Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment by Yaling Dai, Yuhao Zhang, Minguang Yang, Huawei Lin, Yulu Liu, Wenshan Xu, Yanyi Ding, Jing Tao, Weilin Liu

“…In addition, the protein expression and phosphorylation levels of N-methyl-D-aspartate receptor 2B, α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor 1, and Ca2+-calmodulin-dependent protein kinase II increased to varying degrees in the hippocampus of VCI model rats. Conclusion. EA at GV20 and GV24 acupoints increased the basic synaptic transmission efficiency and synaptic plasticity of the hippocampal CA3–CA1 circuit, thereby improving learning and memory ability in rats with VCI.…”
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Multi-organ frailty is enhanced by periodontitis-induced inflammaging by Yoshitaka Kase, Satoru Morikawa, Yuji Okano, Tatsuya Hosoi, Takazumi Yasui, Yoko Taki-Miyashita, Mitsutaka Yakabe, Maraku Goto, Kazuyuki Ishihara, Sumito Ogawa, Taneaki Nakagawa, Hideyuki Okano

“…Cognitive function assessment revealed increased activated microglia and decreased adult neurogenesis in the hippocampus, impairing spatial learning. Thus, periodontitis induced both physical and cognitive frailties. …”
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Time-lapse imaging of identified granule cells in the mouse dentate gyrus after entorhinal lesion in vitro reveals heterogeneous cellular responses to denervation by Davide Greco, Alexander Drakew, Nina Rößler, Nina Rößler, Tassilo Jungenitz, Peter Jedlicka, Peter Jedlicka, Thomas Deller

“…The effects of denervation on neurons can be readily studied in vitro using organotypic slice cultures of entorhinal cortex and hippocampus. Following transection of the entorhino-dentate projection, granule cells (GCs) are denervated and show on average a transient loss of spines on their denervated distal dendrites but not on their non-denervated proximal dendrites. …”
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Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats by Nian Yu, Qing Di, Hao Liu, Yong Hu, Ying Jiang, Yu-kui Yan, Yan-fang Zhang, Ying-dong Zhang

“…Furthermore, PDTC pre-treatment significantly decreased P-gp expression along with NF-κB activation in the hippocampus CA3 area and amygdala complex of rats compared with the EP group, implying that NF-κB activation involved in the seizure susceptibility and seizure induced brain P-gp over-expression. …”
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Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice by Mengjie He, Mengying Hu, Tingqiao Wang, Zeping Zuo, Hongkai Li, Zhiwei Zhao, Yunwen Hao, Xueling Dai, Jianfang Wang, Yaxuan Sun

“…The aim of this study was to investigate the potential effects of Morinda officinalis oligosaccharides (MOO) on depression and its concomitant symptom, sexual dysfunction.MethodsChronic unpredictable mild stress (CUMS)-induced depression model was constructed, and the effects of MOO on depression and sexual abilities were evaluated.ResultsThe results revealed that MOO was able to alleviate CUMS-induced depression-like behavior in mice, to inhibit hippocampal neuron apoptosis, to reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus, to modulate the composition and distribution of gut microbiota, and to increase the abundance of probiotics after continuous gavage of MOO for 28 days. …”
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Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer’s Disease by A. Ahnaou, C. Walsh, N. V. Manyakov, S. A. Youssef, W. H. Drinkenburg

“…The present results demonstrate early dysfunctional hippocampal networks, despite no spreading tau pathology to the hippocampus and frontal cortex. The ability of the K18 seed in the brainstem LC to elicit such robust functional alterations in distant hippocampal structures in the absence of pathology challenges the classic view that tau pathology spread to an area is necessary to elicit functional impairments in that area.…”
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MicroRNA-33 regulates the synaptic plasticity-related gene ARC in temporal lobe epilepsy by Yuchen Xu, Lily Zhang, Yan Yan, Wenbiao Xiao, Wei Zou, Zhaohui Luo, Bo Xiao, Hongyu Long

“…This study aimed to elucidate the expression patterns of miR-33 and ARC in both a rat model of temporal lobe epilepsy (TLE) and human TLE patients, to explore the role of miR-33 in epilepsy onset through its regulation of ARC expression in the hippocampus. Our findings, supported by a Dual-Luciferase reporter assay, suggest that miR-33 can bind to the 3′ UTR region of ARC. …”
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Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice by Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas, Sukonthar Ngampramuan, Saovaros Svasti, Pornthip Chaichompoo

“…This study investigated the effects of heavy iron overload on the blood-brain barrier and neurohistology, particularly in the CA3 region of hippocampus and its contribution to cognitive impairment in β-thalassaemia mice. …”
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Antiamnesic and Neurotrophic Effects of Parkia biglobosa (Jacq.) R. Br (Fabaceae) Aqueous Extract on In Vivo and In Vitro Models of Excitotoxicity by Antoine Kavaye Kandeda, Liliane Yimta Foutse, Corneille Tongoue, Jean Philippe Djientcheu, Théophile Dimo

“…Animals were then euthanized, and biochemical analyses (neurotransmitters, oxidative status, and neuroinflammation) were performed in the prefrontal cortex, hippocampus, and serum. Histological analysis of these organs was also carried out. …”
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The role of olfactory transport in the penetration of manganese oxide nanoparticles from blood into the brain by A. V. Romashchenko, M. B. Sharapova, К. N. Morozova, E. V. Kiseleva, K. E. Kuper, D. V. Petrovskii

“…A comparative analysis of the results showed that the transport of Mn3O4-NPs from the nasal cavity to the brain is more efficient than their local permeation through BBB into CNS from the bloodstream, for example with the accumulation of Mn3O4NPs in the dentate gyrus of the hippocampus, and through the capture and transport of NPs from the blood by olfactory epithelium cells. …”
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Environmental Enrichment Induces Changes in Long-Term Memory for Social Transmission of Food Preference in Aged Mice through a Mechanism Associated with Epigenetic Processes by Simona Cintoli, Maria Cristina Cenni, Bruno Pinto, Silvia Morea, Alessandro Sale, Lamberto Maffei, Nicoletta Berardi

“…Declarative memories depend on the medial temporal lobe system, including the hippocampus, for their formation, but, over days to weeks, they become increasingly dependent on other brain regions such as the neocortex and in particular the prefrontal cortex (PFC), a process known as system consolidation. …”
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Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on Gender by Ayfer Dayi, Sinem Agilkaya, Seda Ozbal, Ferihan Cetin, Ilkay Aksu, Celal Gencoglu, Sultan Cingoz, Cetın Pekcetin, Kazim Tugyan, Berkant Muammer Kayatekin, Nazan Uysal

“…In conclusion, maternal exercise during pregnancy may regulate spatial plasticity in the hippocampus of the offspring by increasing the expression of leptin.…”
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miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure by Yuran Wang, Zeming Wang, Han Hao, Yuwei Zhao, Jian Wang, Weixuan Wang

“…We demonstrated that hypertension exacerbated Pb-induced neuroinflammation in the prefrontal cortex (PFC), hippocampus, and hypothalamus, as evidenced by increased levels of proinflammatory cytokines (IL-6 and TNF-α) and decreased levels of anti-inflammatory cytokines (CD206 and IL-10). …”
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The Comorbidity of Depression and Diabetes Is Involved in the Decidual Protein Induced by Progesterone 1 (Depp1) Dysfunction in the Medial Prefrontal Cortex by Chen Xu, Mengxing Liao, Shize Zhang, Yuang Chen, Xinyue Shulai, Guangji Wang, Jiye Aa

“…Depp1 levels were increased in the mPFC but not in other brain regions, such as the hippocampus or nucleus accumbens, according to Western blot and PCR assays. …”
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Harnessing silica nanoparticles grafted with ascorbic acid to alleviate oxidative stress and impaired brain activity in rats by Essia Hamdi, Slah Hidouri, Ana-Belén Muniz-Gonzalez, Marwa Kechnebbou, Salem Amara

“…Notably, malondialdehyde (MDA) levels, a marker of lipid peroxidation, were significantly reestablished in the frontal cortex and hippocampus following SiO2-NPs@AA. Overall, the study revealed that SiO2-NPs@AA corrected effectively nitric oxide (NO) and monoamine oxidase activities, which confirm their role to preserve neuronal function and mitigate neurotoxicity.…”
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Reorganization of gray matter networks in patients with Moyamoya disease by Huan Zhu, Peijiong Wang, Wenjie Li, Qihang Zhang, Chenyu Zhu, Tong Liu, Tao Yu, Xingju Liu, Qian Zhang, Jizong Zhao, Yan Zhang

“…Ischemic patients had lower BC in the right hippocampus compared to hemorrhagic patients, while hemorrhagic patients had decreased DC in the right triangular part of the inferior frontal gyrus compared to asymptomatic patients (P < 0.05, Bonferroni corrected). …”
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Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis by Xu B, Wang C, Zhu X, Zhu L, Han G, Cui C

“…Using MetaboAnalyst 5.0 and the KEGG database was used to depict the 12 key metabolic pathways.Results: Compared with the control group, the Corilagin induced 20, 9, 11, 7, 16, 19, 14, 15, and 16 differential metabolites in the intestine, lung, kidney, stomach, heart, liver, hippocampus, cerebral cortex, and serum, respectively. …”
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Evaluation of Comparative Efficacy of Ashwagandha (Withania somnifera) vs Brahmi (Bacopa monnieri Linn) on Stress Level and Quality of Sleep in the Subjects Experiencing Mental Str... by Mohnish Vijay Gokhale, Vaishali Kuchewar, Pankaj Yadav, Bhishmani Tarare

“…Sleep deprivation causes loss of sleep-dependent processes in the hippocampus and pyriform cortex, which are responsible for memory and perception. …”
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Combination Therapy with Platelet-Rich Plasma and Epidermal Neural Crest Stem Cells Increases Treatment Efficacy in Vascular Dementia by Somayeh Akbari, Masoud Haghani, Mojtaba Ghobadi, Etrat Hooshmandi, Afshin Borhani Haghighi, Mohammad Saied Salehi, Sareh Pandamooz, Negar Azarpira, Afsoon Afshari, Shahrbanoo Zabihi, Marzieh Nemati, Mahnaz Bayat

“…The mRNA expression levels of IGF-1, TGF-β1, PSD-95, and GSk-3β were measured in the rat hippocampus by quantitative reverse transcription polymerase chain reaction. …”
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Lactococcus lactis and Bifidobacterium bifidum alleviate postmenopausal symptoms by suppressing NF-κB signaling and microbiota dysbiosis by Yoon-Jung Shin, Xiaoyang Ma, Min-Kyung Joo, Ji-Su Baek, Dong-Hyun Kim

“…Oral administration of PL or PB decreased Gv-induced DC-like behavior and tumor necrosis factor (TNF)-α, IL-6, RANK, and/or RANKL expression in the vagina, bone, hypothalamus, hippocampus, and colon, while Gv-suppressed bone osteoprotegerin and brain serotonin and brain-derived neurotrophic factor (BDNF) levels increased. …”
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