflammatory cell distribution, and inflammatory cytokine expression in the bronchoalveolar lavage fluid (BALF), were analyzed. …”
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Effects of Trichinella spiralis and its serine protease inhibitors on intestinal mucosal barrier function by Ruibiao Wang, Yuheng Zhang, Zhixin Li, Jingbo Zhen, Qiankun Li, Qi Zhang, Yuqi Yang, Xueting Liu, Yixin Lu

“…Furthermore, the effects of T. spiralis infection on the jejunal barrier function in mice were investigated. The histopathological analysis indicated significant damage to the jejunum, which peaked at day 7 post-infection (dpi). …”
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Liraglutide alleviates high-fat diet-induced kidney injury in mice by regulating the CaMKKβ/AMPK pathway by Yingli Xuan, Ting-ting Ding, Xiao-lei Mao, Shiqing Pang, Ruibin He, Li Qin, Jiang zi Yuan

“…Besides, hematoxylin–eosin staining and periodic acid-Schiff staining were used to observe the pathological changes of kidney tissue; immunohistochemistry, western blot, and real-time quantitative PCR to assess the calmodulin-dependent protein kinase kinase beta (CaMKKβ)/AMPK signaling pathway activation.Results Liraglutide significantly reduced serum lipid loading, improved kidney function, and relieved kidney histopathological damage and glycogen deposition in the mouse model of obesity-related kidney disease induced by HFD. …”
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Alpha B-crystallin Ameliorates Imbalance of Redox Homeostasis, Inflammation and Apoptosis in an Acute Lung Injury Model with Rats by Seda KOCAK, İbrahim GUNER, Muhittin Onur YAMAN, Tugba EKIZ YILMAZ, Emine Elif GUZEL MEYDANLI, Nermin YELMEN, Gulderen SAHIN

“…However, alpha B-crystallin significantly reduced the lung tissue levels of oxidative, inflamatuvar, and apoptotic parameters in the plasma, lung tissues, and BAL fluid (p&lt;0.05 versus aortic IR). Histopathological results showed that alpha B-crystallin ameliorated the morphological changes related to lung injury (p&lt;0.001). …”
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Effect of Decellularized Amniotic Membrane on the Tendon–Bone Integration in Rotator Cuff Repair: A Comparative Rat Model Study by Jiangtao Wang, Chunbao Li, Jiating Zhang, Mingyang An, Gang Zhao, Samuel D. Stark, Yujie Liu

“…The assessment of specimens was conducted by micro‐CT analysis, histopathological evaluation, and biomechanical testing. …”
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Integrated analysis of biochemical, transcriptomic, and metabolomic response mechanisms in Ussuri catfish (Pseudobagrus ussuriensis) under acute heat stress by Qing Liu, Yang Cao, Ruyi Hu, Libo Gu, Lirong Yang, Yu Liu, Weiwei Wang, Liang Xiao, Bugao Li

“…In this study, we conducted histological observations, biochemical measurements, transcriptomic analysis, and metabolomic analysis on liver tissue from a control group (22 ℃), an acute heat stress group (34 ℃, with samples taken at 0, 3, 6, 12, and 24 h), and a recovery group (sampled 24 h after recovery to 22 ℃). Histopathological analysis showed that liver damage worsened with the duration of heat stress. …”
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Is Amanita phalloides Nephrotoxicity due to Mitochondrial Toxicity? by Jules Weinhard, Justine Serre, Perrine Frère, Clovis Adam, Marie Camille Lafargue, David Buob, Cédric Rafat

“…Although liver injury subsided following the administration of N-acetyl cystein and silibinin, the patient subsequently developed KDIGO stage 3 acute kidney injury. Histopathological examination of the kidney displayed moderate tubular injury characterized by dilated tubular lumens and flattening of the tubular epithelium on optic microscopy. …”
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Acute and Subchronic Toxicity Assessment of Conventional Soxhlet Cymbopogon citratus Leaves Extracts in Sprague–Dawley Rats by Jacob Apibilla Ayembilla, Abdul Raouf Khalid, Sharif Buari Abubakari, Abdul Rashid Adams, Felix Abekah Botchway, Stephen Antwi, Phyllis Naa Yarley Otu, Michael Appiah, George Osei-Adjei, Kwame Owen Kottoh, Peace Ahiabenu-Williams, Olga Quasie

“…Analyses were conducted on the blood, urine, and serum samples of the rats. Histopathological examination of the liver, heart, kidney, spleen, and lungs was carried out at termination. …”
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Strengthening identification and characterization of causes of perinatal deaths in Kaski district of Nepal (Perinatal MITS Nepal) by Nuwadatta Subedi, Sunita Ranabhat, Sanjib Mani Regmi, Mukesh Mallik, Dela Singh, Shree Krishna Shrestha, Bandana Gurung, Arjun Bhattarai, Madan Prasad Baral, Sudhir Raman Parajuli, Ramchandra Bastola, Junu Shrestha, Sahisnuta Basnet, Eva Gauchan, Sabita Paudel

“…The specimens will undergo standard histopathological, microbiological, biochemical, and molecular tests. …”
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Multimodality imaging features of systemic amyloidosis: a case report by Yi Yu, Zhi-Chao Li, Guang-Yin Li, Ting Wang, Yi-Gang Li

“…This case underscores the diagnostic complexity, emphasizing the need for early identification given the grim prognosis associated with systemic AL amyloidosis requiring clinical data, detailed imaging, and histopathological insights. After discharge, the patient became better and followed up in the outpatient. …”
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Evaluation of the Frequency of HLA-DQ2/DQ8 Genes Among Patients with Celiac Disease and Those on a Gluten-Free Diet by Marek K. Kowalski, Danuta Domżał-Magrowska, Ewa Małecka-Wojciesko

“…Methods: The study group included 50 patients, 13 men and 37 women, who had been diagnosed with celiac disease many years ago based on histopathological criteria and improvement of health condition after receiving a gluten-free diet. …”
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Spatiotemporal dynamics and prevention strategies of cervical cancer incidence in Addis Ababa, Ethiopia: an ecological study by Mathewos Assefa, Eva Johanna Kantelhardt, Teferi Gedif Fenta, Tariku Shimels

“…Objective This study analysed the spatial and temporal patterns of cervical cancer incidence in Addis Ababa from 2012 to 2021.Design An ecological study was conducted from 1 September to 30 November 2023 to examine the spatiotemporal trends of cervical cancer incidence.Setting The research was conducted in Addis Ababa, the capital city of Ethiopia.Participants Included were all patients with clinically and/or histopathologically confirmed diagnoses of cervical cancer.Data analysis The study employed advanced analytical tools including R programming, Quantum Geographic Information System V.3.36.0, GeoDa V.1.2.2 and System for Automated Geoscientific Analyses GIS V.9.3.2. …”
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