From Isolation to Application: Utilising Phage‐Antibiotic Synergy in Murine Bacteremia Model to Combat Multidrug‐Resistant Enterococcus faecalis by Fatma Al‐zahraa A. Yehia, Galal Yahya, Eslam M. Elsayed, Javier Serrania, Anke Becker, Salwa E. Gomaa

“…In a mouse bacteremia model, phage‐antibiotic combinations significantly reduced E. faecalis liver burden compared to monotherapies. Histopathological analysis confirmed therapeutic synergy, showing reduced inflammation and improved hepatocyte regeneration. …”
Get full text

Pathological and Molecular Characterization of Grass Carp Co-Infected with Two <i>Aeromonas</i> Species by Wenyao Lv, Zhijie Zhou, Lingli Xie, Xinyue Wang, Yifei Zhou, Lang Gui, Xiaoyan Xu, Yubang Shen, Jiale Li, Junqiang Qiu

“…Quantitative analysis demonstrated significantly elevated bacterial loads in hepatic tissue at 3 days post-infection (dpi). Histopathological evaluation revealed severe hepatic lesions characterized by cellular necrosis, cytoplasmic vacuolization, and hemorrhagic manifestations. …”
Get full text

Metabolomics reveal the mechanism for anti-renal fibrosis effects of an n-butanol extract from Amygdalus mongolica by Gao Chen, Chang Hong, Zhou Hong-Bing, Liu Qing, Bai Ying-Chun, Liu Quan-Li, Bai Wan-Fu, Shi Song-Li

“…Related biochemical indices in rat serum were determined and histopathological morphology observed. Serum metabolomics was assessed with HPLC-Q-TOF-MS. …”
Get full text

Deubiquitinase Ubp5 is essential for pulmonary immune evasion and hematogenous dissemination of Cryptococcus neoformans by Guizhen Wang, Yan Liu, Qianyu Li, Changhui Wang, Wei Fang

“…Attenuated virulence is closely associated with enhanced host immune responses, rather than diminished pathogen fitness alone. Histopathological and leukocyte analyses revealed a shift towards protective adaptive immune responses in ubp5Δ-infected lungs, characterized by lymphocyte-dominated inflammatory infiltration and an increased Th1/Th17 cytokine response. …”
Get full text

Anti-Inflammatory Effects of Artemisia Leaf Extract in Mice with Contact Dermatitis In Vitro and In Vivo by Chanyong Yun, Youngchul Jung, Wonjoo Chun, Beodeul Yang, Junghyun Ryu, Chiyeon Lim, Jung-Hoon Kim, Hyungwoo Kim, Su-In Cho

“…The effects of ALE on histopathological changes and cytokine production in ear tissues were assessed in mice with CD induced by 1-fluoro-2,4-dinitrobenzene (DNFB). …”
Get full text

Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice by Tomoko Kawakami, Nitin Puri, Komal Sodhi, Lars Bellner, Toru Takahashi, Kiyoshi Morita, Rita Rezzani, Tim D. Oury, Nader G. Abraham

“…EC-SOD(−/−) mice exhibited oxidative stress, renal histopathological abnormalities, elevated blood pressure, impaired endothelial function, reduced p-eNOS, p-AKT and increased HO-1 expression; although, HO activity was significantly (P<0.05) attenuated along with attenuation of serum adiponectin and vascular epoxide levels (P<0.05). …”
Get full text

Interleukin-32γ in the Control of Acute Experimental Chagas Disease by Yarlla L. L. Braga, José R. C. Neto, Arthur W. F. Costa, Muriel V. T. Silva, Marcos V. Silva, Mara R. N. Celes, Milton A. P. Oliveira, Leo A. B. Joosten, Fátima Ribeiro-Dias, Rodrigo S. Gomes, Juliana R. Machado

“…For this, C57BL/6 wild-type (WT) and IL-32γTg mice were infected subcutaneously with 1,000 forms of Colombian strain of T. cruzi. In the histopathological analyzes, T. cruzi nests, myocarditis, and collagen were quantified in cardiac tissue. …”
Get full text

Wound healing potential of green synthesized silver nanoparticles of Glycyrrhiza glabra linn root extract: A preclinical study by Laxman S. Vijapur, Mallappa Shalavadi, Anita R. Desai, Jayadev N. Hiremath, Avinash S. Gudigennavar, Somlingesh L. Shidramshettar, Shreyanka R. Hiremath, Malleswara Rao Peram, Bharatesh S. Kittur

“…The study's formulation of synthesized silver nanoparticles demonstrated significant wound healing potential by promoting wound contraction and accelerating healing after 21 days of study, which was demonstrated by histopathological evaluation and complete epithelialization with regenerated hair follicles and higher collagen tissue. …”
Get full text

Desmoplastic Small Round Cell Tumor of Stomach by Ahmed Abu-Zaid, Ayman Azzam, Asma AlNajjar, Hussa Al-Hussaini, Tarek Amin

“…Patient underwent total gastrectomy with D2 lymphadenectomy, splenectomy, and antecolic Roux-en-Y esophagojejunal anastomosis. Histopathological examination revealed coexpression of mesenchymal, epithelial, and neural markers. …”
Get full text

Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis by Gamal Shiha, Ahmed Nabil, Ahmed Lotfy, Reham Soliman, Ayman A. Hassan, Islam S. Ali, Doaa F. Gad, Faten Zahran

“…Liver fibrosis and also antifibrotic efficacy of the treatments were estimated with liver function tests, oxidative stress parameters, apoptotic parameters, histopathological examination, and hydroxyproline contents. …”
Get full text

Induced hepatocyte-like cells derived from adipose-derived stem cells alleviates liver injury in mice infected with Echinococcus Multilocularis by Hui Liu, Xiaojuan Bi, Ning Yang, Xue Zhang, Bingbing Fang, Nuerbaiti Kusuman, Wenmei Ma, Jing Li, Jin Chu, Li Sun, Liang Li, Guodong Lü, Renyong Lin

“…The expression of hepatocyte lineage markers was assessed and iHEPs function was evaluated by Periodic acid-Schiff staining. iHEPs were intravenously transplanted into mice infected with Echinococcus multilocularis. Histopathological analysis and liver function tests were used to assess therapeutic effects. …”
Get full text

Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease by Abhishek A. Revankar, Archana S. Patil, Reshma Karishetti, Krutuja R. Chougule, Priyanka Patil, Abhijit Salokhe

“…In vivo evaluations conducted using the haloperidol-induced PD model revealed significant enhancements in behavioural, biochemical, and histopathological outcomes when compared to both disease controls and the standard treatment group. …”
Get full text

Puerarin pretreatment provides protection against myocardial ischemia/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1 by Yong Yuan, Songqing Lai, Tie Hu, Fajia Hu, Chenchao Zou, Xiuqi Wang, Ming Fang, Jichun Liu, Huang Huang

“…Additionally, Pue significantly alleviated histopathological damage in MIRI-treated myocardium, as evidenced by HE staining and TUNEL assay. …”
Get full text

Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue: Implications for Radiation Proctitis by G. Karamanolis, I. Delladetsima, V. Kouloulias, K. Papaxoinis, I. Panayiotides, D. Haldeopoulos, K. Triantafyllou, N. Kelekis, S. D. Ladas

“…MVD increased significantly only 6 months after radiotherapy (7.3±3.2 versus 10.5±3.1, P<0.005). The histopathological examination revealed inflammatory changes at the completion of radiotherapy regressing in the majority of cases 6 months after. …”
Get full text

Isolation of a Novel Caprine <i>Eimeria christenseni</i> Strain (GC) in Canary Islands and Analysis of Parasitological, Clinical, and Pathological Findings on Experimentally Infect... by Emilio Barba, José Manuel Molina, Francisco Rodríguez, Otilia Ferrer, María Carmen Muñoz, Liliana M. R. Silva, María Cristina Del Río, José Adrián Molina, Anja Taubert, Carlos Hermosilla, Antonio Ruiz

“…Oocyst shedding, clinical signs, and production parameters, in addition to haematological and histopathological features, were monitored. The results showed that the Gran Canaria (GC) <i>E. christenseni</i> strain had similar morphological and biological characteristics to those previously described, but no significant clinical signs were observed despite the high oocyst counts here recorded. …”
Get full text

Antituberculosis Drugs (Rifampicin and Isoniazid) Induce Liver Injury by Regulating NLRP3 Inflammasomes by Qiang Su, Wei Kuang, Weiyi Hao, Jing Liang, Liang Wu, Chunmei Tang, Yali Wang, Tao Liu

“…In this study, rats and hepatic cells were administrated isoniazid (INH) and rifampin (RIF) and then treated with NLRP3-inflammasome inhibitors (INF39 and CP-456773) or NLRP3 siRNA. Histopathological changes that occurred in liver tissue were examined by H&E staining. …”
Get full text

Integrated multi-omics analysis reveals the underlying molecular mechanism for the neurotoxicity of triclosan in zebrafish by Shasha Zhao, Yuhang Ling, Baohua Zhang, Danting Wang, Limei Sun

“…Our results show that TCS exposure significantly induces behavioral disruptions such as anxiety-like behavior, memory problems, and altered social preferences. Histopathological investigations and neural ultrastructural observations demonstrated that TCS could induce variable levels of pyknosis and vacuolation in the cytoplasm of neurons as well as torn mitochondrial membranes, shrinkage and broken or absent cristae. …”
Get full text

Can CT Image Reconstruction Parameters Impact the Predictive Value of Radiomics Features in Grading Pancreatic Neuroendocrine Neoplasms? by Florent Tixier, Felipe Lopez-Ramirez, Alejandra Blanco, Mohammad Yasrab, Ammar A. Javed, Linda C. Chu, Elliot K. Fishman, Satomi Kawamoto

“…However, variations in reconstruction parameters can impact the predictive value of radiomics. 127 patients with histopathologically confirmed PanNENs underwent CT scans with filtered back projection (B20f) and iterative (I26f) reconstruction kernels. 3190 radiomic features were extracted from tumors and pancreatic volumes. …”
Get full text

The influence of different crosslinking agents onto the physical properties, integration behavior and immune response of collagen-based barrier membranes by Yanru Ren, Said Alkildani, Kim Burckhardt, Alexander Köwitsch, Milena Radenkovic, Sanja Stojanovic, Sanja Stojanovic, Stevo Najman, Stevo Najman, Ole Jung, Luo Liu, Mike Barbeck, Mike Barbeck

“…Concurrent with membrane collapse, transmembrane vascularization occurred across all groups. Histopathological and histomorphometry results reveal the intricate interplay of inflammatory cell populations in vascularization. …”
Get full text

Tumor organoids in cancer medicine: from model systems to natural compound screening by Rong Cong, Can Lu, Xinying Li, Zhijie Xu, Yaqin Wang, Shusen Sun

“…These self-assembled 3D cell clusters closely replicate the histopathological, genetic, and phenotypic characteristics of primary tissues, making them invaluable tools in cancer research and drug screening.Objective This review addresses the challenges in developing in vitro models that accurately reflect tumor heterogeneity and explores the application of tumor organoids in cancer research, with a specific focus on the screening of natural products for antitumor therapies.Methods This review synthesizes information from major databases, including Chemical Abstracts, Medicinal and Aromatic Plants Abstracts, ScienceDirect, Google Scholar, Scopus, PubMed and Springer Link. …”
Get full text