Investigation of cardiotoxic effects of marbofloxacin by Devran Coşkun, Burak Dik, Yasemin Korkmaz, Rahmi Canbar, Ayşe Er, Enver Yazar

“…However, cardiotoxic effects of marbofloxacin should be confirmed histopathologically.…”
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A multicenter study investigating the genetic analysis of childhood steroid-resistant nephrotic syndrome: Variants in COL4A5 may not be coincidental. by Sheng Li, Miaoyue Hu, Chao He, Yu Sun, Weifang Huang, Fengying Lei, Yunguang Liu, Zengpo Huang, Yongqiu Meng, Wenjing Liu, Xianqiang Lei, Yanfang Dong, Zihui Lin, Chunlin Huang, Rihong Zhao, Yuanhan Qin

“…Kidney biopsy was performed on 66 patients, and minimal change disease was the most prevalent histopathological diagnosis (29 cases; 32.6%). These findings suggest that children diagnosed with SRNS exhibit a diverse range of genetic alterations. …”
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Clinical and laboratory characteristics of solitary rectal ulcer syndrome: a retrospective analysis of 36 case by Furkan Ali Uygur, Muhammed Emin Göktepe, Gökhan Aydın, Enes Ağırman, Ahmet Cumhur Dülger

“…Laboratory findings revealed significant abnormalities, including mean hemoglobin levels of 10.0 ± 2.4 g/dL and mean CRP levels of 56.7 ± 65.4 mg/L. Histopathological analysis showed that 38.9% of patients had normal biopsy results, whereas inflammation and dysplasia were observed in 41.7% and 2.8% of cases, respectively. …”
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Revealing the impact of tadalafil-loaded proniosomal gel against dexamethasone-delayed wound healing via modulating oxido-inflammatory response and TGF-β/Macrophage activation path... by Nermin A Helmy, Elsayed A Abdel Aziz, Mustafa Abd El Raouf, Reda M S Korany, Doaa A Mansour, Sara M Baraka, Arwa A Hassan, Eman Gomaa, Mennatullah M Faisal, Walaa A A Basha, Esraa M Fahmy, Rashed A Alhotan, Anam Ayyoub, Shaimaa Selim

“…This was in combination with significant amplification of immune response-related genes, CD68 and CD163 (p < 0.05). Moreover, the histopathological, Masson's Trichrome-stain, and immune-histochemical studies indicated a successful tissue recovery with the formation of new blood vessels in groups treated with TAD-loaded proniosomal gel, as manifested by well-organized collagen fibers, upregulation of transforming growth factor β1, and vascular endothelial growth factor immune expression in skin tissues (p < 0.05). …”
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Immunopathological Changes of Streptococcus pneumoniae Causing Respiratory Infection in Lambs by Abbas A Hamzah, Zainab I Ibrahim

“…On day 6 post-exposure, the gross pathological changes in the lung showed pulmonary edema, and emphysema, with mild to moderate lung congestion and emphysematous changes observed on day 14 post-exposure. Histopathologically, severe erosion and necrosis in the trachea and bronchus epithelium, along with inflammation in adjacent mucosa and submucosa, accompanied by focal inflammatory infiltration and emphysema in the lung by day 6 post-exposure, were observed. …”
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Modified citrus pectin ameliorates methotrexate-induced hepatic and pulmonary toxicity: role of Nrf2, galectin-3/TLR-4/NF-κB/TNF-α and TGF-β signaling pathways by Randa Ismail, Heba A. Habib, Aliaa F. Anter, Amr Amin, Gehan H. Heeba

“…MCP enhanced the cytotoxicity of MTX in Nalm6 and JEG3 and did not interfere with its cytotoxicity in the MCF7 cell lines.DiscussionMCP attenuated MTX-induced liver and lung toxicity through antioxidant, anti-fibrotic, anti-inflammatory, and anti-apoptotic influences, as demonstrated by the improved histopathological changes induced by MTX in pulmonary and hepatic tissues. …”
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Therapeutic effects of resveratrol and β-carotene on L-arginine-induced acute pancreatitis through oxidative stress and inflammatory pathways in rats by Arzu Gezer, Hilal Üstündağ, Mustafa Özkaraca, Ebru Karadağ Sari, Cihan Gür

“…The AP + RES and AP + βC groups exhibited preserved β + Langerhans islet size (p < 0.01), suppressed NF-κB, TNF-α, and IL-1β expression, reduced Bax and Caspase-3 levels, and increased Bcl-2 levels (p < 0.01). Histopathological findings supported these results. RES and βC confer significant effects against L-arginine-induced acute pancreatitis by reducing oxidative stress, preserving pancreatic islet integrity, suppressing inflammatory responses, and modulating apoptotic pathways. …”
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Enhanced Detection of Residual Breast Cancer Post-Excisional Biopsy: Comparative Analysis of Contrast-Enhanced MRI with and Without Diffusion-Weighted Imaging by Han Song Mun, Bong Joo Kang, Sung Hun Kim, Ga Eun Park

“…The apparent diffusion coefficient (ADC) values were measured, and the diagnostic outcomes of CE-MRI, CE-MRI with DWI, mammography (MG), and ultrasound (US) were compared with clinical and histopathological data. Results: A total of 152 lesions were analyzed, with 36.2% showing residual malignancy. …”
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Surgical Quality in Rectal Cancer Management: What Can Be Achieved by a Voluntary Observational Study? by Łukasz Dziki, Ronny Otto, Hans Lippert, Paweł Mroczkowski, Olof Jannasch

“…The distribution of histopathological stage, anastomotic leakage, and in-hospital mortality did not change significantly. …”
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Comparison of Clinico-pathologic features and outcomes of ANCA negative and ANCA positive pauci immune crescentic glomerulonephritis: A single centre study by Pallav Gupta, Vinant Bhargava, Manish Malik, Anurag Gupta, Anil K. Bhalla, Ashwini Gupta, Vaibhav Tiwari, Devinder S. Rana, Ramesh L. Sapra

“…The present study compared clinico-pathologic features, Brix’s renal risk score, Berden’s histopathological classes and differences in outcome between ANCAnegative vs ANCA positive PICN patients. …”
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AI predicting recurrence in non-muscle-invasive bladder cancer: systematic review with study strengths and weaknesses by Saram Abbas, Rishad Shafik, Naeem Soomro, Rakesh Heer, Rakesh Heer, Kabita Adhikari

“…., radiomics, clinical, histopathological, genomic) and types of ML models, such as neural networks, deep learning, and random forests. …”
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Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways by Amany Abdlrehim Bekhit, Olivia N. Beshay, Michael A. Fawzy, Sara Mohamed Naguib Abdel-Hafez, Gaber El-Saber Batiha, Farid S. Ataya, Moustafa Fathy

“…Assessment of reactive oxygen species, malondialdehyde, and glutathione contents, and superoxide dismutase activity and histopathological evaluations were done on hepatic tissue. …”
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Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression by Mingyan Chen, Yanfang Zhang, Yangbo Zhao, Kewei Cao, Ruiyan Niu, Dongguang Guo, Zilong Sun

“…Our findings revealed significant damage to the thymus and spleen that was proportional to the dose administered, as evidenced by changes in organ indices and histopathological abnormalities. We observed mitochondrial swelling, chromatin condensation, and nuclear structure disruptions in these organs. …”
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Prevalence and clinicopathological Spectrum of Auto-Immune Liver Diseases & Overlap syndrome by Annapoorani Varadarajan, Archana Rastogi, Rakhi Maiwall, Chhagan Bihari, Sherin Thomas, Vikrant Sood, Saggere Muralikrishna Shasthry

“…Two pathologists independently reviewed the liver biopsies and reassessed 18 histopathological parameters. Results: During the study period, 17664 liver biopsies were received, out of which 1060 (6%) biopsies of AILD were identified. …”
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Computed tomography–guided percutaneous transthoracic core needle biopsy for the diagnosis of mediastinal masses by Sukanta Kodali, Sourindra Nath Banerjee, Jaydip Deb, Pulak Kumar Jana

“…Mediastinal masses encompass a wide spectrum of diseases; therefore, histopathological diagnosis is crucial for adequate surgical or medical treatments. …”
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Varying pixel resolution significantly improves deep learning-based carotid plaque histology segmentation by Yurim Lee, Rashid Al Mukaddim, Tenzin Ngawang, Shahriar Salamat, Carol C. Mitchell, Jenna Maybock, Stephanie M. Wilbrand, Robert J. Dempsey, Tomy Varghese

“…Automating and digitizing histopathological images of these plaques into tissue specific (lipid and calcified) regions can help us compare histologic findings to in vivo imaging and thereby enable us to optimize medical treatments or interventions for patients based on the composition of plaques. …”
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Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors. by Lee E Moore, Michael L Nickerson, Paul Brennan, Jorge R Toro, Erich Jaeger, Jessica Rinsky, Summer S Han, David Zaridze, Vsevolod Matveev, Vladimir Janout, Hellena Kollarova, Vladimir Bencko, Marie Navratilova, Neonilia Szeszenia-Dabrowska, Dana Mates, Laura S Schmidt, Petra Lenz, Sara Karami, W Marston Linehan, Maria Merino, Stephen Chanock, Paolo Boffetta, Wong-Ho Chow, Frederic M Waldman, Nathaniel Rothman

“…Alteration prevalence did not differ by histopathologic characteristics or occupational exposure to trichloroethylene. ccRCC cases with particular VHL germline polymorphisms were more likely to have VHL inactivation through promoter hypermethylation than through sequence alterations in tumor DNA, suggesting that the presence of these SNPs may represent an example of facilitated epigenetic variation (an inherited propensity towards epigenetic variation) in renal tissue. …”
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Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model by Yazhen Xie, Haifeng Xu, Zhijuan Gu

“…The expression levels of oestrogen receptor alpha (ERα) and cyclooxygenase-2 (COX-2) in uterine tissue were measured using immunohistochemical assays, and those of phosphorylated and total extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) were assessed using western blot analysis.Results Treatment with GGD significantly reduced writhing behaviour, histopathological scores, and levels of COX-2, PGE2, and PGF2α in the serum of PD rats. …”
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Unraveling the Beneficial Role of Resveratrol in Fructose-Induced Non-Alcoholic Steatohepatitis with a Focus on the AMPK/Nrf2 Signaling Axis by Soha S. Zakaria, Safaa M. Hanafy

“…<i>Results</i>: Resveratrol effectively alleviated the biochemical and histopathological abnormalities associated with NASH, improving autophagy by raising Beclin 1 levels while reducing inflammation by decreasing IL-6 levels. …”
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Ovario- protective effect of Moringa oleifera leaf extract against cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats by Seham Samir Soliman, Ahmed A. Suliman, Khaled Fathy, Ahmed A. Sedik

“…Moreover, detailed histopathological and ultra- structural observations were conducted. …”
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