Immunomodulatory Properties of HLA-G in Infectious Diseases by Laurence Amiot, Nicolas Vu, Michel Samson

“…HLA-G is a nonclassical major histocompatibility complex molecule first described at the maternal-fetal interface, on extravillous cytotrophoblasts. …”
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FABP6 Expression Correlates with Immune Infiltration and Immunogenicity in Colorectal Cancer Cells by Wenping Lian, Zhongquan Wang, Yajie Ma, Yalin Tong, Xinyu Zhang, Huifang Jin, Shuai Zhao, Ruijing Yu, Shaotan Ju, Xinyun Zhang, Xiaona Guo, Tao Huang, Xianfei Ding, Mengle Peng

“…FABP6 was negatively correlated with immune infiltration, and knockdown of FABP6 increased major histocompatibility complex (MHC) class 1 expression and promoted immune-related chemokine secretion, indicating the immunogenicity enhancement of tumor cells. …”
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Gut Mesenchymal Stromal Cells in Immunity by Valeria Messina, Carla Buccione, Giulia Marotta, Giovanna Ziccheddu, Michele Signore, Gianfranco Mattia, Rossella Puglisi, Benedetto Sacchetti, Livia Biancone, Mauro Valtieri

“…In Crohn’s disease, intestinal MSCs are tightly stacked in a chronic inflammatory milieu, which causes their enforced expression of Class II major histocompatibility complex (MHC). The absence of Class II MHC is a hallmark for immune-modulator and tolerogenic properties of normal MSCs and, vice versa, the expression of HLA-DR is peculiar to antigen presenting cells, that is, immune-activator cells. …”
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The Missing Heritability in T1D and Potential New Targets for Prevention by Brian G. Pierce, Ryan Eberwine, Janelle A. Noble, Michael Habib, Hennady P. Shulha, Zhiping Weng, Elizabeth P. Blankenhorn, John P. Mordes

“…It is strongly associated with susceptibility haplotypes within the major histocompatibility complex, but this association accounts for an estimated 50% of susceptibility. …”
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Citrullinated Autoantigen–Specific T and B Lymphocytes in Rheumatoid Arthritis: Focus on Follicular T Helper Cells and Expansion by Coculture by Tim Ammon, Julia Zeiträg, Vanessa Mayr, Manuela Benedicic, Hans‐Peter Holthoff, Martin Ungerer

“…Novel combinations of major histocompatibility complex class II citrulline epitope tetramers were developed, which enabled robust detection of CAS T cells and showed increases of CAS‐naive T helper cells, Th1.17 cells, CAS total circulating T follicular helper (cTfh) cells, and cTfh1 cells in ACPA+ patients with RA. …”
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Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA by Rayan Najjar, Xiaoxing Wang, Jose Mario Bello Pineda, Hugh Alessi, Alison Bays, Robert K. Bradley, James N. Jarvis, Tomas Mustelin

“…Peptides derived from these novel amino acid sequences were predicted to bind to the individual patients’ class I and II major histocompatibility complex molecules with high affinity. …”
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Unlocking the secrets of the immunopeptidome: MHC molecules, ncRNA peptides, and vesicles in immune response by Arpita Balakrishnan, Arpita Balakrishnan, Gabriela Winiarek, Olga Hołówka, Jakub Godlewski, Agnieszka Bronisz

“…The immunopeptidome, a diverse set of peptides presented by Major Histocompatibility Complex (MHC) molecules, is a critical component of immune recognition and response. …”
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Exploitation of Unconventional CD8 T-Cell Responses Induced by Engineered Cytomegaloviruses for the Development of an HIV-1 Vaccine by Joseph Bruton, Tomáš Hanke

“…Rhesus macaques vaccinated with molecular clone 68-1 of RhCMV (RhCMV68-1) engineered to express simian immunodeficiency virus (SIV) immunogens elicited an unconventional major histocompatibility complex class Ib allele E (MHC-E)-restricted CD8⁺ T-cell response, which consistently protected over half of the animals against a highly pathogenic SIV challenge. …”
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Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus by Lucrezia Furian, Uwe Heemann, Mats Bengtsson, Oriol Bestard, Isabelle Binet, Georg A. Böhmig, John Boletis, David Briggs, Frans H. J. Claas, Lionel Couzi, Emanuele Cozzi, Marta Crespo, Aiko P. J. De Vries, Fritz Diekmann, Magdalena Durlik, Denis Glotz, Ilkka Helantera, Annette Jackson, Stanley C. Jordan, Dirk Kuypers, Dirk Kuypers, Carmen Lefaucheur, Christophe Legendre, Tomas Lorant, Umberto Maggiore, Nizam Mamode, Smaragdi Marinaki, Annick Massart, Thomas Müller, Rainer Oberbauer, Lutz Renders, Dave Roelen, Jean-Luc Taupin, Ondřej Viklický, Angeliki Vittoraki, Annelies E. de Weerd, Maarten Naesens

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Characterization of Urine-Derived Stromal/Stem Cells from Healthy Dogs and Dogs Affected by Chronic Kidney Disease (CKD) by Anna Lange-Consiglio, Filippo Tagliasacchi, Fausto Cremonesi, Claudia Gusmara, Claudia Pollera, Paola Scarpa, Giulia Gaspari, Pietro Riccaboni

“…Cells were able to differentiate into osteogenic, chondrogenic, and adipogenic lines, showed positive expression to mesenchymal/stem markers, negative expression to hematopoietic markers, and major histocompatibility complex (MHCII) antigen. Klotho protein expression was confirmed. …”
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A novel tissue culture method to produce professional antigen-presenting cells from rainbow trout in vitro by Nguyen T. K. Vo, PhD, Lital Sever, PhD, Brian Dixon, PhD, Niels C. Bols, PhD

“…The RT-PCR result showed that the fin-LLCs expressed abundant transcript levels of four markers of pAPCs (Major Histocompatibility (MH) IIα, MH IIβ, S25–7, INXV), three transcript markers of DCs (CD83, CD205, CD209), one transcript marker for macrophages (CSF1R), and one transcript marker for pro-inflammatory responses (IL-1β). …”
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Different MHC class I cell surface expression levels in diverse chicken lines, associations with B blood group, and proposed relationship to antigen-binding repertoire by Michael Kaiser, Jim Kaufman, Susan J. Lamont

“…The Major Histocompatibility Complex (MHC) is a cluster of genes with primarily immune-related functions. …”
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Corporate genome screening India (CoGsI) identified genetic variants association with T2D in young Indian professionals by Shah Fahad Husami, Tavleen Kaur, Love Gupta, Garima Rastogi, Lakhvinder Singh, Pooja Meena, Indu Sharma, Hemender Singh, Varun Sharma

“…Out of 42, three missense variants (rs1402467, rs6050, and rs713598) in Sulfotransferase family 1 C member 4 (SULT1C4), Fibrinogen Alpha Chain (FGA), and Taste 2 Receptor Member 38 (TAS2R38) and two untranslated region (UTR) variants (rs1063320 and rs6296) in Major Histocompatibility Complex, Class I, G (HLA-G) and 5-Hydroxytryptamine Receptor 1B (HTR1B) were associated with the T2D risk. …”
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Advancing risk stratification in kidney transplantation: integrating HLA-derived T-cell epitope and B-cell epitope matching algorithms for enhanced predictive accuracy of HLA compa... by Matthias Niemann, Matthias Niemann, Benedict M. Matern, Benedict M. Matern, Gaurav Gupta, Bekir Tanriover, Fabian Halleck, Klemens Budde, Eric Spierings, Eric Spierings

“…We have statistically evaluated their co-dependency and synergistic effects between models systematically on 400,935 kidney transplantations using Cox proportional hazards and XGBoost models.ResultsMultivariable models of histocompatibility generally outperformed univariable predictors, with a combined model of HLA-A, -B, -DR matching, Snow and PIRCHE-II yielding highest AUC in XGBoost and lowest BIC in Cox models. …”
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Timosin alpha-1 immunomodulating properties by M. V. Mayevskaya

“…Direct antiviral mechanism of Timosin alpha-1 consists in increase of expression of major histocompatibility complex molecules of the 1st class on infected cells and direct suppression of virus replication, and also in elevation of endocellular level of glutathione. …”
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Investigation of intracellular signals generated by γ-interferon and IL-4 leading to the induction of class II antigen expression by S. Vassiliadis, N. Kyrpides, D. Stravopodis, M. Grigoriou, I. Athanassakis, J. Papamatheakis

“…This diversity of activation reveals the existence of a previously unknown complicated network of intracellular interactions able to regulate the same phenotype or cellular event. As major histocompatibility complex antigens (MHC) or human leukocyte antigens (HLA), are important in immune recognition and response, the results show that for human cells a more coherent method of HLA-DR antigen induction is followed after γ-IFN administration, as calcium participation seems to be the first step in signal transduction. …”
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Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma by Haihua Wang, Songqing Fan, Yuting Zhan, Yue Xu, Yao Du, Jiadi Luo, Hongjing Zang, Shuping Peng, Weiyuan Wang

“…The overexpression of EGFR has been linked to its potential role in modulating major histocompatibility complex class I (MHC-I) molecules. We discovered that EGFR, operating in a kinase-independent manner, played a role in stabilizing the expression of SLC7A11, which subsequently inhibited MHC-I antigen presentation. …”
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Advances in growth factor-containing 3D printed scaffolds in orthopedics by Longwen Zhan, Yigui Zhou, Ruitang Liu, Ruilong Sun, Yunfei Li, Yongzheng Tian, Bo Fan

“…More importantly, it can provide an alternative to traditional bone grafting and solve the problems of insufficient autologous bone grafting, poor histocompatibility of grafts, and insufficient induced bone regeneration. …”
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Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics by Lihe Jiang, Lihe Jiang, Lihe Jiang, Peili Wang, Peili Wang, Yixuan Hou, Jingying Chen, Hua Li, Hua Li

“…Identifying robust genetic regulators in this context is imperative.MethodsThis study elucidates IFI30's role in enhancing Major Histocompatibility Complex II (MHC-II) restriction antigen processing. …”
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Significance of immune factors in Crohn's disease development by D. S. Stavtsev, T. A. Astrelina, O. V. Knyazev, T. V. Pukhlikova

“…Series of the population studies, confirming association of HLA antigens with human diseases were carried out. Main histocompatibility complex (MHC) plays the leading role in immune response as well as in development of CD, therefore occurrence of disease is related to changes at genetic level. …”
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